Naturally fluorescent molecules may serve as cancer biomarker
Excess amounts of a naturally fluorescent molecule found in all living cells could serve as a natural biomarker for cancer, according to bioengineers.
NADH, or nicotinamide adenine dinucleotide, is a key coenzyme -- a non-protein molecule necessary for the functioning of an enzyme -- found most...
Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)
SAN DIMAS, Calif., March 10 /PRNewswire/ -- A recent CBS 60 Minutes TV program drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine molecule believed to largely be responsible for the French Paradox, the fact the French have far more people living beyond 100 years and exhibit...
From molecules to populations: Fighting the epidemics of obesity and diabetes
Diabetes is exploding it now afflicts some 200 million individuals worldwide and is fast becoming the No. 1 epidemic of our time. In the U.S. alone, more than 22 million people have diabetes, which is the leading cause of end-stage renal disease, preventable amputations and blindness.
Researcher refining synthetic molecules to prevent HIV resistance
COLUMBIA, Mo. Evolving HIV viral strains and the adverse side effects associated with long-term exposure to current treatments propel scientists to continue exploring alternative HIV treatments. In a new study, a University of Missouri researcher has identified broad-spectrum aptamers. Aptamers ar...
How molecules out of balance lead to human multiple myeloma and other cancers
An international team of scientists has identified processes that are heavily implicated in human multiple myeloma and other B cell cancers, moving us closer to developing quick tests and readouts that could help in the tailored treatment of patients.
B cells, the white blood cells that produce...
Synthetic molecules hold promise for new family of anti-cancer drugs
Jerusalem, June 4, 2008 -- Synthetic molecules
designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.
For their work in developing these harbingers...
Molecules in Medical Technology
Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone
SAN DIMAS, Calif., Dec. 27 /PRNewswire/ -- According to the latest
science, resveratrol pill users are best advised to consume modest doses of
resveratrol plus an array of antioxidant molecules
as typically provided in 3
to 5 glasses of aged, red wine, rather than resveratrol alone.
Progen Terminates PATHWAY Trial & Confirms Focus on Potential High Value Molecules and M&A
BRISBANE, Australia, July 22 /PRNewswire-FirstCall/ -- Following a
thorough review that concluded late yesterday, the Board of Progen
Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) today announced that it
had discontinued the PI-88 phase 3 study in liver cancer. Progen confirmed
Avicena Scientific Collaborator Advances Program for Using Energy Enhancing Molecules to Treat Neuromuscular Diseases
PALO ALTO, Calif., Aug. 24 /PRNewswire-FirstCall/ -- Avicena Group,
Inc. (OTC Bulletin Board: AVGO), a late stage biotechnology company that
develops central nervous system therapeutics for neurodegenerative
diseases, announced today that Mark A. Tarnopolsky, MD, PhD, FRCPC,
professor at McMas...
Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
Quark's Novel siRNA Structures Exhibit Stability and Activity in vitro
FREMONT, Calif., Aug. 27 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a
clinical-stage biopharmaceutical company focused on discovering and
developing novel RNA interference-based therapeutics, announced today that
Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV
Rigel Program to be Presented at Keystone Scientific Meeting
SOUTH SAN FRANCISCO, Calif., March 27, 2007
/PRNewswire-FirstCall/ -- Rigel today announced that Yonchu
Jenkins, Ph.D., Associate Director of Virology, will be presenting
on the company's efforts to develop a small molecule therapeutic t...
OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer
...els of unbound, active chemotherapy and its associated toxicities. Blood vessels in tumor tissue, unlike blood vessels in normal tissue, are porous to molecules
like polyglutamate. Based on preclinical studies, it appears that OPAXIO is preferentially distributed to tumors due to their leaky blood vessels and ...
Molecules in Medical Products
Biomedics® EP Contact Lens
Description:...to patented PC Technology®, which creates a unique material containing molecules
of phosphorylcholine (PC), a substance found naturally in human cell membranes. These molecules
attract and surround themselves with water, keeping Biomedics EP lenses moi...
QuantiGene 2.0 RNA Quantification System
Description:...ification, by amplifying the reporter signal using branched DNA (bDNA) technology. Branched DNA allows immediate quantification of target-specific RNA molecules
from a variety of sample types without RNA purification or target amplification. By measuring RNA directly from crude cell lysates, the assay avoids v...
