Leukemia Risk From MS Drug May Be Up
...esearchers found that for every 1,000 people given mitoxantrone
(Novantrone), an estimated 7.4 people will develop...red with fewer than 2.5 people in prior estimates. mitoxantrone
is an immunosuppressant approved by the U.S. Food ...fully considered against the potential benefits of mitoxantrone
treatment on every single patient, Martinelli urge...
Risk of Leukemia with Multiple Sclerosis Drug Higher Than Thought
...l Meeting in Seattle, April 25 - May 2, 2009.
is an immunosuppressant drug approved by the FDA f...fully considered against the potential benefits of mitoxantrone
treatment on every single patient."
The study participants all had at least one cycle of mitoxantrone
treatment and were observed for at least one year....
New therapy prevents dangerous side effect for lymphoma patients
...have been testing new drug combinations against indolent B cell lymphoma that reduce myelosuppression.
Two years ago, a combination of fludarabine, mitoxantrone
and dexamethasone with rituximab and interferon alpha reduced the incidence of MDS to 4 percent of patients, down from a historical rate of around 10 ...
Radioimmunotherapy After Chemo Safe for Common Lymphoma
...90 (90Y) ibritumombab tiuxetan, following chemotherapy with fludarabine and mitoxantrone
is feasible, well-tolerated and effective in follicular NHL patients.
Th...ty, and efficacy of sequential treatment with six cycles of fludarabine and mitoxantrone
chemotherapy followed by 90Y- ibritumombab tiuxetan as a front-line treatme...
Hope For Patients With Prostate Cancer
... estramustine while the other half was treated with standard care, which is mitoxantrone
Researchers found improved survival among the men who re...very week; a higher dose of docetaxel plus prednisone every three weeks, or mitoxantrone
plus prednisone weekly. Researchers say survival among the men who received...
A Combination Of Drugs Effective In The Treatment Of Hormone-Refractory Prostate Cancer
...rapy regimen combining vinorelbine (Navelbine) and mitoxantrone
(Novantrone)// with the corticosteroid prednisone ...ach treatment cycle consisted of 10 to 12 mg/m2 of mitoxantrone
on day 1, followed by 20 mg/m2 of vinorelbine on d...educed 50% and in 4 cycles it was reduced 75%. The mitoxantrone
dose was reduced 50% in 5 cycles. Although 1 patie...
Mitoxantrone in Medical Technology
Fludarabine, Mitoxantrone and Zevalin(R) Produces 96% Complete Remission Rate in First-Line Treatment of Patients with Follicular Non-Hodgkin's Lymphoma
Phase II study of investigational regimen demonstrates important role of
radioimmunotherapy in converting partial remissions to complete remissions and inducing a high rate of molecular remissions
SEATTLE, March 17 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc.
(CTI) (Nasdaq: C...
Phase II Study of Zevalin(R) Consolidation Following Fludarabine and Mitoxantrone Chemotherapy Results in 100 Percent Complete Remission Rate and 89 Percent Three-Year Progression Free Survival in Patients with Previously Untreated Non-Follicular Indolent
Phase II Investigational Trial Published in CANCER: the Journal of the American Cancer Society
SEATTLE, Jan. 22 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc.
(CTI) (Nasdaq: CTIC ; MTAX) announced today that results of a phase II
clinical study, published in the jou...
Pixantrone Shows Activity in a Preclinical Study of Experimental Autoimmune Myasthenia Gravis (EAMG)
...dy, pixantrone was found to be more effective
at improving both the laboratory and the clinical
mechanism of action is similar to that of mitoxantrone
-- both act as DNA
intercalating agents and inhibi...te that pixantrone is less toxic to the heart than mitoxantrone
prolonged administration may be possible.
Copaxone Treatment over Two Years after Short Term Induction with
Mitoxantrone Provided Sustained Benefits to Active
Relapsing-Remitting Multiple Sclerosis Patients
following brief immunosuppression with mitoxantrone
90 percent reduction in magnetic res...). Treatment with COPAXONE(R)
after induction with mitoxantrone
remained safe and effective
throughout the treatme...to receive 3 monthly intravenous (IV)
infusions of mitoxantrone
(36 mg/m(2) total) followed by a 2-week
Treatment with Copaxone Plus Minocycline Showed Substantial
Reduction of Disease Activity in Patients with Active
Relapsing-Remitting Multiple Sclerosis
...ENT OVER TWO YEARS AFTER SHORT TERM INDUCTION
PROVIDED SUSTAINED BENEFITS TO ACTIVE
RELAPSING-RE... injection) following brief
immunosuppression with mitoxantrone
experienced a 90 percent
reduction in magnetic res...ect of COPAXONE(r) and
"These data shed new light on...
Updated Study Results Reinforce Survival Benefit of Taxotere
(Docetaxel) for Men with Advanced, Hormone-Resistant Prostate
...rvived at least three years, than those treated
with anti-cancer antibiotic mitoxantrone
combined with prednisone.
Patients treated with the Taxotere(R) regimen liv...tate
cancer treated with regimens of Taxotere(R) plus prednisone (n=335)
plus prednisone (n=337). The primary analysis
published in the New England ...
MGI Pharma, Inc. Summarizes Data Presented at the 2007 American
Society of Clinical Oncology (ASCO) Annual Meeting
...rofulven + prednisone +/- capecitabine compared to mitoxantrone
prednisone in patients with HRPC were presented ...oward increased survival in the
irofulven arms vs. mitoxantrone
over the entire study period and
through last foll...en + capecitabine + prednisone, and 7.3 months
+ prednisone. Similarly, patients with
MGI Pharma Summarizes Data Presented at the 2007 American Society
of Clinical Oncology (ASCO) Annual Meeting
+ prednisone +/- capecitabine compared to mitoxantrone
patients with HRPC were presente...oward increased survival in the irofulven arms
over the entire study period and through last
were observed following treatment with mitoxantrone
Treatment related toxicity including...
Publication on Pixantrone Preclinical Studies Demonstrates Reduced
Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and
... significant cardiotoxicity, while
doxorubicin and mitoxantrone
induced significant cardiac damage.
The studies co... equiactive doses
of pixantrone to doxorubicin and mitoxantrone
in mice pre-treated
with a cardiotoxic dose of dox...d minimal or lack of cardiotoxicity as
compared to mitoxantrone
or doxorubicin. The findings reported in
Mitoxantrone in Biological Technology