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Mutants in Medical News

Boffins Develop New Technique to Hunt Illness-causing Mutants in Non-gene DNA

University of Utah geneticists say that they have developed a faster, less expensive technique to hunt illness-causing mutants in large, non-gene stretches of DNA. The development of the new technique is important because diseases can result not only from mutant genes, but also from mutations of o...

Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants

As a breather and news that spells heaven for millions of avian influenza patients there is a research by scientists at St. Jude Children’s Research Hospital //. According to them they have developed in the lab a vaccine that is potent against one antigenic variant of the avian influenza virus H5N1...

Research suggests new cellular targets for HIV drug development

...when pieces of genetic material from several parent HIV viruses combined to form new strains. Such "recombination" is responsible for formation of mutants that easily elude immune system surveillance and escape from anti-HIV drugs. "Macrophages are these little factories producing new hybrid particles...

Salmonella's sweet tooth predicts its downfall

...rs are broken down to create chemical energy. They constructed Salmonella mutants unable to transport glucose into the immune cells they occupy and unable to...mmune system. The next stage of the research will be to test whether the mutants elicit a protective immune response in mice. In Germany the nutrition of...

New oncogene gives valuable insight into hepatocellular tumors in humans

...s, GP130 exons were screened in all samples and the function of 7 different mutants was analysed in HEP3B. A somatic mutation was identified in 65% of the I...so demonstrated was the fact that the expression of the most frequent GP130 mutants in HEP3B cells activates STAT3 in absence of IL-6. The researchers searched...

AAI honors Chen Dong for breakthrough T lymphocyte research

...ptors from their T cells to a mouse model of rheumatoid arthritis. There was plenty of interferon gamma present in the mice, but no arthritis. "The mutants were completely resistant to developing rheumatoid arthritis. There was no joint inflammation, antibody responses were reduced. It was remarkable," Do...

Zebrafish Journal Publishes Skin Pigmentation Studies That Shed Light on the Evolution of Race

... Additional papers focus on natural variation of male ornamental traits of the guppy, the link between pigment and fish behavior, and pigment dilution mutants in fish models connected to lysosome-related organelles and vesicular traffic genes. Zebrafish is an authoritative peer-reviewed journal publ...

Redesigned protein accelerates blood clotting

... is converted into factor VIIIa, the VIIIa cofactor better holds onto the A2 domain, which is the reason that the current study found that more stable mutants increase clotting. In a recent paper in the journal Blood, the team used molecular biology techniques to swap out those three charged residues wit...

Work with fungus uncovering keys to DNA methylation

...ation and DNA methylation," he noted. "DNA methylation seems to be a luxury item in Neurospora, which means we can manipulate it as we wish, making mutants that don't do it and thereby identify important players," Selker said. "We are identifying how DNA methylation is controlled and what it does in this ...

Snoring or soaring? Strength of fruit-fly immune system varies

...ickened flies' circadian rhythms were disturbed. They stumbled around more randomly, and stood still for relatively shorter periods. Moreover, genetic mutants lacking circadian cycles of rest and activity died more quickly on infection with these pathogens than normal flies did. In the new round of experi...
Mutants in Medical Technology

ANA380 Exhibits Activity In Vitro Against Multiple Clinically Relevant Hepatitis B Virus Mutants

Poster Presentation at EASL on April 13, 2007, 2007 SAN DIEGO, and SEOUL, South Korea, April 13 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals, Inc. and LG Life Sciences, Ltd., presented data from an in vitro study showing that ANA380 (LB80380) retains potency against multiple mutant strains of ...

USC Keck School of Medicine's Dr. Alan Epstein Receives Prestigious National Cancer Institute RAID Award for Breakthrough IL-2 Molecule Therapeutic

... for cancer, has licensed the molecule from USC . The technology is covered under U.S. Patent #7371371 issued on May 13, 2008 titled, "Interleukin-2 mutants with Reduced Toxicity." Dimitri Villard, CEO of Pivotal BioSciences, Inc., added, "We are delighted that the National Cancer Institute's RAID P...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

...e inhibitor telaprevir and the nucleoside polymerase inhibitor PSI-6130 are synergistic. These studies also show that ANA598 retains activity against mutants known to confer resistance to other classes of direct antivirals, including protease inhibitors, nucleoside inhibitors, and non-nucleosides that, thro...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

...a safe and well tolerated PKE that potently enhances the pharmacokinetics of target compounds without the risk of promoting the emergence of resistant mutants due to its lack of antiviral activity." Data on SPI-452 at this conference Study 0452-002: Proof of Clinical Concept Study 0452...

Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers

...r (VX-950), and the nucleoside polymerase inhibitor PSI-6130 (the active agent of R7128). These studies also show that ANA598 retains activity against mutants known to confer resistance to other classes of direct antivirals, including protease inhibitors, nucleoside inhibitors and non-nucleosides that bind a...

Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients

...ts of in vitro studies that show ANA598 to be strongly synergistic with interferon-alpha. These studies also show that ANA598 retains activity against mutants known to confer resistance to other classes of direct antivirals, including protease inhibitors, nucleoside inhibitors and non-nucleosides that bind a...

FDA Approves First Hepatitis B Viral Load Test

...andard and reports with the international unit of measure IU/mL. The test was designed to quantify all major Hepatitis B genotypes, including pre-core mutants that can lead to more severe liver disease and reduced response to antiviral therapy. Roche Diagnostics, a leader in molecular diagnostics, has more...

Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)

...o inhibition of selected human cellular proteases. In vitro, the Idenix protease inhibitors exhibited antiviral activity against certain HCV resistant mutants associated with first-generation protease inhibitors currently in clinical development. Pharmacokinetic studies demonstrated adequate oral bioavailabi...

TargeGen Announces Planned Initiation of Clinical Trial of JAK2 Inhibitor TG101348 in Myeloproliferative Disease Patients, and Presentations at ASH

...101348: A Dual Acting JAK2/FLT3 Small Molecule Kinase Inhibitor for the Treatment of AML -- John Hood -- Prospective Identification of Resistance mutants to the JAK2 Inhibitor TG101348 The V617F mutation of JAK2 is implicated in the pathogenesis of certain myeloproliferative diseases, including po...
Mutants in Biological News

200,000 rice mutants available worldwide for scientific investigation

Blacksburg, Va. Scientists across the world are building an extensive repository of genetically modified rice plants in the hope of understanding the function of the approximately 57,000 genes that make up the genome of Oryza sativa. The International Rice Functional Genomics Consortium recently ...

200,000 rice mutants available worldwide for scientific investigation

Blacksburg, Va. Scientists across the world are building an extensive repository of genetically modified rice plants in the hope of understanding the function of the approximately 57,000 genes that make up the genome of Oryza sativa. The International Rice Functional Genomics Consortium recently ...

Drug-proof zebrafish reveal secrets of addiction

...e was determined by measuring whether fish chose to move to a half of the tank where the drug had been given out. By comparing these drug-proof nad mutants to fish with a normal response, Webb and her colleagues discovered a set of 139 genes that respond inappropriately to amphetamine in nad mutants, with...

Structure of protective protein in the eye lens revealed

...ucture of αB-crystallin, which is currently being further refined, the basis has now been established for comparing healthy and disease-promoting mutants and, based on this, for clarifying the way they function. The scientists hope that this will lead to the discovery of new treatments. ...

How mitochondria get their membranes bent

...e structure. In the current issue of the the Journal of Cell Biology Rabl, Soubannier et al. report on their quest of slow-growing baker`s yeast mutants harboring deformed mitochondria. Thereby, they discovered the protein Fcj1 ("Formation of criasta junction protein 1"), which is embedded in the inner...

Fate in fly sensory organ precursor cells could explain human immune disorder

...or cell division has been used as a model to understand how Notch signaling is activated during asymmetric cell division. In a screen of fruit fly mutants that have disrupted peripheral nervous system development, Akhila Rajan and An-chi Tien, two graduate students in Bellen's laboratory, identified a mu...

Rutgers research tackles childhood epilepsy

...up with new strategies for treatment." D'Arcangelo's mutant mice lack a gene (Pten) that suppresses cell growth in some neurons, resulting in these mutants displaying molecular, cellular and physiological traits of cortical dysplasia. The researchers treated the mice with rapamycin. It had already shown p...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

...mmortality' of reproductive germline cells. Their report will appear in the journal Nature and is receiving advance online release. " C. elegans mutants with extreme longevity accomplish this feat, in part, by adopting genetic programs normally restricted to the germline into somatic cells," says Sean ...

Saved by junk DNA

...al evolution, using yeast cells as Darwinian guinea pigs. Their results show that when a repeat is present near a gene, it is possible to select yeast mutants that show vastly increased activity of this gene. However, when the repeat region was removed, this fast evolution was impossible. 'If this was the re...

