New technique boosts protein NMR imaging speeds
Solid-state nuclear magnetic resonance, or SSNMR, is a valuable tool to image and analyze the chemical makeup of proteins and other biomolecules. But the imaging process is time-consuming and requires large amounts of costly isotope-labeled sample for study.
Yoshitaka Ishii, associate professor...
Brain Imaging Study Confirms Cognizin(R) Citicoline Boosts Mental Function; to be Presented at International Society of Sports Nutrition Annual Conference
...sphorus Magnetic Resonance Spectroscopy, " was published in the Journal of nmr
in BioMedicine (Vol 21, Issue 10, Dec 2008, 1066-1075). The citicoline u...oenergetics as measured by phosphorus magnetic resonance spectroscopy
Volume 21, Issue 10, Date: December 2008, Pages: 1066-1075...
Researchers Uncover Why Turmeric Helps Heal
...wer, but it hasn't been known how curcumin works inside the body, explained researcher Ayyalusamy Ramamoorthy and colleagues.
They used solid-state nmr
spectroscopy to examine molecules of curcumin and found that they act like a "biochemical disciplinarian." The molecules insert themselves into cell m...
Saving Money While Protecting Your Health in Tough Economic Times
...ins Dr. Dall. This pre-diabetic condition makes it almost impossible to lose weight on a regular weight loss diet. Dr. Dall uses the findings of the nmr
LipoProfile test ( www.lipoprofile.com ) to identify patients with lipoprotein markers that are common in people with metabolic syndrome and insulin r...
'Holy powder' ingredient makes membranes behave for better health
...iated with biological membranes, and he uses a technique called solid-state nmr
spectroscopy to reveal atom-level details of these important molecules and ...said. His research group recently developed the two-dimensional solid-state nmr
technique that they used to probe curcumin-membrane communication in this s...
ESA to Launch Corona(R) ultra(TM) at Pittcon 2009: Booth #1080
...ation of analytes, possible degradants, or product for hard-to-make, or unavailable drug-synthesis compounds, and is ideal for producing compounds for nmr
or mass spectrometry analysis or biological studies. ESA systems are easy to implement, easy to run, and easy to maintain - so scientists can spend t...
New Johns Hopkins imaging center to widen windows on the brain
...he Molecular Imaging Center in the Broadway Research Building, the Department of Radiology's PET Center, Radiology's MRI Service Center and its Animal nmr
Once high-quality images are generated, the core serves as a bridge to analysis in several ways. For one, it offers trainingboth i...
New Jersey-Based Biotech Start-Up Nexomics Biosciences Gets Off the Ground
...riety of services from bioinformatics, target profiling, gene cloning, recombinant protein expression, laboratory-scale fermentation, crystallization, nmr
structural studies, X-ray crystallographic structural studies, and functional annotation. For more information about Nexomics Biosciences, visit www....
Robotic Device Could Help Stroke Patients
...ype of exercises, they can get better," said A. Aria Tzika, director of the nmr
Surgical Laboratory at Massachusetts General Hospital and lead author of a ...f Health .
SOURCES: A. Aria Tzika, Ph.D., director, nmr
Surgical Laboratory at Massachusetts General Hospital and Shriners Burn Ins...
Robotic technology improves stroke rehabilitation
...own that the brain has the ability to regain function through rehabilitative exercises following a stroke," said A. Aria Tzika, Ph.D., director of the nmr
Surgical Laboratory at Massachusetts General Hospital (MGH) and Shriners Burn Institute and assistant professor in the Department of Surgery at Harvar...
NMR in Medical Technology
Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
RALEIGH, N.C., Dec. 13 /PRNewswire/ -- The most recent study from the
landmark Framingham trial demonstrates the clinical significance of knowing
the number of LDL particles (LDL-P) by NMR
in the management of a patient's
risk for heart disease. This longitudinal outcomes study shows that low
New Insight Into the Controls on a Go-To Enzyme
...ern of those X-rays. To overcome the crystallization bottleneck, a lengthy and unpredictable variable in X-ray crystallography, the investigators used nmr
spectroscopy to tailor the perfect enzyme-inhibitor complex.
