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NMR in Medical News

New technique boosts protein NMR imaging speeds

Solid-state nuclear magnetic resonance, or SSNMR, is a valuable tool to image and analyze the chemical makeup of proteins and other biomolecules. But the imaging process is time-consuming and requires large amounts of costly isotope-labeled sample for study. Yoshitaka Ishii, associate professor...

Brain Imaging Study Confirms Cognizin(R) Citicoline Boosts Mental Function; to be Presented at International Society of Sports Nutrition Annual Conference

...sphorus Magnetic Resonance Spectroscopy, " was published in the Journal of nmr in BioMedicine (Vol 21, Issue 10, Dec 2008, 1066-1075). The citicoline u...oenergetics as measured by phosphorus magnetic resonance spectroscopy nmr in Biomedicine Volume 21, Issue 10, Date: December 2008, Pages: 1066-1075...

Researchers Uncover Why Turmeric Helps Heal

...wer, but it hasn't been known how curcumin works inside the body, explained researcher Ayyalusamy Ramamoorthy and colleagues. They used solid-state nmr spectroscopy to examine molecules of curcumin and found that they act like a "biochemical disciplinarian." The molecules insert themselves into cell m...

Saving Money While Protecting Your Health in Tough Economic Times

...ins Dr. Dall. This pre-diabetic condition makes it almost impossible to lose weight on a regular weight loss diet. Dr. Dall uses the findings of the nmr LipoProfile test ( www.lipoprofile.com ) to identify patients with lipoprotein markers that are common in people with metabolic syndrome and insulin r...

'Holy powder' ingredient makes membranes behave for better health

...iated with biological membranes, and he uses a technique called solid-state nmr spectroscopy to reveal atom-level details of these important molecules and ...said. His research group recently developed the two-dimensional solid-state nmr technique that they used to probe curcumin-membrane communication in this s...

ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #1080

...ation of analytes, possible degradants, or product for hard-to-make, or unavailable drug-synthesis compounds, and is ideal for producing compounds for nmr or mass spectrometry analysis or biological studies. ESA systems are easy to implement, easy to run, and easy to maintain - so scientists can spend t...

New Johns Hopkins imaging center to widen windows on the brain

...he Molecular Imaging Center in the Broadway Research Building, the Department of Radiology's PET Center, Radiology's MRI Service Center and its Animal nmr Service Center. Once high-quality images are generated, the core serves as a bridge to analysis in several ways. For one, it offers trainingboth i...

New Jersey-Based Biotech Start-Up Nexomics Biosciences Gets Off the Ground

...riety of services from bioinformatics, target profiling, gene cloning, recombinant protein expression, laboratory-scale fermentation, crystallization, nmr structural studies, X-ray crystallographic structural studies, and functional annotation. For more information about Nexomics Biosciences, visit www....

Robotic Device Could Help Stroke Patients

...ype of exercises, they can get better," said A. Aria Tzika, director of the nmr Surgical Laboratory at Massachusetts General Hospital and lead author of a ...f Health . SOURCES: A. Aria Tzika, Ph.D., director, nmr Surgical Laboratory at Massachusetts General Hospital and Shriners Burn Ins...

Robotic technology improves stroke rehabilitation

...own that the brain has the ability to regain function through rehabilitative exercises following a stroke," said A. Aria Tzika, Ph.D., director of the nmr Surgical Laboratory at Massachusetts General Hospital (MGH) and Shriners Burn Institute and assistant professor in the Department of Surgery at Harvar...
NMR in Medical Technology

Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)

RALEIGH, N.C., Dec. 13 /PRNewswire/ -- The most recent study from the landmark Framingham trial demonstrates the clinical significance of knowing the number of LDL particles (LDL-P) by NMR in the management of a patient's risk for heart disease. This longitudinal outcomes study shows that low ...

New Insight Into the Controls on a Go-To Enzyme

...ern of those X-rays. To overcome the crystallization bottleneck, a lengthy and unpredictable variable in X-ray crystallography, the investigators used nmr spectroscopy to tailor the perfect enzyme-inhibitor complex. Tudor Moldoveanu, Ph.D., a postdoctoral fellow in Green's laboratory, performed...

