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Myelin in Medical News

Tysabri May Treat Myelin Sheath Damage From MS

Drug makers' study finds therapy has capacity to repair nerve fiber damage TUESDAY, April 28 (HealthDay News) -- The drug Tysabri (natalizumab) appears to regenerate and stabilize damage done to the myelin sheath in people with multiple sclerosis (MS), a study from drug makers Biogen ...

Brain Stem Cells Reverse Myelin Deficiency in Mice

Researchers hope to apply novel finding to neurological disorders in humans THURSDAY, June 5 (HealthDay News) -- Researchers report they have used neural stem cells to correct a congenital brain disorder in mice. Dr. Steven Goldman, of the University of Rochester Medical Center in ...

Collaborative Drug Discovery and Myelin Repair Foundation Announce Partnership

CDD's software will provide the infrastructure for MRF's collaborative research plan BURLINGAME, Calif., May 27 /PRNewswire/ -- Collaborative Drug Discovery, Inc. (CDD) announced today that its web-based software, which organizes preclinical research data to help s...

Antibody leads to repair of myelin sheath in lab study of multiple sclerosis and related disorders

ROCHESTER, Minn. -- Mayo Clinic researchers have found that a human antibody administered in a single low dose in laboratory mouse models can repair myelin, the insulating covering of nerves that when damaged can lead to multiple sclerosis and other disorders of the central nervous system. The ...

Blame Myelin for Many Neuropsychiatric Disorders

What makes the human brain unique? Of the many explanations that can be offered, one that doesn’t come readily to mind is — myelin.// Conventional wisdom holds that myelin, the sheet of fat that coats a neuron’s axon — a long fiber that conducts the neuron’s electrical impulses — is akin to t...

Gray matter under attack in multiple sclerosis

...tral nervous system. It has long been assumed that myelin is the most important target for the misdirected i...n: The protein Contactin-2 is produced both in the myelin sheathing and by neurons in the gray matter and i.... "It could even be that proteins existing both in myelin and in the gray matter are in fact the critical po...

Fat-Derived Stem Cells Might Treat MS

...n of neurosurgery at the University of California, San Diego, said in a news release. In people with MS, the immune system attacks and destroys the myelin sheath that surrounds and protects nerves cells. It's believed that SVF cells, and other stem cells, may limit this immune reaction and promote the gr...

Stem Cell Breakthrough May Lead to MS Treatments

...to grow into critical nervous system support cells called oligodendrocytes, according to a report released Thursday. Oligodendrocytes produce the myelin sheath that surrounds nerve fibers like wire insulation. The findings represent an important step toward embryonic stem cell-based therapies in genera...

Mayo researchers discover mechanism of cell type-specific signaling in tumor development

...he tumor suppressor gene Merlin. When Merlin is absent or mutated, the result is schwannoma, a form of tumor involving Schwann cells which make up the myelin sheath that covers nerves. Merlin has also been shown to play a part in causing melanoma, mesothelioma and possibly colorectal cancers. The researc...

Avastin effective at delaying brain tumor progression in recurrent disease

...xisting standard therapy. Oligodendrogliomas begin in brain cells called oligodendrocytes, which provide support around nerves by building a sheath of myelin and facilitating electrical nerve impulses. The relatively uncommon tumor affects about 2,000 persons annually in the U.S. Most are under age 50. Av...
Myelin in Medical Technology

Dirucotide Does Not Meet Primary Endpoint in Phase III MAESTRO-01 Trial in Secondary Progressive Multiple Sclerosis

...ts, whether as a result of new information, future events or otherwise. (i) Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunology Today, 1991; 12: 277-282. (ii) Ransohoff, R.M. Natalizumab for Multiple Sclerosis. New England Journal of Medicine, 2007 J...

Myelin Removal Beads: Premium Efficiency for Neural Cell Separations and Antibody Stainings

...c announces the worldwide and exclusive release of myelin Removal Beads. Myelin is a specialized membrane wh...em. During preparation of single-cell suspensions, myelin membrane fragments represent the major contaminant... Research Products at Miltenyi Biotec. "Removal of myelin leads to higher purity and recovery of target cell...

Heavy Marijuana Use May Damage Developing Brain in Teens, Young Adults

... suggest damage or an arrest in development of the myelin sheath that surrounds brain cells," said Ashtari. myelin provides a coating around brain cells similar to insulation covering an electrical wire. If myelin does not function properly, signaling within the b...

