Mitoxantrone

Leukemia Risk From MS Drug May Be Up

...esearchers found that for every 1,000 people given mitoxantrone (Novantrone), an estimated 7.4 people will develop...red with fewer than 2.5 people in prior estimates. mitoxantrone is an immunosuppressant approved by the U.S. Food ...fully considered against the potential benefits of mitoxantrone treatment on every single patient, Martinelli urge...

Risk of Leukemia with Multiple Sclerosis Drug Higher Than Thought

...l Meeting in Seattle, April 25 - May 2, 2009. mitoxantrone is an immunosuppressant drug approved by the FDA f...fully considered against the potential benefits of mitoxantrone treatment on every single patient." The study participants all had at least one cycle of mitoxantrone treatment and were observed for at least one year....

New therapy prevents dangerous side effect for lymphoma patients

...have been testing new drug combinations against indolent B cell lymphoma that reduce myelosuppression. Two years ago, a combination of fludarabine, mitoxantrone and dexamethasone with rituximab and interferon alpha reduced the incidence of MDS to 4 percent of patients, down from a historical rate of around 10 ...

Radioimmunotherapy After Chemo Safe for Common Lymphoma

...90 (90Y) ibritumombab tiuxetan, following chemotherapy with fludarabine and mitoxantrone is feasible, well-tolerated and effective in follicular NHL patients. Th...ty, and efficacy of sequential treatment with six cycles of fludarabine and mitoxantrone chemotherapy followed by 90Y- ibritumombab tiuxetan as a front-line treatme...

Hope For Patients With Prostate Cancer

... estramustine while the other half was treated with standard care, which is mitoxantrone and prednisone. Researchers found improved survival among the men who re...very week; a higher dose of docetaxel plus prednisone every three weeks, or mitoxantrone plus prednisone weekly. Researchers say survival among the men who received...

A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer

...rapy regimen combining vinorelbine (Navelbine) and mitoxantrone (Novantrone)// with the corticosteroid prednisone ...ach treatment cycle consisted of 10 to 12 mg/m2 of mitoxantrone on day 1, followed by 20 mg/m2 of vinorelbine on d...educed 50% and in 4 cycles it was reduced 75%. The mitoxantrone dose was reduced 50% in 5 cycles. Although 1 patie...

Mitoxantrone in Medical Technology

Fludarabine, Mitoxantrone and Zevalin(R) Produces 96% Complete Remission Rate in First-Line Treatment of Patients with Follicular Non-Hodgkin's Lymphoma

Phase II study of investigational regimen demonstrates important role of radioimmunotherapy in converting partial remissions to complete remissions and inducing a high rate of molecular remissions SEATTLE, March 17 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq: C...

Phase II Study of Zevalin(R) Consolidation Following Fludarabine and Mitoxantrone Chemotherapy Results in 100 Percent Complete Remission Rate and 89 Percent Three-Year Progression Free Survival in Patients with Previously Untreated Non-Follicular Indolent

Phase II Investigational Trial Published in CANCER: the Journal of the American Cancer Society SEATTLE, Jan. 22 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq: CTIC ; MTAX) announced today that results of a phase II clinical study, published in the jou...

Pixantrone Shows Activity in a Preclinical Study of Experimental Autoimmune Myasthenia Gravis (EAMG)

...dy, pixantrone was found to be more effective than mitoxantrone at improving both the laboratory and the clinical ...ntrone's mechanism of action is similar to that of mitoxantrone -- both act as DNA intercalating agents and inhibi...te that pixantrone is less toxic to the heart than mitoxantrone and prolonged administration may be possible. "T...

Copaxone Treatment over Two Years after Short Term Induction with Mitoxantrone Provided Sustained Benefits to Active Relapsing-Remitting Multiple Sclerosis Patients

... injection) following brief immunosuppression with mitoxantrone experienced a 90 percent reduction in magnetic res...). Treatment with COPAXONE(R) after induction with mitoxantrone remained safe and effective throughout the treatme...to receive 3 monthly intravenous (IV) infusions of mitoxantrone (36 mg/m(2) total) followed by a 2-week washout, t...

