Mucosal

Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers

UC and CD, the two major forms of IBD are chronic, idiopathic inflammatory conditions of the gut with a typically relapsing and remitting course. A prominent feature in mucosal biopsies from patients with active IBD is infiltration by neutrophil granulocytes. Moreover, the number of eosinophil gra...

News briefs from the July issue of CHEST

... patients), researchers from McMaster University in Ontario, Canada, found that LABA therapy had no effect on sputum, bronchoalveolar lavage (BAL), or mucosal inflammatory cell findings in adults or children. LABAs did decrease exhaled nitric oxide levels and BAL albumin levels in adults, suggesting a possib...

Identafi(TM) 3000 Picked by Dentistry Today Magazine as One of the Top 100 Products of 2009

...ice University and British Columbia Cancer Research Centre in Vancouver, Canada. Identafi 3000 represents a quantum leap in the visualization of mucosal abnormalities, including oral cancer or premalignant dysplasia. The technology not only is effective in screening and diagnosing oral cancers but also...

Particle Sciences Further Expands Combination Product Development Capabilities

...article Sciences focuses on emulsions, gels, particulates and drug/device combination products with additional specialized capabilities in topical and mucosal drug delivery. Through a full range of formulation, analytic, and manufacturing services, Particle Sciences provides pharmaceutical companies with a c...

AGA Institute presents cutting-edge research during DDW

...al. (3:00 p.m.)* Adalimumab Induces and Maintains mucosal Healing in Patients With Moderate to Severe Ileoco...al Cell Interface. D. Polk (8:39 a.m.) Changes in mucosal Homeostasis Leading to Hypersensitivity to mucosal Injury in NHE3 Knockout Mice. D. Laubitz et al. (9...

Cancer-causing virus associated with higher risk of new HIV infection

...loser to the surface and also the lesions' skin layer is thinner and more easily shredded, which frequently causes bleeding. These disruptions of the mucosal barrier could allow easier entry for HIV," said Chin-Hong. In addition, HPV activates the immune system. The inflammatory cells recruited to the H...

Mucosal in Medical Technology

Successful Results for Mymetics Corporation's Mucosal HIV/AIDS Vaccine Viral Challenge Significantly Exceeds Expectations

NYON, Switzerland, September 16 /PRNewswire-FirstCall/ -- Mymetics Corporation (OTCBB: MYMX), a vaccine development company, is pleased to announce their preliminary SHIV challenge results on non-human primates previously immunized with the Company's mucosal HIV-AIDS vaccine designed for trigg...

Mymetics' HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model

Mymetics Also Announces Deal for Vaccine Delivery System NYON, Switzerland, March 29, 2007 /PRNewswire-FirstCall/ -- Mymetics Corporation announced today that the Company's HIV vaccine elicited IgA mucosal antibodies in a non-human primate model. Mucosal IgA antibodies are considered a possible fi...

New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease

...ADE therapy on steroid-free remission and complete mucosal healing, the healing of the lining of the bowel, a...ioprine vs. REMICADE monotherapy). Additionally, mucosal healing was achieved in 44 percent of patients rec...30 percent receiving REMICADE monotherapy achieved mucosal healing compared with 17 percent of patients recei...

Induction Chemotherapy Followed by ChemoRadiotherapy Increased Time-to-Treatment Failure Compared to ChemoRadiotherapy Alone in Patients With Unresectable Locally Advanced Head & Neck Cancer

..., and an estimated more than 350,000 will die from the disease. Head and neck cancer is a group of tumors that mostly arise in the cells that line the mucosal surfaces, giving rise to squamous cell carcinoma in the head and neck area, such as the mouth, tongue, tonsils, voice box and throat. "This tri...

Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis

...ssesses stool frequency and the amount of bloody stool per day as recorded in a patient diary, physician global assessment and the assessment of colon mucosal inflammation ascertained by endoscopy. Ulcerative colitis is a chronic inflammatory bowel disease characterized by inflammation and ulceration of...

Alba Therapeutics Corporation Announces the Next Clinical Trial of Its Lead Compound, Larazotide Acetate and Promotions

...clinical Immunology and a vocation for clinical development in the field of mucosal Immunology. Prior to joining Alba in September 2007, Dr. Leon was a Directo...mmatory and Respiratory Diseases at MedImmune where he worked on asthma and mucosal vaccination. He was a Director of Clinical Discovery, Oncology/ Immunology...

