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Mitochondria in Medical News

Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team

PHILADELPHIA Researchers with the University of Pennsylvania School of Veterinary Medicine have demonstrated the process by which the cancer-causing chemical dioxin attacks the cellular machinery, disrupts normal cellular function and ultimately promotes tumor progression. The team identified f...

454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It

BRANFORD, Conn., Sept. 27 /PRNewswire/ -- 454 Life Sciences, a Roche company, today reported that researchers from Pennsylvania State University have used the company's Genome Sequencer(TM) FLX system to sequence the entire mitochondrial genomes from 10 individual woolly mammoths. The study, e...

Cell Protein Could Help Spur Malignancy

...role in the cell nucleus regulating gene expression, is also present in the mitochondria of cells and regulates the electron transport chain in tumor cells, said th...hology and microbiology at New York University's Langone Medical Center. mitochondria -- the energy source in cells -- are known to be critical to tumor cell met...

Research points to a new way to protect kidneys threatened by insufficient blood or toxins

...aused by vascular obstruction, trauma, chemotherapy, even antibiotics cause mitochondria - the cell's powerhouse - to "go to pieces," says Dr. Zheng Dong, cell biol...r. Dong and his colleagues used an inhibitor of the natural fission process mitochondria use to multiply. They will further examine the cell death pathway - and try...

Recent developments at Burnham Institute for Medical Research, May 2009

...ant for the integrity of mitochondria, the energy powerhouses of the cell. The free radicals cause excessive activity of Drp1 that, in turn, cause the mitochondria to fragment. Once this happens, the energy of the nerve cell is compromised and connections to other nerve cells are lost and eventually the nerve cel...

Nicotine May Help Prevent Damage from Bioterrosim Toxin and Growth Factors in Heart Disease News from Molecular Medicine

...study that appears in the May-June 2009 issue of Molecular Medicine, a team of scientists from Argentina report identifying genomic instability in the mitochondria of cells culled from breast cancer tissue. The scientists analyzed two markers along the mitochondrial DNA and found 38 of the 94 tissue samples showe...
Mitochondria in Medical Technology

Miami Jewish Home and Hospital, Berma Research Group and Segal Institute for Clinical Research Enrolling Local Patients in Study of Investigational Therapy to Treat Alzheimer's Disease

...erapy in clinical development for the treatment of Alzheimer's disease. It targets Alzheimer's disease differently than currently available therapies. mitochondria (a cell's primary source of energy) are the target of Dimebon's mechanism of action. Medivation, Inc., the company developing Dimebon and sponsoring...

New Research Shows One in 200 People Born with DNA Mutation That Can Lead to Devastating, Often Fatal Disease

...d or misdiagnosed for years. They develop when the mitochondria - the body's main energy source - do not function properly. mitochondria are responsible for creating more than 90 percent ...ysfunction causes these problems, it is clear that mitochondria are involved because their function is measurably ...

Diverse Approaches to Alzheimer's Therapies Continue to Show Progress at ICAD

...rs to work through a mechanism of action that is distinct from currently marketed Alzheimer's drugs. Dimebon improves impaired mitochondrial function. mitochondria are the central energy source of all cells and impaired mitochondrial function may play a significant role in the loss of brain cell function in Alzhe...

Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease

...Novel Mechanism of Action In a podium presentation at ICAD 2008, Medivation presented new data on Dimebon's novel mitochondrial mechanism of action. mitochondria generate energy for cells and play important roles in mediating cell function and survival. Mitochondrial dysfunction has been linked in the published...

Pressure BioSciences, Inc. Announces $850,000 NIH SBIR Phase II Award for the Development of a New PCT-dependent System for Improved Biomarker Discovery, Diagnostics, and Drug Discovery

...stroke, head injury, and other disorders. As such, mitochondria are recognized as a major potential drug target. W...al isolations and to increase yield and quality of mitochondria from tissues difficult to work with, such as muscl...seases, generally aid research into the roles that mitochondria play in these diseases, and potentially facilitate...

Antipodean Pharmaceuticals Announces Completion of Phase 2 Study of Lead Compound MitoQ(R)

...events liver cell apoptosis. MitoQ(R) is based on a novel technology, targeted lipophilic cations that transport and concentrate antioxidants into the mitochondria -- organelles inside cells that provide energy for life processes -- where they accumulate up to a thousand fold. About Antipodean Antipodean is a...
Mitochondria in Medical Products

QUANTA Lite™ ANA

Features:... Detects G59chromatin (dsDNA and histones), Sm/RNP, SS-A, SS-B, Scl-70, centromere, and PCNA Showscytoplasmic antigens such as Jo-1, mitochondria (M-2) and ribosomal-P protein....
Company:INOVA Diagnostics, Inc.
Mitochondria in Biological News

Bad mitochondria may actually be good for you

Mice with a defective mitochondrial protein called MCLK1 produce elevated amounts of reactive oxygen when young; that should spell disaster, yet according to a study in this week's JBC these mice actually age at a slower rate and live longer than normal mice. Mitochondrial oxidative stress is a...

