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Mitosis in Medical News

EntreMed Reports Second Quarter 2009 Financial Results

...een shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the Flt-3 and FGFR3, kinases which have been shown to play impo...

Molecule tracking reveals mechanism of chromosome separation in dividing cells

...search on molecular machines and motors, Wordeman for work on chromosome movement, and Davis for studies of spindle poles. All are part of the Seattle mitosis Club led by Sue Biggins at the Fred Hutchinson Cancer Research Center. To understand how the kinetochore functions, the scientists sought to uncove...

EntreMed Focuses on Development of ENMD-2076

...stinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. In addition, ENMD-2076 is relatively selective for the Aurora A isoform in comparison ...

Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find

...tem cell and one cell committed to develop into a specific tissue type such as a skin cell, a blood cell or, in this case, a sperm cell. That form of mitosis is called asymmetric division, and it's exactly what stem cells need to maintain a healthy balance between uncommitted and committed cells. Cell di...

Combination of 2 novel anti-cancer agents may help fight CML resistant to current therapy

...agents include MK-0457, a Bcr/Abl kinase inhibitor that also targets another protein called an aurora kinase. Aurora kinase plays an important role in mitosis and cell division. In preclinical studies, MK-0457 is active against the T315I Bcr/Abl mutation, a major cause of imatinib resistance, and has shown p...

Research shines spotlight on a key player in the dance of chromosomes

...h the location and the timing of delivery. They are fueled by a small molecule, adenosine tri-phosphate (ATP). Some motor proteins are essential to mitosis the process by which cell division occurs in higher organisms. During cell division it is important for chromosomes to line up at the middle of the p...

Mitosis gets harder thanks to new gene discovery

...o halves of the cell to slide apart. What makes mitosis so interesting is that it is one of the biological... Natures most important processes, our interest in mitosis stems from the fact that if you want to kill cance...ure drug target. During the different phases of mitosis the pairs of chromosomes within the cell condense ...

Loss of Antenna Leads to Cancer in Insects

... has a role in controlling normal cell movement and tumor cell invasion. Golemis laboratory has also shown that Aurora A and HEF1 interact to initiate mitosis (chromosome separation) during cell division. Suggestively, many cancers produce too much of the Aurora A protein, including breast and colore...

Sea Creature's Toxin Could Lead to Promising Cancer Treatment

...the known drugs caused significant weight loss and loss of white blood cells while AB-5 caused neither side effect. “That the diazonamide toxin blocks mitosis selectively in cancer cells is almost too desirable an outcome to be true,” said Dr. Steven McKnight, chairman of biochemistry and senior author of th...

Run Amok Enzyme Causes Same Problems in Both Humans and Fruit Flies

...raced to misregulation by the aurora-A kinase. This enzyme under normal conditions appears to be critical as a traffic cop for various proteins during mitosis in neuroblasts, they concluded. “In humans, there has been a lot of thought that maybe stem cell populations are at the heart of many cancers,” ...
Mitosis in Medical Technology

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

...een shown to inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 also targets the Flt-3 and FGFR3, kinases which have been shown to play impo...

EntreMed Presents Initial Clinical Results for ENMD-2076

...stinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 targets a defined set of kinases, including Flt-3 and FGFR3, which have been...

EntreMed Receives New Patent for 2-Methoxyestradiol Analogs

...ultiple fronts -- directly by disrupting microtubules, an intracellular matrix necessary for the rapid division of cancer cells, through inhibition of mitosis and induction of apoptosis, and by blocking blood vessels that feed tumors (angiogenesis inhibition). U.S. Patent No. 7,371,741 entitled "Estradiol ...

EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer

...echanism of action, which involves inhibition of the Akt-mTOR pathway, binding importin-b and tubulin, cell cycle arrest, and apoptosis. MKC-1 arrests mitosis by inhibiting an intracellular target important in cellular trafficking that has been shown to be involved in cell division. MKC- 1 has been shown to ...

Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting

...on, these drugs target tubulin, a cytoskeletal protein involved not only in mitosis and cell proliferation, but also in other important cellular functions. Inh...may represent the next generation of anti-mitotic cancer drugs by arresting mitosis and cell proliferation without impacting unrelated, normal cellular functio...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

...s been shown to inhibit a unique profile of angiogenic tyrosine kinase targets in addition to the Aurora kinases. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-981693 is selective for the Aurora A isoform in comparison to Aurora B. Results...

Cytokinetics Reports Additional Clinical Trials Data for Ispinesib

...believes that drugs that inhibit KSP and CENP-E and other mitotic kinesins may represent the next generation of anti-mitotic cancer drugs by arresting mitosis and cell proliferation without impacting unrelated, normal cellular functions, thereby avoiding many of the toxicities commonly experienced by patient...
Mitosis in Medical Dictionary

Zygote

...refer to the group of cells formed by the first few cell divisions, although... The diploid zygote undergoes repeated cellular division by mitosis to grow into the ... The zygote undergoes meiosis immediately, creating four haploid cells. ... Zygote Films productions make innovative u...

Chromosomes

... Homologous Chromosomes . M-Phase In Detail. mitosis In Plant Cells. Embryonic Stem Cells ... Beginning with prophase, the chromosomes appear as doublets. ... The National Fragile X Foundation unit...

Chromosome

...tion about chromosome in the free online English dictionary and ... chromatid - one of two identical strands into which a chromosome splits during mitosis ... Eukaryotic Chromosome Structure ... shortest human chromosome contains 4.6 x ... In its most condensed state during mitosis, the chromoso...
Mitosis in Biological News

DNA template could explain evolutionary shifts

...o others that resulted from shuffling within an exon. Studies of one family two children and a mother demonstrated that the event occurred during mitosis or cell division, a significant finding that further confirms the significance of the event. The researchers noted that finding this mitotic rearra...

Is this the beginning of the end of plant breeding?

...ntroduces. The first steps of both meiosis and mitosis are the replication of the dividing cell's DNA. On...mes condense into tightly bound structures, and in mitosis these form an X shape in which each half of the X ... centre of the X. Thus the differences between mitosis and meiosis are that meiosis has two rounds of div...

Scientists deconstruct cell division

... Baltimore, MDThe last step of the cell cycle is the brief but spectacularly dynamic and complicated mitosis phase, which leads to the duplication of one mother cell into two daughter cells. In mitosis, the chromosomes condense and the nucleus breaks down. Fi...

Mutant host cell protein sequesters critical HIV-1 element

...everse transcriptase, providing a better treatment outcome," explains Dr. He. The researchers found that a mutant form of Src-associated protein in mitosis of 68kDa (Sam68), a host cellular protein involved in HIV-1 pathogenesis, specifically interacts with nef mRNA and directly suppresses Nef expression....

UCSB scientists show how certain vegetables combat cancer

...nticancer drugs taxol and vincristine inhibit cell division during mitosis. mitosis is the process in which the duplicated DNA in the form of chromosomes is ac... powerful anticancer agents, interferes with microtubule functioning during mitosis in a similar manner to the more powerful anticancer drugs. However SFN is ...

Proteins strangle cell during division

... squeezes the cell into two so that two new daughter cells are formed. At first it looks like mitosis, as discussed in many a biology lesson. However, mitosis is the process whereby the chromosomes are distributed between the two daughter cells. Cell division is the process whereby the two daughter cells are...

Cholesterol-lowering drugs and the effect on muscle repair and regeneration

...aim of the study was to determine SC viability during proliferation when treated with statins which may be indicative of the ability of SCs to undergo mitosis (i.e. divide to make new cells). The research team used primary cell lines isolated from quadriceps muscle biopsies. SC were mixed and grown for 4...

How chemo kills tumors: research to reduce side effects

... race starts between two competing cellular signalling networks. One network is trying to kill the cell, the other is trying to cause the cell to exit mitosis and thus allow the cell to survive. The winner of the race decides the fate of the cell; death or survival. "The factors influencing the race not o...