Why the thumb of the right hand is on the left hand side

...lls process the signals of the signaling molecules and how they react." mutants do not react to high concentrations Already during her time as a post d... high-resolution fluorescence microscopy, we have now shown that in the new mutants a small genetic alteration at the extracellular part of this protein inhibi...
Mutants in Biological Technology

Single-Cell Complementation of Barley Mlo Mutants Using a PDS-1000/He Hepta System

Ralph Panstruga, Brigitte Schauf, and Paul Schulze-Lefert, Max-Planck-Institut fr Zchtungsforschung, Carl-von-Linn-Weg 10, 50829 Kln, Germany e-mail: panstrug@mpiz-koeln.mpg.de Abstract Transient expression via particle bombardment is widely use...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...ication covering its L.E.A.P.S.(TM) immune therapy drugs (vaccines) for the prevention/treatment of H1N1, swine, bird flu, Influenza A and/or evolving mutants or variants of these viruses. Some experts believe that by the next flu season the swine flu virus will have evolved and/or combined with other virus...

Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights

...e inhibitor telaprevir and the nucleoside polymerase inhibitor PSI-6130 are synergistic. These studies also show that ANA598 retains activity against mutants known to confer resistance to other classes of direct antivirals, including protease inhibitors, nucleoside inhibitors and non-nucleosides that, throu...

Sloning and the Kornberg group at Stanford University starting evaluation project regarding the synthesis of a Statistically Randomized Gene Library

...el Prize Laureate in Chemistry 2006) at Stanford University will perform in vivo screens based on the library provided by Sloning to identify relevant mutants of a S. cerevisiae RNA Polymerase II. Jan Van den Brulle, Scientific Director at Sloning commented, “We are looking forward to work togethe...

Arpida Presents Preclinical Data on AR-2474 at ICAAC

...ble for causing infections of the skin, eye and mouth. F1-2099: AR-2474 demonstrated little or no propensity for resistance development. No resistant mutants to AR-2474 could be selected using different methodologies. F1-2098: The data showed that AR-2474 is bactericidal, exhibits a post antibiotic effect ...

SGX Provides Update on BCR-ABL Collaboration

...formulation studies. One of the candidates from the collaboration, SGX393, is a potent inhibitor of the T315I mutant (as well as other drug resistant mutants and wild type BCR-ABL) and has its most likely application in drug resistant CML. Pursuant to an amendment to the license and collaboration agreement,...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

...rticles for Biolistic applications. Bibliography 1. Anziano, P. Q. and Butow, R. A., Splicing-defective mutants of the yeast mitochondrial COXI gene can be corrected by transformation with a hybrid maturase gene, Proc. Nat. Acad. Sci., 88...

Temporal Temperature Gradient Electrophoresis: A Powerful Technique to Screen Mutations

...ation of 1.25x or 1.5x improved the resolution of the homoduplex bands and heteroduplex bands, thus making it easier to identify mutants from wild-type samples. Conclusions The DCode instrument is designed for multiple electrophoretic mutat...

A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis

... (Figure 3c). DGGE of the 5' HinFI amplicon detected 8 of the 12 mutants known to be present in the amplified product. DGGE of the 3' HinFI amplicon detected 9 of the 12 mutants known to be present. DGGE of the 3' overlap amplicon detected al...

RNA Interference and Gene Silencing: History and Overview

...to select for RNAi-defective C. elegans mutants and have led to large numbers of gene knockout stu...sRNA prior to cleavage or the siRNAs directly. But mutants of these genes have varying phenotypes, w...8">18 ). In C. elegans ego-1 mutants ("ego" stands for "enhancer of glp-1 "),...
Mutants in Biological Products

Bacterial Strain BMH 71-18 mutS, Glycerol Stock (noncompetent) from Promega

Description:...stem and is Tets, which allows for cycling between antibiotic resistances. The BMH 71-18 is Tetr, therefore it can only be used to select Ampr or CATr mutants or in the GeneEditor System....
Company:Promega

Bacterial Strain ES1301 mutS, Glycerol Stock (noncompetent) from Promega

Description:...stem and is Tets, which allows for cycling between antibiotic resistances. The BMH 71-18 is Tetr, therefore it can only be used to select Ampr or CATr mutants or in the GeneEditor System....
Company:Promega
Mutants in Biological Definition

Cell growth

...ime t = 2 in the diagram, below) and the rate of increase in cell size is slowed, the time period between cell divisions is increased. Yeast cell size mutants were isolated that begin cell division before reaching the normal size ( wee mutants). The Wee1 protein is a tyrosine kinase . It normally phosphor...