Modigene Awarded Israeli Government Grant to Support Development of Its Longer-Acting Interferon Beta

...ering from MS, an autoimmune neurological disorder affecting the insulating myelin layers of the brain and spinal cord. If unchecked, over time the immune system attack on myelin leads to poor coordination, severe disabilities and premature death. Annual...

Shire Enhances its Orphan Drug Pipeline With the Acquisition of a New Clinical Candidate for Metachromatic Leukodystrophy

...degenerative disease. Symptoms and Patient Outlook Sulfatide accumulation in the central and peripheral nervous system leads to destruction of the myelin sheath (demyelination). MLD has a spectrum of disease which can arise in infants and young children with a range of symptoms, though most are related ...

Acorda Therapeutics Presents Data from its Phase 3 Study of Fampridine-SR in Multiple Sclerosis at the American Academy of Neurology Meeting

... but the smallest axons have a special covering of a fatty substance called myelin that acts as insulation to preserve and speed these nerve signals, much lik...lectrical cord helps preserve the transmission of electricity. In MS, the myelin becomes damaged and the axon cannot effectively transmit electrical impulse...

Data to be presented at AAN Meeting -Study results of drug candidate for MS

...ligodendrocytes - cells that help form myelin in the CNS. Stimulation of S1P receptors on oligodendrocytes may help limit demyelination and/or promote myelin repair. (Barske et al) In the third study, conducted in an established animal model of MS [experimental autoimmune encephalomyelitis (EAE) in rats],...

Acorda Therapeutics Presents Fampridine-SR Data at ACTRIMS Meeting

... but the smallest axons have a special covering of a fatty substance called myelin that acts as insulation to preserve and speed these nerve signals, much lik...lectrical cord helps preserve the transmission of electricity. In MS, the myelin becomes damaged and the axon cannot effectively transmit electrical impulse...

Opexa Presents Tovaxin Research at Federation of Clinical Immunology Societies Annual Meeting

...e poster, entitled "Identifying New Immunodominant myelin Peptides in Relapsing Remitting Multiple Sclerosis...a to identify several myelin protein peptides from myelin basic protein (MBP), myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as being immuno...

Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis

...have demonstrated that T-cell vaccination depletes myelin reactive T-cells in peripheral blood. In the extension study patient population, the myelin reactive T-cell frequencies were reduced by 84% an...nd 12 months on study, respectively. Reductions in myelin reactive T-cell frequencies in the dose escalation...
Myelin in Medical Dictionary

Myelin

Myelin is the protective sheath around axons in the nervous system, and is often ... The myelin sheath contains a variety of fatty substances (lipids), and contains ... The two major causes of Multiple Sclerosis and treatments for the two major causes. ... This bacteria gets inside the m...

Water On The Brain

... shunt in the brain of Theo Dahl: ... relaxation in brain . All the signal from water in brain has T. 2. times greater. than 10 ms ... myelin water fraction and performance on. various ... Often called " water on the brain ," hydrocephalus can cause babies' and young ... a br...

Tremor

... support to ... University Of Miami Research Study On Essential Tremor ... common type of tremor seen in people. with MS is caused by loss of myelin on ... Tremor can aff ect the limbs, head, body, or the muscles needed for speech or sexual ... orthostatic tremor , information, awareness and...

Syndrome

...in the liver (fatty liver) ... Learn about Guillain-Barre Syndrome (GBS) - an autoimmune disease of the nervous system due to damage of the myelin sheath around the nerves on Medicinenet.com Asperger's syndrome — Comprehensive overview covers symptoms, treatment for a disorder affecting ...

Leukodystrophy

...characterized by progressive degeneration of the white matter of the brain. The leukodystrophies are caused by imperfect growth or development of the myelin sheath, the fatty covering that acts as an insulator around nerve... leukodystrophy ( ′lükə′distrəfē ) ( medicine ) A condition thought to resu...

Krabbe disease

...ften fatal degenerative disorder that affects the myelin sheath of the nervous system. This condition is i...ngolipidosis caused by ... In Krabbe disease , myelin composition is not qualitatively abnormal. ... ...d enzyme deficiency that leads to the loss of myelin , the substance that wraps nerve cells and ...

Guillain-barre Syndrome

...national - www.gbsfi.com ... Learn about Guillain - Barre Syndrome (GBS) - an autoimmune disease of the nervous system due to damage of the myelin sheath around the nerves on Medicinenet.com Guillain - Barre Syndrome is an autoimmune disorder that causes weakness and ... What is the lo...