Death, division or cancer? Newly discovered checkpoint process holds the line in cell division

...ent, 250 million cells in your body are undergoing mitosis in order to replenish cells that die as a result o... Technion, discovered the ability of MCF2 to block mitosis by shutting down an ubiquitin ligase enzyme known ...heckpoint proteins themselves are faulty, however, mitosis results in aneuploidy, the loss or gain of chromos...

How molecular muscles help cells divide

...bles and how all the pieces get to the right place to get the job done. Time-lapse imaging and computer modeling demonstrated that cells undergoing mitosis set up small clusters of proteins, or nodes, on the inside of the cell membrane around the equator of the cell. Proteins in these nodes begin to put o...
Mitosis in Biological Technology

EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting

...stinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. ENMD-2076 targets a defined set of kinases, including Flt-3 and FGFR3, which have been...

EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma

...stinct profile of angiogenic tyrosine kinase targets in addition to Aurora A kinase and other oncogenic proteins. Aurora kinases are key regulators of mitosis (cell division), and are often over-expressed in human cancers. In addition, ENMD-2076 is relatively selective for the Aurora A isoform in comparison ...

Quantitative Analysis of the Cell Cycle in Imaging Applications

...s commit to DNA synthesis (S phase) and replicate their chromosomal DNA. The G2 phase (second gap) follows when cells continue to grow and prepare for mitosis (M phase, division). The G2 gap allows time for the cell to complete its DNA replication before initiating mitosis. During mitosis, the cell...

Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000

...ified by their pink nuclei.

Figure 2 depicts the effect of Mitomycin C (MMC), a cytostatic drug that inhibits mitosis causing cells to accumulate in G2 phase of the cell cycle. Cells were incubated with increasing concentrations of MMC (as indicated below each set of ...

Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

...eate cells with micronuclei. As cells are exposed to higher doses of compounds, cell cycle inhibition and cytotoxicity results in cell arrest prior to mitosis preventing micronuclei formation, with a resulting drop in micronuclei frequency at higher compound doses. This is evident from examination of prolife...

siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)

...following gene knockdown. For example, treatment of cells with cyclin A2 siRNA (CCNA2) resulted in a significant accumulation of cells in prophase and mitosis to a similar degree to that observed for cyclin B1 (CCNB1), corresponding with the requirement for cyclin A for G1/S and G2/M transitions. In confirma...

Assessing Gene Function with siRNA Libraries

... to monitor the percent of cells undergoing mitosis at any given point in time, with and wi... the fraction of time that cells spend in mitosis versus the rest of the cell cycle. Thus...sfected with a control scrambled siRNA, undergoing mitosis (mitotic index range of 2.1 to 2.3). Th...
Mitosis in Biological Products

PPase-2A from Promega

Description:...38kDa catalytic subunit, PPase-2A has broad substrate specificity and may play a regulatory role in DNA replication, transcription, protein synthesis, mitosis and glycogen metabolism. PPase-2A is stimulated in vitro by basic proteins such as protamine, histones and polylysine. The enzyme is inhibited by seve...
Company:Promega
Mitosis in Biological Definition

Mitosis

Overview of the major events in mitosis In biology , mitosis is the process of chromosome segregation and nuclear division that follows replication of the genetic material in eukaryotic cells. This process assures that each daughter nucleus receives a complete copy of the or...

Mitosis

Overview of the major events in mitosis In biology , mitosis is the process of chromosome segregation and nuclear division that follows replication of the genetic material in eukaryotic cells. This process assures that each daughter nucleus receives a complete copy of the or...

Anaphase

... Anaphase ( Greek : ανά = up and φάσις = stage) is the stage of meiosis or mitosis when chromosomes separate. Each chromatid moves to opposite poles of the cell (opposite ends of the nuclear spindle ). Anaphase is preceded by ...

Apoptosis

...s to the proliferation and subsequent destruction of a mass of cells equal to an individual's body weight. Homeostasis is achieved when the rate of mitosis (cell proliferation) in the tissue is balanced by cell death. If this equilibrium is disturbed, either of two things happen: The cells are divid...

Cancer

...tumor suppressor genes. In general, mutations in both types of genes are necessary, as a mutation limited to an oncogene would be suppressed by normal mitosis control. Mutations can have various causes. Particular causes have been linked to specific types of cancer. Tobacco smoking is associated with l...

