Transgenomic Obtains Exclusive License to Mitochondrial DNA Damage Detection Technology
OMAHA, Neb., Dec. 4 /PRNewswire-FirstCall/ -- Transgenomic
(OTC Bulletin Board: TBIO) today announced that the Clayton Foundation for
Research of Houston, Texas through its technology transfer entity, the
Research Development Foundation, has granted the Company an exclusive license
to patents cove...
MitoAction Develops On-Line Resource for Mitochondrial Disease Care Providers
Online Clinicians Guide to Mitochondrial
Disease Now Available, sponsored by Edison Pharma
Boston (PRWEB) July 23, 2008 -- MitoAction.org announces today the completion of the Clinicians Symptom Guide to MITO Management, a comprehensive online resource designed to assis...
UMDF Statement on the Connection Between Mitochondrial Disease and Autism
PITTSBURGH, April 11 /PRNewswire-USNewswire/ -- The United
Mitochondrial Disease Foundation released the following statement from its
executive director and CEO, Chuck Mohan, in light of the National Vaccine
Advisory Committee's (NVAC) meeting of its Vaccine Safety Working Group and
United Mitochondrial Disease Foundation Statement on Vaccines, Autism and Mitochondrial Disease
PITTSBURGH, March 6 /PRNewswire-USNewswire/ -- Statement from Chuck
Mohan, executive director and CEO of the United Mitochondrial
Foundation on reports of possible links between childhood vaccinations and
"There are no scientific studies documenting tha...
Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
Changes in tissue similar to effects of aging, report suggests
THURSDAY, Feb. 14 (HealthDay News) -- A single change in the DNA of mitochondria -- the cellular power plants that generate energy in all human cells -- has been found to cause degenerative heart and muscle disease in mice,...
In silico modeling helps predict severity of mitochondrial disease
A team of researchers in Australia, the United Kingdom and the United States has revealed how mitochondrial
diseases are passed from the mother to the next generation in a mouse model system. The study, which was published on-line in Nature Genetics*, shows for the first time how mitochondrial
Mitochondrial in Medical Technology
Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
OMAHA, Neb., April 30 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC
Bulletin Board: TBIO), a global genetic analysis and services company,
today announced the National Cancer Institute had approved a proposal to
perform mutational analysis and sequencing of the mitochondrial
Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C
...et's first generation nucleoside polymerase inhibitor, RG7128 (formerly known as R7128). In vitro studies of PSI-7851 have not shown evidence of any mitochondrial
or other cellular toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated pan genotype activity in vit...
Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome
...e. Cellular studies have determined that this compound acts as a plasma and mitochondrial
membrane stabilizer and a potent antioxidant.
"Cardax has pioneere...ptionally safe, small molecule compounds that impact inflammation driven by mitochondrial
oxidative stress. The Company's first product localizes intracellularly in ...
Michael J. Fox Foundation Awards Over $2 Million for Validation of 10 Parkinson's Therapeutic Targets
...Federale de Lausanne (Switzerland) and Deniz Kirik, MD, PhD, Lund University (Sweden)
Validation of cyclophilin D, a protein involved in the mitochondrial
permeability transi tion, as a target for Parkinson' s disease therapy
Mathieu Lesort, PhD, University of Alabama at Birmingham
Metabolic Solutions Development Company Announces Preliminary Results from Phase IIa Clinical Trial
"Our drug development program focuses on a different molecular target," said Colca. "We believe that selective activation of the novel mitochondrial
target will produce a significantly improved safety profile for individuals with type 2 diabetes. If the results of this study can be successfully ex...
Pfizer and Medivation Initiate Phase 3 Trial of Dimebon Added to Donepezil in Patients with Alzheimer's Disease
...). In preclinical models of AD and HD explored thus far, Dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial
function in a way that prevents neuron death and dysfunction. The Dimebon mechanism is thought to be distinct from currently available AD medications...
Mitochondrial in Medical Dictionary
...chromosome material. ... Whenever a translocation is found in a child, the parents' chromosomes are ... Subsequent translocation across the mitochondrial
outer membrane is driven by a ... Protein translocation into mitochondria: the role of TIM complexes. Trends ... Detailed information on tran...