Biotin-Trapper Streptavidin Magnetic Beads
Description:... BioVintages Biotin-Trapper Streptavidin Magnetic Beads (1 mm - 2 mm) are designed for single-step capture of biotinylated molecules
such as DNA, RNA or protein from cell lysates or hybridization reactions....
BcMag Streptavidin Magnetic Beads
Description:... The BcMag Streptavidin magnetic beads are designed for rapid, single-step capture of biotinylated molecules
such as DNA, RNA, antibody or protein from cell lysates or hybridization reactions. Due to its highly dispersed, it can also be used for cell sorting...
MagnaBind Streptavidin Beads
Description:...ic acids and cells using affinity binding, while retaining biological activity. Streptavidin has been coated on the particles to separate biotinylated molecules
from unbiotinylated molecules. To remove the MagnaBind Beads from the suspension, an external magnetic field is used....
Company:Pierce Biotechnology, Inc.
Description:...oncentrations of agarose MP allows rapid migration of high molecular weight molecules
without significant restriction. Agarose MP is especially well suited for p...ectrophoresis. The high gel strength reduces separation times for large DNA molecules
while maintaining high resolution. Agarose MP is also suited for the prepar...
Company:Roche Applied Science
Molecules in Medical Definition
Artificial induction of immunity
...d a toxoid .
See also Botulism
The use of simple molecules
such as toxoids for immunization tends to produce a low response by the imm...emporary approach for "boosting" the immune response of simpler immunogenic molecules
(known as antigens ) is to conjugate the antigens. Conjugation is the at...
Depolarization-induced suppression of inhibition
...otransmitter. The use of endocannabinoids such as anandamide and 2-arachidonoyl glycerol in this method of signalling is quite logical, since both molecules
can be synthesized relatively easily from lipids in the plasma membrane, a fundamental constituent of all cells. DSI is therefore the primary cortical...
Cryostasis (clathrate hydrates)
...lyols (i.e., insects, amphibians), thermal hysteresis proteins (insects, fish).  
Clathrate hydrates are a class of solids in which gas molecules
occupy "cages" made up of hydrogen-bonded water molecules. These "cages" are unstable when empty, collapsing into conventional ice crystal structure, ...
...s cells with a T cell receptor able to bind MHC class I/II or peptide molecules
with at least a weak affinity. This eliminates (by a process called "death ... the thymus. Precursors enter the thymus at the cortico-medullary junction. molecules
known to be important for thymus entry include CD44 , P-selectin (CD62P)...
Molecules in Medical Dictionary
... Wind is the flow of air or other gases that compose an atmosphere . On Earth and within other planetary atmospheres, wind consists of air molecules
in motion. In outer space, solar wind is the movement of gases or charged... Wind power is the conversion of wind energy into a useful for...
Urine specific gravity
...ific gravity , left column at the junction of the dark and ... The specific gravity of urine is the concentration of these excreted molecules
... Urine specific gravity is a laboratory test that measures the concentration of ... Decreased urine specific gravity may be due to:...
...me. Cookbooks. Kitchen Tools. Entertaining. Home Helpers. Small Electrics ... The processes of smelling and tasting are complex. They begin when molecules
are released by ... cells are stimulated by the taste of food and beverage. ... There are ways to cook venison so that it doesn't taste sooo...
...l life; thus premature infants born ... Each surfactant molecule has a hydrophilic (water-loving) head that is attracted ... The surfactant molecules
surround the stain particles, break them up and force ... DOW surfactants include many familiar anionic and nonionic products. Learn more here. ...
...oxide in order to satisfy their energy requirements. In the living organism, energy is liberated, along with carbon dioxide, through the oxidation of molecules
containing carbon. The term respiration also denotes the exchange of the respiratory gases (oxygen and carbon dioxide)... Organisms that utili...
...features of proteins . ... translated proteins and link the free ends together to form a circular protein . ... Proteins are generally large molecules
(e.g., the muscle protein titin or ... Another area of protein research attempts to engineer proteins with entirely new ... ... contain si...
Molecules in Biological News
Small molecules mimic natural gene regulators
ANN ARBOR, Mich.---In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Scientists at the Un...