Ono Enters into a New Fragment-Based Drug Discovery Agreement with Evotec

...ease target. The platform integrates, among other things, protein X-ray crystallography, computational chemistry, structural biology, biochemical, and nmr based fragment screening in combination with its high-quality fragment libraries. In the collaboration it is combined with Evotec's expertise in medic...

Low-Density Cholesterol Subfractions: Not all LDL-C Particles are Created Equal

...abolic syndrome and coronary events. Each patient receives a color-coded graphical representation of their particle breakdown and subsequent risk. The nmr LipoProfile (LipoScience, Inc.) also measures LDL particle size and distribution, by nuclear magnetic resonance spectroscopy blood test. The LipoPro...
NMR in Medical Dictionary

Chest MRI

...RI Click Here. For More Information on Chest /Heart MRA Click Here ... Chest MRI (Magnetic Resonance Imaging - Chest , MRI of the Thorax, nmr - Chest , ... A chest MRI uses powerful magnets and radio waves to construct pictures of ... ...

Abdominal MRI

...e the related entries: Negative Oral Contrast Agents, Automatic ... Abdominal MRI (Magnetic Resonance Imaging - Abdomen, MRI of the Abdomen, nmr - Abdomen, Nuclear Magnetic Resonance - Abdomen) information center covers description, ... ...
NMR in Biological News

LDL particle measurement by NMR recognized by ADA, ACC

Raleigh, NC, March 28, 2008 - The American Diabetes Association (ADA) and the American College of Cardiology (ACC) issued a consensus statement today that states the measurement of LDL particle number by nuclear magnetic resonance (NMR) is one of the more accurate ways to evaluate cardiometabolic ...

Structural biology scores with protein snapshot

...gest membrane-spanning protein to date. Although nmr methods are routinely used to "take molecular pict...ofessor of Biochemistry, and colleagues report the nmr structure of the large bacterial protein diacylgly...ane spans). The group's ability to determine the nmr structure of DAGK suggests that similar methods ca...

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

...omic nuclei of a protein interact with an intense magnetic field. Since nmr spectroscopy works best with small proteins not large flexible molecules l...ique that allowed them to look at the protein from numerous angles with the nmr spectrometer, and subtract out the overlapping areas to form a more complet...

American Chemical Society Weekly PressPac -- April 15, 2009

...n works inside the body. Using a high-tech instrument termed solid-state nmr spectroscopy, the scientists discovered that molecules of curcumin act like...ining the Effects of Lipophillic Drugs on Membrane Structure by Solid-State nmr Spectroscopy the Case of the Antioxidant Curcumin" DOWNLOAD FULL TEXT A...

Protein structure determined in living cells

...d, and analyzed in single crystals or in solution. nmr spectroscopy detects signals from the nuclei of hy...the measurements relies on the method of "in-cell" nmr spectroscopy that was developed a few years ago by...nt time are required to measure a multidimensional nmr spectrum", says Peter Gntert. "Unfortunately, the ...

Inactivity of proteins behind longer shelf life when freezing

...ults in the protein being preserved in a state of minimum energy and biological activity comes to a stop," says researcher Heln Jansson at the Swedish nmr Centre, University of Gothenburg, Sweden. ...

Tracking poultry litter phosphorus: Threat of accumulation?

...arva Peninsula. Specifically, Hill and Cade-Menun measured changes in phosphorus forms along a spatial transect on two active poultry farms. Using 31P nmr and supporting analytical methods, they found that phytate concentration was high in manures (about 50% of total P) but was not retained in crop soils...

13 UCR faculty members recognized by American Association for the Advancement of Science

...ly friendly arthropod management programs." Cynthia K. Larive, a professor of chemistry and a UCR alumna: "For significant contributions in applying nmr diffusion measurements to characterize complex mixtures, polydisperse samples, and ligand-protein interactions." Carol J. Lovatt, a professor of pla...

American Association for the Advancement of Science honors four Iowa Staters

...ar Magnetic Resonance (NMR) program at the U.S. Department of Energy's Ames Laboratory. Schmidt-Rohr was honored for "using and developing solid-state nmr to answer important questions about diverse materials, including synthetic polymers, bone, soil and fuel cell membranes." Schmidt-Rohr's research pr...

