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Myostatin in Medical News

Muscling in on type 2 diabetes

...lly occurring mutations in the gene which controls myostatin results in doublemuscling in cattle, dogs and even... the body building community believe that blocking myostatin is a shortcut to the Arnold Schwarzenegger body. The flipside is that producing too much myostatin has been linked with muscle wasting conditions suc...

Researchers discover target that could ease spinal muscular atrophy symptoms

...esearchers inhibited myostatin, a protein that limits muscle tissue growth. myostatin activity can be reduced significantly by enabling several proteins that bind to myostatin, including follistatin. When myostatin is inhibited, muscle mass and strength increase. SMA is caused by the ...

Myostatin inhibitors may improve recovery of wartime limb injuries

...oldiers, researchers say. They are studying two myostatin inhibitors in mice with limb injuries, first to se...is enabling laboratory studies of two experimental myostatin inhibitors: a decoy receptor and a binding protein...ns of injured limbs before and after treatment. myostatin is primarily produced by muscle cells. Females ten...

New potential treatment for muscular dystrophy appears to be safe

...and strength. A new study, the first to evaluate a myostatin inhibitor in patients, assessed its safety in adul...o four groups given sequentially higher doses of a myostatin inhibitor called MYO-029 produced by Wyeth Pharmac...rts the hypothesis that systemic administration of myostatin inhibitors provides an adequate safety margin for ...

Drugs to bulk up muscles may make injuries more likely

...for some medical conditions. Such drugs, called myostatin inhibitors, also are stirring interest among body ...sity of Michigan study in mice suggests that while myostatin inhibitors may indeed bulk up muscles, they may al...scle injuries more likely. Those interested in myostatin inhibitors need to be aware of the fact that by do...

Hope For Patients With Muscular Dystrophy

...her tests revealed the child had a mutation in his myostatin gene that effectively kept his body from producing the myostatin protein, which is known to regulate muscle growth....ly as he grows up. The original research on the myostatin gene was conducted by researchers in 1997. They fo...

Myostatin gene could hold the key to treatment for DMD

...discovered that drugs or molecules used to inhibit myostatin - a protein that inhibits muscle growth - might pr...h in mice with DMD is increased by the loss of the myostatin gene. She teamed with Hopkins geneticist Se-Jin Lee to create a strain of mice lacking the myostatin gene which were later bred with mice with DMD. The...
Myostatin in Medical Technology

Acceleron Pharma's ACE-031 Increases Muscle Mass and Strength in Preclinical Studies

...d other negative regulators of muscle mass and strength. Over-expression of myostatin has been shown to cause a loss in muscle mass and strength, and inhibition of myostatin results in the selective increase in skeletal muscle mass and strength. In ...

Accelreon Pharma's ACE-031Shown to Increase Muscle Mass in Preclinical Studies

... involving the loss of muscle mass, strength and function. ActRIIB binds to myostatin (GDF-8) and other negative regulators of muscle mass and strength. Over-expression of myostatin has been shown to cause a loss in muscle mass and strength, and inhibition ...
Myostatin in Biological News

Scientists show drug can counteract muscular dystrophy in mice

... "If you block myostatin, you get big muscles." One way of inactivating myostatin is to upregulate follistatin. Basically, what follistatin does is to prevent myostatin from working, says Dr. Sartorelli. When his group treated the cells with de...

A new kind of mutation could explain numerous phenotypic variations in various species

... the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The result is that the absence of myostatin provokes a muscular hypertrophy among Texel sheep. A mechanism observed i...

Mouse study: New muscle-building agent beats all previous ones

...s twice as big as normal mice. An antibody against myostatin now in clinical trials caused mice to develop musc.... The researchers' expectation is that blocking myostatin might help maintain critical muscle strength in pe...e business end of a cellular docking point for the myostatin protein, and it probably works in part by mopping ...
Myostatin in Biological Dictionary

Skeletal muscle

... layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They are... myostatin suppresses skeletal muscle development. ... Activation of Skeletal Muscle . The contraction of skeletal muscle is controlled by the nervous...
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(Date:4/22/2014)... release is available in German . ... important intracellular signaling molecules, but their mode of action ... of cellular function and behavior, while at high concentrations ... and DNA. To analyze how redox signaling unfolds in ... microscopy technique has been developed jointly by the teams ...
(Date:4/22/2014)... help rein in massive health care spending, a new ... find ways to incentivize pharmaceutical companies and device makers ... of examining existing medical technologies and their use, a ... what drugs and medical devices get created in the ... care spending with as little loss of health as ...
(Date:4/22/2014)... all seem to know who we say is neurotic and ... unable to act but simply doesn,t want to., ... of nearly 4,000 college students in 19 countries has uncovered ... and moving forward with life. Turns out that when they ... don,t like it as much as non-neurotics. Therefore persuasive communications ...
(Date:4/22/2014)... demonstrated the first size-based form of chromatography that ... living cells. This unique physical approach to probing ... whether a cell lives or dies, remains normal ... conventional microscopy. , "We,ve developed membrane-embedded nanodot array ... probe and manipulate membrane assemblies, including signaling clusters, ...
(Date:4/22/2014)... release is available in German . ... Laboratories of the University of Vienna and the Medical University ... now shown how double stranded RNA, such as viral genetic ... During the immune response against viral infection, the protein ADAR1 ... it modifies viral RNA to inhibit reproduction of the virus. ...
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(Date:4/23/2014)... A biomedical engineer at the University of Houston ... make blood transfusions safer. His work is supported by ... Health (NIH). , Blood transfusions save millions of ... absolute necessities. Without them, for instance, routine surgeries would ... however. There,s strong evidence that transfusions of red blood ...
(Date:4/23/2014)... used to read quickly. It involves visual searching ... and/ or sentences. Similarly to humans, biological systems ... genetic information. Genes that need to be read ... encoding message, the easier it will be to ... de Cincia (IGC, Portugal) and Centre for Molecular ...
(Date:4/23/2014)... one can argue that if we were to follow a ... we canthen we can solve the climate problem without doing ... climate researchers, in the current issue of Bulletin of ... significant action on climate change now makes it more likely ... Wigley explains in an exclusive Bulletin interview. ...
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