Small molecules might block mutant protein production in Huntington's disease
DALLAS May 3, 2009 Molecules
that selectively interfere with protein production can stop human cells from making the abnormal molecules
that cause Huntington's disease, researchers at UT Southwestern Medical Center have found.
These man-made molecules
also were effective against the abnormal ...
Dancing 'adatoms' help chemists understand how water molecules split
RICHLAND, Wash. -- Single oxygen atoms dancing on a metal oxide slab, glowing brighter here and dimmer there, have helped chemists better understand how water splits into oxygen and hydrogen. In the process, the scientists have visualized a chemical reaction that had previously only been talked ab...
Small molecules block cancer gene
HOUSTON (March 10, 2009) Finding molecules
that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, ...
Scripps research team identifies key molecules that inhibit viral production
The research, led by Professor Donny Strosberg of Scripps Florida, was published on March 4, 2009, in the Journal of General Virology 's advance, online edition, Papers in Press.
In the new study, Strosberg and his colleagues describe peptides (molecules of two or more amino acids) derived fr...
New models question old assumptions about how many molecules it takes to control cell division
Blacksburg, Va. -- A single cell whether a yeast cell or one of your cells is exquisitely sensitive to its surroundings. It receives input signals, processes the information, makes decisions, and issues commands for making the proper response. As with any control system, noise errors, slip-ups,...
Molecules in Biological Technology
Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria
An international team of scientists has determined the structure of the chlorophyll molecules
in green bacteria that are responsible for harvesting light energy. The team's results one day could be used to build artificial photosynthetic systems, such as those that convert solar energy to electri...
Researchers develop new way to see single RNA molecules inside living cells
Biomedical engineers have developed a new type of probe that allows them to visualize single ribonucleic acid (RNA) molecules
within live cells more easily than existing methods. The tool will help scientists learn more about how RNA operates within living cells.
Techniques scientists currently...
Heptares Secures GBP21 Million in Series A Fund Raising to Accelerate Development of Pipeline of Small Molecules Against High-Value GPCR Drug Targets
LONDON, February 24 /PRNewswire/ --
- Syndicate Comprises Leading Sector Investors Clarus Ventures, MVM Life
Science Partners and Novartis Option Fund
Heptares Therapeutics Ltd, the drug discovery company focused on drugs
targeting G-protein-coupled receptors (GPCRs), announces t...
New label-free method tracks molecules and drugs in live cells
CAMBRIDGE, Mass. -- A new type of highly sensitive microscopy developed by researchers at Harvard University could greatly expand the limits of modern biomedical imaging, allowing scientists to track the location of minuscule metabolites and drugs in living cells and tissues without the use of any...
Arisyn Therapeutics Inc. Acquires Highly Novel Portfolio of Therapeutic Small Molecules for Infectious Disease and Cancer
FREDERICK, Md., Sept. 23 /PRNewswire/ -- Arisyn Therapeutics Inc.
(Arisyn) announced today day that it has successfully acquired from UAF
Technologies and Research, L.L.C. (UTR) a series of highly novel small
molecule inhibitors with a well-defined preclinical efficacy spectrum
against a varie...
Tethered molecules act as light-driven reversible nanoswitches
Our ability to see is based on molecules
in the eye that flip from one conformation to another when exposed to visible light. Now, a new technique for attaching light-sensitive organic molecules
to metal surfaces allows the molecules
to be switched between two different configurations in response...
Molecules in Biological Products
Rabbit Anti-NFkB p105 / p50, phospho (Ser337) Antibody, Unconjugated from Raybiotech, Inc.
Description:... Rabbit anti-NFkB p105/p50 (Ser337) Class: Antibody Product Group: Signalling molecules
and phospho-specific Antibody...
Mouse Anti-Human IkBa / MAD-3 Antibody, Unconjugated from Raybiotech, Inc.
Description:... Mouse anti-IkBa/MAD-3 Class: Antibody Product Group: Signalling molecules
and phospho-specific Antibody...
Rabbit Anti-NFkB p105 / p50, phospho (Ser529) Antibody, Unconjugated from Raybiotech, Inc.
Description:... Rabbit anti-NFkB p105/p50 (Ser529) Class: Antibody Product Group: Signalling molecules
and phospho-specific Antibody...
