Modulation

AUA Foundation announces 2009 Research Scholar Program award winners

...en named AUA Foundation Research Scholars for 2009: Scott Delacroix, MD, MD Anderson Cancer Center Evaluation of Nicotinamide N-Metyhltransferase modulation on Chemotherapeutic Susceptibility of Clear Cell Renal Cell Carcinoma Smitha Dutt, PhD, University of California, Davis School of Medicine Role of...

Cardium Receives Preliminary Notification of Inclusion in the Russell 3000(R) Index and Russell Global(R) Index

...elated indications. Cardium's InnerCool Therapies subsidiary is a San Diego-based medical technology company in the emerging field of temperature modulation therapy to rapidly and controllably cool the body in order to reduce cell death and damage following acute ischemic events such as cardiac arrest or s...

Reduced-Radiation Heart Scans Don't Compromise on Quality

...y tested several techniques to lower radiation exposure, including minimized scan range, heart rate reduction, electrocardiographic-gated tube current modulation and reduced tube voltage in suitable patients. Participants included almost 4,900 patients undergoing CCTA at 15 hospital imaging centers ranging f...

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...terferon in response to the vaccine, while the cells from mice in the various control groups did not. The L.E.A.P.S. technology is a novel T-cell modulation platform technology that enables CEL-SCI to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identi...

Cardiatis Multilayer Aneurysm Repair System, MARS, Receives CE Mark Approval for Treating Peripheral Aneurysms

...ARS) is based on non-invasive paradigm shifting technology that treats aneurysms, regardless of their location, endovasculary through hemodynamic flow modulation and parent artery repair techniques. The received CE Mark is for the peripheral indication and clinical development is underway for cerebral and thora...

New Immune Approach for Treatment of Alzheimer's Disease

...tment of Alzheimer's disease. Dr. Tobinick's presentation, entitled TNF modulation for treatment of Alzheimer's Disease, will review the remarkable results wh... 550-2. 6. Tobinick, E., H. Gross, A. Weinberger, and H. Cohen, TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot study. MedGenMed, 200...

Modulation in Medical Technology

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... lower doses of anti-CD3 monoclonal antibody, causing partial TCR modulation, are efficacious in this model, and that high doses resulting in full TCR modulation are not required to achieve similar rates of remission. These data, combined with a rigorous Phase 2 clinical development program assessing mor...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

...implications for our ability to develop an effective treatment for swine flu and other H1N1 flu viruses." L.E.A.P.S. technology is a novel T-cell modulation platform technology that enables CEL-SCI to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identi...

Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults

... its antiepileptic effect in humans is not yet clear. In preclinical studies, the mechanism of action for Vimpat(R) has been shown to involve the modulation of sodium channel activity in the nervous system. Sodium channels play a crucial role in regulating the activity of the nervous system to help nerve c...

Essentialis Meets Primary Endpoint in Phase 2b Trial of DCCR for Treatment of Hypertriglyceridemia and is Granted Extensive Patent Coverage in the US

...ic diseases. The company's portfolio of products is targeted at the ATP-sensitive potassium channel, a metabolically-regulated membrane protein whose modulation has the potential to impact a wide range of cardiovascular and metabolic diseases. The company's lead product has completed Phase 2 studies in dyslip...

Cardium Announces Completion of Patient Recruitment in Phase 2b Clinical Trial of Excellarate(TM) for the Potential Treatment of Diabetic Foot Ulcers

...elated indications. Cardium's InnerCool Therapies subsidiary is a San Diego-based medical technology company in the emerging field of temperature modulation therapy to rapidly and controllably cool the body in order to reduce cell death and damage following acute ischemic events such as cardiac arrest or s...

VentiRx Pharmaceuticals Initiates Phase I Clinical Trial of VTX-1463, a Novel TLR8 Agonist for the Treatment of Allergic Rhinitis

...ficer at VentiRx. "Allergic diseases affect approximately twenty percent of the overall population. Based on strong preclinical data, we expect that modulation of the innate immune response will provide a benefit to people that suffer from these diseases." About VentiRx Pharmaceuticals VentiRx Pharma...

Modulation in Medical Products

CFI HMC(r) Series for Hoffman Modulation Contrast

Description: These objectives have been completely redesigned by Nikon allowing the contrast direction to be changed using a modulator inside the objective. That direction, once set, is maintained over the entire magnification range from 10x to 40x. Apodized phase contrast objectives Nikon's Apodized phase cont...
Company:Nikon

XL2000 Fiber Optic Light Source

Description:...has an integral reflector, extremely high brightness, excellent color rendering, stable color over life and operating range, instant-on operation, and modulation capability....
Company:PerkinElmer Life And Analytical Sciences, Inc.