Tudor Moldoveanu, Ph.D., a postdoctoral fellow in Green's laboratory, performed...
Ono Enters into a New Fragment-Based Drug Discovery Agreement with Evotec
...ease target. The platform integrates, among
other things, protein X-ray crystallography, computational chemistry,
structural biology, biochemical, and nmr
based fragment screening in
combination with its high-quality fragment libraries. In the collaboration
it is combined with Evotec's expertise in medic...
Low-Density Cholesterol Subfractions: Not all LDL-C Particles are Created Equal
...abolic syndrome and coronary events. Each patient receives a color-coded graphical representation of their particle breakdown and subsequent risk. The nmr
LipoProfile (LipoScience, Inc.) also measures LDL particle size and distribution, by nuclear magnetic resonance spectroscopy blood test. The LipoPro...
NMR in Medical Dictionary
...RI Click Here. For More Information on Chest /Heart MRA Click Here ... Chest MRI (Magnetic Resonance Imaging - Chest , MRI of the Thorax, nmr
- Chest , ... A chest MRI uses powerful magnets and radio waves to construct pictures of ... ...
...e the related entries: Negative Oral Contrast Agents, Automatic ... Abdominal MRI (Magnetic Resonance Imaging - Abdomen, MRI of the Abdomen, nmr
- Abdomen, Nuclear Magnetic Resonance - Abdomen) information center covers description, ... ...
NMR in Biological News
LDL particle measurement by NMR recognized by ADA, ACC
Raleigh, NC, March 28, 2008 - The American Diabetes Association (ADA) and the American College of Cardiology (ACC) issued a consensus statement today that states the measurement of LDL particle number by nuclear magnetic resonance (NMR) is one of the more accurate ways to evaluate cardiometabolic ...
Structural biology scores with protein snapshot
...gest membrane-spanning protein to date.
methods are routinely used to "take molecular pict...ofessor of Biochemistry, and colleagues report the nmr
structure of the large bacterial protein diacylgly...ane spans).
The group's ability to determine the nmr
structure of DAGK suggests that similar methods ca...
'Disordered' amino acids may really be there to provide wiggle room for signaling protein
...omic nuclei of a protein interact with an intense magnetic field.
spectroscopy works best with small proteins not large flexible molecules l...ique that allowed them to look at the protein from numerous angles with the nmr
spectrometer, and subtract out the overlapping areas to form a more complet...
American Chemical Society Weekly PressPac -- April 15, 2009
...n works inside the body.
Using a high-tech instrument termed solid-state nmr
spectroscopy, the scientists discovered that molecules of curcumin act like...ining the Effects of Lipophillic Drugs on Membrane Structure by Solid-State nmr
Spectroscopy the Case of the Antioxidant Curcumin"
DOWNLOAD FULL TEXT A...
Protein structure determined in living cells
...d, and analyzed in single crystals or in solution. nmr
spectroscopy detects signals from the nuclei of hy...the measurements relies on the method of "in-cell" nmr
spectroscopy that was developed a few years ago by...nt time are required to measure a multidimensional nmr
spectrum", says Peter Gntert. "Unfortunately, the ...
Inactivity of proteins behind longer shelf life when freezing
...ults in the protein being preserved in a state of minimum energy and biological activity comes to a stop," says researcher Heln Jansson at the Swedish nmr
Centre, University of Gothenburg, Sweden.
Tracking poultry litter phosphorus: Threat of accumulation?
...arva Peninsula. Specifically, Hill and Cade-Menun measured changes in phosphorus forms along a spatial transect on two active poultry farms. Using 31P nmr
and supporting analytical methods, they found that phytate concentration was high in manures (about 50% of total P) but was not retained in crop soils...
13 UCR faculty members recognized by American Association for the Advancement of Science
...ly friendly arthropod management programs."
Cynthia K. Larive, a professor of chemistry and a UCR alumna: "For significant contributions in applying nmr
diffusion measurements to characterize complex mixtures, polydisperse samples, and ligand-protein interactions."
Carol J. Lovatt, a professor of pla...
