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Mutant in Medical News

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dep...

'Intrabody' can mop up mutant protein in Huntington's disease model

Scientists have created a tool for mopping up the clumps of mutant protein that drive neurodegeneration in Huntington's disease. Emory University researchers engineered a virus to make an intracellular antibody or "intrabody" against huntingtin, the protein whose mutant forms poison the brain cell...

Effect of mutant p53 stability on tumorigenesis and drug design

In the May 15th issue of G&D, Dr. Guillermina Lozano (MD Anderson Cancer Center) and colleagues reveal how the stabilization of a mutated form of p53 affects oncogenesis, and lends startling new insight into the potential pitfalls of using Mdm2 inhibitors for cancer therapy. "Our data are both ...

Chronic Kidney Disease Related To Mutant Gene

Scientists at the University of Michigan Medical School have uncovered the reason for a severe form of kidney affliction and renal failure //in children, which is because of mutations in a gene called phospholipase C epsilon or PLCE1. Discovering the mutant gene is crucial to scientists becau...

Gene Transfer Using Mutant Form of Good Cholesterol Cuts Vascular Plaque and Inflammation

Transfer of a gene that produces a mutant form of good cholesterol provides significantly better anti-plaque and anti-inflammation benefits than therapy// using the “normal” HDL gene, according to a mouse study conducted by cardiology researchers at Cedars-Sinai Medical Center and reported in the O...

New Drugs To Combat Mutant Bugs

A newly approved drug to battle super bugs, including MRSA, has found its way to the markets of Scotland.// Clinicians welcomed the news as Tygacil, is one of the few new antibiotics to come on to the market in the past 15 years. Micro organisms have undergone mutations that enabled the...

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Mutant in Medical Technology

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

LOS ANGELES & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 - AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused on the discovery and development of novel, targeted cancer medicines, today announced encouraging preclinical data of AV-412, a novel, next generation oral tyrosine ki...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... said Perlmutter. "Not only is the improvement in progression-free survival limited to patients with wild-type KRAS tumors, but patients with KRAS mutant tumors were negatively affected when Vectibix was added to a standard chemotherapy regimen. We believe Vectibix should not be used in patients with tu...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

... with CdLS. In the current study, Krantz did a genome-wide analysis of mutant cell lines from 16 patients with severe CdLS. All the cells had mutations i...mbia. Liu et al, "Transcriptional dysregulation in NIPBL and cohesin mutant human cells," PloS Biology , published online, May 26, 2009. About Th...

Mutant Genes in High-Risk Childhood Leukemias Identified

...her types of leukemias and related diseases. "Further studies of these mutant JAK proteins revealed that the changes in their molecular structures could ...e, in test tube studies, we found that drugs blocking the activation of the mutant JAK kinases prevented uncontrolled growth suggesting that drugs that target...

Doctors Urge Precaution to Shield Against Swine Flu

...kly across the globe, medical options are limited. The current strain is a mutant of H1N1, containing a unique combination of pig, bird and human DNA, that c...mmune defense called "acquired immunity" will also be challenged by the new mutant strain of swine flu. It is so radically different from prior strains that ...

British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection

..., scientists at Nottingham will use a technology called ClosTron to produce mutant versions of the hypervirulent strains. They will knock out genes one by one and then compare the mutant version to the standard organism to assess the function of each cell. ...
Mutant in Medical Dictionary

Virus

... with classical ... Parent: Dengue virus type 1 ... Like the major vaccinia virus (VV) core protein precursors, p4b and p25K, the 25 ... The mutant virus was designed to have Tet operator in front of A12L open reading ... displayarticle ... The maize streak virus causes one of the most des...

Splinter

...), recording artists. ... Splinter (TMNT), a character from the Teenage mutant Ninja Turtles series. ... Master Splinter , or simply Splinter is a fictional character in the Teenage mutant Ninja Turtles universe. Splinter is a giant anthropomorphic rat who is th...

Marrow

...l body weight, i.e. approximately 2.6 kg (5.7 lbs.) in adults. Marrow (Sarah), is a Marvel Comics character, associated with the X-Men. She is a mutant whose bones grow out of her skin and can be removed from her body, providing her with potential knives and clubs as well as body armor. marrow ...