Guillain

...g's Disease (ALS) Meningitis ... Learn about Guillain -Barre Syndrome (GBS) - an autoimmune disease of the nervous system due to damage of the myelin sheath around the nerves on Medicinenet.com Guillain -Barré syndrome is very rare: It only affects 1 or 2 people in every 100, ... Diseases &a...
Myelin in Biological News

Claudin 11 stops the leaks in neuronal myelin sheaths

Devaux and Gow demonstrate how a tight junction protein called claudin 11 makes the neuronal myelin sheath a snug fit. The study will be published in the December 1, 2008 issue of the Journal of Cell Biology ( www.jcb.org ). Like the rubber coating on a copper wire, the myelin sheatha membran...

Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

A new UCLA imaging study shows that age-related breakdown of myelin, the fatty insulation coating the brain's internal wiring, correlates strongly with the presence of a key genetic risk factor for Alzheimer disease. The findings are detailed in the January edition of the peer-reviewed journal Ar...

Researchers design first model motor nerve system that's insulated and organized like the human body

...ct explained: "The nodes of Ranvier act like power station relays along the myelin sheath. They chemically boost signals, allowing them to get across breaks i...el system to explore the origins of diabetic neuropathy. Once the causes of myelin degradation are identified, targets for new drug therapies can be tested wi...

MS study offers theory for why repair of brain's wiring fails

...s attack oligodendrocytes, ultimately damaging the myelin sheath to the point that the electrical signals tr...to recruit fresh, immature oligodendrocytes to the myelin sheath to repair the damage, for a time. This expl... see if they could determine what was slowing down myelin repair. They lesioned a small region of white matt...

Neural stem cell differentiation factor discovered

...iate into neurons, astrocytes or oligodendrocytes. Astrocytes have supportive functions in the environment of neurons, while oligodendrocytes form the myelin layer around axons in order to accelerate neuronal signal transmission. But how does a neural stem cell know" which way it is supposed to develop? On ...

One size does not fit all

... demonstrates that statin therapy in mice inhibits myelin repair or remyelination in the central nervous sys... nervous system-accessible immune therapies on the myelin repair processes in patients with MS and other pro...ous system (CNS), in which immune cells attack the myelin sheath (the protective insulation of nerve fibres)...

Protein identified as critical to insulating the body's wiring could also become treatment target

...f MCG's Institute of Molecular Medicine and Genetics. Without erbin, the myelin production system falls apart. Eventually raw, over-exposed nerves can die....sitting there but they can't do anything without the receptor." Impaired myelin formation and maintenance is implicated in a variety of neurological and ps...

Human ES cells progress slowly in myelin's direction

...oligodendrocytes, which are responsible for making myelin in the central nervous system. myelin forms an insulating sheath that surrounds nerve fi...te precursor cells that may be used to repair lost myelin sheaths. These findings also raise awareness of th...

American Chemical Society Weekly PressPac -- April 1, 2009

...jectable medicines, making it easier for patients to take the medication over long periods of time. Most of the drugs ease the immune system damage to myelin or offer protection to already-damaged nerves. ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, April 6, 2009 "Hope in a pill" This story will b...

Genetic study shows direct link between vitamin D and MS susceptibility 'gene'

...condition, which results from the loss of nerve fibres and their protective myelin sheath in the brain and spinal cord, causing neurological damage. The ca...te these T cells, which then go on to attack the body, leading to a loss of myelin on the nerve fibres. "Our study implies that taking vitamin D supplement...
Myelin in Biological Technology

UCF team's advanced nerve cell system could help cure diabetic neuropathy, related diseases

...uropathy, and other conditions caused by a loss of myelin insulation around nerves can be debilitating and e...o travel long distances because of breaks in their myelin insulation called nodes of Ranvier, each of which ... travel their normal path from node to node due to myelin breakdown. Within the brain and spinal cord, where...

BioMS Medical reports results of exploratory phase II trial of dirucotide in relapsing remitting multiple sclerosis

...de ---------------- Dirucotide is a synthetic peptide that consists of 17 amino acids having a sequence identical to that of a portion of human myelin basic protein (MBP). Dirucotide is being investigated for the potential treatment of multiple sclerosis (MS), an autoimmune disease caused by immune a...