Morphogenesis

...yonic development to Christiane Nsslein-Volhard , Edward B. Lewis and Eric Wieschaus . Their researches on genetic screening for embryo patterning mutants revealed the role played in early embryologic development by Hox genes like bicoid . An example of a homeotic mutation is the so-called antennape...

Gene

... give rise to differences in traits, for example eye color. A gene's most common allele is called the wild type allele, and rare alleles are called mutants . Normally, RNA is an intermediate product in the translation of a molecular gene into a protein. However, for some gene sequences, RNA molecules...

Molecular biology

...of the effect of genetic differences on organisms. Often this can be inferred by the absence of a normal component (e.g. one gene ). The study of " mutants " – organisms which lack one or more functional components with respect to the so-called " wild type " or normal phenotype . Genetic interacti...

Molecular genetics

...The aim of this technique is to identify mutations that produce a certain phenotype . A mutagen is very often used to accelerate this process. Once mutants have been isolated, the mutated gene can be molecularly identified. Reverse genetics Main article: Reverse genetics While forward ge...

Morphogenesis

...yonic development to Christiane Nsslein-Volhard , Edward B. Lewis and Eric Wieschaus . Their researches on genetic screening for embryo patterning mutants revealed the role played in early embryologic development by Hox genes like bicoid . An example of a homeotic mutation is the so-called antennape...

Thomas Hunt Morgan

...ssive. Morgan thus named the gene white , starting the tradition of naming genes after their mutant allele . As Morgan continued to cross-breed the mutants back to one another, he noticed that only males displayed the white-eyed trait. From this, he concluded that (1) some traits were sex-linked , (2) t...
Mutants in Biological Dictionary

Transversion

.... With the same transversion from the blaOXY-2 gene only a fivefold increase was ... Conversely, GC TA transversion increased in mutL or mutS mutants in stationary phase. ... The rate of lacZ GC TA transversion was determined by the method of Lea and ... 2. Which of the substitutions in questio...

Topoisomerase

...merase II in Therapy-Related Acute Promyelocytic Leukemia of topoisomerase III has no effect on the accumula ... topoisomerase III RuvC double mutants that can be ... type-1 topoisomerase is capable of performing a type-2 ... Topoisomerase II is necessary for many biological processes involvin...

Thylakoids

...is of thylakoids from PS1 mutants. ... the 1500 to 1800 cm-1 frequency range for the thylakoids of WT and PS1 mutants. ... ... Western blots of mutants and normal thylakoids (antisera were kindly provided ... thylakoids , we believe the new polypeptides in the mutant are related to ... Thylakoi...

Spermatogenesis

...is and spermiogenesis. ... Spermatogenesis is maintained and regulated by male steroid ... 4. Translational control during spermatogenesis . 5. mutants that affect sperm meiosis ... Spermatogenesis is the process that creates sperm from initially ... The period of spermatogenesis followin...

Saturation mutagenesis

...cient one-step site-directed and site- saturation mutagenesis protocol ... With saturation mutagenesis , it is possible to create a library of mutants ... Recently, a report of a new approach, termed saturation mutagenesis , was published (3) ... to offer optimized oligonucleotides for saturat...

Replication fork

...ter of progressing replication forks with DNA damage or with sequences ... Replication fork reversal was proposed to occur (i) in helicase mutants (in a ... ... part and the open part is called a replication fork . ... Problem: it reaches the replication fork , but the helicase is movi...

Pseudorevertant

...the pseudorevertant , up-regulated transcripts included stress-responsive ... A mutant BamHI endonuclease, E77K, belongs to a class of catalytic mutants that bind DNA efficiently but cleave DNA at a ... Both pseudorevertant proteins ... malZ is a member of the mal regulon. ... From such a malQ m...

Proteolysis

...de. ... This is indicative of proteolysis occurring in vivo and has ... By performing concentration-dependent proteolysis , HDAC1 double point mutants ... In addition, the limited proteolysis experiments support a model where ... Online Shopping at SpotCost.com - New and used books like Proteol...

Post-meiotic segregation

...med in ... Meiotic segregation ... abnormal chromosome content, or post - meiotic selection of some genotypes through ... mei-9 and Ercc1 mutants also have defects in meiotic recombination. ... In some NCOs, post - meiotic segregation (PMS) is observed, indicting failure to ... chromoso...

Phototropism

... Our laboratory is interested in learning the ... Molecular analysis of Photomorphogenesis. Molecular genetics of plant development using tomato mutants ... ...
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