...es ... Cytoplasmic male sterility is the total or partial male sterility associated with plant biology as the result of specific nuclear and mitochondrial
interactions. Male sterility is the failure of plants to produce functional anthers, pollen, or male gametes. Tennessee Oncology doctors provide...
...etal Muscle. The Muscle Fiber. Thick and Thin Filaments. The anatomy of a sarcomere ... Activation of Skeletal Muscle ... Skeletal muscle mitochondrial
dysfunction is hypothesized to contribute to the ... To test this, we evaluated skeletal muscle mitochondria and exercise capacity in ... In...
...iterally, a myopathy is a disease of the muscle tissue itself. ... Online Medical Dictionary and glossary with medical definitions ... The mitochondrial
myopathies are a group of neuromuscular diseases caused by ... Information and support for parents and medical professionals about x-linked, ......
...s involved in metabolic diseases have been identified and cloned, ... Metabolic Disease Center. University of California San Diego ... The mitochondrial
and Metabolic Disease Center at UCSD has the goal of raising a ... Metabolic disorders information including symptoms, diagnosis, misdiagnos...
... if you smoke. From the National Heart Lung and Blood Institute ... Important It is possible that the main title of the report PEPCK Deficiency , mitochondrial
is not the name you expected. Please check the synonyms listing to find ... Iron deficiency anemia — Comprehensive overview covers symptoms, c...
Mitochondrial in Biological News
Large reservoir of mitochondrial DNA mutations identified in humans
Blacksburg, Va. Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial
DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,...
Hebrew University develops novel approach for treating mitochondrial disorders
A novel concept for the treatment of mitochondrial
disorders using directed enzyme replacement therapy (DERT) has won for a Hebrew University of Jerusalem doctoral candidate one of this year's Kaye Innovation Awards. The awards were presented at this year's 71st meeting of the Hebrew University Bo...
Zebrafish to shed light on human mitochondrial diseases
Zebrafish can now be used to study COX deficiencies in humans, a
discovery that gives scientists an unprecedented window to view the
earliest stages of mitochondrial
impairments that lead to potentially
fatal metabolic disorders, according to researchers at the University of
Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Monday, August 13, 2007 Today, researchers report for the first time that genetic variants in mitochondriaenergy-producing structures harboring DNA that are inherited only from the motherare directly linked to metabolic markers for type 2 diabetes. The study, which highlights the role of mito...
Few clues about African ancestry to be found in mitochondrial DNA Mitochondrial
DNA may not hold the key to your origins after all. A study published today in the open access journal BMC Biology reveals that fewer than 10% of African American mitochondrial
DNA sequences analysed can be matched to mitochondrial
DNA from one single African ethnic group. There has b...
New mitochondrial DNA gene chip may be early cancer diagnosis tool
A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute's Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial
DNA as an early indicator for certain types of cancer. A...
Mitochondrial in Biological Technology
MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test
Highly Sensitive Genetic Test Provides Early Diagnosis of Mitochondrial
LOS ANGELES, June 9 /PRNewswire/ -- MEDomics, LLC ( www.medomics.com ) announces an innovative test for early diagnosis of mitochondrial
diseases, a group of disorders that can result in neurological dysfunctio...
REPLI-g Mitochondrial DNA Kit
For reliable whole genome amplification from human mitochondrial
DNA in total DNA samples
The REPLI-g Mitochondrial
DNA Kit provides specific and uniform whole genome amplification from human mitochondrial
DNA in total DNA samples. The simple procedure enriches for ...
The measurement of DNA condensation and mitochondrial changes during apoptosis and necrosis in cell based assays
Key words: In Cell Analyzer • apoptosis • multiplexing • cell based assays
Apoptosis represents a gene-directed, morphologically and biochemically distinct form of programmed cell death. Inappropriate control of apoptosis is associated...
Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences
...ulina Cortes-Hernandez, M.D., Ph.D.
Laboratory of Jodi M. Nunnari, Ph.D.
University of California, Davis
division and cell death
For full biographies and information regarding the fellows' research subjects, please vis...
