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Microvascular in Medical News

Insight into mechanisms of diabetes-induced microvascular disease reveals new therapies

New findings from Bristol scientists could lead to future treatments to prevent lower limb amputations in diabetes - which currently affect 100 people a week in the UK (source Diabetes UK). The research from the University of Bristol is published online in Circulation Research and was funded ...

Cell transplantation and cardiac repair

...m this data," said corresponding author Dr. Hans Dohman of the Hospital Pro-Cardiaco in Rio de Janeiro, Brazil. While previous reports observed that microvascular obstruction impairing cell uptake by the heart could be an issue, the team hypothesized that an intravenous approach may overcome that potential. "...

Effect of Strict Diabetes Control on Heart Still Unclear

...or measuring blood sugar levels looks at hemoglobin A1C values spread over two to three months. "The central role of glucose control in preventing microvascular eye, kidney and nerve disease is fairly well-established," said Dr. Rick Bergenstahl, executive director of the International Diabetes Center in Minne...

Sangamo BioSciences Presents Positive Phase 2 ZFP Therapeutic Data at ADA 2009

...nical trials have shown us that the dual angiogenic and neurotrophic effects of SB-509 are most effective in the later stages of DN when both diabetic microvascular disease and metabolic neuropathy are evident. The statistically significant improvement in SB-509-treated subjects across multiple independent clinica...

Drug May Lessen Amputation Risk for Diabetics

.... People with previous cardiovascular disease, microvascular disease, previous non-traumatic amputation or skin...ery atherosclerosis from those related to diabetic microvascular disease. The study found virtually no differenc...n height. "Classic markers of macrovascular and microvascular risk were associated with lower-extremity amputati...

Study: Women with hard to diagnose chest pain symptoms at higher risk for cardiovascular events

... events were those with four or more cardiac risk factors. The physicians hypothesize that this difficult to diagnose chest pain could be caused by microvascular angina and endothelial dysfunction, affecting blood vessels in which the layers of the cells are not functioning properly and may be undetectable by s...

Sporadic play activity as beneficial to child health as continuous bouts of exercise, study suggests

...including waist circumference, aerobic fitness and microvascular function (an early indicator of cardiovascular ris...e strongly associated with waist circumference and microvascular health than the intensity or the duration of activ...aviour in young children have been associated with microvascular function. The findings from this study enrich our ...

Growth factor TGF-B helps maintain health of retinal blood vessels

...uture studies are aimed at exploring what other molecules are involved in maintaining healthy blood vessels and how these relate to the development of microvascular diseases. ...

Less of a stink in diabetes patients?

... to good health, whereas an imbalance could indicate disease. In the case of diabetes, common complications of the disease are high blood pressure and microvascular dysfunction, which leads to damage of the tiny blood vessels (microvessels) that deliver blood, oxygen and nutrients to the eyes, skin, nerves and kid...

Cardiovascular Disease and Diabetes: New Blog and Slide Presentation on the Diabetes Best Practices Website Discuss the Most Recent Studies in this Field

...ime occurrence of a major cardiovascular event and there was no difference in the rate of death from any cause. In addition there was no difference in microvascular complications. The VADT study concludes that "For now, appropriate management of hypertension, dyslipidemia, and other cardiovascular risk fa...
Microvascular in Medical Technology

Large, Long-Term Study Shows Avandia Has No Increased Overall Cardiovascular Risk Compared to Other Commonly Used Diabetes Medicines

...ly five years) previously demonstrated by Avandia versus metformin and sulfonylurea in the ADOPT study. Although RECORD was not designed to study microvascular endpoints, previous studies such as the United Kingdom Prospective Diabetes Study, which studied other medicines, have found that improved glycaemic c...

Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy

...nful neuropathies, approximately 3.6 million Americans experience PDN. PDN is thought to result from chronic hyperglycemia, which can lead to diabetic microvascular injury involving small blood vessels that supply nerves (vasa nervorum), particularly the sensory, motor and autonomic nerve fibers. Patients with PDN...

Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels

...uture studies are aimed at exploring what other molecules are involved in maintaining healthy blood vessels and how these relate to the development of microvascular diseases. Other authors of the study include: Magali Saint-Geniez, Arindel SR Maharaj, Eiichi Sekiyama & Angel E. Maldonado, also of the Sch...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

...tin therapy. These new findings, together with the microvascular benefits associated with fenofibrate, argue for co...a median of 5 years could reduce macrovascular and microvascular complications of type 2 diabetes. Macrovascular st...mary) and total cardiovascular events (secondary). microvascular endpoints were laser treatment for diabetic retino...

