Study identifies mechanism underlying multidrug resistance in fungi
A team of researchers led by Anders Nr, PhD, of the Massachusetts General Hospital (MGH) Cancer Center has identified a mechanism controlling multidrug
resistance in fungi. This discovery could help advance treatments for opportunistic fungal infections that frequently plague individuals with comp...
New Report Just Published: World Multiple Myeloma Therapeutics Market Report
...ma Market (2006):
Breakdown of Typical Length of Treatment
Cycle and Cost per Cycle (In US$) (includes corresponding
Resistance: A Challenge to Reckon With II-9
Gene Therapy Exudes Hope II-9
Challenges Encountered in Clinical Trials II-10
FDA's Antidotes ...
Viral Genetics Has Option Under Issued Key Patent for Cancer Drug
...form newly detected tumors that are increasingly resistant to treatment. The growing popularity of "cocktails" of chemotherapy drugs has given rise to multidrug
resistant tumor cells that are even more difficult to destroy.
Drug sensitive tumor cells, under the selective pressure of treatment with drugs,...
Superbug risk to war wounded
...diers who survive severe injuries on battlefields such as those in Iraq and Afghanistan can be at risk from developing infections of their wounds with multidrug
resistant bacteria. The potentially lethal microbes include superbugs such as methicillin resistant Staphylococcus aureus (MRSA), Acinetobacter bau...
Statement From Sequella Founder and CEO, Dr. Carol Nacy at the 'Stop TB' Meeting in Brazil on the Eve of World TB Day
... RIO DE JANEIRO, Brazil, March 23 /PRNewswire-USNewswire/ -- "With multidrug
(MDR) and extremely drug (XDR) resistant tuberculosis on the rise, the world-wide financial crisis is of major concern to the international health com...
Pilot Study Using Video Cell Phones for Mobile Direct Observation Treatment (MDOT) to Monitor Medication Compliance of TB Patients
...to two week's medication where compliance cannot be monitored effectively. Non-compliance with the medication protocol can lead to the more dangerous multidrug
The goal of the MDOT Pilot Project was to determine if mobile technology would be an acceptable alternative for both the patient an...
NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting
...cteria. In past in-vitro studies, NVC-422 has shown a broad therapeutic index with broad spectrum activity against bacteria of all types, including multidrug
resistant species, shedding viruses including adenoviruses and herpes viruses, yeasts and fungi. In addition, NVC-422 has previously shown, in-vivo ...
New twist on old medical technology may prevent amputations
... (MDRAB) infections is oftentimes treated with an older class of drugs known as polymyxins, including colistin, one of the last-resort antibiotics for multidrug
resistant A. baumannii. Approaches commonly used to overcome MDR infections after orthopaedic injuries include applying a large dose of antibiotic loc...
E. coli persists against antibiotics through HipA-induced dormancy
...e possibility of adding a new class of drugs to therapy against chronic and multidrug
resistant bacterial infection.
Working in Escherichia coli, the team sol...Brennan and colleagues demonstrated the molecular details of HipA's role in multidrug
tolerance and HipB's role keeping HipA under wraps in a series of experimen...
New approach, old drug show promise against hepatitis C, Stanford research shows
...developing useful medicines.
Should clemizole prove effective in human trials, Glenn said, it could become an essential component in a new class of multidrug
treatments for hepatitis C. Other components could be drugs under development elsewhere that target specific enzymes in the virus. The goal is to impr...
Multidrug in Medical Technology
Adventrx Announces Positive Data From Multidrug Therapy With
Data Presented at American Association for Cancer Research Annual
SAN DIEGO, April 18, 2007 /PRNewswire-FirstCall/ -- ADVENTRX
Pharmaceuticals, Inc. , a biopharmaceutical research and
development company focused on commercializing proprietary product
candidates for the treatment of cancer ...
Alfacell Provides Shareholder Update
...um, are used in the first line therapy of cancer. These genes, known as the multidrug
resistance (MDR) gene1 and the multidrug
resistance associated protein gene make proteins which act like pumps to ke...