How mitochondria get their membranes bent

This release is available in German . Mitochondria are the powerhouses of cells. Underneath their smooth surface they harbor an elaborately folded inner membrane. It holds a multitude of bottleneck like invaginations, which expand into elongated cavities (cristae). The narrow shape of the...

Protein regulates movement of mitochondria in brain cells

Scientists have identified a protein in the brain that plays a key role in the function of mitochondria the part of the cell that supplies energy, supports cellular activity, and potentially wards off threats from disease. The discovery, which was reported today in the Journal of Cell Biology ,...

A link between mitochondria and tumor formation in stem cells

Researchers report on a previously unknown relationship between stem cell potency and the metabolic rate of their mitochondria a cell's energy makers. Stem cells with more active mitochondria also have a greater capacity to differentiate and are more likely to form tumors. These findings, appe...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

...ia, the energy generating 'powerplants' of the body, in the hopes that more mitochondria will result in a better power supply. Researchers now show that the stress-...producing mitochondria. Infectious bacteria, like Legionella , target the mitochondria and might use them to supplement their own needs and survival requirements....

'Show me the money!' MDA greenlights grants

...arded a three-year $400,000 grant to continue research into diseases of the mitochondria caused by genetic mutations. mitochondria are the powerhouse of the cell and, when they fail, can cause muscle weakne...

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Mitochondria in Biological Technology

Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences

... Veronica Eisner, Ph.D. Laboratory of Gyorgy Hajnoczky, M.D., Ph.D. Thomas Jefferson University mitochondria and muscular disease Ramon A. Jorquera, Ph.D. Laboratory of J. Troy Littleton, M.D., Ph.D. Ma...

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

...ue," says Steve S Sommer, MD, PhD, Founder and President of MEDomics. mitochondria are the "power plants" of the cell, providing energy for cellular processes... a fraction that differs. When both normal and mutant molecules exist, the mitochondria are said to be "heteroplasmic." The heteroplasmic fraction of mutations can...

New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the World's Leading Bioenergetics Researchers

...ding When and How to Use Intact Cells and Isolated mitochondria in Investigating Cellular Bioenergetics " with re...lar bioenergetics must decide when to use isolated mitochondria and when to use whole cells. In addition, the info...ll make breakthroughs in understanding the role of mitochondria in conditions such as neurodegeneration." "Mo...

Medivation Presents New Data on Dimebon's Novel Mechanism of Action

...s "Neurodegenerative Diseases: Biology & Therapeutics" meeting. mitochondria and Cell Function mitochondria generate energy for cells and play important roles in mediating cell functi...

Nu Skin Scientists Correlate the Appearance of Aging With arNOX Free Radical Generator

...OX) proteins that are located on external cell membranes. ECTO-NOX proteins become increasingly active to generate additional metabolic energy as cell mitochondria age and produce less energy. arNOX has been identified in all cells tested, including serum and saliva and the dermis and epidermis. Its unique proper...

Samaritan Partners 'Forgetful' Rat Model to Taconic to Commercialize

...rats demonstrated Caprospinol's efficacy by, -- clearing beta-amyloid plaque formation -- restoring the memory of tested rats -- protecting mitochondria function -- protecting cell viability -- decreasing cell death Samaritan Pharmaceuticals: "Transforming Today's Science Into Tomorrow's Cures." ...
Mitochondria in Biological Products

Mouse Anti-Bovine Complex V (F1F0 ATP Synthase) Heart Mitochondria Monoclonal Antibody, Unconjugated, Clone 12F4AD8AF8 from MitoScience LLC

Description: 100 g monoclonal antibody which can immunocapture up to 50 g of Complex V from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture. The Complex V immunocapture kit allows isolation of the ATP synthase complex (E.C. 3.6.3.14) from small amounts of tissue...
Company:MitoScience LLC

Isolated Mitochondria Staining Kit from Sigma-Aldrich

Description: The kit measures mitochondria intactness and detects events that dissipate the mitochondrial membrane potential. Features and Benefits: Fast, simple, and convenient method for staining isolated mitochondria and for assaying mitochondria intactness Contains all the reagents required for the dete...
Company:Sigma-Aldrich

Mouse Anti-Bovine Complex IV Monoclonal Antibody, Unconjugated, Clone 31E91B82G9 from MitoScience LLC

Description:... 100 g monoclonal antibody which can immunocapture ~10 g of Complex IV from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture....
Company:MitoScience LLC