Medivation Completes Enrollment in Confirmatory, Pivotal Phase 3 'CONNECTION' Trial of Dimebon in Patients With Alzheimer's Disease
...eimer's disease and Huntington disease explored thus far, dimebon has been shown to inhibit brain cell death, potentially by stabilizing and improving mitochondrial
function in a way that prevents neuron death and dysfunction. The dimebon mechanism is thought to be distinct from that of currently available Alzheim...
New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the World's Leading Bioenergetics Researchers
...ahorse Bioscience, Inc. to organize an advanced XF mitochondrial
workshop and will share their years of experience ...ed learning experience with the world's leaders in mitochondrial
"The workshop will help researc...he Buck Institute for Age Research specializing in mitochondrial
dysfunction. He is also a visiting Professor in th...
Mitochondrial in Biological Products
Mitochondrial in Biological Definition
...Caspases, or its mouse homolog, called DIABLO), a mitochondrial
protein, is released into the cytosol . SMAC bin...ompletely understood. But it has been found that a mitochondrial
outer-membrane protein, VDAC2, interacts with BAK ...displace VDAC2: BAK and BAX are activated, and the mitochondrial
outer-membrane becomes permeable, aparently these ...
...e particles of 9 nm diameter that pepper the inner mitochondrial
membrane. They were originally called elementary p...ondria , were ATP synthase is located in the inner mitochondrial
membrane (so that F 1 -part sticks into mitochondrial
matrix, were ATP synthesis takes place).
...mitochondrion functioned as a kind of electrochemical capacitor , using the energy of NADH and FADH 2 to create a proton gradient across the mitochondrial
membrane and that this energy was used by a reversible proton pump , the ATP synthase , to create ATP . This was a radical proposal at the time,...
...lmost) all of the genetic information of a lifeform, the "host" egg cell will develop into an organism genetically identical to the nucleus "donor". mitochondrial
DNA , which is not transferred by this process, is generally ignored as its effects on organisms are thought to be relatively minor.
The term clone...
...ss takes place in mitochondria , were ATP synthase is located in the inner mitochondrial
membrane (so that F 1 -part sticks into mitochondrial
matrix, were ATP synthesis takes place).
...ease , past gestational diabetes , polycystic ovary syndrome , chronic pancreatitis , hepatic steatosis (fatty liver), cystic fibrosis , several mitochondrial
neuropathies and myopathies, myotonic dystrophy , Friedreich's ataxia , some of the inherited forms of neonatal hyperinsulinism and many others. Ri...
Mitochondrial in Biological Dictionary
...ely as ... Interlocked RNA circle formation by a self - splicing yeast mitochondrial
group I intron ... investigated the in vitro self - splicing of a class II mitochondrial
... Self - splicing of group II introns in vitro: Mapping of the bra...
... of mRNA translation; once the two ... There are two types of Ribosomes : free and bound. ... Ribosome Structure ... Ribosomes ... Eukaryotic mitochondrial
and chloroplast ribosomes differ from both of the examples shown. ... The ribosomes operate in chains when translating a mRNA. The ribosome ...
Ribosomal DNA genes
...ylation in ribosomal RNA genes of Arabidopsis thaliana. ... The ribosomal genes coding for the 45S rRNA precursor of the three largest ... mitochondrial
DNA contains 37 genes , all of which are essential for normal ... gene often make the 12S RNA in human cells look similar to bacterial ribos...
... Using restriction enzymes to create Recombinant DNA . ... X 2 copies=46 strands of DNA . Plus several thousand copies of very small circular mitochondrial
DNA . ... Recombinant DNA Technology. The term "biotechnology" often refers to the ... The technique of recombinant DNA , illustrated above...
...f the Pseudogene Suite provides an opportunity for ... Numt census ... and a corresponding nuclear pseudogene . Proc. R. Soc. ... A Translocated mitochondrial
Cytochrome b Pseudogene in Voles (Rodentia: Microtus) ... New evidence from molecular geneticists joins with the immense body of clues from other...
... and health issues. ... A process in which a proton gradient across a mitochondrial
membrane and ... In most cases the proton motive force is generated ... force and an energy conserving redox loop,2 another ... Huang3 describe mitochondrial
chemiosmosis and proton motive force in action. ... ...