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Mitochondrial in Medical News

Transgenomic Obtains Exclusive License to Mitochondrial DNA Damage Detection Technology

OMAHA, Neb., Dec. 4 /PRNewswire-FirstCall/ -- Transgenomic (OTC Bulletin Board: TBIO) today announced that the Clayton Foundation for Research of Houston, Texas through its technology transfer entity, the Research Development Foundation, has granted the Company an exclusive license to patents cove...

MitoAction Develops On-Line Resource for Mitochondrial Disease Care Providers

Online Clinicians Guide to Mitochondrial Disease Now Available, sponsored by Edison Pharma Boston (PRWEB) July 23, 2008 -- MitoAction.org announces today the completion of the Clinicians Symptom Guide to MITO Management, a comprehensive online resource designed to assis...

UMDF Statement on the Connection Between Mitochondrial Disease and Autism

PITTSBURGH, April 11 /PRNewswire-USNewswire/ -- The United Mitochondrial Disease Foundation released the following statement from its executive director and CEO, Chuck Mohan, in light of the National Vaccine Advisory Committee's (NVAC) meeting of its Vaccine Safety Working Group and recent pub...

United Mitochondrial Disease Foundation Statement on Vaccines, Autism and Mitochondrial Disease

PITTSBURGH, March 6 /PRNewswire-USNewswire/ -- Statement from Chuck Mohan, executive director and CEO of the United Mitochondrial Disease Foundation on reports of possible links between childhood vaccinations and mitochondrial diseases: "There are no scientific studies documenting tha...

Single Mutation in Mitochondrial DNA Weakens Heart, Muscles

Changes in tissue similar to effects of aging, report suggests THURSDAY, Feb. 14 (HealthDay News) -- A single change in the DNA of mitochondria -- the cellular power plants that generate energy in all human cells -- has been found to cause degenerative heart and muscle disease in mice,...

In silico modeling helps predict severity of mitochondrial disease

A team of researchers in Australia, the United Kingdom and the United States has revealed how mitochondrial diseases are passed from the mother to the next generation in a mouse model system. The study, which was published on-line in Nature Genetics*, shows for the first time how mitochondrial dis...
Mitochondrial in Medical Technology

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

OMAHA, Neb., April 30 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO), a global genetic analysis and services company, today announced the National Cancer Institute had approved a proposal to perform mutational analysis and sequencing of the mitochondrial genes in the N...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

...et's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In vitro studies of PSI-7851 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated pan genotype activity in vit...

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

...e. Cellular studies have determined that this compound acts as a plasma and mitochondrial membrane stabilizer and a potent antioxidant. "Cardax has pioneere...ptionally safe, small molecule compounds that impact inflammation driven by mitochondrial oxidative stress. The Company's first product localizes intracellularly in ...

Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets

...Federale de Lausanne (Switzerland) and Deniz Kirik, MD, PhD, Lund University (Sweden) Validation of cyclophilin D, a protein involved in the mitochondrial permeability transi tion, as a target for Parkinson' s disease therapy Mathieu Lesort, PhD, University of Alabama at Birmingham The t...

Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial

...one loss. "Our drug development program focuses on a different molecular target," said Colca. "We believe that selective activation of the novel mitochondrial target will produce a significantly improved safety profile for individuals with type 2 diabetes. If the results of this study can be successfully ex...

Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimer's Disease

...). In preclinical models of AD and HD explored thus far, Dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial function in a way that prevents neuron death and dysfunction. The Dimebon mechanism is thought to be distinct from currently available AD medications...
Mitochondrial in Medical Dictionary

Translocation

...chromosome material. ... Whenever a translocation is found in a child, the parents' chromosomes are ... Subsequent translocation across the mitochondrial outer membrane is driven by a ... Protein translocation into mitochondria: the role of TIM complexes. Trends ... Detailed information on tran...

Sterility

...es ... Cytoplasmic male sterility is the total or partial male sterility associated with plant biology as the result of specific nuclear and mitochondrial interactions. Male sterility is the failure of plants to produce functional anthers, pollen, or male gametes. Tennessee Oncology doctors provide...

Skeletal

...etal Muscle. The Muscle Fiber. Thick and Thin Filaments. The anatomy of a sarcomere ... Activation of Skeletal Muscle ... Skeletal muscle mitochondrial dysfunction is hypothesized to contribute to the ... To test this, we evaluated skeletal muscle mitochondria and exercise capacity in ... In...

Myopathy

...iterally, a myopathy is a disease of the muscle tissue itself. ... Online Medical Dictionary and glossary with medical definitions ... The mitochondrial myopathies are a group of neuromuscular diseases caused by ... Information and support for parents and medical professionals about x-linked, ......

