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Motif in Medical News

BioInformatics, LLC New Report - Exploring the Epigenetics Market: Opportunities for Product Placement and Innovations

...pliers and desired improvements with each. The following suppliers were provided as choices in the survey: Abcam (LSE: ABC.L) Abnova Active motif Affinity Bioreagents (Thermo Fisher Scientific (NYSE: TMO )) Alexis Biochemicals (Enzo Life Sciences) (NYSE: ENZ ) Aviva Systems Biology B...

Gene Explains How High-Fructose Diets Lead to Insulin Resistance

...erging role of gene/environment interaction in modulating the metabolic phenotype and disease pathogenesis. Thus, perturbations of the same regulatory motif may produce vastly different metabolic responses, depending on the specific combinations of dietary nutrients," wrote Carlos Hernandez and Jiandie Lin...

Death on film

... much attention. Film researcher Andreas Jacobsson at the University of Gothenburg, Sweden uses a comparative perspective in his thesis to analyse the motif of death in different film cultures. Death is understood and presented in different ways in different cultures. The author of the thesis deals with...

Bunker Hill Community College Celebrates 'Wear Red Day'

...ar Red Day - Friday, February 6th - to raise awareness that cardiovascular disease is the leading cause of death in women. Stickers with the red-dress motif - national symbol of this health campaign - were handed out to the entire College community, many of whom also sported red shirts, ties, jackets, and ...

Key protein molecule linked to diverse human chronic inflammatory diseases

...stance. At the molecular level, Li's laboratory discovered that IRAK-1 prefers to phosphorylate transcription factors harboring the Serine-Proline motif including STAT-3 and NFAT. Subsequently, STAT-3 and NFAT are involved in modulating the expression of distinct inflammatory mediators responsible for ...

'Pink Power Moms' Unite in Atlanta for Day of Pampering and Recognition

...comfortable, stylish and functional Bright Starts(TM) Pretty in Pink(TM) Cradling Bouncer will be updated this winter with a fresh, new on- trend pink motif that appeals to today's moms. This popular bouncer will continue to benefit baby with seven melodies, volume control, and soothing vibration. The soft...

MIT Creates 3-D Scaffold for Growing Stem Cells

...ular microenvironments may play a more important role for cell survival and for carrying out cell functions than previously thought." The active motif method could be readily adapted to studying cell-to-cell interaction, cell migrations, tumor and cancer cell interaction with normal cells, cell-based...

Romantic and discreet trends in lingerie

... Bold men also can find fancy underwear designs. Bruno Banani recommends the line Art for the man who is a child at heart. It features a large print motif of blue clouds with redbrick houses and human figures. More mature art lovers are sent toward the Fresco line featuring abstract faces, snappy squiggl...
Motif in Medical Products

Bottega Veneta Sunglasses Collection

Features:...e maisons delicate, exclusive icon. The new oversized, square acetate frames include a refined profile texturing, with the brands hallmark interweave motif in metal inserts between the temples and the front. The colour range opts for natural shades of dark Havana brown, dark olive, black and beige. The ...
Company:Safilo Group

Yves Saint Laurent Eyewear

Features:...stication and elegance. Whether it's vintage or strictly contemporary, the styles are expansive and expressive. Luxurious details such as the metallic motif are inspired by the Vincennes bag or the engraved Yves Saint Laurent plate attached to the legs. The colour ranges are highly sought-after and give th...
Company:Safilo Group
Motif in Medical Dictionary

Immunofluorescence

...nce was performed with O4 and a phosphoAkt Ser473 ... PhosphoAkt Ser473 and O4 immunofluorescence measurements were obtained from 32 ... Active motif offers research kits, assays and biocomputing systems that help researchers study the function, regulation and interactions between genes, proteins an...
Motif in Biological News

Protein that promotes cancer cell growth identified

... division and invasion. The researchers also identified an RXDLL amino acid motif that controls the signaling from the EGF receptor through the protein kinas...th wildtype Caspase-8. Sequence homology studies helped to identify a RXDLL motif in the protein, a sequence that has been shown in other proteins to functio...

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

...HERF1 to serve as a signaling adaptor, an important link between different proteins in a pathway. Oddly, researchers have noted that the ezrin-binding motif conveniently fits into a cleft on the surface of the PDZ domains, but assumes a helical structure, which is highly unusual for this class of proteins....

