Modeling

Mathematical modeling predicts response to Herceptin

PHILADELPHIA Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new paper in Cancer Research , a journal of the American Association for Cancer Research, illustrates how the technique may answer questions about Herceptin resistance. Sofia...

Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference

Companies whose disability case managers rely only on standard return-to-work durations may be throwing away millions of dollars, says Reed Group President, Guidelines, Jon Seymour, MD. Westminster, CO (Vocus) July 16, 2009 -- Companies whose disability case managers re...

Virginia Bioinformatics Institute to develop petascale computer modeling capabilities

Blacksburg, Va. The National Science Foundation (NSF) has awarded a four-year, $1,450,000 grant to the Network Dynamics and Simulation Science Laboratory (NDSSL) at the Virginia Bioinformatics Institute (VBI) at Virginia Tech and partners to develop petascale computing environments that model bil...

MDGuidelines Offers New Predictive Modeling Feature

Industry-Changing Technology Provides More Accurate Return-to-Work Durations for Disability and Workers' Compensation Cases Westminster, CO (PRWEB) June 25, 2009 -- Two grocery checkers--a 28-year-old female triathlete and a 53-year-old male with diabetes--each break a...

A new computer modeling program can help hospitals prepare for the worst

A new and novel computer modeling platform developed through intensive, multidisciplinary collaboration at New York University can help hospitals and cities to be more prepared for catastrophic public health scenarios, according to an article published in the American Medical Association's Disast...

Computer modeling shows strategies to rein in epidemics need to be retooled for rural populations

An infectious disease striking a large city may seem like a disastrous scenario -- millions of people sharing apartment buildings, crammed on buses and trains and brushing past one another on crowded sidewalks. A group of Kansas State University engineers is finding that a truly disastrous epid...

Modeling in Medical Technology

Pharsight Invited to Present on HIV Modeling and Simulation at ASCPT Annual Meeting

Dr. Bill Poland Will Present on Strategic Use of in Vitro and Literature Data to Predict Effects of New HIV Therapies MOUNTAIN VIEW, Calif., March 28 /PRNewswire-FirstCall/ -- Pharsight Corporation (Nasdaq: PHST ), a leading provider of software, strategic consulting, and regulat...

Novel Human Tissue Transgenic Cancer Model May Offer Significant Advance Toward Accurately Modeling Human Cancer

LOS ANGELES & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 18, 2007 - AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused on the discovery and development of novel, targeted cancer medicines, presented today findings from its novel human-in-mouse (HIM) tissue transgenic cancer model syste...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

...ckout mutations in a whole organism. Rats are physiologically more similar to humans than are mice for many traits and are ideal subjects for modeling human diseases. Extensive genetic characterization has revealed that approximately 90 percent of the rat's 25,000-30,000 estimated genes are analogou...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

...ad (HCV RNA) from baseline at day 8. SCH 900518 was well tolerated, with no drug related serious adverse events. Pharmacokinetic and pharmacodynamic modeling from this study was used to design the ongoing Phase IIa dose-finding study of SCH 900518 with ritonavir in combination with PEGINTRON and REBETOL. T...

VirtualScopics' Quantitative Imaging Provides Primary Endpoint in Cartilage Repair Pivotal Clinical Trial

...ider of imaging solutions to accelerate drug and medical device development. VirtualScopics has developed a robust software platform for analysis and modeling of both structural and functional medical images. In combination with VirtualScopics' industry-leading experience and expertise in advanced imaging b...

Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study

...mselves from HIV. Even a partially effective microbicide could have a profound impact on the dynamics of HIV transmission. According to mathematical modeling conducted by the London School of Hygiene and Tropical Medicine, 2.5 million HIV infections could be averted over three years if a microbicide with 60...

