JCI online early table of contents: March 3, 2008
... human disease and develop better therapies for it and related disorders.
TITLE: Targeted mutation of mouse skeletal muscle sodium channel produces myotonia
and potassium-sensitive weakness
Lawrence J. Hayward
University of Massachusetts Medical School, Worcester, Massachusetts, USA.
JCI table of contents: Nov. 15, 2007
...ting this aberrant exon 7a inclusion and reversing myotonia
in mouse models of DM1. A nucleic acid compound kn...tored the function of ClC-1 protein and eliminated myotonia
in the mice. The authors therefore suggested that ...it might be possible to use this approach to treat myotonia
in individuals with DM1.
TITLE: Correction of C...
Muscular Dystrophy Treatment Shows Promise
...isturbances, cataracts, droopy eyelids, not only myotonia," Cwik explained. myotonia
involves a "difficulty relaxing muscles but also muscle weakness, which is ...cal Investigation , focuses on myotonia.
The researchers postulated that myotonia
was caused by a problem with the pathway that electrical charges use to mov...
congenita is a genetic, neuromuscular ion channel...omuscular disorder characterized by “paradoxical” myotonia
. This type of... Visit Our MDA News Section a...earch News for Updates. Home> Diseases >MC. myotonia
Congenita (Thomsen Disease; Becker Disease) Cli...