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Mutated in Medical News

Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias

According to the investigators at St. Jude Children's Research Hospital it was found that a gene responsible for regulating the normal mammary gland function during nursing can also initiate leukemias. // This gene results in leukemia only if it undergoes mutation and fuses with another gene. Th...

AIDS Virus getting mutated for good

Dr. Eric Artz and team from the Institute of Tropical Medicine has published the results of the work in the journal AIDS, in which they have said that the HIV virus has become less pathogenic// due to reduced multiplication rate and is now more sensitive to anti-retroviral drugs compared to the str...

Turkey bird flu strain found to be mutated

Researchers have found a slight mutation in the haemagglutinin protein of the bird flu virus. Haemagglutinin antigen is responsible for attaching of the virus to the host and the variability // and fragmentation of this antigen is responsible for evolution of new strains of the virus, if a person o...

Micromet, Inc. Reports Second Quarter 2009 Financial Results

...the currently marketed EGFR-specific monoclonal antibodies Erbitux(R) (cetuximab) and Vectibix(R) (panitumumab) appeared to overcome the resistance of mutated tumor cells to those monoclonal antibodies. Micromet also presented data at the AACR meeting indicating that its BiTE antibody MT110 can direct T cell...

Scientists Decode HIV Genome

...essor of microbiology and immunology, said in the release. "If it doesn't grow as well when you disrupt the virus with mutations, then you know you've mutated or affected something that was important to the virus." The study appears in the Aug. 6 issue of the journal Nature . More information The...

Finding key to cancer drug Gleevec's limitations

...reatment known to cure CML. Imatinib, one of several targeted cancer therapies developed in recent years, inhibits certain enzymes associated with mutated genes that are involved in CML. Cancer researchers have suspected but have not known until now that certain cells that set events in motion toward C...

Abnormal Brain Circuits May Prevent Movement Disorder

...who presented with the uncontrollable movements. While their brains show the same abnormal network, only approximately 30% of people who carry the mutated gene called DYT1 will develop the involuntary movements that can prevent them from living a normal life, according to Dr. Eidelberg. The puzzle wa...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

...e known as copy number alterations (CNAs). To identify point mutations, the researchers also performed DNA re-sequencing of 25 genes that are commonly mutated in adult AML. Point mutations involve a single chemical change in the molecular building blocks of DNA. The data demonstrated that, in contrast...

Molecule plays early role in nonsmoking lung cancer

... that EGFR regulates miR-21. For example, altering EGFR levels caused corresponding changes in miR-21. Last, the investigators took cells that had a mutated EGFR gene and treated them with an anti-EGFR agent (the agent was related to gefitinib and erlotinib, targeted drugs used to treat lung cancers with E...

U.S. Expects 160 Million Doses of Swine Flu Vaccine by October

... the vaccine for the seasonal flu. Also on Thursday, experts at the U.S. Centers for Disease Control and Prevention said that the virus has not yet mutated to become more dangerous, although they continue to follow its progress globally, the AP reported. Dr. Nancy Cox, chief of CDC's influenza division,...

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Mutated in Medical Technology

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...ion of EGFR, thereby inhibiting downstream events that lead to malignant signaling. However, it is hypothesized that in patients whose tumors harbor a mutated KRAS gene, the KRAS protein is always turned "on," regardless of whether the EGFR has been activated or therapeutically inhibited. KRAS mutation...

Encouraging First Data on New Targeted Treatment for Patients With Melanoma - the Deadliest Form of Skin Cancer

...PLX4032 works by targeting and destroying tumour cells carrying the BRAF mutation. BRAF is an important mediator of cell growth and division, but when mutated is known to cause 60% of melanomas, the most deadly form of skin cancer, and approximately eight percent of all solid tumours. PLX4032's potency and s...

Mutant Genes in High-Risk Childhood Leukemias Identified

... ALL. That analysis revealed mutations in about 10 percent of the cases in a family of protein kinases called JAK, whose members were also known to be mutated in other types of leukemias and related diseases. "Further studies of these mutant JAK proteins revealed that the changes in their molecular stru...

