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Mitotic in Medical News

Journal of Clinical Oncology Publishes TREANDA Study Demonstrating Significant Improvement in Overall Response and Progression-Free Survival in Chronic Lymphocytic Leukemia

...ath by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway). Cephalon holds exclusive rights to market and develop TREANDA in the United States. TREANDA is licensed ...

Scientists discover key event in prostate cancer progression

...mone-independent prostate cancer, however, the receptors are reprogrammed to selectively regulate genes involved in actual cell division, that is, the mitotic phase of the cycle. A gene called UBE2C was a standout among these genes, and increased expression of that gene correlated with progression to the ...

17 of America's Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences

...ation of stem cells Jenn i fer G . D eL u c a, Ph. D . C olora d o St a te U n iv e r s i t y Mechanisms of mitotic chromosome segregation P a tr i ck J. Pad d iso n , Ph. D . Fred Hu t ch i nson Ca n cer R esea r ch Ce n ter...

A breakthrough in gastric carcinogenesis

... Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various k...e MIN of gastric cancer patients. Both MIN and CHFR hypermethylation induce mitotic check point disruption and confer a survival advantage to the cells, howeve...

From mother to daughters: A central mystery in cell division solved

..., that are also used in muscle. During cell division, the genome is replicated and the two copies are separated to opposite sides of the cell by the mitotic spindle. The spindle then directs the assembly of a contractile ring, which forms a belt around the cell middle. As happens during muscle contra...

Exercise Keeps the Brain Young

...e researchers then looked at the ability of the brain to continue to produce neural cells. In middle-aged mice, the number of neural progenitor and mitotic cells in the hippocampus, a brain region intimately associated with learning and memory, decreased dramatically, Kuo explained. "Compared to the se...
Mitotic in Medical Technology

Oncolytics Biotech(R) Inc. Announces Publication of Research on Synergistic Activity of Reovirus and Chemotherapy in NSCLC

...emotherapeutic agents, and that the reovirus-taxane combination most effectively achieves synergy through accelerated apoptosis triggered by prolonged mitotic arrest. About Oncolytics Biotech Inc. Oncolytics is a Calgary-based biotechnology company focused on the development of oncolytic viruses as...

Journal of Clinical Oncology Publishes Study of Cephalon Medication TREANDA Plus Rituximab in Relapsed Non-Hodgkin's Lymphoma

...eads to cell death by a process known as apoptosis (programmed cell death) and potentially by an alternate cell death (non-apoptotic) pathway known as mitotic catastrophe (a disruption of normal cell division). The exact mechanism of action of TREANDA remains unknown. Cephalon holds exclusive rights to mar...

Kosan Initiates Phase 2 Trial of Epothilone KOS-1584 in Non-Small Cell Lung Cancer

...ance its value for potential pharmaceutical collaborators." KOS-1584 is a member of a class of cytotoxic macrolides (epothilones) capable of causing mitotic arrest by polymerization of cellular microtubules. Since microtubules are essential for mitosis, motility, secretion and proliferation, the observed a...

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

...hibitor of Aurora kinases, has preclinical anti-activity and induces apoptosis Session: Heat Shock Protein Inhibitors, Aurora Kinase and other mitotic Inhibitors Abstract #5648 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center About Sunesis Pharmaceuticals Sunesis i...

EntreMed Commences Continuous Dosing Clinical Trial For MKC-1

... To date, MKC-1 has been evaluated in over 400 patients in multiple Phase 1 and 2 clinical trials. MKC-1 has been shown to induce apoptosis, inhibit mitotic spindle formation, and prevent chromosome segregation in the M-phase (mitosis) of the cell cycle. Furthermore, MKC-1 inhibits the PI3K-Akt-mTOR signal...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

...showing tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Ak...
Mitotic in Medical Products

Fluorescent HEp-2 ANA

Features:... Abundant easy-to-read mitotic cells Clear pattern identification Ready-to-use pattern controls and conjugates Substrate slides Positive pattern controls for: homogeneous, c...
Company:Immuno Concepts N.A. Ltd.

Fluorescent HEp-2000 ANA

Features:...lity Assurance for the Indirect Immunofluorescence Test for Autoantibodies to Nuclear Antigen (IF-ANA). Approved Guideline lA. Abundant easy-to-read mitotic cells Clear pattern identification Ready-to-use pattern controls and conjugates Positive pattern controls for: - homogeneous - centromere - SS-A...
Company:Immuno Concepts N.A. Ltd.
Mitotic in Medical Dictionary

Tumor

.... measured all tumor markers. ... Tumor size, lymph node status, and lymphatic or vascular ... is not known whether tumor markers, such as mitotic index, ... ... type of pituitary tumor , is covered separately. ( Refer to the PDQ summary on Adult Brain Tumor Treatment for more ... ACTH-PRO...

