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Multiprotein in Medical News

Molecule tracking reveals mechanism of chromosome separation in dividing cells

...s conserved during evolution as a good way of getting the job done. The question is how this mechanism works. Previous studies implicated a large, multiprotein complex, Ndc80, as a direct contact point between kinetochores and microtubules. However, researchers had only a static view of the complex. The UW re...

Protein's essential role in repairing damaged cells revealed

...tances, the body's cells grow, divide and eventually die. When something damages a healthy cell's DNA -- such as radiation or exposure to a toxin -- a multiprotein complex steps in to repair the breakage and activate other fundamental cellular processes. The MRN complex, comprised of the Mre11, Rad50 and NBS1...

JCI table of contents: Nov. 8, 2007

...tagonist dramatically reduced bleomycin-induced inflammation in normal mice. Further analysis revealed that a protein known as ASC, which is part of a multiprotein complex known as the inflammasome, was required for the production of IL-1-beta by the lung in response to exposure to bleomycin. These data indicate ...
Multiprotein in Biological News

EMBL scientists develop first fully automated pipeline for multiprotein complex production

Most cellular processes are carried out by molecular machines that consist of many interacting proteins. These protein complexes lie at the heart of life science research, but they are notoriously hard to study. Their abundance is often too low to extract them directly from cells and generating th...

CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery

...g gene transcription the process inside the nucleus of cells by which DNA, the genetic material, is copied into RNA molecules a large, ever-changing multiprotein complex is enlisted to assist the DNA-copying enzyme in its challenging job. Like an exquisitely choreographed dance, each step in the process has...

Conaway Lab identifies novel mechanism for regulation of gene expression

...unpacking" DNA from nucleosomes to allow access to chromosomal DNA. Previously, the Conaway Lab demonstrated that Uch37 is associated with another multiprotein complex, the proteasome a large protein complex that degrades unneeded or damaged proteins. In the new paper, the team shows that when bound to INO80...

Stowers Proteomics Center devises method for assigning probabilities to human protein interactions

... it also holds promise in facilitating the development of treatments for disease. By having insight regarding the most probable contacts within a multiprotein complex, we can devise targeted strategies to disrupt specific interactions, said Mihaela Sardiu, Ph.D., Postdoctoral Research Associate and lead auth...

Changing environment organizes genetic structure

...d in molecules, molecules into amino acids and amino acids into secondary structures, domains and proteins," Deem said. "This hierarchy continues with multiprotein complexes, protein regulation pathways, cells, organs, individuals, species and ecosystems. Our research suggests that modularity and hierarchy are pr...

Scripps research study shows humans and plants share common regulatory pathway

...g off SGT1 did not alter levels of Nod1." In an earlier study, Ulevitch’s laboratory reported that Nod1 also interacted with the COP9 complex, a multiprotein complex that is known to play a role in a number of development pathways in plants and that has a mammalian counterpart. This interaction, Ulevitch no...

Proteins may behave differently in natural environments

... When in an environment similar to that in which they exist naturally, proteins and multiprotein assemblies may demonstrate actions or dynamics different than those they exhibit when in the static form in which they are most often studied, said re...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

...it makes these specific sized RNAs is important to the process," Doudna said. The small RNA fragments created by Dicer are then assimilated into large multiprotein complexes and guide those molecules to destinations in the cell where they turn off genes. "The size of these small RNAs is a determinant of their ...

Molecule does more than slice and dice RNA

...it makes these specific sized RNAs is important to the process," Doudna said. The small RNA fragments created by Dicer are then assimilated into large multiprotein complexes and guide those molecules to destinations in the cell where they turn off genes. "The size of these small RNAs is a determinant of their ...
Multiprotein in Biological Technology

Whole Gel Eluter Purification of a Functional Multiprotein DNA Replication Complex, Rev A

HaiYan Jiang a,e , Robert J. Hickey a-e, h , Pamela E. Bechtel f , Philip W. Wills a, e , SuHua Han a,e , Timothy D. Tom a-g , YueTong Wei a,e , and Linda H. Malkas a-e,+ , (a) Department of Pharmacology and Experimental Therapeutics (b) Program in M...
Multiprotein in Biological Products

Rabbit Anti-Aph-1aL, S Loop (92-115) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc

Description:... Polyclonal Antibody against Aph-1a (Aph-1aL,S Loop 92-115), O2F1 Affinity Purified Antibody The gamma secretase is a multiprotein complex consisting of presenilin, nicastrin, Aph-1 and Pen-2; all four proteins are necessary for full proteolytic activity. The gamma secretase compl...
Company:Covance Research Products, Inc
Multiprotein in Biological Definition

Quaternary structure

... . Examples of proteins with quaternary structure include hemoglobin , DNA polymerase , and ion channels . Other assemblies referred to instead as multiprotein complexes also possess quaternary structure. Examples include nucleosomes and microtubules . Changes in quaternary structure are called conformat...
Multiprotein in Biological Dictionary

Splicing factor

...33 kDa. ASF SF2 also mediates... a b "Entrez Gene: SF3B1 splicing factor 3b, subunit 1, 155kDa" ... Molecular architecture of the multiprotein splicing factor SF3b. ... Human protein-coding gene SF1. Represented by 1013 ESTs from 378 cDNA libraries. ... Homo sapiens splicing f...

Proteasome

... of the 26S proteasome . ... The Proteasome -Glo™ Cell-Based Assays(a,b) are homogeneous, luminescent assays ... The 26S proteasome is a 2.5MDa multiprotein complex found in all eukaryotic cells. ... Designed to assay compounds for their ability to modulate proteasomal activity ... The ubiquitin/ prot...
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