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Modulating in Medical News

Study demonstrates the anti-inflammatory properties of pine bark extract

...nol turns to the root of the problem, completely stopping the production of COX-2 in inflammation. Thus far, Pycnogenol seems to be a unique tool for modulating inflammatory processes." These pharmacologic findings are consistent with past clinical trials of Pycnogenol that showed significantly lowered leuk...

Study Demonstrates the Anti-Inflammatory Properties of Pine Bark Extract on Inflammatory Mediators COX-2 and 5-LOX

... turns to the root of the problem, completely stopping the production of COX-2 in inflammation. Thus far, Pycnogenol(R) seems to be a unique tool for modulating inflammatory processes." These pharmacologic findings are consistent with past clinical trials of Pycnogenol(R) that showed significantly low...

New Report Shows Record Number of Medicines Currently in Development to Treat Diabetes

...lls, a dysfunction that causes high sugar level in type 2 diabetes. A medicine that that addresses the underlying cause of type 2 diabetes by modulating genes responsible for insulin sensitization. A medicine that stimulates the release of insulin only when glucose levels become too high and by...

New Report Released in North Carolina Shows Record Number of Medicines in Development to Treat Diabetes

...eas cells, a dysfunction that causes high sugar level in type 2 diabetes. A medicine that addresses the underlying cause of type 2 diabetes by modulating genes responsible for insulin sensitization. A medicine that stimulates the release of insulin only when glucose levels become too high and by...

Migraine prevention by targeting glutamate receptors?

...ing how badly new drugs are needed. Given the role of glutamate in the pathophysiology of migraine, the future of migraine prophylaxis, may lie in modulating one of the receptors in the glutamate system, mGluR5. At the forthcoming annual meeting of the American Academy of Neurology in Seattle (April 25 ...

VIDEO from Medialink and Siemens: New Technology Makes Tracking Tumors Easier

...iemens' Artiste, finds and targets tumors giving them the proper dose of radiation each time. By using multiple sets of beams from multiple areas and modulating each beam to allow different energy at different parts of the beam, doctors can calculate doses so that they treat the tumors but exclude healthy tiss...

N30 Pharma Forms Scientific Advisory Board

...our SAB," Mr. Elia said. "Our goal is to work together to design and execute experiments that demonstrate the substantial potential clinical impact of modulating endogenous Nitric Oxide bioavailability." About N30 Pharma N30 Pharma is a cardiopulmonary medicine company focused on the modulation of endoge...

UCI researchers find new way to fight cocaine addiction

...on, Chung and Civelli discovered that mice lacking key receptors for MCH exhibited significantly fewer cocaine cravings. They hope to learn whether modulating MCH might be beneficial in treating other dopamine-related disorders as well. ...

Also in the March 24 JNCI

...rs of tissue invasion and metastasis (the latter including cell-adhesion molecules, matricellular proteins, and selected matrix metalloproteinases) in modulating melanoma outcomes," the authors conclude. "These results, however, need to be validated in adequately powered prospective studies." Contact: Ren...

University of Pennsylvania researchers find that the unexpected is a key to human learning

...ublished this week in the journal Science , suggests that neurons in the human substantia nigra, or SN, play a central role in reward-based learning, modulating learning based on the discrepancy between the expected and the realized outcome. "This is the first study to directly record neural activity underl...
Modulating in Medical Technology

AndroScience Corporation Announces Phase 2a Study Results on ASC-J9(TM) for the Treatment of Acne

... development and commercialization. Through enhancing androgen receptor protein degradation, ASC-J9(TM) represents the first topical agent directed at modulating the effect of androgens (male hormones), through the androgen receptor, a key causative factor in the pathogenesis of acne. Charles Shih, Ph.D., ...

