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Monocytes in Medical News

UCLA scientists identify how immune cells may help predict Alzheimer's risk

...which from birth act as the immune system's janitors, traveling through the brain and body and gobbling up waste products including amyloid beta. The monocytes were incubated overnight with amyloid beta, which was labeled with a fluorescent marker. Using a common laboratory method known as flow cytometry, res...

JCI online early table of contents: May 1, 2009

...iant NKT cells did not kill neuroblastoma cells in vitro, but they did kill monocytes pulsed with tumor antigens. Consistent with this, the growth of neuroblastoma cells was substantially impaired in mice infused with monocytes and V-alpha-24-invariant NKT cells, when compared to mice only receiving mo...

How cells change gears: New insights published in Nature Genetics

... possible regarding the activity of the transcription factor network during the processes of differentiation and maturation into immune cells known as monocytes and macrophages. Computational work performed at UC San Diego after all the laboratory data had been collected allowed the researchers to identify spe...

Researchers identify how binge drinking may drive heart disease

...lp from the immune system. Among other cell types, monocytes arrive with the goal of preventing infection, but ...lood after binge drinking, increased the number of monocytes that can adhere to cells lining blood vessels by 7...ls In between infections and injuries, dormant monocytes ride along with the bloodstream until they "realiz...

Study Suggests How Cancers Spread to Lungs

...oughout the body. In cancer-free lungs, local cells respond by producing a second signal: a pair of molecules called S100A8 and S100A9. Nearby lung monocytes respond to these messages by producing the third and final message, called SAA3. This causes immune cells called macrophages to amplify the signal ev...

Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find

...rst of all whether being infected with HIV enables monocytes to do what they don't usually doescape from blood ...HIVand that produces HIV in those cells, including monocytes and T cells, in which the virus multiplies in peop...ic mouse line, HIV/GFP-TG mice, whose HIV-infected monocytes carried the GFP gene. This meant that the...

Tiny magnets offer breakthrough in gene therapy for cancer

...rsity of Nottingham. The technique involves inserting nanomagnets into monocytes - a type of white blood cell used to carry gene therapy - and injecting the...e tumour to create a magnetic field and found that this attracted many more monocytes into the tumour. The head of the laboratory in which the work was done,...

Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion

...tissue has a higher density of macrophages and the monocytes from which these immune system cells derive. These... the researchers added monocyte-like cell lines or monocytes obtained from the blood of normal people to less a...invasive, indicating that the cancer cells and the monocytes were indeed communicating with each other. But how...

Biomarker May Signal HIV Progression

...rt of the human body's immune system that protects against blood-borne pathogens and moves quickly to sites of infection within the body's tissues. As monocytes enter tissue, they undergo a series of changes. The researchers investigated these alterations by examining 18 patients with HIV and seven individ...

Expansion of monocyte subset could serve as a biomarker for HIV progressions

...art of the human bodys immune system that protects against blood-borne pathogens and moves quickly to sites of infection within the bodys tissues. As monocytes enter tissue, they undergo a series of changes to become macrophages. The researchers were investigating alterations in this monocyte subset in pa...
Monocytes in Medical Technology

VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE

...rt, entitled " Identification of Splenic Reservoir monocytes and Their Deployment to Inflammatory Sites ," rese...l Hospital's Center for Systems Biology found that monocytes were held in concentration in the spleen and relea...o the biological activity of the recruited splenic monocytes at the disease site, thus helping to confirm "unam...

Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies

...h and UT Southwestern Medical Center confirmed previous observations that in vitro, anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, most likely via cell-mediated mechanisms such as antibody-dependent cell-mediat...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

...y human anti-PS antibody, PGN635, to confirm previous observations that in vitro , anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, most likely via cell-mediated mechanisms such as antibody-dependent cell-mediat...

ChemoCentryx Initiates Clinical Trial of CCR1 Inhibitor CCX354

...erage throughout the dosing regimen thought to be critical for efficacy. The chemokine receptor CCR1 drives the recruitment of immune cells, such as monocytes and macrophages, associated with the inflammation underlying certain autoimmune diseases such as rheumatoid arthritis (RA), as well as other inflammat...

Pharmacyclics Reports Multiple Presentations at AACR on Its HDAC and Selective HDAC Inhibitors

...human T-cell lymphomas and leukemias in vitro. PCI-34051 exhibits anti-inflammatory properties, such as blocking secretion of cytokines from activated monocytes and other inflammatory cells, and has been shown to prevent hypersensitivity in animal models. "We believe that PCI-34051 is a truly selective HDAC-...

IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology

...che, tachycardia (fast heart rate), hypo- and hypertension, fatigue and shortness of breath, all of which are consistent events with the activation of monocytes and macrophages by L-MTP-PE and the flu-like symptoms that follow cytokine release. These side effects are readily prevented or treated with acetamino...

