How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?

The Gram negative bacterium H pylori is involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma. Adhesion of the bacteria to the gastric mucosa is an essential step for colonization and infection. It is therefore important to know factors that ...

A better mesh: Researchers 'tighten' body's protective coating

...or the INBT. The team showed that tiny strands in the mucus layer -- the mucin fibers -- naturally tend to bundle and bunch together, creating gaps large ...gent to the mix, Lai and his colleagues partially disrupted the bundling of mucin fibers, a procedure that decreased the size of the holes in the mesh. Parti...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...EK); matrix metalloproteinase-2 (MMP-2); MMP-9; melanin; mesothelin (CAK1); methionine aminopeptidase 2 (MetAP2); motility-related protein-1 (MRP- 1); mucin 1 (MUC1); murine double minute 2 (MDM2), HDM2; N-acetylated alpha- linked acidic dipeptidase (NAALADase); N-cadherin (NCAD); neural precursor cell exp...

JCI online early table of contents: Jan. 2, 2008

...uggested that TIM-1specific antibody therapy might provide a new approach to preventing transplant rejection. TITLE: The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model AUTHOR CONTACT: Mohamed H. Sayegh Brigham and Womens Hospital, and Children...

Cure For Persistent Oral Fungal Problem May Be Possible

...to treat potential oral infections up to double their original power. One peptide called MUC7 12-mer, which occurs naturally in the human salivary mucin molecule is quite effective for treating oral fungal infections. Even active in very low concentrations, when used with inhibitors, the peptide killed...

Mucin in Medical Technology

ISTA Pharmaceuticals Announces Positive Results for Phase IIb Study of Ecabet Sodium

...et sodium represents a new class of molecules that increase the quantity of mucin produced by conjunctival goblet cells and corneal epithelia. mucin is a glycoprotein component of tear film that lubricates while retarding mo...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

...9 protein is implicated in a range of characteristic features of asthma, including increased airway inflammation, obstruction and hyperresponsiveness, mucin production and mast cell generation. Earlier preclinical study results have demonstrated that inhibition of IL-9 leads to decreased airway inflammatio...

ISTA Pharmaceuticals Announces Positive Preliminary Results from Ecabet Sodium Phase IIb Study

...ot only improves the quality of tears by enhancing mucin production, but may increase the quantity of tears...w class of molecules that increase the quantity of mucin produced by conjunctival goblet cells and corneal epithelia. mucin is a glycoprotein component of tear film that lubr...

Mucin in Medical Dictionary

Mucosa

...ult to anastomose with nasal mucosa . ... fibrous adhesions between the lacrimal sac mucosa and the head of the stent may ... ... different mucin genes in the ileal mucosa of patients with Crohn's disease and controls. ... healthy and involved ileal mucosa suggests a primary or very .....

Mucin in Biological News

SinuNase Phase 3 show almost 100 percent of chronic sinusitis cases are from fungal-induced inflamma

...ges in the sinuses. At the time of enrollment, all patients have had nasal mucin collected. Subsequently, these specimens are being tested for eosinophilic...atient's nose and tests for eMBP, which is uniquely detectable in the nasal mucin of patients with CS. ...

Smoking turns on genes -- permanently

... smoking: reversible (TFF3, encoding a structural component of mucus; CABYR, in it's newly discovered bronchial role), partially reversible (MUC5AC, a mucin gene) and irreversible (GSK3B, involved in COX2 regulation). These findings were tested against a second cohort of current, former and non-smokers. ...

Progress toward an antitumor vaccine

...od is based on an immunocompatible connection by way of a sulfur atom, namely, a thioether. Epithelial tumor cells have unusually large amounts of mucin MUC1 on their surface. This MUC1, in comparison with its “normal” cousins, is also modified in a very characteristic manner. Mucins are mucilaginous s...

Mucin in Biological Technology

Drug Reduces Airway Mucus in Preclinical Asthma Model

...American Journal of Respiratory Cell and Molecular Biology 2008; 38: 256-262, entitled, "Chronic Exposure to Beta-Blockers Attenuates Inflammation and mucin Content in a Murine Asthma Model," airway mucus hypersecretion and inflammation were almost completely reversed upon treatment with certain beta block...