New way of viewing cells could lead to easier routes for drug manufacture

...nology analyzes the magnetic properties of an atom's nucleus. While best known as medical diagnostic imaging technology, Weliky and colleagues view nmr as a powerful approach to analyzing biological molecules, including bacterial inclusion bodies. Because the inclusion body protein appeared to be pred...
NMR in Biological Technology

Bruker Introduces HyperQuant™, a Unique Bench-Top NMR Reader to Quantify Hyperpolarization

At the 2008 World Molecular Imaging Congress (for details, see www.wmicmeeting.org ), Bruker BioSpin introduces HyperQuant™, a bench-top NMR reader for precisely quantifying both the magnetic hyperpolarization as well as the thermal polarization of a sample. The HyperQuant applies time-dom...

New Dual Cold Probe From Varian, Inc. Increases Sensitivity and Reduces Analysis Times for 13C NMR Experiments

PALO ALTO, Calif., March 10 /PRNewswire-FirstCall/ -- Varian, Inc. (Nasdaq: VARI ) announced today its new XSens(TM) Dual Cold Probe. Designed for use with the Varian NMR System, the new probe is Varian's most sensitive probe for 13C detected NMR experiments. The XSens Probe offers producti...

Double Resonance Probe for Liquid State NMR Applications From Varian, Inc. Increases Productivity for Routine Analyses

PALO ALTO, Calif., March 10 /PRNewswire-FirstCall/ -- Varian, Inc. (NasdaqGS: VARI) announced the release of its new OneNMR(TM) Probe for double resonance NMR applications involving liquid-state samples. The OneNMR Probe product line incorporates proprietary Varian technologies that enable use...

First step to converting solar energy using 'artificial leaf'

.... They did this using a combination of solid state nmr and X-ray diffraction (see attachment). X-ray diff...nabled them to determine the overall structure and nmr allowed them to penetrate deeply into the molecule... article he showed how also with a combination of nmr and another technique, namely electron microscopy ...

Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria

...team then went a step further and used solid-state nmr spectroscopy -- a technique in which samples are s...formation about the molecules of interest. "The nmr data revealed to us that the individual chlorophyl...ed gross structural details and distances, and the nmr results allowed us to quantify these distances as ...

Transforming medical diagnosis with new scanning technology

...aid: "We have been able to increase sensitivity in nmr by over 1000 times so data that once took 90 days ...This development opens up the possibility of using nmr techniques to better understand the fundamental fu...use. Dr Tonio Gianotti, Director and International nmr Research and Development Co-ordinator for Bruker B...

Varian, Inc. Announces First Quarter 2009 Preliminary Results

... Results, Preliminary. Sales were below expectations in the first quarter primarily due to lower revenues from research products (in particular nmr and imaging systems). Despite order weakness late in the quarter, in particular for certain vacuum and analytical products, total company orders excee...

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

...that is characteristic of atherosclerosis. The RWTH Aachen University scientists characterized the structure of the PF4-RANTES interactions using nmr spectroscopy and then designed a series of peptides to disrupt those interactions. One such peptide, termed CKEY2, is comprised of sequences from the ...

New Dual Wavelength X-ray Diffractometer From Oxford Diffraction, Now a Part of Varian, Inc., Allows Increased Throughput for Challenging Single Crystal Analyses

...s of proteins and small molecules," said Martin O'Donoghue, Senior Vice President, Scientific Instruments, Varian, Inc. "This solution complements our nmr products, strengthening our strategy of giving our customers ease of use while gathering extremely detailed structural information on large numbers of...

LLNL researchers peer into water in carbon nanotubes

...nner than a human hair. The confined water exhibited very different properties from that of bulk water, and this allowed it to be distinguished in the nmr spectrum. Carbon nanotubes have long been touted for their superior thermal, mechanical and electrical properties, but recent work suggests they ca...
NMR in Biological Products

Varian NMR System from Varian, Inc.

Description: Engineered with new technology incorporating the sophisticated DirectDrive architecture and designed for unsurpassed flexibility, the new Varian NMR System is undeniably the most advanced spectrometer available today. The Varian NMR System features parallel controllers for each transmitter an...
Company:Varian, Inc.