Cequent tkRNAi Technology to be Presented at the Centennial Meeting of the American Association for Cancer Research
...rogression into cancer.
Tuesday, April 21 Modulation of ABCB1-Mediated multidrug
by TransKingdom RNA Interference (tk...he effectiveness of using
tkRNAi against an important multidrug
mechanism seen in solid cancers such as ga...
NovaBay Pharmaceuticals Announces Lead Anti-infective Product Candidate, NVC-422, Shown to be Effective in Treating Topical Fungal Infection
...sistance. In-vitro studies to date have shown that NVC-422 has a potentially expansive therapeutic utility against bacteria of all types, including multidrug
resistant species; shedding viruses including adenoviruses; and herpes viruses, yeasts and fungi. In addition, in Phase I human studies, NVC-422 has ...
Rendell Administration Announces Health Research Grants From Tobacco Settlement Funds
...atients. The project will assess the health and economic impacts of these novel strategies on the prevention and control of infections caused by these multidrug
resistant bacteria. A. baumannii is a severe, difficult-to-treat infection in seriously ill hospitalized patients. C. difficile is resistant to nu...
Unibioscreen and Drais Pharmaceuticals Partner to Develop and Commercialize UNBS 5162 for Treatment of Cancer
...he targeted treatment of cancer and its
metastases. The company's focus is on cytotoxic/cytostatic
chemotherapeutics that kill apoptosis-resistant and multidrug
cancer cells, and anti-migratory drug candidates that fight metastases.
Most of Unibioscreen's drug candidates are derived from molecules ob...
Rib-X Pharmaceuticals, Inc. Announces Recent and Upcoming Presentations at Scientific Conferences
...he 50S Ribosomal Subunit." RX-04 is Rib-X's de
novo design of three completely new series of antibacterials showing
promising activity against serious multidrug
pathogens, including, Pseudomonas aeruginosa, Stenotrophomonas maltophilia,
Klebsiella pneumoniae, Acinetobacter baumanii and ...
Kosan Initiates Phase 2 Trial of Epothilone KOS-1584 in Non-Small Cell Lung Cancer
...ignificant antitumor activity in a range of
xenograft models, including non-small cell lung cancer models resistant to
paclitaxel and those expressing multidrug
resistance. A long elimination
half-life was seen in Phase I trials. KOS-1584 has demonstrated antitumor
activity and favorable tolerability in Phase ...
Pharmasset Presents Clevudine and Racivir Data at the International
HIV Drug Resistance Workshop
...wer than 3 TAMs at day 28. Clonal genotypic analysis
of virus from responders indicated that the M184V mutation was
found on all clones in addition to multidrug
mutations observed with first line therapy failure.
Clevudine is an oral, once-daily pyrimidine nucleoside a...
New Research Demonstrates Broad Efficacy of Azixa (MPC-6827)
Against Multiple Tumor Types and in Drug Resistant Cell Lines
...ubulin-disrupting cancer treatments, MPC-6827 had
efficacy against tumor cells that over-expressed the three main
protein transporters responsible for multidrug
indicating that MPC-6827 may prove effective against drug resistant
tumors in a clinical setting.
MPC-6827 is one of two compounds curre...
Multidrug in Medical Dictionary
...as found—in 1947, just four years after the drug ... Drug resistance . multidrug
resistance . multidrug
tolerance ... Drug resistance is the phenomenon whereby widespread ...
Multidrug in Biological News
New study reveals structure of E. coli multidrug transporter protein
This new study could potentially help researchers find new ways to avoid the problem of multidrug
resistance and enhance the potency of existing drug compounds.
The study is being published in ScienceXpress, an advance online edition of the journal Science, on May 5.
"The development of antib...
New polysaccharide may help combat multidrug resistance in cancer
In a recent study published in the Journal of Biological Chemistry, scientists report that a molecule previously thought to play a purely structural and inert role in cells is actually involved in multidrug
resistance in cancer. Using antagonists for this molecule, the researchers were able to sens...