Cartilage

... of the cartilage model. Interstitial Interstitial growth results in an increase of cartilage mass and occurs from within. Chondrocytes undergo mitosis within their lacuna but remain imprisoned in the matrix, which results in clusters of cells called isogenous groups . Cartilage in fetal devel...

Cell division

... Eukaryotic cells usually undergo a process of nuclear division, called mitosis , followed by division of the cell, called cytokinesis . A diploid cell... Cell cycle Cell growth External link How Cells Divide: mitosis vs. Meiosis ...

Cell growth

...sis. Eukaryotic cell reproduction either involves mitosis or a more complex process called meiosis . mitosis and meiosis are sometimes called the two " nuclear... articles on DNA replication , binary fission , mitosis , meiosis , and cytokinesis . The rest of this a...

Centriole

... the chromosomes are pulled apart. Some animal cells may be able to separate without centrioles. Centrioles assist the cell through the process of mitosis . External link Medical Engineer - Centrioles are not Autonomous Electron microscopic images of centrioles ...

Centromere

...romosome where the kinetochore is assembled. Thus, it is the site where spindle fibers of the mitotic spindle attach to the chromosome during mitosis . It is also the site of the primary constriction visible in microscopy images of chromosomes. In most eukaryotes, the centromere has no defined D...
Mitosis in Biological Dictionary

Mitosis

Mitosis is the process in which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets in two daughter nuclei. It is generally followed immediately by cytokinesis, which divides the nuclei,... (Click to enlarge) mitosis (Academy Artworks) mitosis n....

Telophase

..." (stage), is a stage in either meiosis or mitosis in an eukaryotic cell reversing the effects of ... column. ... telophase n. The final stage of mitosis or meiosis during which the chromosomes of da...zens' Compendium (Redirected from Telophase ) ... mitosis is the process during which an eukaryotic cell ....

Spermatogonia

...a and are a specific type of stem ... Type B spermatogonia undergo mitosis to produce diploid intermediate cells ... Information about sperma...al transduction into spermatogonia are not well understood. ... The mitosis of differentiating spermatogonia , the meiosis of spermatocytes, and .....

Sister Chromatids

...ing the sister chromatids during synthesis through the G2 phase and into mitosis phase. When two sister chromatids are bound along their lengths by cohes.... Our understanding of the mechanism of sister chromatid ... During mitosis replicated chromosomes ( sister chromatids ) ... two sister chromat...

Sister chromatid

...r chromatid cohesion is mediated by a multi-subunit protein complex ... Our understanding of the mechanism of sister chromatid ... During mitosis replicated chromosomes ( sister chromatids ) ... and third, sister chromatid cohe ... ...

S phase

...ine dictionary with pronunciation, synonyms, and translation of S phase . ... S phase in cell cyc... Mitosis. Phases of mitosis. Stages of mitosis ... S phase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Hierarchical clas...

Recombination frequency

...he process by which a strand of genetic material is broken and then joined to a different DNA molecule. In eukaryotes recombination occurs in mitosis as a common mechanism of DNA repair and in... ... influence the frequency and distribution of meiotic recombination events within ... sequenc...

Recombination

...he process by which a strand of genetic material is broken and then joined to a different DNA molecule. In eukaryotes recombination occurs in mitosis as a common mechanism of DNA repair and in... Genetic recombination , the process by which genetic material is broken and ... Crossover (gene...

Prophase

... Prophase is a stage of mitosis in which the chromatin condenses into a highly ...c) 2009 prophase ent. ... The first stage of mitosis is known as the prophase , where the nuclear ch...ed DNA strands slowly wrap... Genetics: stages of mitosis ... Prophase - Wikipedia, the free encyclopedia...

Prometaphase

... Prometaphase is the phase of mitosis following prophase and preceding metaphase, in ...e, prometaphase , metaphase, anaphase and ... mitosis (Preprophase, Prophase, Prometaphase , Metaphas...eferences cell division ( in cell (biology): mitosis and cytokinesis )...
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