Corning disposable NMR tube caps, 5mm from Sigma-Aldrich

Description: These are replacement caps for No. CLS6980 5mm PYREX NMR tubes. Proper method to remove caps is to slice them from the tube. Caps come in eight assorted/mixed colors. Packed in bags of 100....
Company:Sigma-Aldrich

Pyrex brand 5mm diameter NMR tubes from Sigma-Aldrich

Description: These precision 5mm diameter, 7 inch long PYREX NMR tubes are made from quality borosilicate glass for compatibility with ground joints, valves, and vacuum racks. They are designed for use on NMR spectrometers running from 300 to 500MHz. They have an O.D. of 4.97 + 0.000-0.013mm and an I.D. of 4.20...
Company:Sigma-Aldrich

EvoQuest Protein Production Services from Invitrogen

Description:...ry techniques to express, purify, and characterize proteins that match your needs: Structure/Function Studies, Activity Assays, X-ray Crystallography, nmr (metabolic labelling), Protein-protein interactions, High-Throughput Screening (HTS), in vivo studies (low endotoxin)...
Company:Invitrogen

HeavyPeptide Basic Kit from Thermo Scientific

Description:... For relative and/or absolute quantification with standard accuracy requirements using MS or nmr instruments...
Company:Thermo Scientific

Metabolic Profiler from Bruker Daltonics

Description:...er is an integrated platform for metabolism studies, and analysis of complex mixtures. It features an HPLC-microTOF ESI-TOF system, an optional Avance nmr spectrometer and integrated software for data acquisition, evaluation and statistical analysis for applications like: Assessment of the metabolic prof...
Company:Bruker Daltonics

ProteoSpin Micro CBED Kit from Norgen Biotek Corporation

Description:...nal elution performed with volatile or non-volatile buffers suitable for: Mass Spectrometry SDS-PAGE Isoelectric Focusing X-ray Crystallography nmr Spectroscopy...
Company:Norgen Biotek Corporation
NMR in Biological Definition

Biochemistry

...hemistry has advanced, especially since the mid- 20th century , with the development of new techniques such as chromatography , X-ray diffraction , nmr , radioisotopic labelling , electron microscopy and molecular dynamics simulations. These techniques allowed for the discovery and detailed analy...

Magnetic resonance imaging

... with radiation exposure. Scientists still use nmr when discussing non-medical devices operating on...o known as MRSI (MRS Imaging) and Volume Selective nmr Spectroscopy, is a technique which combines the sp...hemical information about that region, as would an nmr spectrum of that region. Functional MRI Fu...

Proteomics

...ics . This concerns the high-throughput determination of protein structures in three-dimensional space. Common methods are x-ray crystallography and nmr spectroscopy . Interaction proteomics . This concerns the investigation of protein interactions on the atomic, molecular and cellular levels P...

Structural biology

...e their structures generally involving measurements on vast numbers of identical molecules at the same time. These methods include crystallography , nmr , Electron Microscopy and circular dichroism . Most often researchers use them to study the static " native states " of macromolecules. But variati...

Tertiary structure

... conformation of a protein from its primary sequence . Conventionally, tertiary structures are deduced through crystallography or multidimensional nmr . The study of protein tertiary structure is known as structural biology . See also: primary structure -- secondary structure -- quaternary ...
NMR in Biological Dictionary

Structural biology

... Structural Biology Center is a 501 (c) (3) corporation incorporated ... nmr Structural Biology in Life Sciences in the Post-Genomic Era Infrastructure ... The nmr Structural Biology Facility at UConn Health Center provides a state-of-...

Phospholipid bilayer

...rs on patch-clamp pi... a reasonable model of a phospholipid bilayer , we have studied the system using ... Molecular Dynamics Simulations and H nmr Study of the GalCer/DPPG Lipid Bilayer ... Galactocerebroside- phospholipi d interactions in bilayer membranes ... measure phospholipid di...

Macromolecules

...re the only macromolecules that are not polymers. Lipids are ... Textbook Reference - Macromolecules : Giant Polymers, pp. 37-38 ... Shop for nmr of Macromolecules - Books at Shop.com. Following the enormous increase in the use of nuclear magnetic resonance to study the conformations and... ...
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