Mucosal in Medical Products

Tegress™ Urethral Implant

Description:...e Vinyl Alcohol copolymer (EVOH) in a Dimethyl Sulfoxide (DMSO) carrier forms a soft hydrophilic implant that reinforces the integrity of the urethras mucosal seal. Over time, host fiber ingrowth incorporates Tegress™ Implant for true remodeling of surrounding urethral mucos....
Company:Bard Urological Division

Ncircle® Nitinol Tipless Stone Extractors with Delta Wire®

Description:...in calyceal stone capture by allowing the basket to open at the base of the calyx and encircle the stone. The tipless design reduces the likelihood of mucosal damage and perforation. Delta Wire construction provides increased radial force of the basket. Supplied sterile in peel-open packages. Intended for on...
Company:Cook Incorporated

Ncircle® Nitinol Tipless Stone Extractors - RHR Replacement Stone Extractors

Description:...in calyceal stone capture by allowing the basket to open at the base of the calyx and encircle the stone. The tipless design reduces the likelihood of mucosal damage and perforation. The 2.2, 3.0 and 3.2 French versions have a flexible sheath which permits continuous, full deflection of a flexible ureterosco...
Company:Cook Incorporated

Ncircle® Nitinol Tipless Stone Extractor - Helical Basket with Unidex Handle

Description:...in calyceal stone capture by allowing the basket to open at the base of the calyx and encircle the stone. The tipless design reduces the likelihood of mucosal damage and perforation. The 2.2, 3.0 and 3.2 French versions have a flexible sheath which permits continuous, full deflection of a flexible ureterosco...
Company:Cook Urological

Ncircle® Nitinol Tipless Stone Extractor with Unidex Handle

Description:...in calyceal stone capture by allowing the basket to open at the base of the calyx and encircle the stone. The tipless design reduces the likelihood of mucosal damage and perforation. The 2.2, 3.0 and 3.2 French versions have a flexible sheath which permits continuous, full deflection of a flexible ureterosco...
Company:Cook Urological

NCircle Nitinol Tipless Stone Extractors

Description:...in calyceal stone capture by allowing the basket to open at the base of the calyx and encircle the stone. The tipless design reduces the likelihood of mucosal damage and perforation. The 2.2, 3.0 and 3.2 French versions have a flexible sheath which permits continuous, full deflection of a flexible ureterosco...
Company:Cook Urological

Mucosal in Medical Definition

Pathology

...icine , is the medical specialty concerned with diagnosing diseases based on the analysis of body fluids, such as plasma, urine, stool, respiratory or mucosal secretions, inflammatory exudates, and pleural, pericardial, peritoneal, synovial, or cerebrospinal fluid. The practice of clinical pathology is cente...

Mucosal in Medical Dictionary

Reflux

...disease (GERD), gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease is defined as chronic symptoms or mucosal damage produced by the abnormal reflux in the... Causes, symptoms, diagnosis, and treatments for GERD, acid reflux , and heartburn. Learn...

Purpura

...derneath the skin. Purpura measure 0.3-1 cm, whereas petechiae measure less than 3... Purpura is the result of hemorrhage into the skin or mucosal membrane. ... Purpura may be secondary to thrombocytopenia, platelet dysfunction, coagulation ... Henoch-Schönlein purpura is an IgA-mediate...

Pyogenic granuloma

...ma is a relatively common skin growth that presents as a shiny red mass. ... pregnancy variant of pyogenic granuloma most often occurs on the mucosal ... The pyogenic granuloma is a benign, localized mass of exuberant granulation ... Pyogenic granuloma of the oral and oropharyngeal regio...

Protein C

...lotting. ... The world's first wiki where authorship really matters. Due credit and ... Activated protein C reduces stress-induced gastric mucosal injury in rats by ... Compare Cheap Prices for Protein C at NexTag.com. Find Great Bargains on Sporting Goods, Toys, Collectibles, Car Parts...

Pepsin

...or Pepsin Nutritional Supplements Get information, facts, and pictures about pepsin at Encyclopedia.com. ... pepsin enzyme produced in the mucosal lining of the stomach that acts to degrade ... Information about pepsin in the free online English dictionary and encyclopedia. ... A substanc...

Papilloma

...ng symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis. The papilloma is a benign mucosal mass produced by a strain of the ... The papilloma is not contagious, like a wart, and can be removed by conservative ... Detailed information...

Mucosal in Biological News

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...et al suggest that "gastrin may serve as a rheostat for the stomach. Gastrin likely plays a central role in the safety network for the protection from mucosal damages caused by gastric acid secretion induced by gastrin itself, and thus either too much or too little gastrin can predispose to carcinogenesis. T...

Tips from the journals of the American Society for Microbiology

... 1918 and H5N1 virus. In contrast, mice receiving two intramuscular immunizations of 1918 VLPs were only protected against the 1918 viral challenge. mucosal vaccination with 1918 VLPs induced higher levels of cross-reactivity in mice and complete survival in ferrets challenged with a lethal dose of the H5N...

Nanotechnology holds promise for STD drug delivery

...created a stable "time release" vehicle for delivery of siRNAs to sensitive mucosal tissue like that of the female reproductive system. They found that the... those found in cell membranes, liposomes are potentially more toxic to the mucosal tissues and are unable to provide sustained release. In the current work, t...

UTSA, Health Science Center collaborate with Merck & Co. to develop chlamydia vaccine

... conducted research for more than 20 years in chlamydia pathogenesis and vaccine development, while Arulanandam has researched vaccine development and mucosal immunity for more than 12 years. Both Zhong's and Arulanandam's laboratories are working hard with the Merck group to identify the most efficacious...