American Association for the Advancement of Science honors four Iowa Staters
...ar Magnetic Resonance (NMR) program at the U.S. Department of Energy's Ames Laboratory. Schmidt-Rohr was honored for "using and developing solid-state nmr
to answer important questions about diverse materials, including synthetic polymers, bone, soil and fuel cell membranes."
Schmidt-Rohr's research pr...
New way of viewing cells could lead to easier routes for drug manufacture
...nology analyzes the magnetic properties of an atom's nucleus.
While best known as medical diagnostic imaging technology, Weliky and colleagues view nmr
as a powerful approach to analyzing biological molecules, including bacterial inclusion bodies. Because the inclusion body protein appeared to be pred...
NMR in Biological Technology
Bruker Introduces HyperQuant™, a Unique Bench-Top NMR Reader to Quantify Hyperpolarization
At the 2008 World Molecular Imaging Congress (for details, see www.wmicmeeting.org ), Bruker BioSpin introduces HyperQuant™, a bench-top NMR
reader for precisely quantifying both the magnetic hyperpolarization as well as the thermal polarization of a sample. The HyperQuant applies time-dom...
New Dual Cold Probe From Varian, Inc. Increases Sensitivity and Reduces Analysis Times for 13C NMR Experiments
PALO ALTO, Calif., March 10 /PRNewswire-FirstCall/ -- Varian, Inc.
(Nasdaq: VARI ) announced today its new XSens(TM) Dual Cold Probe. Designed
for use with the Varian NMR
System, the new probe is Varian's most
sensitive probe for 13C detected NMR
The XSens Probe offers producti...
Double Resonance Probe for Liquid State NMR Applications From Varian, Inc. Increases Productivity for Routine Analyses
PALO ALTO, Calif., March 10 /PRNewswire-FirstCall/ -- Varian, Inc.
(NasdaqGS: VARI) announced the release of its new OneNMR(TM) Probe for
double resonance NMR
applications involving liquid-state samples. The
OneNMR Probe product line incorporates proprietary Varian technologies that
First step to converting solar energy using 'artificial leaf'
.... They did this using a combination of solid state nmr
and X-ray diffraction (see attachment). X-ray diff...nabled them to determine the overall structure and nmr
allowed them to penetrate deeply into the molecule... article he showed how also with a combination of nmr
and another technique, namely electron microscopy ...
Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria
...team then went a step further and used solid-state nmr
spectroscopy -- a technique in which samples are s...formation about the molecules of interest.
data revealed to us that the individual chlorophyl...ed gross structural details and distances, and the nmr
results allowed us to quantify these distances as ...
Transforming medical diagnosis with new scanning technology
...aid: "We have been able to increase sensitivity in nmr
by over 1000 times so data that once took 90 days ...This development opens up the possibility of using nmr
techniques to better understand the fundamental fu...use. Dr Tonio Gianotti, Director and International nmr
Research and Development Co-ordinator for Bruker B...
Varian, Inc. Announces First Quarter 2009 Preliminary Results
Sales were below expectations in the first quarter primarily due to lower
revenues from research products (in particular nmr
and imaging systems).
Despite order weakness late in the quarter, in particular for certain vacuum
and analytical products, total company orders excee...
Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
...that is characteristic of atherosclerosis.
The RWTH Aachen University scientists characterized the structure of the PF4-RANTES interactions using nmr
spectroscopy and then designed a series of peptides to disrupt those interactions. One such peptide, termed CKEY2, is comprised of sequences from the ...
New Dual Wavelength X-ray Diffractometer From Oxford Diffraction, Now a Part of Varian, Inc., Allows Increased Throughput for Challenging Single Crystal Analyses
...s of proteins and small molecules," said Martin O'Donoghue, Senior
Vice President, Scientific Instruments, Varian, Inc. "This solution
complements our nmr
products, strengthening our strategy of giving our
customers ease of use while gathering extremely detailed structural
information on large numbers of...
LLNL researchers peer into water in carbon nanotubes
...nner than a human hair. The confined water exhibited very different properties from that of bulk water, and this allowed it to be distinguished in the nmr
Carbon nanotubes have long been touted for their superior thermal, mechanical and electrical properties, but recent work suggests they ca...