Gene Therapy

...rapy is the insertion of genes into an individual's cells and tissues to treat a disease, such as a hereditary disease in which a deleterious mutant allele is replaced with a functional one. Although the technology is... An overview of genomics and medicine highlighting the areas of gene test...
Mutant in Biological News

Small molecules might block mutant protein production in Huntington's disease

DALLAS May 3, 2009 Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found. These man-made molecules also were effective against the abnormal ...

No helicopter moms among Rutgers mutant mice

NEW BRUNSWICK, N.J. First, he discovered a gene that controls innate fear in animals. Now Rutgers geneticist Gleb Shumyatsky has shown that the same gene promotes "helicopter mom" behavior in mice. The gene, known as stathmin or oncoprotein 18, motivates female animals to protect newborn pups and...

MIT researchers offer glimpse of rare mutant cells

CAMBRIDGE, Mass. -- MIT biological engineers have developed a new imaging system that allows them to see cells that have undergone a specific mutation. The work, which could help scientists understand how precancerous mutations arise, marks the first time researchers have been able to pinpoint ...

Scientists solve 30-year-old mystery of mutant mouse's kidney woes

Researchers seeking insights into kidney failure in human infants have located the source of a 30-year-old mystery mutation that causes similar problems in a mouse line. Scientists have known of the mouse line's naturally occurring mutation since the early 1970s. Researchers at Washington Univer...

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

Transfer of a gene that produces a mutant form of good cholesterol provides significantly better anti-plaque and anti-inflammation benefits than therapy using the "normal" HDL gene, according to a mouse study conducted by cardiology researchers at Cedars-Sinai Medical Center and reported in the Oct...

Researcher gets NSF grant to create mutant maize lines

A Boyce Thompson Institute (BTI) researcher at Cornell University has received a grant to help assemble a unique database of DNA mutations in maize (corn). The project not only will allow researchers to study the effects of knocking out the function of single genes, one at a time, but also will ...

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Mutant in Biological Technology

Detection of Mutant K-ras in a Kindred With Hereditary Pancreatic Cancer by DGGE

David A. Crispin,* Ru Chen,* Michael B. Kimmey,** Teresa A. Brentnall** * Departments of Pathology and **Medicine, Division of Gastroenterology, University of Washington, Seattle, Washington. Introduction ...

CEL-SCI Corporation Releases Letter to Shareholders

... found to be circulating. We must anticipate its evolution and prepare for mutant strains to appear from remote regions of the globe. Those mutant strains of the virus could possess virulence and other properties that far ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...e A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective vaccine/treatment that could potentially fight such a mutant virus. Geert Kersten, Chief Executive Officer of CEL-SCI said, "By filing this provisional patent in the U.S., we are preserving our rights to ...

Fruit fly steps in to fight human disease

... "By putting mutant genes from human patients into fruit flies, we've created the first ever fl...showed no difference in ordinary fruit flies. However, fruit flies with the mutant YARS genes, showed clear symptoms of CMT such as a reduced capacity to move...

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

...l identical, or there may be a fraction that differs. When both normal and mutant molecules exist, the mitochondria are said to be "heteroplasmic." The heter...lizing NextGen sequencing technology. The error rate determines how small a mutant fraction is reliably detected. MEDomics uses the Applied Biosystems SOLiD(T...

Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria

...orosome. They used genetic techniques to create a mutant bacterium with a more regular internal structure, ...e of the chlorosome. First, the team created a mutant bacterium in order to determine why the chlorophyl...eria grow faster at all light intensities than the mutant form. "Indeed, the reason that chlorophylls becam...
Mutant in Biological Products

Topoisomerase I (Vaccinia) from Molecular Cloning Laboratories (MCLAB)

Description:...transcription in vitro Studying chromatin reconstitution in vitro Determining the degree of supercoiling of naturally occurring DNA Detecting mutant plasmids that differ in length by only one base-pair Increasing restriction endonuclease digestion of resistant DNA substrates by "unwinding" the D...
Company:Molecular Cloning Laboratories (MCLAB)

MDR1 Shift Assay from CHEMICON

Description:...tive and specific detection of MDR1 expression. In addition, the kit is valuable for the study of structure-function relationships in cells expressing mutant MDR1 molecules. • The kit includes the UIC2 antibody, a conformation-sensitive mouse monoclonal against human MDR1, and an isotype-matched ne...
Company:CHEMICON