Solace Pharmaceuticals Initiates Phase IIa Trial of Glial Cell Modulator SLC022 in Post-Herpetic Neuralgia

...l biological understanding of disease targets that play a role in the pathogenesis of pain and that have disease-modifying potential in two key areas: modulating the activity of glial cells and intervening in the tetrohydrobiopterin (BH4) pathway. SLC022, the company's lead drug candidate, is in phase II clinic...

Raptor Pharmaceuticals Provides Update on Targeting Platforms

...es." Raptor also announced that the Patent Office of Japan will issue Raptor's patent application 2003-515208 entitled "Compositions and Methods for modulating Blood-Brain Barrier Transport." Allowed claims concern methods for identifying molecules that cross from blood to brain through a specific receptor-de...

Palatin Technologies Presents PL-3994 Clinical Trial Results at the 12th Annual Scientific Meeting of the Heart Failure Association of America

...a large and diverse number of physiologic functions, and therapeutic agents modulating this system may have the potential to treat a variety of conditions and dis...ceptor system has numerous cardiovascular functions, and therapeutic agents modulating this system may be useful in treatment of heart failure, hypertension and o...

Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis

...aid Kevin C. Gorman, President and Chief Executive Officer, Neurocrine Biosciences. "We began this program nine years ago with the hope of selectively modulating the GnRH system with an oral antagonist. This trial and our previous Phase II studies have now shown that this is possible. Elagolix is a first in cla...

Preliminary Phase 2 Results of R788 in Lymphoma Show Benefit in Diffuse Large B-Cell and SLL/CLL

... host a conference call today at 8:00 a.m. EDT to discuss these results (see conference call details below). "The results of this study suggest that modulating the B-cell signaling pathway with R788 may represent a new therapeutic approach to non-Hodgkin's lymphoma particularly in DLBCL and SLL/CLL," said Ell...

FTY720, a novel oral therapy in development for MS, shows sustained benefits for the majority of patients after three years of treatment

...n free of relapses as the study progresses." FTY720 has the potential to be the first in a new class of therapies for MS that act on inflammation by modulating sphingosine-1-phosphate receptors (S1P-R), reducing the number of inflammatory immune cells, called lymphocytes, from reaching the brain. In addition,...

Clinical Update - Debio 0614 (Istaroxime) in Acute Heart Failure

...S with a post discharge event rate (readmissions/deaths) of 35% at 60 days. Debio 0614 is a first in class luso-inotropic agent with calcium cycling modulating properties. It was discovered and developed up to phase IIa by sigma-tau and is currently being developed by Debiopharm for the treatment of acute h...

Interim Phase 2 Data for Exelixis' XL880 Show Anti-Tumor Activity in Papillary Renal Cell Cancer

...disease, highlight the potential utility of XL880 and its potent effects in modulating both MET and VEGFR2 in the clinical setting. We are excited about the potential therapeutic utility of modulating these targets in a variety of solid tumor types." As of October 10, 2007, ...

deCODE Launches Phase II Clinical Testing of DG051 for the Prevention of Heart Attack

...in a dose dependent manner. LTB4 is a pro-inflammatory molecule that deCODE's gene discovery and functional biology work identified as a key factor in modulating risk of heart attack. The Phase I studies showed DG051 to be safe and well-tolerated at all dose levels tested, with a favourable pharmacokinetic prof...
Modulating in Medical Products

Acetylcholine Receptor Modulating Antibody

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

IGFBP-4 ELISA Test

Description:... in Pediatrics. 6: 462-467, 1994 Collett-Solberg PF & Cohen P. The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action IN Rosenfield RL (ed) Growth and Growth Disorders. WB Saunders Company, Philadelphia, vol. 25, no. 3, pp 591-614, 1996 Rajaram S, et al. E...
Company:Diagnostic Systems Laboratories, Inc.

Free IGF-I IRMA Test

Description:...specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I IRMA Test (With Extraction)

Description:...specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I ELISA Test (With Extraction)

Description:...specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I IRMA Test (Non-Extraction)

Description:...specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I ELISA Test (Non-Extraction)

Description:...specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3...
Company:Diagnostic Systems Laboratories, Inc.