Modeling in Medical Products

CoreTherm™ Microwave Thermotherapy System

Features:... Intraprostatic temperature monitoring > Temperature monitoring at the point of prostatic tissue ablation Calculated cell-kill > Unique real-time modeling of prostatic cell-kill Intraprostatic blood flow index > Microwave power can be adjusted to account for the variability in each individual patient's i...
Company:GYRUS ACMI

Neuro-Patch Synthetic Dura Substitute

Features:... Biostable, does not change its structure even after implantation. Excellent tissue compatibility. Elastic and flexible, permits easy cutting, modeling and suturing. Packaged sterile, ready to implant....
Company:AESCULAP

Modeling in Medical Dictionary

Protein S

...o forms: a free form and a complex form bound to complement protein C4b. The Problem of Protein Folding. Mountain Climbing and Computational modeling ... Molecule of the Month images by David S . Goodsell, The Scripps Research Institute ... S . T. U. V. W. XYZ. List of All Topics. Related Topi...

CHEM

...Pool & Spa Chemicals ... The CEO and founder of Chem -Way Corporation has been in chemical ... L-Chem develops CAD software (Cell-Design) for modeling and simulation of electrochemical systems. ... The definitive software for computer aided design (CAD) ... Bio- Chem Fluidics, Manufacturer of So...

Modeling in Biological News

Petascale climate modeling heats up at University of Miami

VIRGINIA KEY, Fla. The development of powerful supercomputers capable of analyzing decades of data in the blink of an eye mark a technological milestone capable of bringing comprehensive changes to science, medicine, engineering, and business worldwide. Researchers at the University of Miami's Ro...

Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding

An algorithm utilizing structure mapping and thermodynamics is introduced for RNA pseudoknot prediction. The method finds the minimum free energy in the context of the biological folding direction (5 to 3) of RNA sequences. It also identifies information about the flexibility of the RNA. Mappi...

ASU researchers use NASA satellites to improve pollution modeling

TEMPE, Ariz. -- Detecting pollution, like catching criminals, requires evidence and witnesses; but on the scale of countries, continents and oceans, having enough detectors is easier said than done. A team of air quality modelers, climatologists and air policy specialists at Arizona State Univ...

Computer modeling reveals hidden conversations within cells

University of California, San Diego biochemists have developed a computer program that helps explain a long-standing mystery: how the same proteins can play different roles in a wide range of cellular processes, including those leading to immune responses and cancer. Prior to the UCSD team's fin...

Scientists find universal rules for food-web stability

...ing other complex systems, such as human metabolism or gene regulation. Generalists stabilize, specialists destabilize Applying this innovative modeling approach together with colleagues at the International Institute for Applied Systems Analysis (IIASA) in Laxenburg, Austria, and Princeton University,...

Obama administration announces more than $327 million in Recovery Act funding for science research

... integrated climate research, which blends climate modeling with modeling of human factors such as economics and choices abo..., including $4.9 million for integrated assessment modeling for climate; and $867,000 for mathematical analysi...

Modeling in Biological Technology

METTLER TOLEDO and AAPS: Utilization of Process Modeling and Advanced Process Control in QbD based Drug Development and Manufacturing

METTLER TOLEDO invites you to view our latest particle characterization technologies at the American Association of Pharmaceutical Scientists (AAPS) Workshop: Utilization of Process Modeling and Advanced Process Control in QbD based Drug Development and Manufacturing. C...

ExonHit Launches Mouse Genome SpliceArray(TM) for use in Human Disease Modeling Studies

PARIS, November 28 /PRNewswire-FirstCall/ -- ExonHit Therapeutics S.A. (Alternext: ALEHT), a drug and diagnostic discovery company, announces today the availability of its new SpliceArray(TM) for use in studying mouse models of human disease. These SpliceArray(TM) products help our clients acceler...

Pharsight to Present on Literature-Based Disease Modeling Approaches at AAPS National Biotechnology Conference

Dr. Farkad Ezzet Will Present on the Strategic Value of Literature Modeling to Assess Disease Progression and Drug Attributes in Clinical Development MOUNTAIN VIEW, Calif., June 17 /PRNewswire-FirstCall/ -- Pharsight Corporation (Nasdaq: PHST ), a leading provider of software, strategic consul...

ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics

PARIS, May 6 /PRNewswire-FirstCall/ -- ExonHit Therapeutics S.A. (Alternext: ALEHT), a drug and diagnostic discovery company, announces today the availability of its new SpliceArray(TM) for use in disease modeling and toxicogenomic applications by the basic and pre-clinical research communitie...