Germ

...ocal properties ... Germ cells are progenitors of the gametes. These singled-out cells move through the gut to the developing gonads and undergo mitotic proliferation followed by meiosis and differentiation into either eggs or sperm . Plants do not have a germ line set aside in early... Germ...

Chromosomes

...ssional ... The chromosomes of Drosophila willistoni were first described by Metz (1916) and ... obtained by AluI, HaeIII and C‐banding in the mitotic chromosomes of D. ... When the chromosomes are replicated and getting ready to divide, they consist of ... Some of the proteins in the chromo...
Mitotic in Biological News

Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation

...the same genetic information as their mother, with reduced risk of cancer. When segregating, chromosomes attach and move along proteins tracks (the mitotic spindle), from the centre of the cell to the poles. The centromere is the area of the chromosome that directs this attachment by controlling the assem...

DNA template could explain evolutionary shifts

...during mitosis or cell division, a significant finding that further confirms the significance of the event. The researchers noted that finding this mitotic rearrangement of the gene in the mother, who did not have the disorder, of two children with a neuropathy suggests that the mechanism might be conside...

The downside of microtubule stability

...reunite, the researchers found that dynamin 2 was essential for the capture step, not for transportation. Dynamin 2 also clings to microtubules of the mitotic spindle, and the team next wants to determine whether the protein regulates microtuble dynamics during the cell cycle. ...

Is this the beginning of the end of plant breeding?

... are normally meiotic which make pollen and egg cells and are replaced by mitotic divisions. The work, by a team of researchers in France and Austria, is pot...ous pairs of chromosomes while the second meiotic division is just like the mitotic di vision: the chromosomes line up at the middle of the new cell and the ch...

Slicing chromosomes leads to new insights into cell division

...rate between the resulting daughter cells. Forces in a structure called the mitotic spindle guide the replicated chromosomes to opposing sides as one cell even... long, thin tubes that form a central component of the cytoskeleton and the mitotic spindle. They serve as intracellular structural supports and as railways al...

Exercise increases brain growth factor and receptors, prevents stem cell drop in middle age

...in the mice. As expected, the study found that neurogenesis drops off sharply in middle-aged mice. For example, the number of neural progenitor and mitotic (dividing) cells in the hippocampus of middle-aged mice was only 5% of that observed in the young mice. The researchers also found that exercise si...
Mitotic in Biological Technology

Nerviano Medical Sciences Receives Approval From the FDA to Enter Phase I Clinical Trials for Their Polo Like Kinase (PLK) Inhibitor

... Nerviano Medical Sciences to begin a phase I clinical study with its selective PLK-1 small molecule inhibitor for the treatment of cancer. PLK-1 is a mitotic kinase required for the proliferation of cancer cells. This new compound is orally bioavailable, highly efficient and well tolerated in preclinical mo...

Neuralstem Receives Final Notice of Allowance for New Stem Cell Immortalization Technology Patent

...behind this patent allows us to grow practically unlimited quantities of neural stem cells from all regions of the brain without regard to the natural mitotic (growth) limits of cells from a particular region. Equally important, this technology is a next-generation immortalization process that avoids the har...

RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research

...idge group was able to show that ubiquitination of Cdc20 is required to prevent a cell from dividing before all of its chromosomes are lined up on the mitotic spindle. This cell cycle checkpoint is essential to prevent serious genetic damage in animals from yeast to humans. "We were delighted to hel...

EntreMed's MKC-1 Meets Primary Efficacy Endpoint in Non-Small Cell Lung Cancer Clinical Trial

...showing tumor growth inhibition or regression in multiple preclinical models, including paclitaxel-resistant models. MKC-1 has been shown to inhibit mitotic spindle formation, prevent chromosome segregation in the M-phase (mitosis) of the cell cycle, and induce apoptosis. Furthermore, MKC-1 inhibits the Ak...

Cephalon Receives FDA Approval for TREANDA, a Novel Chemotherapy for Chronic Lymphocytic Leukemia

...ich leads to cell death by a process known as apoptosis (programmed cell death) as well as by an alternate cell death (non-apoptotic) pathway known as mitotic catastrophe (a disruption of normal cell division). The exact mechanism of action of TREANDA remains unknown. In December 2007, Cephalon submitted a...