IDM Pharma Announces Updated Phase 3 Mifamurtide (L-MTP-PE) Data Confirms Statistically Superior Overall Survival in Osteosarcoma Patients

...che, tachycardia (fast heart rate), hypo- and hypertension, fatigue and shortness of breath, all of which are consistent events with the activation of monocytes and macrophages by L-MTP-PE and the flu-like symptoms that follow cytokine release. These side effects are readily prevented or treated with acetamino...

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

...d TLR9. TLRs7 and 9 are present within B cells, which secrete high levels of interferon-alpha and contribute to disease severity. TLR8 is expressed in monocytes and other dendritic cells, which are thought to produce proinflammatory cytokines, which further contribute to disease process. Other studies have ind...

Vion Pharmaceuticals Announces Initiation of a Phase I/II Trial of Cloretazine(R) (VNP40101M) in Combination with Temodar(R) in Adult Brain Tumors

...lative studies conducted as part of the trial will measure: (i) the level of O6 alkylguanine DNA alkyltransferase (AGT) expression in peripheral blood monocytes before treatment with temozolomide and just prior to the administration of Cloretazine(R) (VNP40101M); (ii) the status of O6- methylguanine-methyltran...
Monocytes in Medical Dictionary

Monocyte

...hage ... Monocyte Count. Neutropenia. Neutropenia Causes. Neutrophil ... monocytes move into tissue and become macrophages ... The IL1A gene is also ... - Definition of Monocyte at Dictionary.com a free online dictionary ... monocytes constitute from 3 to 8 percent of the white blood cells in humans. ... ...
Monocytes in Biological News

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...lly human anti-PS antibody, PGN635, to confirm previous observations that in vitro, anti-PS antibodies stimulate the tumor microenvironment to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, most likely via cell-mediated mechanisms such as antibody-dependent cell-mediat...

New origin found for a critical immune response

...missing other chemokines or chemokine receptors. They found that mice without the Ccr2 chemokine receptor that controls the migration of inflammatory monocytes had much lower accumulation of monocyte-derived dendritic cells and TH1 responses. The scientists concluded that there is a blood-derived lymph no...

New discovery may lead to new class of allergy drugs

...cells during an allergic reaction. Through a series of laboratory procedures, they tracked changes in immune cell type and found that eotaxin inhibits monocytes becoming dendritic cells (that find foreign invaders so other immune cells can neutralize them), resulting in more "fighter" cells being present durin...

Peering inside the skull of a mouse to solve meningitis mystery

...f experiments revealed that the real villains were monocytes and neutrophils, two types of white blood cells th...fected cells, the T-cells appeared to be summoning monocytes and neutrophils to the site of infection, like a s...discovered a totally new targetthe neutrophils and monocytes recruited by the T-cells," Dr. Dustin says. "If yo...

AVS 55th International Symposium & Exhibition, Oct. 19-24

...DIES TRAP CELLS "...We demonstrate the ease of trapping for bubbles, spheres, rod-like debris, non-spherical motile phytoplankton, macrophages, and monocytes in different fluid media..." See: http://www.avssymposium.org/paper.asp?abstractID=1215 . GRAPHENE -- THE CARBON FLATLAND. Andrei Geim, w...

UC Davis researchers discover new drug target for inflammatory disease

...onocytes, which are important first-line defenders for the immune system responsible for attacking foreign substances in the body. At elevated levels, monocytes indicate an overresponsive immune system. The involvement of integrins to the inflammatory process is of particular interest to study co-author Ki...

Tumor-inhibiting protein could be effective in treating leukemia

...dy, "The Novel Angiogenic Inhibitor, Angiocidin, Induces Differentiation of monocytes to Macropahges," will be published in the July 15 issue of the journal Can...s against bloodborne pathogens and moves quickly to sites of infection. As monocytes enter tissue, they undergo a series of changes to become macrophages. Wh...

Biomarkers allow doctors to match therapy to patient

...eatment with sunitinib, the ccEPC increases paralleled the rise in plasma VEGF levels; they decreased during the two-week off period, Vroling reports. monocytes and hematopoietic progenitor cells (HPCs) demonstrated the opposite pattern, according to Vroling. In a preliminary analysis, we found a significa...

Lipoic acid could reduce atherosclerosis, weight gain

...matory disease, which begins when certain types of white blood cells called monocytes bind to adhesion molecules on the walls of arteries. This in turn allows the monocytes to enter the arterial wall, there they become inflammatory macrophages that...

Inflammation markers identify fatigue in breast cancer survivors

... monocytes. In some survivors, however, many of the IL-6R are shed from the monocytes and are soluble within the blood plasma. Those free-floating receptors can ...itial immune responses within people. "IL-6 contributes to an activation of monocytes in the blood, and enables antigen presenting cells to activate T cells as p...
Monocytes in Biological Technology

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

... the anti-HIV L.E.A.P.S. vaccine, human blood cell monocytes purified from several different donors became matu..., cell appearance and production of IL-12. Unlike monocytes treated with other maturation agents, the L.E.A.P....ually associated with IL-12 production. Untreated monocytes or...