ACRYSOF IQ IOL

Description:... Human corneal characteristics were analyzed to create a design that provides improved image quality. MTF (measured in the laboratory) stands for modulation transfer function, a highly accurate optical measurement designed to demonstrate the ability of a lens to produce a quality image with high contrast. ...
Company:Alcon Laboratories

Amo Phaco Model Diplomax

Description:... Multiple modulation Phaco (MMP) programmability with eight surgeon settings for maximum versatility. The combination of the peristaltic power balanced pump and the piezoe...
Company:Diagnostic Instrument Group

PM-9000 Express Patient Monitor

Features:...tCO2 (Oridion) /Mainstream EtCO2 (Welch Allyn) Maximum 96-hour graphic and tabular trend of all parameters Large font display SpO2 pulse-tone modulation (Pitch Tone) 40-second full-disclosure waveform review Alarm light indicator Compact flash memory card option Li-ion battery Suitable f...
Company:Mindray

Sonotom 110 for minimal invasive surgery

Features:... on the front panel of the generator make this equipment easier to use. The general design ensures perfect hygiene. Electronic tuning provides correct modulation and fully automatic stabilization of the resonance frequency of the instruments during operation and after changing instruments. Exposure to ultrasoun...
Company:Berchtold Corporation

Modulation in Medical Definition

Therapeutic gene modulation

Therapeutic gene modulation refers the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduc...

Depolarization-induced suppression of inhibition

...yramidal cells. J Neurosci 12:4122-4132. Vincent P, Armstrong CM, Marty A. (1992) Inhibitory synaptic currents in rat cerebellar Purkinje cells: modulation by postsynaptic depolarization. J. Physiol. (London) 456, p. 453–471. Wilson RI, Nicoll RA. (2001) Endogenous cannabinoids mediate retrograde si...

Modulation in Medical Dictionary

Histamine

...whether histamine regulates IL-6 synthesis. ... Histamine alone did not induce protein synthesis or mRNA accumulation for IL-6. ... Response modulation by Histamine . Mechanical/Chemical. Pharmacodynamics-Mechanism of Action ... Histamine : Storage and Release ... Brief and Straightforward Guide...

Antimicrobial

...TRIBUTION AND ACTIVITIES OF ANTIMICROBIAL HOST DEFENSE PEPTIDES. ANTIVIRAL ACTIVITY ... DEVELOPMENT OF ANTIMICROBIAL PEPTIDES FOR CLINICAL ... modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression ... All the compounds show an appreciable antimicrobial activity. ... ...

Modulation in Biological News

Krumlauf Lab demonstrates modulation of gene expression by protein coding regions

A research team at the Stowers Institute has discovered how the expression of one of the Hox master control genes is regulated in a specific segment of the developing brain. The findings provide important insight into how and where the brain develops some of its unique and important structures. ...

Stem cell research: From molecular physiology to therapeutic applications

...Cs have not yet been clearly defined. In this review, Professor Robert Zhao summarizes the current literature on the complex mechanism of MSCs' immune modulation and clinical studies, and discusses future directions for utilizing MSCs for clinical treatments[2]. Professor Hongkui Deng from Peking University ...

Key protein regulating inflammation may prove relevant to controlling sepsis

... of the regulatory mechanisms of NFκB and expanded the functional scope of NFκB. More important, such findings offer new opportunities for modulation of the NFκB signaling pathway and for exploring new therapeutic strategies in various human diseases such as cancer and sepsis." ...

Breakthrough in the treatment of bacterial meningitis

...organisms to cross the blood-brain barrier. Their findings, published today in The Journal of Clinical Investigation , suggest that disruption or modulation of this interaction of bacterial adhesins with the receptor might offer unexpectedly broad protection against bacterial meningitis and may provide a t...

Journal of General Physiology explores mysteries of TRP channels in latest Perspectives series

...iversity), and Sangsu Bang and Sun Wook Hwang (Korea University Graduate School of Medicine), who share their views about the questions concerning the modulation of the functional properties of the TRPA1 channel and, in particular, that regarding its temperature sensitivity. ...

JDRF-funded researchers discover proteins regulating human beta cell replication

...oliferate is a fundamentally important one for JDRF's Regeneration Program. Dr. Stewart and his colleagues address this question by demonstrating that modulation of specific cell cycle control proteins stimulates human beta cell replication. By identifying the control points for human beta cell cycle progressio...