JCI online early table of contents: March 6, 2008

...ls the SBDS protein was found to be located at the mitotic spindle, a structure that forms when a cell is div...ents of a cell. Consistent with a role for SBDS in mitotic spindle stability, BMSCs from individuals with SDS...o the treatment of individuals with SDS. TITLE: mitotic spindle destabilization and genomic instability in...
Mitotic in Biological Products

Anti-MPM-2, phospho-Ser / Thr-Pro (Mitotic protein monoclonal #2) Antibody, Agarose Conjugated from Upstate

Description:...-phospho-Ser/Thr-Pro, MPM-2, agarose conjugate Formulation: PBS with 0.05% sodium azide Quality Assurance: routinely evaluated by immunoprecipitating mitotic MPM2 antigens from colcemid treated human HeLa cells as shown by subsequent immunoblot using the monoclonal anti-phospho-Ser/Thr-Pro, MPM2 (05-368)...
Company:Upstate

Mouse Anti-Human XPMC2H Polyclonal Antibody, Unconjugated from Novus Biologicals

Description:... Mouse polyclonal antibody to REXO4 - XPMC2 prevents mitotic catastrophe 2 homolog (Xenopus laevis)...
Company:Novus Biologicals
Mitotic in Biological Definition

Centromere

...The centromere is a region of a eukaryotic chromosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis . It is also the site of the primary constriction visible in microscopy images of chromosomes. In...

Chromatid

...cess of mitosis or meiosis . Each chromosome consists of two exactly identical (" sister ") chromatids. After they have been pulled apart by the mitotic spindle , chromatids are called "chromosomes". Sister chromatids are joined at a point called the centromere . In non-gametic, non-dividing human ce...

Cytoskeleton

...ciated with dyneins and kinesins they transport organelles like mitochondria or vesicles .) the axoneme of cilia and flagella the mitotic spindle synthesis of the cell wall in plants. The prokaryotic cytoskeleton The cytoskeleton was previously considered to be a feature only ...

Meiosis

...ribed earlier, meiotic nuclear division consists of two stages, called meiosis I and meiosis II . It starts with a cell in the same state as does a mitotic division. However, the alignment of chromosomes for prophase is different. Homologous chromosomes join into tetrads (so called because each tetrad c...

Microbiology

...t 12 to 24 hours for Mycobacterium tuberculosis ) Cells can easily survive in isolation from other cells Unicellular eukaryotes reproduce by mitotic division and prokaryotes by binary fission . This allows for the propagation of genetically identical ( clonal ) populations. They may be froz...

Mitosis

...entrosomes and nucleus of a cell in the process of mitotic division. (Schfer.) I to III, prophase; IV, metaph...hought of as cellular ropes or poles) and forming mitotic spindles . By increasing the length of the spindle... control this process by generating a signal - the mitotic spindle checkpoint - that tells the cell to wait...
Mitotic in Biological Dictionary

Tubulin

...aryote ... Drosophila has four ß- tubulin genes: each encodes a distinct isoform. ... Maternally encoded ß1 tubulin is incorporated into zygotic mitotic spindles. ... The four ß- tubulin genes of Drosophila each encode a distinct isoform. ... The ß3- tubulin gene encodes a divergent isoform expr...

Syngamy

...rs only in ... e. They undergo meiosis or syngamy , not both. ... a. The sporophyte undergoes syngamy to produce spores. ... At the end of a mitotic cell division, the two daughter ... A. syngamy . B. DNA replication. C. cell growth, division and differentiation. A or B B or C A or C ... ...

Stem cell

... Stem cells are cells found in most, if not all, multi-cellular organisms. They are characterized by the ability to renew themselves through mitotic cell division and differentiating into a diverse range of specialized cell ... Embryonic stem cells (ES cells) are stem cells derived from t...

Spindle Fibers

...Origins. Welcome Teachers and ... But microtubular spindle fibers and a mitotic process comparable to that of ... Titin in insect spermatocyte spindle ... plane (the metaphase plate) halfway between the spindle poles. ... The mitotic spindle contains the fibers (microtubules) responsible for ... Muscl...

Sister Chromatids

...zed on paired sister chromatids and dissociates from them, as ... In mitotic cells, sister chromatids are held ... phenomenon, called sister - chro...ohesion, enables cells to ... of sister chromatids to opposite ... mitotic metaphase chromosomes show sister chromatids ... of sister - chrom...

Sister chromatid

...ms, Sister chromatid antonyms. Information about Sister chromatid ... chromatid (redirected from Sister chromatid ) Also found in: ... mitotic metaphase chromosomes show sister chromatids ... The maintenance of sister - chromatid cohesion is essential to ... the sister chromatids...
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