Study finds multidrug-resistant gram-negative bacteria high in long-term care
...tant organismsmethicillin-resistant Staphylococcus aureas (MRSA) and vancomycin-resistant enterococci (VRE).
"Recently, it has become apparent that multidrug
resistance among gram-negative bacteria is becoming an even greater problem in these facilities, with nearly half of long-term care facility residents...
Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
...infected cells, as well as some therapeutics aimed at alleviating psychiatric conditions.
"We've long known that P-glycoprotein plays a key role in multidrug
resistance in cancer patients, and this work helps us understand how the protein can act on such a wide range of compounds," said Jean Chin, Ph.D., of...
Scientists in Hungary and Portugal get research boost
Gergely Szakcs is moving from the USA to set up his laboratory at the Hungarian Academy of Sciences in Budapest, Hungary to research multidrug
resistance in cancer. Szakcs is the third awardee to establish a lab in Hungary of the total 11 scientists receiving the 2007 EMBO Installation Grants...
American Chemical Society's Weekly PressPac -- Sept. 19, 2007
...ug-resistant strains has reduced the effectiveness of those medications. Researchers are developing more accurate diagnostic tests, new drugs to fight multidrug
resistant strains, and ones that are more compatible with individuals who are undergoing treatment for HIV. Scientists are also developing more effect...
Technology reveals 'lock and key' proteins behind diseases
...by mutation, causes cystic fibrosis, a hereditary disease that results in progressive disability and early death. Another important ABC protein is the multidrug
Resistance Protein (MRP), which normally removes drug metabolites and toxins from cells in our bodies but when overzealous can contribute to the drug ...
Gallium: A new antibacterial agent?
...h is chemically similar to Fe and can disrupt biological systems by substituting for Fe, inhibits the in vitro growth of Pseudomonas aeruginonsa; even multidrug
resistant strains of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aeruginonsa forming biofilms, the multi-cellu...
Will the plague pathogen become resistant to antibiotics?
...lic health concern."
Genetic ability to disable antibiotics, including multidrug
resistance (MDR) sequences, is carried on plasmids, small circles of DNA th...tates.
"What we've done is revealed a mechanism for the acquisition of multidrug
resistance in Y. pestis. Obviously, this is an event that might have seriou...
Pollution threatens coral health by preventing lesions from healing, UCF study shows
... itself to already damaged proteins and causes them to degrade more, also were found at those sites.
At three offshore sites, elevated levels of a multidrug
resistance protein were found. That helps the coral defend itself against contaminants, but it is metabolically costly for coral to produce, leaving l...
Multidrug in Biological Technology
University of Lodz Invests in the Unique Cellaxess(R)HT System for Research on Multidrug Resistance Genes in Cancer
GOTHENBURG, Sweden, July 22 /PRNewswire/ -- Cellectricon, a leading
provider of cell-based screening solutions for research and drug discovery,
today announced its collaboration with University of Lodz, Poland. Under the
agreement University of Lodz invests in Cellaxess(R)HT, the world's first...
Clinical Data Acquires Epidauros Biotechnologie AG, Significantly Enhancing Proprietary Genetic Biomarker Portfolio
...reof, or to reflect the occurrence of or non-occurrence of
any events. (1) multidrug
Resistance 1, aka ABCB1 or ATP-Binding Cassette, Subfamiliy B, Member 1 (2) Organic Cation Transporter 1 (3) multidrug
Resistance-Associated Protein 1, aka ABCC1 or ATP-Binding Cassette, Su...
The Genesis of Gendicine: The Story Behind the First Gene Therapy
oncogenic functions that contribute to
tumorigenicity. Most importantly, mutant
p53 proteins have been associated with the
upregulation of the multidrug
(MDR) gene, which results in tumor
resistance to a variety of
chemotherapeutics. Introduction of
exogenous wild-type p53 gene and
Multidrug in Biological Products