New label-free method tracks molecules and drugs in live cells

...alance of saturated and unsaturated fats in our diets." SRS microscopy could also prove useful in neuroimaging, since neurons are coated with fatty myelin sheaths. The researchers' use of SRS microscopy to analyze skin tissue could also open new frontiers in drug development. Xie and colleagues used S...

MS Drug Development Agreement Based on WEHI's Medicinal Chemistry

...ellinone could block a potassium channel called Kv1.3. This potassium channel selectively inhibits autoreactive T cells, such as those that attack the myelin sheath in people with MS. Dr Baell says, "Our research in this area had a rocky start, but when our first patents were published in 2003, Start-Up A...

Lilly and BioMS Medical Announce Global Licensing and Development Agreement

... ---------- About MBP8298 MBP8298 is a synthetic peptide that consists of 17 amino acids having a sequence identical to that of a portion of human myelin basic protein (MBP). MBP8298 is being developed for the potential treatment of multiple sclerosis (MS), an autoimmune disease caused by immune attack ...

BioMS Medical achieves enrollment milestone in U.S. phase III multiple sclerosis trial

...omponents. The proposed mechanism of action of MBP8298 is, by design, to re-introduce such a state of "tolerance" to a critical portion of the nerve's myelin Basic Protein that is an immunological site of attack in many MS patients. This is accomplished by the I.V. injection of MBP8298 every six months. Ph...

LiquiChip Kits for bead-based cytokine and kinase assays

... Kinase assay without radioactivity The LiquiChip Ser/Thr Kinase Kit is based on the phosphorylation of myelin basic protein (MBP) immobilized on LiquiChip beads. After incubation with a sample, phosphorylation of serine and threonine residues...
Myelin in Biological Products

Mouse Anti-Human MBP aa67-74 Monoclonal Antibody, Unconjugated from AbD Serotec

Description:... MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
Company:AbD Serotec
Myelin in Biological Definition

Axon

...of each foot. These single-cell fibers may extend a metre or even longer. In vertebrates generally, the axons of many neurons are sheathed in myelin , which is formed by either of two types of glial cells : Schwann cells ensheathing peripheral neurons and oligodendrocytes insulating those of...

Brain

...d on the surface of cerebral cortex, as well as in clusters called nuclei deep within the brain. White matter refers to axons and their surrounding myelin insulation, which gives this tissue its white color. White matter is found in bundles of fibers known as tracts which connect the different parts of ...

Cell growth

...as rapid action potential propagation. Mammals also use this trick for increasing the speed of signals in the nervous system, but they can also use myelin to accomplish this, so most human neurons are releatively small. h Other experimental systems for the study of cell size regulation One common...

Magnetic resonance imaging

...ical tissues however the diffusion is very often anisotropic . For example a molecule inside the axon of a neuron has a low probability to cross a myelin membrane. Therefore the molecule will move principally along the axis of the neural fiber. Conversely if we know that molecules locally diffuse princ...

Neuron

...e rapidly, generally speaking. Many neurons have insulating sheaths of myelin around their axons, which enable their action potentials to travel faster...tral nervous system and Schwann cells in the peripheral nervous system. The myelin sheath in peripheral nerves normally runs along the axon in sections about ...
Myelin in Biological Dictionary

Myelin

Myelin is a dielectric material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth glial cell: Schwann... myelin also myeline ( ) n. A white fatty material, composed c...

Schwann cells

.... In myelinated axons, Schwann cells form the myelin sheath (see below). The sheath is not continuous..... In myelinated axons, Schwann cells form the myelin sheath (see below) ... Theodor Schwann Theod...to-one ... Other Schwann cells do not produce myelin but continue to ensheath one or more ... Origi...

Peripheral protein

...r toxin-3. Phosducin family ... Peripheral myelin protein 22 is produced primarily by specialized...alled ... The buildup of unprocessed peripheral myelin protein 22 probably also disrupts ... Schwan...ral nervous system that connects the brain ... myelin peripheral protein . ...

Nodes of Ranvier

... Nodes of Ranvier are the gaps formed between the myelin sheaths generated by different cells. A myelin sheath is a many-layered coating, largely composed of a fatty substance ...

Myelin sheath

... myelin is a dielectric material that forms a layer, the myelin sheath , usually around only the axon of a neuro...for the proper functioning of the nervous system. myelin is an outgrowth glial cell: Schwann... Support...
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