NMR in Biological Products
Varian NMR System from Varian, Inc.
Description: Engineered with new technology incorporating the sophisticated DirectDrive architecture and designed for unsurpassed flexibility, the new Varian NMR
System is undeniably the most advanced spectrometer available today.
The Varian NMR
System features parallel controllers for each transmitter an...
Corning disposable NMR tube caps, 5mm from Sigma-Aldrich
Description: These are replacement caps for No. CLS6980 5mm PYREX NMR
tubes. Proper method to remove caps is to slice them from the tube. Caps come in eight assorted/mixed colors. Packed in bags of 100....
Pyrex brand 5mm diameter NMR tubes from Sigma-Aldrich
Description: These precision 5mm diameter, 7 inch long PYREX NMR
tubes are made from quality borosilicate glass for compatibility with ground joints, valves, and vacuum racks. They are designed for use on NMR
spectrometers running from 300 to 500MHz. They have an O.D. of 4.97 + 0.000-0.013mm and an I.D. of 4.20...
EvoQuest Protein Production Services from Invitrogen
Description:...ry techniques to express, purify, and characterize proteins that match your needs: Structure/Function Studies, Activity Assays, X-ray Crystallography, nmr
(metabolic labelling), Protein-protein interactions, High-Throughput Screening (HTS), in vivo studies (low endotoxin)...
HeavyPeptide Basic Kit from Thermo Scientific
Description:... For relative and/or absolute quantification with standard accuracy requirements using MS or nmr
Metabolic Profiler from Bruker Daltonics
Description:...er is an integrated platform for metabolism studies, and analysis of complex mixtures. It features an HPLC-microTOF ESI-TOF system, an optional Avance nmr
spectrometer and integrated software for data acquisition, evaluation and statistical analysis for applications like:
Assessment of the metabolic prof...
ProteoSpin Micro CBED Kit from Norgen Biotek Corporation
Description:...nal elution performed with volatile or non-volatile buffers suitable for:
Company:Norgen Biotek Corporation
NMR in Biological Definition
...hemistry has advanced, especially since the mid- 20th century , with the development of new techniques such as chromatography , X-ray diffraction , nmr
, radioisotopic labelling , electron microscopy and molecular dynamics simulations. These techniques allowed for the discovery and detailed analy...
Magnetic resonance imaging
... with radiation exposure. Scientists still use nmr
when discussing non-medical devices operating on...o known as MRSI (MRS Imaging) and Volume Selective nmr
Spectroscopy, is a technique which combines the sp...hemical information about that region, as would an nmr
spectrum of that region.
...ics . This concerns the high-throughput determination of protein structures in three-dimensional space. Common methods are x-ray crystallography and nmr
Interaction proteomics . This concerns the investigation of protein interactions on the atomic, molecular and cellular levels
...e their structures generally involving measurements on vast numbers of identical molecules at the same time. These methods include crystallography , nmr
, Electron Microscopy and circular dichroism . Most often researchers use them to study the static " native states " of macromolecules. But variati...
... conformation of a protein from its primary sequence . Conventionally, tertiary structures are deduced through crystallography or multidimensional nmr
. The study of protein tertiary structure is known as structural biology .
See also: primary structure -- secondary structure -- quaternary ...
NMR in Biological Dictionary
... Structural Biology Center is a 501 (c) (3) corporation incorporated ... nmr
Structural Biology in Life Sciences in the Post-Genomic Era Infrastructure ... The nmr
Structural Biology Facility at UConn Health Center provides a state-of-...
...rs on patch-clamp pi... a reasonable model of a phospholipid bilayer , we have studied the system using ... Molecular Dynamics Simulations and H nmr
Study of the GalCer/DPPG Lipid Bilayer ... Galactocerebroside- phospholipi d interactions in bilayer membranes ... measure phospholipid di...
...re the only macromolecules that are not polymers. Lipids are ... Textbook Reference - Macromolecules : Giant Polymers, pp. 37-38 ... Shop for nmr
of Macromolecules - Books at Shop.com. Following the enormous increase in the use of nuclear magnetic resonance to study the conformations and... ...