First Clinical Experience With Soliris(R) in Treating Patients With Two Rare Complement-Mediated Diseases Presented at ASH Annual Meeting

...vastating nature of this disease and the lack of effective treatments," said Dr. Nuernberger. "Initial data suggest that eculizumab reduced hemolysis, microvascular thrombosis, and blood vessel inflammation, thereby appearing to improve the course of aHUS. If clinical trials confirm these results, eculizumab may t...

Study Shows Lantus(R) Helped People Living with Type 2 Diabetes Reach the ADA's Recommended Target for Blood Sugar Control

... to approach 9% before adding insulin. In general, every percentage point drop in A1C blood test results (e.g., from 8.0% to 7.0%) reduces the risk of microvascular complications (eye, kidney, and nerve diseases) by 40%. The most common side effect of any insulin, including Lantus(R), is hypoglycemia, which may ...

Dynamis Therapeutics, Inc. Discovers RAGE Inhibitor

... (AGEs). Scientists expect that a RAGE inhibitor would be an important addition to the arsenal of drugs to treat diabetic kidney disease, retinopathy, microvascular disease, Alzheimer's, inflammatory diseases, some cancers, and aging. A patent has been filed on the discovery. A team of Dynamis Therapeutics' sc...

Statement from the American Diabetes Association Related to ACCORD Trial Announcement

...a, patients with limited life expectancies, children, individuals with comorbid conditions, and those with longstanding diabetes and minimal or stable microvascular complications." This recent announcement by ACCORD investigators suggests that very intensive glucose lowering treatment aimed at normalizing bloo...

Synvista Announces New Data Showing Haptoglobin Type Predicts Effectiveness of Tight Glycemic Control on Cardiovascular Outcomes in Patients with Diabetes

...aid Noah Berkowitz, M.D., Ph.D., President and Chief Executive Officer of Synvista. "While it is widely accepted that tight glycemic control can limit microvascular disease like retinopathy in patients with diabetes, the potential benefits of such control on macrovascular disease have been less clear. This large, ...

First-of-its-Kind National Report Reveals Estimated High Prevalence and Heavy Cost of Type 2 Diabetes Complications in America

... 2.1 percent without diabetes - Stroke occurs in 6.6 percent of people with diabetes vs. 1.8 percent without diabetes In terms of microvascular complications, which relate to small blood vessels, the prevalence is as follows: - Chronic kidney disease(1) occurs in 27.8 percent of people ...
Microvascular in Medical Products

Dingo Microvascular Clamp

Description: The use of some micro vascular clamps can be associated with vessel damage and thrombosis. With use, Stainless steel changes its elasticity, causing increased clamping pressure. It is known that pressures above 30g/mm2 may be associated with endothelial damage. Dingo clamps are made from titanium w...
Company:Beating Heart Surgical Instruments (Vitalcor)

Cueva Cranial Nerve Electrodes

Description:...yields high-quality, stable real-time recordings. This unique approach provides you with valuable information during the removal of acoustic neuromas, microvascular decompressions, vestibular nerve sections and posterior cranial fossa surgeries. Each cranial nerve electrode kit includes: one 2.0 mm or 3.0 mm crani...
Company:Ad-Tech Medical

Oxyflo 4000

Description:... Oxyflo is a highly featured laser doppler system for continuous monitoring of microvascular blood perfusion from multiple tissue sites. This latest generation system incorporates developments in Digital Signal Processing (DSP) and laser Doppl...
Company:Oxford Optronix Ltd.

Oxylab LDF

Description:... Oxylab LDF is a high performance laser doppler system for the continuous monitoring of microvascular (tissue) blood perfusion. This latest generation single-channel system incorporates all the advantages introduced with its multi-channel brother (Oxyf...
Company:Oxford Optronix Ltd.

Oxyflo 2000

Description:... Oxyflo is a highly featured laser doppler system for continuous monitoring of microvascular blood perfusion from multiple tissue sites. This latest generation system incorporates developments in Digital Signal Processing (DSP) and laser Doppl...
Company:Oxford Optronix Ltd.
Microvascular in Medical Dictionary

Vascular spasm

... Health Topics A-Z. Must Reads ... Even though many cardiologists ignore it, vascular spasm happens. ... Top row shows vascular spasm with microvascular filling defects. ... Vascular spasm is a poorly understood but critical biomedical process because it ... Supporting this notion, vascular ...

Foot ulcers

...type 1 and type 2 diabetes. ... the sooner diabetic foot ulcers are treated, the better ... Describes peripheral neuropathy, charcot foot , microvascular disease, and treatment. ... Diabetic Foot Ulcers . Diabetics are prone to foot ulcerations due ... Diabetic foot ulcers are sores that oc...

Diabetic neuropathy

... Diabetic neuropathies are neuropathic disorders that are associated with diabetes mellitus. These conditions are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves (vasa nervorum). Relatively common conditions which may... Reviews the causes and symp...
Microvascular in Biological News

Ovarian transplantation: New technique gives greatly improved results in this delicate operation

...hnique is much easier to perform than the delicate microvascular technique, which they described last year in an ef...duration of ovarian graft function. With the microvascular technique, the tiny blood vessels supplying the ov...isation of the ovarian graft. "We believed that microvascular transplant would give us a longer duration of ovar...

Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment

...ther studies are needed to determine the therapeutic potential of ASP-440, the research underscores the relevance of the kallikrein system in diabetic microvascular disease." In previous JDRF-funded research, Joslin researchers identified plasma kallikrein as a potential therapeutic target in people with diabet...

Hypertension develops early, silently, in African-American men

...s through with each beat of the heart. "Although having a similar cardiovascular risk factor profile as young white men, diffuse macrovascular and microvascular dysfunction is present at a young age in apparently healthy African American men," the authors wrote. "Values seen are comparable to values often repo...

Where optics meets medicine

... to systematically study the effect of these clots on the cognitive decline of the Alzheimer's mice. Presentation FTuE4, "Femtosecond Laser-Induced microvascular Clots Trigger Alzheimer's Disease Pathology," Tuesday, Oct. 21, 9:15 a.m., Highland E, Rochester Riverside Convention Center POTENTIAL NON-INVASI...

Breakthrough optical technology to assess colon cancer risk, accuracy

...troenterology, the official journal of the American Gastroenterological Association (AGA) Institute. The study used fiber optic technology to map microvascular blood content in patients during colonoscopy. The results provide the first indication that the early increase in blood supply (EIBS) is detectable in...

Backpack straps can decrease blood flow in the shoulder and arm

...ght brachial artery was measured using ultrasound and the index finger pulp microvascular flow was measured using the photoplethysmography method. Baseline flows wer...backpack loads of just 26 pounds decrease upper extremity macrovascular and microvascular blood flows, and may result in a loss of fine motor control and increased f...

Researchers create system to build transplant tissue

...tep forward, Cornell engineers describe in the journal Nature Materials a microvascular system they have developed that can nourish growing tissues. The researche...ng and one of the paper's senior authors. "Simply embedding this mimic of a microvascular system allows you to maintain the core of the tissue during culture." Gel s...

Now, self-healing materials can mimic human skin, healing again and again

...lf time after time. The new materials rely upon embedded, three-dimensional microvascular networks that emulate biological circulatory systems. “In the same manner...ven healing cycles. This limitation might be overcome by implementing a new microvascular design based on dual networks, the researchers suggest. The improved design...

Active ingredient in common Chinese herb shown to reduce hypertension

...t once a day for two weeks. After the two-week treatment period, mean arterial blood pressure was measured in the right carotid artery. To examine the microvascular actions of tanshinone IIA researchers applied it topically to the hamsters¡¯ cheek pouch or mice cremaster muscles to achieve the final concentration ...

Cancer cells forming blood vessels send their copper to the edge

...ings of the National Academy of Sciences, or PNAS. "We began our study," Finney explained, " by examining a model of angiogenesis that uses human microvascular endothelial cells to form capillary-like structures within about eight hours of being stimulated with specific growth factors. We then examined the di...
Microvascular in Biological Technology

Nile Therapeutics Announces Focus on CD-NP for Acute Heart Failure and Termination of 2NTX-99 Program

...scular wall from atherogenic stimuli. The unique activity profile of 2NTX-99 suggests potential utility in a range of atherosclerotic, thrombotic, and microvascular diseases, including intermittent claudication, diabetic nephropathy and pulmonary arterial hypertension. About Nile Therapeutics Nile Therape...

Unique New Initiative by World-Recognized Specialists in Heart Disease and Diabetes to Reduce Residual Vascular Risk Launched Today

...are. The R3i, a worldwide, academic, multidisciplinary non-profit organization, aims to successfully address the excessively high risk of macro- and microvascular complications in patients with atherogenic dyslipidemia, characterized by elevated triglycerides and low levels of high-density lipoprotein (HDL) chol...

OmniGuide Introduces The BeamPath Neuro(TM): A CO2 Laser Fiber for Brain And Spine Surgery

...now have the ability to perform precise dissection, cutting, debulking, and microvascular coagulation using a hand-held, no-touch instrument. "Neurosurgeons have l...nants. -- Debulking--shrinks tumor mass in a layer-by-layer fashion. -- microvascular Coagulation--enables the surgeon to operate on appropriate tumors with...

Cardium Launches New AWARE Clinical Study Website

...y understood. Some researchers believe the differences may be the result of microvascular disease, the narrowing or stiffening of the smaller arteries and arterioles that nourish the heart. While microvascular disease is believed to affect both men and women with coronary heart diseas...