New polymer coatings prevent corrosion, even when scratched

...system offers a general approach to self-healing coatings that operates across a broad spectrum of coating chemistries," Braun said. "The microcapsule motif also provides a delivery mechanism for corrosion inhibitors, antimicrobial agents, and other functional chemicals." ...

Scientists reveal the key mechanisms for affinity between transient binding proteins

... surface of another proteins, the so-called lineal motif or peptide. The difficulty lies in the fact that t...ids that are found in nearby regions of the lineal motif but do not form part of it. "The binding strength ...eins is determined by contacts found in the lineal motif but it is the contextual residues that hold inform...

Researchers discover the structural alphabet of RNA

...nstraints that are found in known structures. "We introduced a new first-order object to represent nucleotide relationships, the nucleotide cyclic motif (NCM). We reasoned that using NCMs could allow us to arrive at better models of the 3D structure of RNA molecules, " explains Franois Major. "Compared...

Pathogens use previously undescribed mechanism to sabotage host immune system

... innate immune responses and are frequent targets of pathogenic effectors in both plants and animal systems. All MAPKs contain a threonine -X-tyrosine motif and require phosphorylation of both threonine and tyrosine for activation. Previous work demonstrated that members of the OspF family, including OspF ...

Relationship between environmental stress and cancer elucidated

...about whether or not SIRT1 is of benefit. Dr. Yang may have found one reason: mice SIRT1 doesnt contain sumoylation motif. When he created sumoylation motif in mice, SIRT1 activity went up. Dr. Yang will do follow up studies to see if these mice live longer but says SIRT1 may simply have a different functi...

Researchers discover new strategies for antibiotic resistance

...nusually high rates of mutation or modification at specific sites within these molecules. To do so, the y core structure often contains a "b bulge" motif a region that affords structural variations otherwise prohibited in protein biochemistry. "The ability of host defense molecules to change so quic...

Exploring the molecular origin of blood clot flexibility

...his change by pulling engineered strands of fibrinogen molecules using an atomic force microscope. This alpha-helical coiled-coil "spring" is a common motif in protein structure, first identified more than 50 years ago and so its stretchiness may have broader implications in biology and medicine. By u...

Small molecule dervived from Rb2/p130 could act as cancer therapeutic

...till produce the same functionality as p21, explained Giordano. "We thought we could narrow down the spacer region that contains the protein-like motif to a small portion that could be delivered as a small molecule or peptide," Giordano said. They discovered a 39 amino-acid-long sequence, which t...
Motif in Biological Technology

New method may accelerate drug discovery for difficult diseases like Parkinson's

... only the first four amino acids to work and those amino acids had a common motif (cysteine any amino acid a hydrophobic amino acid cysteine). This particular four-amino-acid motif is very similar to some important biochemical structures, including molecul...

It's raining pentagons

...rfaces may be good too." Ice structures are usually built out of simple hexagonal arrangements of water molecules and this hexagonal building block motif is easily observed in the structures of snowflakes. However, during their studies Dr Angelos Michaelides and co-workers from the Fritz Haber Institute...

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

...s. One such peptide, termed CKEY2, is comprised of sequences from the RANTES protein. CKEY2 was shown to be stable and formed the secondary structural motif found in RANTES when stabilized by disulfide bridged cysteines at both ends of the peptide. The scientists demonstrated that CKEY2 disrupts PF4-RANTES...

Study reveals principles behind stability and electronic properties of gold nanoclusters

...ral metallic core of 14 gold atoms and a protective layer of 24 gold atoms bound to sulfur. "In 2006, we predicted that gold atoms in this bonding motif were divided in two groups those that made the metal core and those that helped to protected it," explained Hkkinen. "Now there was evidence that thi...

FlexiPlate siRNA

... using the RefSNP database. This increases siRNA potency, as an siRNA spanning a SNP will vary in its effectiveness. Interferon motif avoidance siRNAs are screened for multiple sequence motifs known to result in an interferon response (3, 4). siRNAs with such m...

Protein Depletion for Plasma and Serum Proteomic Analysis

...ogy 2003, 4 :74-80.
  • Han KK, Martinage A: Possible relationship between coding recognition amino acid sequence motif or residue(s) and posttranslational chemical modification of proteins. Int. J. Biochem. 1992, 24 :1349-1363.
  • ...

    Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers

    ...out the requirement for ubiquitin modification. 5 To convert ZsGreen into a proteasomal substrate, its C-terminus was fused to a specific degradation motif that targets the fusion for removal by the proteasome. Under normal conditions, the fluorescence of the cells is very low because ZsProSenso...

    Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A

    ...ysteine protease ER 60, Exp Parasitol 86, 17 (1997) Gillingham AK and Munro S, The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin, EMBO Rep 1, 524529 (2000) Grevelding CG et al., Female-specific gene express...

    Quantitative Analysis of Protein-DNA Associations in Vivo Using Real-Time PCR, Rev A

    ...and Discussion Previous studies have documented that Pdx1 binds in vitro specifically to promoter elements containing the TAAT motif (Watada et al. 1996, Ohneda et al. 2000). However, none of these studies have examined directly the specificity of promoter bind...

    Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

    ...n and its similarity to plasma retinol-binding protein, Nature, 383385 (1986). 11. Godovac-Zimmerman, J., The structural motif of -lactoglobulin and retinol-binding protein: a basic framework for binding and transport of small hydrophobic molecules? Trend...
  • Motif in Biological Products

    Goat Anti-FbxL7 Polyclonal Antibody, Unconjugated from GeneTex

    Description:... Goat polyclonal to FbxL7 The F box, named after cyclin F in which it was originally observed, is an approximately 40-amino acid motif that binds SKP1. F-box proteins are components of modular E3 ubiquitin protein ligases called SCFs (SKP1, cullin, F-box proteins), which function in p...
    Company:GeneTex

    Mouse Anti-PDK1 Docking Motif, phospho (Ser / Thr) Monoclonal Antibody, Unconjugated, Clone 18A2 from Cell Signaling Technology

    Description:... Phospho- (Ser/Thr) PDK1 Docking motif (18A2) Mouse mAb...
    Company:Cell Signaling Technology

    Mouse Anti-14-3-3 Binding Motif, phospho (Ser) Monoclonal Antibody, Unconjugated, Clone 4E2 from Cell Signaling Technology

    Description:... Phospho- (Ser) 14-3-3 Binding motif (4E2) Mouse mAb...
    Company:Cell Signaling Technology

    Expression from Genamics

    Description:...quence Support, Restriction Analysis, Primer Design and Analysis, ORF Prediction, Pattern Finding, Reverse Translation, GenBank Searching, Pattern and motif Identification, Multiple Sequence Alignment, and Protein Structure Prediction....
    Company:Genamics

    Expression from Genamics

    Description:...ce Support, Restriction Analysis, PCR Primer Design and Analysis, ORF Prediction, Pattern Finding, Reverse Translation, GenBank Searching, Pattern and motif Identification, Multiple Sequence Alignment, and Protein Structure Prediction. The graphical representation of annotated sequences allows the user to ...
    Company:Genamics

    Rabbit Anti-JNK1, phospho (Thr183 / Tyr185) Polyclonal Antibody, Unconjugated from GeneTex

    Description:...are characterized by their requirement for dual phosphorylation at a conserved T-E-Y motif. While JNK1 is activated by dual phosphorylation at a T-P-Y motif and p38 is also activated by dual phosphorylation at a T-G-Y motif....
    Company:GeneTex
    Motif in Biological Definition

    Alpha helix

    ... In proteins , the α helix is a major structural motif in secondary structure . It was first postulated by Linus Pauling , Robert Corey , and Herman Branson in 1951 based on the known crystal structu...

    Bioinformatics

    ...on. See also: sequence analysis , sequence profiling tool , sequence motif . Computational evolutionary biology Evolutionary biology is the s...and de novo (from scratch) physics-based modeling. See also structural motif . Modeling biological systems Main article: Systems biology Sy...

    Bioinformatics

    ...on. See also: sequence analysis , sequence profiling tool , sequence motif . Computational evolutionary biology Evolutionary biology is the s...and de novo (from scratch) physics-based modeling. See also structural motif . Modeling biological systems Main article: Systems biology Sy...

    DNA sequence

    ... or anti-sense (see DNA ), and either coding or noncoding . DNA sequences can also contain " junk DNA ". See also DNA DNA motif ...