DNA blueprint for healthier and more efficient cows

...n enhanced natural ability to defend itself from disease. "This may be an evolutionary response to an increased risk of opportunistic infections at mucosal surfaces caused by the large number of bacteria and fungi carried in the rumen (the largest of the four compartments that make up the bovine stomach),...

When intestinal bacteria go surfing

...infection they infest the intestinal mucosa, causing injury in the process, in contrast to benign bacteria. The EHECs adhere to the surface of the mucosal cells and alter them internally: a part of the cellular supportive skeleton - the actin skeleton - is rearranged in such a manner that the cell surfac...

Mucosal in Biological Technology

The Law Offices of Brian D. Witzer Wins 6+ Million Dollar Verdict

...and death. Symptoms begin with flu-like symptoms followed by a painful red or purplish rash that spreads and blisters, eventually causing the skin and mucosal membranes to shed or slough off. SJS/TEN is almost always caused by severe allergic reaction to certain over-the-counter and prescription drugs. SJS...

Biomodels Expands Efforts in Cancer Supportive Care, Pulmonary Fibrosis; Preclinical Research Organization Names Dr. Stephen T. Sonis as Partner

...of Stephen T. Sonis DMD, DMSc to partner. Dr. Sonis, a world-renowned expert in the clinical treatment and research of cancer regimen-related mucosal toxicities, said the company's collaborative work with pharmaceutical and biotechnology clients in the area of cancer supportive care is expected to g...

Particle Sciences and Microfluidics Collaborate to Share Formulation and Nanotechnology Expertise for Pharmaceutical Drug Product Development, Analysis and Commercialization

...article Sciences focuses on emulsions, gels, particulates and drug/device combination products with additional specialized capabilities in topical and mucosal drug delivery. Through a full range of formulation, analytic, and manufacturing services, Particle Sciences provides pharmaceutical companies with a c...

Hector Garcia Joins Particle Sciences as Director of Quality Assurance

...article Sciences focuses on emulsions, gels, particulates and drug/device combination products with additional specialized capabilities in topical and mucosal drug delivery. Through a full range of formulation, analytic, and manufacturing services, Particle Sciences provides pharmaceutical companies with a c...

Particle Sciences Completes Development of First Product Incorporating its Unique Surface Modification System

...article Sciences focuses on emulsions, gels, particulates and drug/device combination products with additional specialized capabilities in topical and mucosal drug delivery. Through a full range of formulation, analytic, and manufacturing services, Particle Sciences provides pharmaceutical companies with a c...

Sopherion Therapeutics, LLC Announces Publication of Phase I/II Myocet(R) (Nonpegylated Liposomal Doxorubicin) Data in Advanced Breast Cancer Patients

...ced nonoperable breast cancer, while it exceeded 21 months in those with metastatic disease. The most common adverse events included alopecia (85.1%), mucosal inflammation (57.4%), asthenia (51.8%) and nausea (50%). Only two patients went off study due to "dermatitis". A bout Myocet (TM) (Nonpegylat...

Mucosal in Biological Products

Prostaglandin E2-d4 from Cayman Chemical

Description:...s of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. The affini...
Company:Cayman Chemical

Prostaglandin E2-d4 from Cayman Chemical

Description:...s of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. The affini...
Company:Cayman Chemical

Mucosal in Biological Definition

Antibody

... (23%), IgG3 (7%) and IgG4 (4%). IgA IgA represent about 15 to 20% of immunoglobulins in the blood although it is primarily secreted across the mucosal tract into the stomach and intestines . It is also found in maternal milk , tears and saliva . This immunoglobulin helps to fight against path...

Fungus

...most of the infections they cause are mild and self-limiting. This resistance is due to: Fatty acid content of the skin . pH of the skin, mucosal surfaces and body fluids Epithelial turnover Normal flora Transferrin Cilia of respiratory tract . When fungi do pass the r...

Lysozyme

...umber of secretions , such as tears . This protein is present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN) and released to the mucosal secretions. This enzyme functions by attacking peptidoglycan by hydrolyzing the bond that connects N-acetylmuramic acid with carbon four of N...

Mucosal in Biological Dictionary

Intestinal villi

...we damage the villi along the intestinal lining. ... arterioles were significantly decreased in the rat intestinal villi ... the changes in mucosal perfusion in intestinal villi during nor ... ... the intestinal epithelium causing blunting of the villi , tissue ... The villi on the l...

Buccal cavity

... cavity and pharynx, the lowest figure recorded during ... Cancer of the Buccal Cavity and Pharynx: INCIDENCE. TABLE 2-A ... Within the oral mucosal cavity , the buccal region offers an attractive route of ... within the oral cavity (i.e., sublingual, buccal , and local drug delivery) ... ...

B lymphocytes

...ocytes were found in increased numbers in both the ... We observed that murine ILF B lymphocytes are composed of a relatively ... Importantly, mucosal B lymphocytes have been observed to play both pathogenic ... Most B and T lymphocytes in the body are in a partially differentiated "rest...