Free IGF-I ELISA Test

Description:...specific cell-surface receptors. In the circulation, IGF-I is bound to IGF-binding proteins (IGFBPs), which appear to regulate the actions of IGF-I by modulating the interaction of IGF-I with the Type 1 IGF receptor. The majority of IGF-I in blood is bound to a high molecular weight ternary complex with IGFBP-3...
Company:Diagnostic Systems Laboratories, Inc.
Modulating in Biological News

Bladder cells feel stretch

...primal stretch-detector in urothelial cells. Given that TRPV4 is critically involved in the sensing mechanism in the bladder, development of chemicals modulating TRPV4 activity may be useful for treatment of bladder disorders such as overactive bladder and pollakiuria." ...

Hormone levels contribute to stress resilience

...ed the hippocampus that is very sensitive to the negative effects of stress. "Animal studies have shown that DHEA buffers against stress, in part, by modulating receptors in this region of the brain," explained Dr. Morgan. "These findings are important in understanding why and how soldiers may differ in their ...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

...f and on. It's called a metamaterial since it consists of an array of microscopic split metal rings. The rings can be controlled by nearby electrodes; modulating the ring's capacitance, in turn, modulates the radiation; that is, the THz light (sometimes called T rays) can be switched so as to pass through or no...

Heart protein regulates blood vessel maintenance

...sel. This is important because dysfunction in vasomotor tone is thought to cause high blood pressure. Our study demonstrates that FHL2 is essential in modulating the physical state of vSMCs, which is essential in regulating vascular motor function," says Hata. ...

Researchers find snippet of RNA that helps make individuals remarkably alike

...hers eliminated miR-7, the networks remained intact but only under uniform environmental conditions. When the researchers perturbed the environment by modulating the temperature, the networks failed to keep things intact, and animals suffered from developmental defects. If the microRNA was present, however, the...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

...studies have detected OGF and OGFr in both the cytoplasmic and the nuclear compartments. The OGF-OGFr axis is known to regulate cell proliferation by modulating cyclin dependent kinase inhibitors, resulting in a retardation of cells at the G1-S interface of the cell cycle. To address the question of the locat...

Tips from the American Journal of Pathology

...ki M, Gerner-Schmidt KW, Nusrat A, Klapproth J-M A: The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating Rho GTPases. Am J Pathol 2009, 174: 1347-1357 Mouse Model of Human Psoriasis Researchers led by Nicole Ward at Case Western Reserve Univ...

Researchers identify a cell type that limits stroke damage

...migrate to the brain during the first few days after a stroke. They limit the extent of secondary damage by blocking the production of neurotoxins and modulating the action of lymphocytes and microglia in the brain. ...

Krumlauf Lab demonstrates modulation of gene expression by protein coding regions

... gene expression utilize methods that exclude protein coding domains. Our group has now discovered that protein coding regions can also play a role in modulating gene expression. This work has important implications for identifying the regulatory logic contained in mammalian genomes." "Our findings provide ...

Researchers identify new anti-tumor gene

... and evade destruction, Fisher noted that SARI could be an effective anti-cancer treatment for many tumors. "Additionally, IFNs are powerful immune modulating agents that contribute to the immune response to cancer and they are effective inhibitors of new blood vessel formation, the process of angiogenesis, ...
Modulating in Biological Technology

Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome

BOSTON and THE WOODLANDS, Texas, Aug. 21 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX ) presented data today describing the structure-activity relationship (SAR) of a class of internally-developed compounds that includes LX1031 and other compounds under evaluation by ...

Solace Pharmaceuticals Appoints Professor David Julius, Renowned Pain Physiologist, to Scientific Advisory Board

...l biological understanding of disease targets that play a role in the pathogenesis of pain and that have disease-modifying potential in two key areas: modulating the activity of glial cells and intervening in the tetrohydrobiopterin (BH4) pathway. SLC022, the company's lead drug candidate, is in phase II clinic...

Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital

...ll Program at Children's Hospital Boston and a scientific founder of Fate Therapeutics, expand the Company's broad intellectual property portfolio for modulating the activity and state of stem cells. Fate Therapeutics is utilizing its adult stem cell biology engine and induced pluripotent stem (iPS) cell techn...

Fate Therapeutics and Stemgent Launch Catalyst: A Unique Industry Program for First Access to the Most Advanced Induced Pluripotent Stem Cell Technology

...or therapeutic benefit." About Fate Therapeutics, Inc. Fate Therapeutics is interrogating stem cell biology to develop therapeutics based on modulating cell fate and to enable a new drug discovery paradigm with the Company's proprietary induced-pluripotent stem (iPS) cell technology. The Company's fi...

Joseph Loscalzo, M.D., PhD. to Join N30 Pharma Board and Chair Scientific Advisory Board

...n the Board of N30 at an exciting time for the company. N30 is developing compounds of substantial potential importance that offer a unique means for modulating endogenous NO in the cardiovascular and pulmonary systems, and I look forward to helping the Board in managing the future of the Company," Dr. Loscalz...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

...receptor phosphoprotein modulator (DPPM), and inhibitor of serotonin reuptake. These additional actions clearly differentiate ITI-007 from other sleep modulating drugs. The present Phase II data suggest the beneficial effects on sleep are a result of ITI-007's distinctive neuropharmacological mechanisms beyond...

Team develops new metamaterial device

...ved it can function as a state-of-the-art device in the complex terahertz range of the electromagnetic spectrum, setting a standard of performance for modulating tiny waves of radiation, according to a team of researchers from Boston College, the Los Alamos and Sandia national laboratories, and Boston Universi...

Human clinical study demonstrates superior Neptune Krill Oil NKO(R) pharmacokinetic profile

...ital cell processes. They are one of the principal constituents of High Density Lipoprotein (good cholesterol) and play, as such, an important role in modulating cholesterol efflux. Acasti Pharma's proprietary novel phospholipids functionalize the polyunsaturated omega-3 fatty acids EPA and DHA, which have been...

Palatin Technologies to Report Fiscal Year 2009 First Quarter Results; Conference Call and Webcast on November 17, 2008

...a large and diverse number of physiologic functions, and therapeutic agents modulating this system may have the potential to treat a variety of conditions and dis...ceptor system has numerous cardiovascular functions, and therapeutic agents modulating this system may be useful in treatment of heart failure, hypertension and o...

Palatin Technologies, Inc. Revised Call-In Number for Teleconference and Webcast to be held on September 30, 2008

...a large and diverse number of physiologic functions, and therapeutic agents modulating this system may have the potential to treat a variety of conditions and dis...ceptor system has numerous cardiovascular functions, and therapeutic agents modulating this system may be useful in treatment of heart failure, hypertension and o...
Modulating in Biological Definition

Enzyme

...nce. Enzymes may speed up biochemical reactions by a factor of one thousand times or more. They also provide a means to control the reaction rates by modulating enzymatic activity. Contents showTocToggle("show","hide") 1 Etymology and history 2 Structure and function 2.1 Rate of enz...
Modulating in Biological Dictionary

Quaternary structure

... Quaternary structure and amyloid. X-ray Diffraction of Scrapie Prion. Interactive prion models ... Certainly, the quaternary structure has a modulating ... TUTORIAL ON PEPTIDE AND PROTEIN STRUCTURE . IV. QUATERNARY STRUCTURE ... Quaternary Structure is the combination of two or more chains...

Glycoprotein

.... Cancer is a leading cause of death worldwide with WHO global estimates projecting a 12 million death rate by 2015 and ... A suface glycoprotein modulating drug ... glycoprotein . Definition from Wiktionary, a free dictionary. Jump to: navigation, search ... Retrieved from "http://en.wiktionary.org /w...
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Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
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