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

... by platelets. Heteromerization of PF4 and RANTES results in recruitment of monocytes (a type of white blood cell and part of the body's immune system) to the ar...TES. In vitro assays demonstrated that CKEY2 inhibited the recruitment of monocytes to endothelial cells. Finally, the scientists demonstrated that mice that a...

Depth of MedImmune's Respiratory Disease Research Program Highlighted at Annual Meeting of the American Thoracic Society

...ation page A603 The preceding presentations will occur on Tuesday, May 20 from 8:15 a.m. - 4:15 p.m., Metro Toronto Convention Centre, Area B. -- monocytes and Macrophages in Inflammation, Immunity and Injury (Poster Session: Role for Alveolar Macrophages in Limiting Primary RSV Immunopathology, p...

Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting

... displays both anti-neoplastic and anti-inflammatory activities by inducing apoptosis in T-cell derived tumors and blocking IL-1B secretion in monocytes Abstract #742: 8:00 a.m. - 12:00 p.m. Presenter: Sriram Balasubramanian, Ph.D., Pharmacyclics, Inc. -- Session: Histone Deacetylase Inhibitor...

A New Era in Cell Biology: German Company Develops Groundbreaking Alternative to Stem Cell Therapy

...hat is active in the fields of cellular medicine and in vitro diagnostics. Blasticon has at its disposal a patented technology that enables it to turn monocytes (mature white blood cells) from extracted blood into PCMO (programmable cells of monocytic origin = stem-cell-like human cells) and to differentiate t...

IDM Pharma Receives Not Approvable Letter for Mifamurtide (L-MTP-PE) for the Treatment of Osteosarcoma

...che, tachycardia (fast heart rate), hypo- and hypertension, fatigue and shortness of breath, all of which are consistent events with the activation of monocytes and macrophages by L-MTP-PE and the flu-like symptoms that follow cytokine release. L-MTP-PE was granted orphan drug status in the United States in 2...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

... (e.g. "monocyte activation cytokine assay") the endotoxins are detected via mediators (e.g. II 1 , II 6, TNF-a). Thereby mainly monocytes or leukocytes like RAW264.7, MonoMac 6 or THP 1 11 are used. The in-vitro pyrogenic test (IPT) is a patented procedure to detect...

High-throughput gene expression analysis to screen for anti-asthma drugs

...s speed the progresstoward new specific drugs to fight asthma. Materials and methods Peripheral blood monocytes (PBMCs) were grown in 96-well plates with 200,000 cells per well. The cells were treated with different drug candidates for 30 minut...
Monocytes in Biological Definition

Full blood count

... bacterial infection. Lymphocytes - Higher with some viral infections such as glandular fever . Also raised in lymphocytic leukaemia CLL . monocytes - May be raised in bacterial infection Eosinophil granulocytes - Increased in parasitic infections. Basophil granulocytes A manual coun...
Monocytes in Biological Dictionary

Monocytes

Monocyte is a type of white blood cell, part of the human body's immune system. Monocytes have two main functions in the immune system: (1) replenish resident macrophages and dendritic cells under normal states, and (2) in... Monocytes develop in the bone marrow and reach maturity...

Phagocytes

...sion of monocytes. Human macrophages are about 21 micrometres in diameter. monocytes and macrophages are phagocytes , acting in both non-specific defense as...... are large white cells that can swallow and digest microbes and other ... monocytes are phagocytes that circulate in the blood. ... your description goes ...

Lymphocytes

...ific peptide antigens through the receptors on their lymphocytes . monocytes ... consist of lymphocytes and monocytes with ... cytotoxic T lymphocytes (CTLs) that kill virus-infected and, pe...

Leukocytes

...cks hemoglobin, has a nucleus, is capable of motility, and ... Leukocytes are divided into five classes based on morphological and tinctorial ... monocytes are larger than other leukocytes , and they mature into macrophages ... We also find leukocytes and, in addition, blood platelets. ... In contra...

Erythrocytes

...lular Ca, K(Ca)channel, Ca pump proteolysis ... of packed erythrocytes were lysed ... erythrocytes . hemoglobin. immunoglobulin. lymphocytes. monocytes ... Red blood cells (also called erythrocytes ) make up about 40% of the blood's volume. ... 1 Cell-based antioxidant protection in erythrocyt...

Dendritic cell

... as macrophages. ... Dendritic cell migration. Cytokines & Receptors. Antigen presentation. Cancer research ... 17/04/2009 Review on blood monocytes and relationship with dendritic cells ... 4 Dendritic cells and cytokines. 5 Relationship to HIV, allergy, and autoimmune diseases ... Pla...
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