Arrayit to Mass Produce Rapid H1N1 Swine Flu Test Chip

...t test will allow researchers and clinicians to detect the presence of the virus in infected patients and livestock and to distinguish the threatening mutated strain from less harmful variants in humans and swine. Using its state-of-the-art manufacturing facility, Arrayit plans to begin mass production of it...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

...struction of these cancer cells. In mice, daily EGFR BiTE antibody doses as low as 0.1 microgram/kilogram were sufficient to prevent tumor growth from mutated human colorectal cancer cells. Studies in a relevant non-human primate species suggest that active serum levels of the cetuximab-based BiTE antibody a...

Cancer Therapy & Research Center at The University of Texas Health Science Center and Oncolytics Biotech(R) Inc. Announce Multi-Trial Clinical Research Collaboration

...hemotherapy for various cancer indications. These indications are expected to include melanoma, pancreatic cancer, squamous cell lung, liver and K-RAS mutated colorectal cancers in combination with standard chemotherapeutics. This research program is in addition to Phase 2 trials in sarcoma and refractory he...

Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells

...nt of treatment strategies covering those patients who are not able to benefit from this important new treatment option as their tumors carry the KRAS mutated gene. This mutation is found in approximately 35 to 40 percent of patients with this disease. "Given that more than 95 percent of colon cancer patie...

Lilly and Deciphera Pharmaceuticals Announce Licensing and Collaboration Agreement

...se therapies. We are very pleased to have Lilly as our partner in this endeavor." About B-Raf Inhibitors BRAF kinase is one of the most frequently mutated members of the kinase family across all cancers, and is particularly common in malignant melanomas, colon, and thyroid cancers. The V600E mutant form ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

...at bind to CCR5 -- so-called "R5" strains. A small fraction of the population carries a mutation in their CCR5 gene, called the delta32 mutation. This mutated version of the gene results in a truncated CCR5 protein which cannot be used by HIV as a co-receptor. Individuals that have mutant delta 32 versions o...

Nektar Announces Expanded Phase 2 Clinical Development Plan For NKTR-102 (PEG-irinotecan)

...dy for NKTR-102 Will Target Newly-Identified K-Ras mutated Oncogene Population in Patients with Advanced C...haracterized colorectal cancer patients with K-Ras mutated gene status in its Phase 2 study in advanced color...hat up to 45% of colorectal cancer cases have this mutated K-Ras gene. To target this newly- characterized K-...
Mutated in Medical Definition

Autoimmune regulator

...mmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self. It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 ( APS-1 ), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectod...
Mutated in Medical Dictionary

Virus

...against cyber criminals. - - From birds to humans to disaster, the science of a potential global killer. ... This is because the virus has not mutated – at least not yet – to be optimally ... Learn more about how to install security software to help protect your computer from viruses and other ...

Sickle cell trait

...he cells'... sickle cell trait n. A hereditary condition, usually harmless and without symptoms, in which an individual carries only one mutated hemoglobin gene ... Questions (FAQs) - Questions submitted to the Web about Sickle Cell Trait ... Sports trainers warn about sickle cel...

Familial Hypercholesterolemia

...ssed down through families in which a person has high levels of "bad" ... Rarely, a person with familial hypercholesterolemia is born with two mutated ... MedlinePlus Encyclopedia: Familial hypercholesterolemia ... Familial hypercholesterolemia is a condition passed down through families ...

Ataxia Telangiectasia

...ia - telangiectasia - Overview, Ataxia - telangiectasia is rare childhood ... The disease results from defects in the ataxia telangiectasia mutated (ATM) gene. ... Ataxia Telangiectasia information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, for...
Mutated in Biological News

A new method to identify mutated genes in human diseases

Researchers from the University of Turin, Italy and the University of Nijmegen, The Netherlands, have devised a new method that may help the medical community to determine the genetic basis of many common diseases. Their findings are described in an article published March 21st in the open-access ...

Abnormal brain circuits may prevent movement disorder

...who presented with the uncontrollable movements. While their brains show the same abnormal network, only approximately 30% of people who carry the mutated gene called DYT1 will develop the involuntary movements that can prevent them from living a normal life, according to Dr. Eidelberg. The puzzle wa...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...e known as copy number alterations (CNAs). To identify point mutations, the researchers also performed DNA re-sequencing of 25 genes that are commonly mutated in adult AML. Point mutations involve a single chemical change in the molecular building blocks of DNA. The data demonstrated that, in contrast to ...