BioPrime Plus Array CGH Indirect Genomic Labeling Module from Invitrogen

Description:...enow fragment of DNA polymerase I and random primers to effectively label genomic targets for sensitive genomic profiling experiments. Exo-Klenow is a mutant of the large fragment of the DNA polymerase I holoenzyme that has both 5 and 35 exonuclease activity removed. The lack of exonuclease activity makes t...
Company:Invitrogen

BioPrime Array CGH Genomic Labeling System from Invitrogen

Description:...enow fragment of DNA polymerase I and random primers to effectively label genomic targets for sensitive genomic profiling experiments. Exo-Klenow is a mutant of the large fragment of the DNA polymerase I holoenzyme that has both 5 and 35 exonuclease activity removed. The lack of exonuclease activity makes t...
Company:Invitrogen
Mutant in Biological Definition

Allele

... result in a blood type of "AB". A wild type allele is an allele which is considered to be "normal" for the organism in question, as opposed to a mutant allele which is usually a relatively new modification. ...

Cilium

...ry cilium in the renal tube cells can lead to polycystic kidney disease (PKD). In another genetic disorder called Bardet-Biedl syndrome (BBS), the mutant gene products are the components in the basal body and cilia. ...

Morphogenesis

...e transcription factor. If this transcription factor is damaged, the fly grows legs on its head instead of antennae. See images of this "antennapedia" mutant and others, at FlyBase . The term morphogenesis can also be used to describe the development of unicellular life forms that do not have an embryoni...

Ewens's sampling formula

...ion is in statistical equilibrium under mutation and genetic drift and the role of selection at the locus in question is negligible, and (3) every mutant allele is novel. This is a probability distribution on the set of all partitions of the integer n . Among probabilists and statisticians it is...

Gene therapy

...ividual's cells and tissues to treat a disease , and hereditary diseases in particular. Gene therapy typically aims to supplement a defective mutant allele with a functional one. Although the technology is still in its infancy, it has been used with some success. Antisense therapy is not stric...

Morphogenesis

...e transcription factor. If this transcription factor is damaged, the fly grows legs on its head instead of antennae. See images of this "antennapedia" mutant and others, at FlyBase . The term morphogenesis can also be used to describe the development of unicellular life forms that do not have an embryoni...
Mutant in Biological Dictionary

Wild-type

...ow our services ... wild type n. The typical form of an organism, strain, gene, or characteristic as it occurs in nature, as distinguished from mutant forms that may Michigan native plants, including forbs (wildflowers), grasses, sedges, trees, ... Join Naturalist Photographer, Mark S. Carlson and...

Wildtype

...chigan genotypes. ... wild type n. The typical form of an organism, strain, gene, or characteristic as it occurs in nature, as distinguished from mutant forms that may At Wildtype we build platform-independent, full-featured, fast, and reliable ... Wildtype Informatics LLC was first formed in 20...

Wild type

...iduals with the ... wild type n. The typical form of an organism, strain, gene, or characteristic as it occurs in nature, as distinguished from mutant forms that may Puff's domain, housing Pokemon fanlistings and fansites. ... Type - Wild is about 90% complete! I hope to have the wishlist up by ...

Viral oncogene

...al . Bacterial. Bovine. Canine. Chicken/Avian. Feline. Hamster ... Raf1 (v-raf-leukemia viral oncogene 1) acts as a mitogenic protein kinase; mutant forms may play ... murine leukemia viral (v-raf-1) oncogene homolog 1 (3611 ... ...

UvrA

...the nucleotide excision repair pathway are ... groups, it was necessary to inactivate the uvrA dependent nucleotide excision repair gene. ... mutant strain deficient in alkA tagA and uvrA , then exposed ... Crystal Structure of Bacillus stearothermophilus UvrA Provid... In addition, UvrA ...

Thylakoids

...s. ... ... Western blots of mutants and normal thylakoids (antisera were kindly provided ... thylakoids , we believe the new polypeptides in the mutant are related to ... Thylakoids have a membrane and contain lipids, proteins, and chlorophyll. The thylakoids are suspended in a fluid called the...
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