    Genomics

    ...0% source: Americans for Medical Progress Daffodil 35% Steven Rose in The Guardian 22 Jan 2004 See also DNA motif gene therapy genetic engineering structural genomics List of omics topics in biology Sources and external links PLOS ...

    Secondary structure

    ...sis of RNA. See also : primary structure — tertiary structure — quaternary structure — translation — structural motif Alignment Both protein and RNA secondary structures can be used to analyze sequences by alignment. These alignments can be made more accur...

    Sequencing

    ...linear depiction cannot capture their tendency to branch and to bond to one another in different ways. See also Genetic code Sequence motif External links Information on genome projects, and the data they have produced at the National Center for Biotechnology Information (...

    Structural biology

    ...prediction . See also: primary structure , secondary structure , tertiary structure , quaternary structure , structural domain , structural motif , protein subunit , cooperativity , chaperonin , structural genomics , Important publications in structural biology External links ...
    Motif in Biological Dictionary

    Motif

    Look up Motif in Wiktionary, the free dictionary. ... Motif (narrative), any recurring element in a story that has symbolic significance ... In music, a motif or motive (pronunciation) is a short musical idea, a salient recurring figure, musical fragment or succession of notes that has...

    Zinc finger

    ...ins often bind to DNA and RNA because their shape allows close ... Finding Zinc Fingers that Bind ... Zinc fingers are a common protein motif ... A particular six zinc finger combination fused with a repressor should silence ... ...

    Transposase

    ...alignment of the transposase amino acid sequences from these IS1 family ... These results strongly suggest that IS1 transposase has the D-D-E motif and thus ... Tn5 transposase is the key enzyme in forming transposomes for random transposon insertions. ... of cut out fragments with tran...

    Transmembrane proteins

    ...brane proteins traverse the lipid membrane one or more times and consist ... Many transmembrane proteins are N-glycosylated on Asn-X-Ser/Thr motif in the ER, ... Transmembrane proteins are amphipathic, in that they have hydrophobic and hydrophilic regions ... These are the transmembrane ...

    Structural biology

    ...l Biology 2009, 9:46 (13July2009) ... BMC Structural Biology 2009, 9:52 (3August2009) ... Sequence and structural analysis of the Asp-box motif ... BMC Structural Biology 2009, 9:46 (13July2009) ... ExPASy Molecular Biology Server/SWISS-PROT Database. FastLane - Research Awards Datab...

    Regulatory region

    ...isation in the 5' region . ... The observation that the 5' regulatory regions of Hkg are less enriched in S ... ... of this type is the 14 bp motif in the regulatory region of the β2-tubulin ... Did regulatory regions of retrogenes originate from their parental genes? ... ... locus) in...

    Pseudoknot

    ...iewer. ... Most ab initio pseudoknot predicting methods provide very few folding scenarios ... In this study, we introduce the Pseudoknot Local motif Model and Dynamic Partner ... This structure has a " pseudoknot ," indicated by the presence of crossed arcs in ... Of the 43 sequences, 11 are ps...

    Peptidyl transferase

    ...units, catalyzes the transfer of formylmethionine from the tRNA to which it is attached... Binding of CCdApPuro by a peptidyl transferase -like motif in the ... peptidyl transferase center that may serve as a probe and/or ... The peptidyl transfer is a nucleophilic attack of the α-amino ...

    Palindromic Sequence

    ...cessfully cleaved by IN. ... The palindromic sequence in the 2-LTR circles generated in retroviral ... We find evidence that the palindromic motif has a clear consensus sequence , whereas Liao et al. ... optimal target site is a palindromic sequence /structural ... A palindromic sequ...

    Leucine zipper

    ...eucine scissors, is a super secondary structural motif found in proteins that creates adhesion forces ...agram being used showing a leucine zipper motif binding to DNA? ... which to me says leucine ...ember of the ... Secondly, the leucine - zipper motif of PKG binds to that of MYPT1 to ... Moreover,...
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    (Date:9/29/2014)... -- Plants have a symbiotic relationship with certain ... nutrients and defend against invaders an important ... vegetables. Now, scientist have discovered that plants may ... ensuring that sprouting plants are colonized from the ... Dame, presented their findings today at the 5th ...
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