ISU researchers find possible treatment for spinal muscular atrophy

... Most Spinal Muscular Atrophy sufferers -- more than 95 percent -- have a mutated or deleted gene called Survival Motor Neuron 1 (SMN1) that doesn't correctl...the working SMN protein. When SMN2 makes enough SMN, it compensates for the mutated or malfunctioning SMN1 gene. All proteins in human bodies are made by cop...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

... SALT LAKE CITY University of Utah researchers and their colleagues have identified the gene that is mutated in a hereditary form of a rare neuroendocrine tumor called paraganglioma (PGL). The gene, called hSDH5, is required for activation of an enzyme comple...

Promising new treatment for Alzheimer's suggested based on Hebrew University research

...ts solved a mystery as to why people who carried a mutated gene known as BChE-K were prone to more rapid deve...eli populations. In theory, the carriers of the mutated gene should actually be more protected from the devastating effects of the disease, since the mutated protein (the enzyme that is the product of the gen...

UTSA infectious disease researchers advancing vaccine against Valley fever

...y Fever, known in scientific circles as coccidioidomycosis. A live, attenuated vaccine is used as a preventative treatment based upon creation of a mutated form of the pathogen that is no longer capable of causing disease. Coccidioides , a soil-dwelling fungus, is responsible for significantly increa...

Measuring intellectual disability

...rnia, Davis have developed a specific and quantitative means of measuring levels of the fragile X mental retardation 1 (FMR1) protein (FMRP), which is mutated in fragile X syndrome. The related report by Iwahashi et al, "A quantitative ELISA assay for the fragile X mental retardation 1 protein," appears in ...

Fate in fly sensory organ precursor cells could explain human immune disorder

...vation of a class of immune cells called the T-cells. T-cell function is compromised in patients with Wiskott-Aldrich syndrome. Since the gene WASp is mutated in the patients with Wiskott-Aldrich syndrome, the work done by Bellen and his colleagues suggest that defects in the presentation of Delta could expl...

Cancer-causing protein can also help fight the tumors it causes

... Oncogenes are genes that when mutated or expressed in high concentrations can cause norm...he immune system. The immune cell that adopts the mutated Ras gets activated and reacts against the cancerou... is certain, however, is that once t-cells acquire mutated Ras, they are able to generate clones with the abi...
Mutated in Biological Technology

Medicago's H1N1 pandemic vaccine candidate shows positive response in 100% of vaccinated animals after a single dose

...04 virus. In a continuation of this study, Medicago tested the immune response of its H1N1 vaccine against the California/07 virus, a more current and mutated strain and showed positive immune response after a single dose of 5 micrograms. The challenge of current pandemic influenza vaccines is they have to m...

OMT announces a breakthrough in the development of a novel human antibody platform

... rat immunoglobulin. The mutations in rat immunoglobulin caused no off-target effects in other genes, and offspring of the ZFN-edited rats carried the mutated genes. Together, these results demonstrate the ability to generate heritable, specific and permanent modifications in a mammal using standard microin...

New method may accelerate drug discovery for difficult diseases like Parkinson's

...me. Also, earlier work conducted by Aaron Gitler and Melissa Geddie in the Lindquist lab found that the normal version of the gene PARK9, which can be mutated in Parkinson's disease patients, protects cells from toxic levels of manganese. With these possible modes of action in mind, Kritzer and colleague...

Oncolytics Biotech(R) Inc. Announces 2009 First Quarter Results

... various cancer indications. These indications are expected to include melanoma, pancreatic cancer, squamous cell lung, liver and K-RAS mutated colorectal cancers in combination with standard chemotherapeutics. Latest Highlights Subsequent to quarter end, the Company announced...

VIRxSYS Publishes New Study on RNA Therapy

...ke more apoA-I protein than it normally does, and in separate experiments we instructed the liver to make the correct form of Factor VIII instead of a mutated form. We also added an RNA molecule that makes a monoclonal antibody that is not normally produced in liver," said VIRxSYS Executive Vice President of...

Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS

... bind to CCR5 -- so-called "R5" strains. A small fraction of the population carries a mutation in their CCR5 gene, called the delta32 mutation. This mutated version of the gene produces malformed CCR5 proteins, which cannot be used by HIV as a co-receptor. Individuals that have two copies of this mutant f...

Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting

...zed, controlled clinical trial ("408") which showed that mCRC patients with mutated KRAS tumors do not respond to Vectibix monotherapy. Conversely, patients ...and PFS in patients with wild-type KRAS genes, and redirect patients with a mutated KRAS gene to alternative therapies," said Sean Harper. "We are thrilled t...

RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research

...e RNAi-resistant versions of both a wildtype and a mutated protein (Cdc20). In the mutated version, all 23 lysines found in the wildtype prot... natural copy of a protein and replacing it with a mutated version has previously been possible only through ...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

...1 inhibits the Akt-mTOR signaling pathways, which may occur through inhibition of the mTOR/rictor pathway. The Akt-mTOR pathway is the most frequently mutated pathway in human tumors and mutations have been shown to promote tumor progression and decrease survival in cancer patients. EntreMed Vice President a...

Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic

...at bind to CCR5 -- so-called "R5" strains. A small fraction of the population carries a mutation in their CCR5 gene, called the delta32 mutation. This mutated version of the gene produces malformed CCR5 proteins, which cannot be used by HIV as a co-receptor. Individuals that have two copies of this mutant fo...
Mutated in Biological Products

Bax-Inhibiting Peptide, Negative Control from Calbiochem

Description:...IP-NC H-IPMIK-OH Lyophilized solid. Supplied as a trifluoroacetate salt. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable mutated analog of the Bax-Inhibiting Peptide, V5 (Cat. No. 196810) that serves as a negative control. Does not suppress Bax-mediated apoptosis (~200 μM). ...
Company:Calbiochem

Random DNA mutagenesis Service from Yorkshire Bioscience Ltd

Description:... We can introduce random mutations to the gene supplied by a customer. mutated DNA will be then cloned into a vector of choice to obtain a library of the mutated DNA. Mutation frequency can be set to a desired value within 1-20 mutation...
Company:Yorkshire Bioscience Ltd
Mutated in Biological Definition

Fitness landscape

... or at least a very good, solution is then found in the following way. Initially, a population of random solutions is created. Then, the solutions are mutated and selected for those with higher fitness, until a satisfying solution has been found. Evolutionary optimization techniques are particularly useful...

Molecular genetics

...dentify mutations that produce a certain phenotype . A mutagen is very often used to accelerate this process. Once mutants have been isolated, the mutated gene can be molecularly identified. Reverse genetics Main article: Reverse genetics While forward genetic screens are productive, a m...

Polymerase chain reaction

...tagenesis Mutagenesis is a way of making changes to the sequence of nucleotides in the DNA. There are situations in which one is interested in mutated (changed) copies of a given DNA strand, for example, when trying to assess the function of a gene or in in-vitro protein evolution . Mutations can...
Mutated in Biological Dictionary

Viral oncogene

...e NF-κB family of transcription factors. The REL gene is amplified or mutated in several human B-cell lymphomas,... The official name of this gene ...roteins, Viral :: physiology :: [Transcriptional repressive activity of mutated E2 protein of human papillomavirus 2 (HPV-2) ... Human RALA (v-ral s...

Tumor suppressor

... A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. will be revie...

Transposable element

... Elements . Insert Information. Protocols. External Links. References ... A transposable element can be used as probes to clone genes that are mutated by ... Transposable element sequences are abundant yet poorly understood components of ... Our understanding of transposable elements owes ...

Proto-oncogene

... An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a cancer cel... and voila! ... oncogenes in oncogenesis, and how the proto - oncogene is mutated to give rise to ... Britannica online encyclopedia article on proto - o...

Oncogene

... An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a cancer cel... is a sequence of deoxyribonucleic acid (DNA) that has been altered or mutated from its original form, the proto- oncogene . Operating as a positive growt...

Insecta

.... ... Insecta - Photograph gallery of many different species of insect arranged ... Imagine a world where bugs rule! Imagine designing your own mutated bug which ... Insecta is published as a joint venture with Sierra Madre Games of Arizona. ... ...

Hela cell

... factor articles relating to ' ... replicating cells such as HeLa , A431, and ... Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3. ... Stable Cell Lines. NFkB Reporter A549 HeLa , 293, NIH3T3 ... NFkb p50 Knockdown HeLa Stable Cell Line. AP-1 Reporter 293. GR Repo...

Deamination

...removal of the amino group, ... Examples of deamination which involves the removal of an amino group. ... As shown in the above figure, it may be mutated to uracil by deamination . ... ... of our nitrogenous waste comes from the breakdown of amino acids. This occurs by deamination . Deamination ...
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