Mouse Anti-JNK, phospho (Thr183 / Thr185) Antibody, Unconjugated from Raybiotech, Inc.
Description:... Mouse anti-JNK (PT183/185) Class: Antibody Product Group: Signalling molecules
and phospho-specific Antibody...
0.5-10 Kb RNA Ladder from Invitrogen
Description:...fy size estimation. The 1.5 kb band is more intense than the other bands allowing easy orientation and identification of RNA bands on the gel. All RNA molecules
in the ladder are polyA-tailed (40 nt) for convenient use as control templates for cDNA synthesis. 0.5-10 Kb RNA RNA Ladder is supplied at 1 g/l in 10...
Phagocytosis Fluorometric (dichlorofluorescein) Assay Kit, OxyBURST from Molecular Probes (Invitrogen)
Description:...and then complexed with purified rabbit polyclonal anti-BSA IgG antibodies. When these immune complexes bind to Fc receptors, the nonfluorescent H2DCF molecules
are internalized within the phagovacuole and subsequently oxidized to green fluorescent dichlorofluorescein (DCF). Fc OxyBURST Green assay reagent has...
Company:Molecular Probes (Invitrogen)
Molecules in Biological Definition
...r white light, which consists of electromagnetic radiation at all frequencies, passing through a sample of cold gas. For any collection of atoms or molecules
, there are certain specific amounts of energy required to change state; for individual atoms, these correspond to an electron moving from one orb...
...cur. For a reaction to occur between two colliding molecules
they must collide in the correct orientation and possess a certain minimum amount of energy. As the molecules
approach their electron clouds repel. This require...ergy available, this repulsion is overcome and the molecules
get close enough for attractions between the...
... , this process requires chemical energy .
In this form of transport, molecules
move against either an electrical or concentration gradient (collectively ...
Primary active transport directly uses energy to transport molecules
across a membrane. Most of the enzymes that perform this type of transport ...
... ATP also plays an important role in the synthesis of nucleic acids . ATP molecules
are also used to store the energy plants make in cellular respiration .
...ds . Initially glucose is broken down into pyruvate in the cytosol . Two molecules
of ATP are generated for each molecule of glucose. The terminal stages of A...
4 Affinity Chromatography Protocols
Usually the starting point is an undefined heterogeneous group of molecules
in solution, such as a cell lysate, growth medium or blood serum. The molecule of interest will have a well known and defined property which can be ex...
...tion. Moreover, the sequential model dictates that molecules
of substrate bind via an induced fit protocol. Na...ubunits need not exist in the same conformation
of substrate bind via induced fit protocol
conf...teric activation , such as the binding of oxygen molecules
to haemoglobin , occurs when the binding of one l...
Molecules in Biological Dictionary
...onary with ... Uracil is therefore structurally analogous to thymine in molecules
of DNA. ... Uracil is one of the five main nucleobases found in the nu...yclopedia. ... Uracil is therefore structurally analogous to thymine in molecules
of DNA. ... Definition of uracil from the Merriam-Webster Online Dicti...
...seudoknots regulates translation. ... ... whose products are small RNA molecules
apparently having major roles ... These genes produce untranslated RNA molecules
that are processed into short (17 ... ... acid ( RNA ) is a ... RNA . 2...
...rtant roles in ... Pfam is a large collection of protein families, represented by multiple sequence alignments and ... Several ubiquitin -like molecules
have been discovered, ... All products relating to Ubiquitin ... Ubiquitin beginning with A - J ... E1 Ubiquitin Activating Enzyme antibody. ...
... suppressor genes encode proteins that normally serve as a brake on cell growth. ... Scientists have discovered that specialized complex sugar molecules
that anchor cells into place act as tumor suppressors in breast and prostate cancers. A tumor suppressor gene is a gene that reduces ...
...ors are specialized integral membrane proteins that take part in communication between the the cell and the outside world. Extracellular signaling molecules
attach to the receptor , triggering... G protein-coupled receptors (GPCRs), also known as seven- transmembrane domain receptors, 7TM receptors, h...
...e sequence are ... The transport protein molecules
that arrive at the surface membrane contribute ......sting states. ... Proteins are very important molecules
in our cells. ... Cytochromes operate in the elect...ertebrates. ... Transport Proteins . Carrier molecules
... These transport proteins are often globula...