Metabolic Diseases

...s involved in metabolic diseases have been identified and cloned, ... Metabolic Disease Center. University of California San Diego ... The mitochondrial and Metabolic Disease Center at UCSD has the goal of raising a ... Metabolic disorders information including symptoms, diagnosis, misdiagnos...

Deficiency

... if you smoke. From the National Heart Lung and Blood Institute ... Important It is possible that the main title of the report PEPCK Deficiency , mitochondrial is not the name you expected. Please check the synonyms listing to find ... Iron deficiency anemia — Comprehensive overview covers symptoms, c...
Mitochondrial in Biological News

Large reservoir of mitochondrial DNA mutations identified in humans

Blacksburg, Va. Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,...

Hebrew University develops novel approach for treating mitochondrial disorders

A novel concept for the treatment of mitochondrial disorders using directed enzyme replacement therapy (DERT) has won for a Hebrew University of Jerusalem doctoral candidate one of this year's Kaye Innovation Awards. The awards were presented at this year's 71st meeting of the Hebrew University Bo...

Zebrafish to shed light on human mitochondrial diseases

Zebrafish can now be used to study COX deficiencies in humans, a discovery that gives scientists an unprecedented window to view the earliest stages of mitochondrial impairments that lead to potentially fatal metabolic disorders, according to researchers at the University of Oregon. COX deficien...

Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes

Monday, August 13, 2007 Today, researchers report for the first time that genetic variants in mitochondriaenergy-producing structures harboring DNA that are inherited only from the motherare directly linked to metabolic markers for type 2 diabetes. The study, which highlights the role of mito...

Few clues about African ancestry to be found in mitochondrial DNA

Mitochondrial DNA may not hold the key to your origins after all. A study published today in the open access journal BMC Biology reveals that fewer than 10% of African American mitochondrial DNA sequences analysed can be matched to mitochondrial DNA from one single African ethnic group. There has b...

New mitochondrial DNA gene chip may be early cancer diagnosis tool

A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute's Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer. A...
Mitochondrial in Biological Technology

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

Highly Sensitive Genetic Test Provides Early Diagnosis of Mitochondrial Diseases LOS ANGELES, June 9 /PRNewswire/ -- MEDomics, LLC ( www.medomics.com ) announces an innovative test for early diagnosis of mitochondrial diseases, a group of disorders that can result in neurological dysfunctio...

REPLI-g Mitochondrial DNA Kit

For reliable whole genome amplification from human mitochondrial DNA in total DNA samples The REPLI-g Mitochondrial DNA Kit provides specific and uniform whole genome amplification from human mitochondrial DNA in total DNA samples. The simple procedure enriches for ...

The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays

Key words: In Cell Analyzer • apoptosis • multiplexing • cell based assays Apoptosis represents a gene-directed, morphologically and biochemically distinct form of programmed cell death. Inappropriate control of apoptosis is associated...

Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences

...ulina Cortes-Hernandez, M.D., Ph.D. Laboratory of Jodi M. Nunnari, Ph.D. University of California, Davis mitochondrial division and cell death For full biographies and information regarding the fellows' research subjects, please vis...

Medivation Completes Enrollment in Confirmatory, Pivotal Phase 3 'CONNECTION' Trial of Dimebon in Patients With Alzheimer's Disease

...eimer's disease and Huntington disease explored thus far, dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial function in a way that prevents neuron death and dysfunction. The dimebon mechanism is thought to be distinct from that of currently available Alzheim...

New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the World's Leading Bioenergetics Researchers

...ahorse Bioscience, Inc. to organize an advanced XF mitochondrial workshop and will share their years of experience ...ed learning experience with the world's leaders in mitochondrial physiology." "The workshop will help researc...he Buck Institute for Age Research specializing in mitochondrial dysfunction. He is also a visiting Professor in th...
Mitochondrial in Biological Products

MitoLight® Mitochondrial Apoptosis Detection Kit from Upstate

Description: ...
Company:Upstate

DePsipher Mitochondrial Membrane Potential Disruption Kit from R&D Systems

Description: Kit for Detection of Mitochondrial Membrane Potential...
Company:R&D Systems

MitoPT Detection of Mitochondrial Permeability from B-Bridge International

Description: The MitoPT kit is used in conjunction with your existing apoptosis protocols. Grow your cells in culture and induce apoptosis according to your existing procedure (also reserve a non-induced population of cells as a negative control). Once you have induced apoptosis in your cells, add the 1X MitoPT...
Company:B-Bridge International

MitoLight Mitochondrial Apoptosis Detection Kit from CHEMICON

Description: Disruption of the mitochondrial transmembrane potential is one of the earliest intracellular events that occur following induction of apoptosis. The MitoLight Apoptosis Detection Kit utilizes a lipophilic cation, termed as MitoLight, as a mitochondrial activity marker. MitoLight is a mitochondrial...
Company:CHEMICON