Modulation in Biological Technology

Cardium's InnerCool Therapies Unit Announces Italian Commercialization Agreement for Portfolio of Temperature Modulation Systems

SAN DIEGO, June 19 /PRNewswire-FirstCall/ -- Cardium Therapeutics (Amex: CXM ) and its operating unit InnerCool Therapies announced today that InnerCool has entered into a exclusive commercialization agreement with N.G.C. Medical S.p.A., a leading Italian distributor of medical products. N.G....

Cardium's InnerCool Therapies Unit Announces European Commercialization Agreement for Portfolio of Temperature Modulation Systems

SAN DIEGO, April 1, 2008 /PRNewswire-FirstCall/ -- Cardium Therapeutics (Amex: CXM ) and its operating unit InnerCool Therapies announced today that InnerCool has entered into a European commercialization agreement with Euromed Medizinisch GmbH (Euromed), a leading distributor of cardiology m...

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

... production of the protein vascular endothelial growth factor (VEGF) in tumors. PTC discovered PTC299 through PTC's proprietary GEMS (Gene Expression modulation by Small-Molecules) technology by targeting the post-transcriptional processes that regulate VEGF formation. Overexpression of VEGF plays a key role ...

Cardium's InnerCool Therapies Business to Be Acquired By Royal Philips Electronics

...nt will be completed in the time frame expected by the parties, or at all, the acquisition will effectively accelerate InnerCool's patient temperature modulation business or expand its market, that product modifications or launches will be successful or that the resulting products will be favorably received in ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...mune response. These results were obtained for L.E.A.P.S. vaccines against herpes simplex and HIV. The L.E.A.P.S. technology is a novel T-cell modulation platform technology that enables CEL-SCI to design and synthesize proprietary immunogens. Any disease for which an antigenic sequence has been identi...

PTC Therapeutics Receives $2.6 Million in Government Grants

...oduction of the protein vascular endothelial growth factor, or VEGF, in tumors. PTC discovered PTC299 through PTC's proprietary GEMS (Gene Expression modulation by Small-Molecules) technology by targeting the post-transcriptional processes that regulate VEGF formation. Overexpression of VEGF plays a key role ...

Modulation in Biological Products

Ubiquitin Fraction I Extract from GeneTex

Description:...lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruct...
Company:GeneTex

IRS Extract from GeneTex

Description:...lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruct...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:...lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruct...
Company:GeneTex

Ubiquitin Fraction I from ABR-Affinity BioReagents

Description:...lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruc...
Company:ABR-Affinity BioReagents

Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:...lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruct...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:...lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstruct...
Company:GeneTex

Modulation in Biological Definition

Protein

...pe or concentration . Some forms of regulation include: Allosteric modulation : When the binding of a ligand at one site on a protein affects the binding of ligand at another site. Covalent modulation : When the covalent modification of a protein affects the binding of a lig...

RNA

...he active site of the enzyme. The synthesis continues until a termination sequence is reached. The resulting RNA molecule is the primary transcript . modulation of the rate of initiation of RNA synthesis is one of the most important ways in which gene expression is regulated. RNA world hypothesis Th...

Modulation in Biological Dictionary

Uropod

...uts to the uropod motor system were investigated in ... It is also suggested that the uropod response to body rolling during walking is ... II. modulation Of uropod motoneurone excitation by leg proprioception. M ... The uropod motoneurones showed little or no synaptic response when the treadmill ......

Proton-motive force

...oton - motive force is caused to 3/4 by the membrane potential, and ... BioInfoBank Library :: Proton - Motive Force :: radiation effects :: modulation of energy-dependent quenching of excitons in antennae of higher plants. Coupling of ... BioInfoBank Library :: Proton - Motive Force :: physio...

Pineal gland

... The pineal gland is a small endocrine gland in the vertebrate brain. It produces melatonin, a hormone that affects the modulation of wake/sleep patterns and photoperiodic (seasonal) functions. It is shaped like a tiny pine cone, and is located near to the center of the... ... ...

Micronucleus

...gy), Ciliates have one or more macronuclei and from one to several micronuclei . The macronuclei control ... Enhanced Micronucleus Formation and modulation of Bcl-2:Bax in MCF-7 Cells Following Exposure to Binary Mixtures, Location: Main Section of EHP Online Information about micronucleus in the fre...

Gene modification

...GM) and gene splicing are terms that apply to the direct manipulation of an organism's genes. Genetic engineering is different from... Gene modulation redirects here. For information on therapeutic regulation of gene expression, see therapeutic gene modulation. Genetic modification , sometime...

Gene expression

... of a functional gene product. These products are often proteins, but in non-protein coding genes such as rRNA genes or tRNA genes, the... Gene modulation redirects here. For information on therapeutic regulation of gene expression , see therapeutic gene modulation. GXD collects and integrates the ...