Cellix Ltd. Launches VenaEC Biochip for Flow-based Cell-adhesion Assays

... include a Human Coronary Artery Endothelial Cell (HCAEC) monolayer for the investigation of monocyte adhesion for cardiovascular diseases and a Human microvascular Endothelial Cell (HMVEC) monolayer for the investigation of eosinophil adhesion for respiratory diseases. About Cellix Ltd. Cellix Ltd. is a priva...

JCI table of contents: Dec. 3, 2007

...em, suggesting that inflammatory revascularization following ischemia is actually what leads to fibrosis and chronic rejection of the organ. TITLE: microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis AUTHOR CONTACT: Mark R. Nicolls Medical Service (111P), Palo...

Nile Therapeutics, Inc. to Present at Upcoming BIO Investor Forum

...(NO) to the vasculature. Nile believes that the unique activity profile of 2NTX-99 has potential utility in a range of atherosclerotic, thrombotic and microvascular diseases. More information on Nile can be found at http://www.nilethera.com . Contact: Daron Evans Chief Financial Officer Nile Therapeutic...

Nile Therapeutics, Inc. Adds to Executive Management Team

...(NO) to the vasculature. Nile believes that the unique activity profile of 2NTX-99 has potential utility in a range of atherosclerotic, thrombotic and microvascular diseases. More information on Nile can be found at http://www.nilethera.com . Contact: Daron Evans Chief Financial Officer Nile Therapeutics, I...

Deliver siRNAs Into Primary Cells

...ine aortic vascular smooth muscle cells (BAVSMC), bovine adrenal microvascular endothelial cells (BAMEC), mouse embryo fibroblast (MEF), rhesus monkey stem cells (RMSC), bovine lung microvascular endothelial cells (BLMVEC) are shown in blue. Hard-to-transfec...

Primary cells, rat heart endothel

...036 12/1999 Cell line Primary cells: microvascular endothelial cells from rat hearts, 4 days in culture Transfection with Plasmid pEGFP-C...
Microvascular in Biological Products

BBMVEC (B840-05) from European Collection of Cell Cultures (ECACC)

Description:... Bovine Brain microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
Company:European Collection of Cell Cultures (ECACC)
Microvascular in Biological Dictionary

Erythrocytes

...l ... In health, erythrocytes are removed from circulation by two routes: ... Adherence of erythrocytes infected with Plasmodium falciparum to microvascular ... Erythrocytes infected with this parasite adhere in vitro to purified CD36, a ... What is Erythrocytes ? Meaning of Erythrocytes medica...
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(Date:4/17/2014)... Experimental Biology and Medicine a multidisciplinary research ... Kenis in the Institute of Genomic Biology (IGB) ... Urbana-Champaign describe their recent work on subcellular redox ... cell functions including energy metabolism, signaling, and transcriptional ... normal cellular behavior, redox status has been recognized ...
(Date:4/17/2014)... has created a new technology for modifying human ... the body and selectively target cancer and other ... that monitor and modify human physiology is a ... existing technology enabled bioengineers to build such devices ... in a customized fashion. , "The project addressed ...
(Date:4/17/2014)... 17, 2014-- Colic affects about one in five infants ... pediatric visits during the first several months after birth. ... was showing promise; however, the April 1, 2014 issue ... Valerie) reported on a study, "Probiotics and Infant Colic," ... reuteri for infant colic did not reduce ...
(Date:4/17/2014)... off depression among retirees, particularly among those who live ... The Journals of Gerontology, Series B: Psychological Sciences and ... Use and Depression Among Retired Older Adults in the ... that Internet use reduced the probability of a depressed ... , Late-life depression affects between 5 and 10 million ...
(Date:4/17/2014)... therapy improves general blood flow and alleviates muscle ... researchers at the University of Illinois at Chicago. ... print in the Archives of Physical Medicine ... vascular function in people who had not exercised, ... of their level of physical activity. , Improved ...
Breaking Medicine News(10 mins):Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Internet use may cut retirees' depression 2Health News:Massage therapy improves circulation, eases muscle soreness 2
(Date:4/17/2014)... IPCC meeting painted a stark warning on the possible ... a greenhouse effect 32 times that of carbon dioxide. ... humic substances act as fully regenerable electron acceptors which ... in wetlands instead of being released to the atmosphere. ... disrupted it may enter into a vicious cycle to ...
(Date:4/17/2014)... Indiana University researchers have detected new early-warning signs of ... discovery could have far-reaching implications for the diagnosis and ... over 25 million Americans. , "We had not expected ... such early stages," said Ann Elsner, professor and associate ... author of the study. "We set out to study ...
(Date:4/17/2014)... at the University of Texas Medical Branch at ... women treated with radiation for cervical cancer should ... , The UTMB researchers, finding a high ... survivors treated with radiation, offer new recommendations that ... cancer screening about eight years after their initial ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3Radiation therapy for cervical cancer increases risk for colorectal cancer 2
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