Smac/DIABLO, Human, Recombinant, E. coli from Calbiochem

Description:... Second mitochondria Derived Activator of Caspase/DIABLO Liquid. In 100 mM KCl, 20 mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. Amino acid residues 56 - 239 of human Smac/...
Company:Calbiochem

Mouse Anti-Porcine Pyruvate Dehydrogenase (PDH), complex Immunocapture Kit Monoclonal Antibody, Protein G-Agarose Conjugated, Clone 15D3G9C11 from MitoScience LLC

Description:...ly crosslinked to protein G-agarose beads which can immunocapture ~13 g of PDH complex from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture. The pyruvate dehydrogenase complex (PDH) immunocapture kit allows isolation of PDH from small amounts of tissue. This fac...
Company:MitoScience LLC

Mito Casp from BACHEM

Description:...ells. At the same time the mitochondrial membrane potential is visualized by a cell-permeable cationic red fluorescent dye which is accumulated by the mitochondria of healthy but not apoptotic cells. The kit can be used in conjunction with other antibodies or stains. Application: Fluorescence via flow cytometry, ...
Company:BACHEM

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Mitochondria in Biological Definition

Adenosine triphosphate

...al name for ATP is 9--D-ribofuranosyladenine-5'-triphosphate. Synthesis ATP can be produced by various cellular processes, most typically in mitochondria by oxidative phosphorylation under the catalytic influence of ATP synthase or in the case of plants in chloroplasts by photosynthesis . The ma...

Apoptosis

...osis; while in other types of cells (type II), the Fas DISC starts a feed-back loop that spirals into increasing release of pro-apoptotic factors from mitochondria (see below), and the amplified activation of caspase-8. Downstream from TNF-R1 and Fas activation - at least in mammalian cells - a balance between ...

ATP synthase

...TP is the common "energy currency" of cells. In mitochondria , the F O F 1 ATP synthase has a long history of ...le is correlated with ATPase activity in uncoupled mitochondria and with the ATPase activity in submitochondrial particles created by exposing mitochondria to ultrasound. This ATPase activity was further as...

ATPase

...where they are in high concentration. This process is considered active transport . ATP synthetase The ATP synthetase (or ATP synthase ) of mitochondria and chloroplasts is an anabolic enzyme that harnesses the energy of a transmembrane proton gradient as an energy source for adding an inorgani...

Bacterium

...l structure lacking a cell nucleus , cytoskeleton, and organelles such as mitochondria and chloroplasts . Their cell structure is further described in the artic... old organisms, appearing about 3.7 billion years ago. Two organelles , mitochondria and chloroplasts , are generally believed to have been derived from endo...

Cellular respiration

...NAD, a hydrogen carrier, to give NADH+H + . NADH+H + later proceeds to the mitochondria for use in the electron transport chain. The two molecules of 1,3 diphosp...s as the cost of moving pyruvate into mitochondria. This takes place in the mitochondria in eukaryotic cells , and at the cell membrane in prokaryotic cells . ...
Mitochondria in Biological Dictionary

Mitochondria

In cell biology, a mitochondrion is a membrane-enclosed organelle found in most eukaryotic cells. These organelles range from 0.5–10 micrometers (μm) in diameter. Mitochondria are sometimes described as "cellular power... Mitochondria are tubular-shaped organelles that are fou...

Symbiogenesis

... and the Origin of Species, which proposed that chloroplasts originate from cyanobacteria captured by a protozoan. Today both chloroplasts and mitochondria are believed to have such an origin;... Symbiogenesis Symbiogenesis is the merging of two separate organisms to form a ... Symbiogenesis : th...

Self-splicing

...class II mitochondrial ... Self - splicing of group II introns in vitro: Mapping of the branch point and ... Group II intron bl1 from yeast mitochondria can undergo self - splicing in vitro. ... Self - splicing occurs in vitro (for a few of the introns studied to date), but ... They are lar...

RFLP

... primer and ... Custom D4-labeled primers are ordered from Proligo.com. ... posted to therapeutic rflp recombinant mtdna mouse mitotarget mitochondria ... posted to rflp snp by guhjy on 2008-07-23 17:45:21 as along with 1 person and 2 ... I. Overview of T-RFLP method for community studies. Te...

Plastid

...om. Provides advanced students with a basic knowledge of plastid biology and recent developments in the field... posted to protein plastid mitochondria import endosymbiosis chloroplasts by ... Plastid biotechnology: prospects for herbicide and insect resistance, metabolic ... Definition and ...

Phosphorylation

...te designed by SuperIT Web Studio, an atlanta web development software company, for the client of Raybiotech, Inc. Oxidative phosphorylation in mitochondria and basic chemiosmotic concepts. ... Since oxidative phosphorylation is much more efficient (30 vs. 2 ATP per glucose) ... ...
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