Campbell Alliance Managed Markets Practice to Take a Leadership Role at the CBI Forum on Effective Product Pricing and Modeling Strategies

RALEIGH, N.C., April 3, 2008 /PRNewswire/ -- Campbell Alliance, the leading management consulting firm specializing in the pharmaceutical and biotech industries, today announced that its Managed Markets Practice will take a leadership role at the Premier Bio/Pharmaceutical Forum on Effective P...

Pharsight Invited to Present on Oncology Modeling and Simulation at Quantitative Pharmacology Symposium in China

Dr. Rene Bruno Will Present on the Value of Clinical Trial Simulations to Predict Efficacy and Survival Benefit of Anticancer Agents MOUNTAIN VIEW, Calif., Oct. 22 /PRNewswire-FirstCall/ -- Pharsight Corporation (OTC Bulletin Board: PHST), a leading provider of software, strategic consult...

Modeling in Biological Definition

Bioinformatics

...ession and protein-protein interactions , and the modeling of evolution . The terms bioinformatics and co...ession analysis 2.3 Structure prediction 2.4 modeling biological systems 2.5 Other applications ...ased modeling. See also structural motif . modeling biological systems Main article: Systems biol...

Biomechanics

...teins such as collagen and elastin, for example, exhibit such a behavior. Some common material models include the Neo-Hookean behavior, often used for modeling elastin, and the famous Fung-elastic exponential model. See also Mechanics orthosis physiology anatomy Important publications...

Competitive exclusion principle

...ion of the second competitor in the long run. The competitive exclusion principle is a theoretical concept that follows from abstract mathematical modeling . The conditions under which competitive exclusion must hold are not very well understood; several natural ecosystems are known in which competitive...

Bioinformatics

...ession and protein-protein interactions , and the modeling of evolution . The terms bioinformatics and co...ession analysis 2.3 Structure prediction 2.4 modeling biological systems 2.5 Other applications ...ased modeling. See also structural motif . modeling biological systems Main article: Systems biol...

DNA

...toward the helical axis or away, and ultimately what were the explicit angles and coordinates of all the bonds and atoms. Such questions motivated the modeling efforts of Watson and Crick. Discovery that complementary nucleotides occur in equal proportions In their modeling, Watson and Crick restricte...

Gene regulatory network

...e the functions for each gene "node", to assist in modeling behaviour of a cell (see systems biology ). Ma...ow predictions of the models to be tested. Various modeling techniques have been used, including boolean netwo...er, Hamid Bolouri (editors), (2001) Computational modeling of Genetic and Biochemical Networks Computational...

Modeling in Biological Dictionary

Zygote

... single cell. The term is also used more loosely to refer to the group of cells formed by the first few cell divisions, although... 3D computer modeling company. zygote ( ) n. The cell formed by the union of two gametes, especially a fertilized ovum before cleavage ... results in the diploi...

Transgenic mouse

...ible. ... must be reiterated by mating with non- transgenic mice to demonstrate germ ... Transgenic mice have become powerful reagents for modeling genetic disorders, ... To generate a standard transgenic mouse , a bacterial or viral vector containing ... ... years since, these " transgeni...

Synteny

...comparison of the general structures of genomes of many ... Comparative genomics and synteny are hot topics in biology and are frequently ... modeling and Displaying Synteny w/ SynView - presented by Steve Fischer at the ... ... the genomes of mouse and humans - synteny ... 1. Synteny betw...

Sequence homology

...two photolyase cofactors but ... Keywords: homology modeling, comparative modeling, sequence alignments, protein ... the various homology modeling programs starting from a common sequence alignment. ... Homology -extended sequence alignment. V. A. Simossis,1 J. Kleinjung,1 and J. Heringa1...

Primer extension

...on is based on the highly accurate DNA polymerase enzyme, ... Predicting the success of primer extension genotyping assays using statistical modeling ... Changes in primer concentration and extension temperature modulate ... SNP typing by apyrase-mediated allele-specific primer extension ...

Poikilothermic

...rates and the invertebrates — that secure ... Ectotherms are "cold-blooded" or poikilothermic . ... about.png! What is ILCYM? Insect Life Cycle modeling is a software that helps define phenological models of poikilothermic organism (insects) based on temperature ... ... multitissue analysis of the...