Treatment with Copaxone Plus Minocycline Showed Substantial Reduction of Disease Activity in Patients with Active Relapsing-Remitting Multiple Sclerosis

...ENT OVER TWO YEARS AFTER SHORT TERM INDUCTION WITH mitoxantrone PROVIDED SUSTAINED BENEFITS TO ACTIVE RELAPSING-RE... injection) following brief immunosuppression with mitoxantrone experienced a 90 percent reduction in magnetic res...ect of COPAXONE(r) and mitoxantrone. -more- GA mitoxantrone Combination/Page 2 "These data shed new light on...

Updated Study Results Reinforce Survival Benefit of Taxotere (Docetaxel) for Men with Advanced, Hormone-Resistant Prostate Cancer

...rvived at least three years, than those treated with anti-cancer antibiotic mitoxantrone combined with prednisone. Patients treated with the Taxotere(R) regimen liv...tate cancer treated with regimens of Taxotere(R) plus prednisone (n=335) or mitoxantrone plus prednisone (n=337). The primary analysis published in the New England ...

MGI Pharma, Inc. Summarizes Data Presented at the 2007 American Society of Clinical Oncology (ASCO) Annual Meeting

...rofulven + prednisone +/- capecitabine compared to mitoxantrone + prednisone in patients with HRPC were presented ...oward increased survival in the irofulven arms vs. mitoxantrone over the entire study period and through last foll...en + capecitabine + prednisone, and 7.3 months for mitoxantrone + prednisone. Similarly, patients with disease-rel...

MGI Pharma Summarizes Data Presented at the 2007 American Society of Clinical Oncology (ASCO) Annual Meeting

...fulven + prednisone +/- capecitabine compared to mitoxantrone + prednisone in patients with HRPC were presente...oward increased survival in the irofulven arms vs. mitoxantrone over the entire study period and through last foll...A responses were observed following treatment with mitoxantrone + prednisone. Treatment related toxicity including...

Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone

... significant cardiotoxicity, while doxorubicin and mitoxantrone induced significant cardiac damage. The studies co... equiactive doses of pixantrone to doxorubicin and mitoxantrone in mice pre-treated with a cardiotoxic dose of dox...d minimal or lack of cardiotoxicity as compared to mitoxantrone or doxorubicin. The findings reported in this arti...

Mitoxantrone in Biological Technology

OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009

...ceiving OGX-011 in combination with either mitoxantrone or docetaxel retreatment as second-line ch... the randomized 22 patients receiving OGX-011 plus mitoxantrone arm was 11.4 months, based on a median fol...on study comparing first-line docetaxel to mitoxantrone in metastatic CRPC, referred to as the TAX...

OncoGenex Achieves Key Regulatory Milestone for Lead Product Candidate, OGX-011

...minary findings related to pain palliation reported reductions in pain or analgesic use in approximately 50% of evaluable patients treated with either mitoxantrone plus OGX-011 or retreated with docetaxel plus OGX-011. These data are better than expected when compared to the 22-35% of patients receiving first-lin...

OncoGenex receives completed Special Protocol Assessment for primary registration study of lead drug candidate OGX-011

...herapy and required second-line chemotherapy: 22 patients were treated with mitoxantrone plus OGX-011 and 20 patients with docetaxel retreatment plus OGX-011. While...e chemotherapy, median survival has been estimated at 11.4 months in the mitoxantrone plus OGX-011 group and 14.7 months in the docetaxel retreatment plus OGX...

OncoGenex reports lead drug candidate OGX-011 achieved primary endpoint in Phase 2 Trial with second-line chemotherapy for prostate cancer

...therapy: Patients received a median of 6 cycles of mitoxantrone or 7.5 cycles of docetaxel as second-line che...50 percent of evaluable patients treated with mitoxantrone and in 67 percent of evaluable patients retreated ...cetaxel therapy with a median of 0.7 months in the mitoxantrone treated group or 2.1 months in the docetaxel retre...