APO LOGIX - JC-1 Mitochondrial Membrane Potential Detection Kit from BACHEM

Description: In situ detection of apoptosis and mitochondrial membrane potential. The mitochondrial permeability transition event provides an early indication of the initiation of cellular apoptosis. This process is typically defined as a collapse in the electrochemical gradient across the mitochondrial membran...
Company:BACHEM

Mouse Anti-Bovine Complex V (F1F0 ATP Synthase) Heart Mitochondria Monoclonal Antibody, Unconjugated, Clone 12F4AD8AF8 from MitoScience LLC

Description:...ifications. Potential uses for the Complex V immunocapture kit include but are not limited to examining alterations of Complex V subunits in inherited mitochondrial diseases, Alzheimers disease, angiogenesis, hypertension and aging....
Company:MitoScience LLC

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Mitochondrial in Biological Definition

Apoptosis

...Caspases, or its mouse homolog, called DIABLO), a mitochondrial protein, is released into the cytosol . SMAC bin...ompletely understood. But it has been found that a mitochondrial outer-membrane protein, VDAC2, interacts with BAK ...displace VDAC2: BAK and BAX are activated, and the mitochondrial outer-membrane becomes permeable, aparently these ...

ATP synthase

...e particles of 9 nm diameter that pepper the inner mitochondrial membrane. They were originally called elementary p...ondria , were ATP synthase is located in the inner mitochondrial membrane (so that F 1 -part sticks into mitochondrial matrix, were ATP synthesis takes place). Plan...

Chemiosmotic hypothesis

...mitochondrion functioned as a kind of electrochemical capacitor , using the energy of NADH and FADH 2 to create a proton gradient across the mitochondrial membrane and that this energy was used by a reversible proton pump , the ATP synthase , to create ATP . This was a radical proposal at the time,...

Cloning

...lmost) all of the genetic information of a lifeform, the "host" egg cell will develop into an organism genetically identical to the nucleus "donor". mitochondrial DNA , which is not transferred by this process, is generally ignored as its effects on organisms are thought to be relatively minor. The term clone...

Ion gradient

...ss takes place in mitochondria , were ATP synthase is located in the inner mitochondrial membrane (so that F 1 -part sticks into mitochondrial matrix, were ATP synthesis takes place). See also Transmembrane po...

Diabetes mellitus

...ease , past gestational diabetes , polycystic ovary syndrome , chronic pancreatitis , hepatic steatosis (fatty liver), cystic fibrosis , several mitochondrial neuropathies and myopathies, myotonic dystrophy , Friedreich's ataxia , some of the inherited forms of neonatal hyperinsulinism and many others. Ri...
Mitochondrial in Biological Dictionary

Self-splicing

...ely as ... Interlocked RNA circle formation by a self - splicing yeast mitochondrial group I intron ... investigated the in vitro self - splicing of a class II mitochondrial ... Self - splicing of group II introns in vitro: Mapping of the bra...

Ribosomes

... of mRNA translation; once the two ... There are two types of Ribosomes : free and bound. ... Ribosome Structure ... Ribosomes ... Eukaryotic mitochondrial and chloroplast ribosomes differ from both of the examples shown. ... The ribosomes operate in chains when translating a mRNA. The ribosome ...

Ribosomal DNA genes

...ylation in ribosomal RNA genes of Arabidopsis thaliana. ... The ribosomal genes coding for the 45S rRNA precursor of the three largest ... mitochondrial DNA contains 37 genes , all of which are essential for normal ... gene often make the 12S RNA in human cells look similar to bacterial ribos...

Recombinant DNA

... Using restriction enzymes to create Recombinant DNA . ... X 2 copies=46 strands of DNA . Plus several thousand copies of very small circular mitochondrial DNA . ... Recombinant DNA Technology. The term "biotechnology" often refers to the ... The technique of recombinant DNA , illustrated above...

Pseudogene

...f the Pseudogene Suite provides an opportunity for ... Numt census ... and a corresponding nuclear pseudogene . Proc. R. Soc. ... A Translocated mitochondrial Cytochrome b Pseudogene in Voles (Rodentia: Microtus) ... New evidence from molecular geneticists joins with the immense body of clues from other...

Proton-motive force

... and health issues. ... A process in which a proton gradient across a mitochondrial membrane and ... In most cases the proton motive force is generated ... force and an energy conserving redox loop,2 another ... Huang3 describe mitochondrial chemiosmosis and proton motive force in action. ... ...
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Breaking Biology News(10 mins):NUS researchers discover for the first time that a rare bush frog breeds in bamboo 2NUS researchers discover for the first time that a rare bush frog breeds in bamboo 3Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2Synapses always on the starting blocks 2Synapses always on the starting blocks 3
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