Henry Ford Hospital: Unique Patient Study -- No Informed Consent
The study, called RAMPART, will compare an intramuscular injection of midazolam
(Versed) to an intravenous (IV) dose of lorazepam (Ativan). Both drugs are...e, IV diazepam (Valium). The goal is to determine if an auto-injector with midazolam
can stop seizures as fast as starting an IV and giving lorazepam.
Hospira's Precedex(R) Phase IV Study Published in the Journal of the American Medical Association
...mmonly used gamma-aminobutyric acid (GABA)-agonist midazolam
greater-than-24-hour sedation of mechanically ...ASS), there was no difference between Precedex and midazolam
in time at
targeted sedation level, the study's pr...ithin the target RASS range,
while patients in the midazolam
group spent 75.1 percent of the time in the
Newer Sedative May Reduce Delirium in ICU Patients
... amount of time at the target level of sedation as midazolam
[Versed], there were significant outcome improveme...ad more delirium-free days than patients receiving midazolam
(2.5 days vs. 1.7 days), the researchers found.
...n patients receiving midazolam. Patients receiving midazolam
remained on ventilators almost two days longer tha...
Sedative Could Be Deadly in People With Seizures
... a median of 63 hours and a median peak infusion rate of 67 micrograms per kilogram per minute. The other seven patients received other drugs, such as midazolam
In the propofol group, three patients had sudden unexplained cardiac arrest, resulting in two deaths. There were no deaths in th...
Antiseizure Drug Could be Fatal
...was used in 32 (82 percent) of the patients (group A) for a
median of 63 hours and a median peak infusion rate of 67 mcg/kg/min. Other
agents, such as midazolam
and pentobarbital, were used in the other seven
(18 percent) patients (group B). Within group A, three patients had sudden
unexplained cardiac arrest ...
Anti-seizure drug could be fatal
...was used in 32 (82 percent) of the patients (group A) for a median of 63 hours and a median peak infusion rate of 67 mcg/kg/min. Other agents, such as midazolam
and pentobarbital, were used in the other seven (18 percent) patients (group B). Within group A, three patients had sudden unexplained cardiac arrest ...
Effects of anesthesia on the heart
...l in LQT2 but not in LQT1 models, whereas thiopental prolonged the QT interval in both LQT1 and LQT2, though the increase was less pronounced in LQT1. midazolam
prolonged the QT duration in both LQT1 and LQT2 but not in controls, while propofol significantly increased the QT interval in both LQT1 and LQT2 mode...
Penn research offers road map to safer pain control, cost savings during colonoscopies
...the sedatives propofol and remifentanil, while the other received the drugs midazolam
and fentanyl. Those in the propofol arm took only about half as long to be ...ble to walk unassisted sooner after their procedure than those who received midazolam
and fentanyl for sedation, the research also points to ways to reduce staff...
Fruits and vegetables found to interact with drugs in a dangerous way
...ts, Histamine H1 antagonists, immunosuppressants, and erectile dysfunction drugs. Caution has to be taken in particular with sedatives like triazolam, midazolam
and diazepam that could cause excessive sedation in patients with dental problems.
As little as 6.0 oz of grapefruit juice may lower the amount o...
Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA
...inidine, rifampin, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, St. John's wort, lovastatin, simvastatin, pimozide, midazolam
and triazolam due to the potential for serious and/or life-threatening events or loss of efficacy. -- A drug interaction study in healthy subject...
MGI Pharma Announces Positive Results from a Pivotal Phase 3 Study
of Aquavan Injection in Patients Undergoing Bronchoscopy
...e), 65% were
classified as P2, 4% were classified as P3, and none were
classified as P4. One patient in this study experienced hypoxia
after receiving midazolam
subsequent to administration of a bolus
dose of 6.5 mg/kg Aquavan, which resolved following verbal
Minor Surgery Safety Study Results
Aquavan (Fospropofol Disodium) Injection Data Presented at
Digestive Disease Week 2007
...A total of 312 patients in 18 sites were pre-treated with
fentanyl citrate (50 (mu)g) and then received either Aquavan 2.0
mg/kg, Aquavan 6.5 mg/kg or midazolam
0.02 mg/kg (2:3:1 ratio).
Gastroenterologists administered the sedatives, as is consistent
with a large percentage of routine colonoscopies. Patients ...
New Aptivus(R) (tipranavir) Oral Solution Approved for Treatment-Experienced Pediatric and Adolescent HIV Patients
...none, quinidine, rifampin, dihydroergotamine, ergonovine,
ergotamine, methylergonovine, cisapride, St. John's wort, lovastatin,
simvastatin, pimozide, midazolam
(oral) and triazolam due to the potential
for serious and/or life-threatening events or loss of efficacy.
-- A drug interaction study in healthy sub...
Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method
...three different cytochrome P450s enzymatic activities; the hydroxylation of midazolam
(CYP3A4), hydroxylation of tolbutamide (CYP2C9) and Odemethylation of dextr...grade from Sigma- Aldrich Corporation (St. Louis, MO) with the exception of midazolam
and α-hydroxymidazolam standard solutions (1 mg/mL and 100 μg/mL ...