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Microsomal in Medical News

Surface Logix Raises $20 Million in Financing and Starts Phase 2b Clinical Trial of SLx-4090 in Dyslipidemia and Diabetes

...d lipid disorders." About SLx-4090 in Dyslipidemia, Diabetes and Obesity SLx-4090 is a novel, oral, non-systemically available inhibitor of microsomal triglyceride transfer protein (MTP) that acts by blocking the formation of particles known as chylomicrons in enterocytes, thereby reducing the uptake...

Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides

... Pediatrics at the University of Pittsburgh School of Medicine. Their research suggests that FoxO1 is vital to the regulation of a protein known as microsomal triglyceride transfer protein (MTP). MTP facilitates the production of very low-density lipoproteins (VLDL), which are produced in extreme excess in p...

Attenuation of NASH by stimulation of free fatty acid metabolism

...ne receptor (CAR) agonist (TCPOBOP) can induce genes involved in fatty acid microsomal omega-oxidation and beta-oxidation pathways, resulting in a reduction in th...osis in animals with simultaneous increased expression of genes involved in microsomal omega-oxidation and peroxisomal beta-oxidation pathways. Therefore, this re...

Traffic Fumes Plus Genes Boosts Kids' Asthma Risk

... variants have also been linked to the development of asthma and other respiratory diseases. In this new study, researchers analyzed the children's microsomal epoxide hydrolase (EPHX1) levels and genetic variations in gluathione S-transferase P1 (GSTP1) -- enzymes that help rid the body of toxins, including ...

Genetic predisposition increases childhood asthma risk

...ociations between number of genetic variants and exposure to toxins among more than 3,000 study participants. Researchers found that high levels of microsomal epoxide hydrolase (EPHX1)an enzyme that metabolizes polyaromatic hydrocarbons (PAH) in vehicle emissionswas associated with an increased risk for life...

New Therapy to Treat Patients With Severely Elevated Cholesterol Levels

...y, had a remarkable 51% reduction in low-density lipoprotein (LDL) or “bad cholesterol” levels. "Our study shows that targeted inhibition of the microsomal triglyceride transfer protein (MTP) is highly effective in reducing cholesterol levels in these very high risk patients,” stated Daniel J. Rader, MD, ...
Microsomal in Medical Technology

Isis Reports Preclinical Data Supporting Liver Safety of ISIS 301012

...apoB) is associated with reduced liver fat content. This observation is in contrast to the effects of either small molecule or antisense inhibitors of microsomal triglyceride transfer protein (MTP), another component of the cholesterol export pathway, which cause severe liver fat accumulation in the same animal...

Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism

...vestigational drug candidate SLx-4090, a first-in-class enterocyte-specific microsomal triglyceride transfer protein (MTP) inhibitor being developed for the treat...ged from 5 to 14 days. About SLx-4090 in Dyslipidemia SLx-4090 is a novel microsomal triglyceride transfer protein (MTP) inhibitor being developed for the treat...
Microsomal in Medical Products

Thyroid Microsomal II

Description: Our ELISA products for autoimmune testing feature single-well ANA screen and ENA screen ELISAs, as well as specific reflex tests including dsDNA, and 6 individual ENA kits: Sm, Sm/RNP, SS-A (Ro), SS-B (La), Scl-70 and Jo-1. In addition, our autoimmune ELISA family includes a full line of products f...
Company:Inverness Medical Innovations
Microsomal in Biological News

Biophysical Society announces 2008 International Travel Awards

...e Approach. Feride Severcan, Middle East Technical University, Ankara, Turkey, The Investigation of Ionizing Radiation- Induced Damages on Liver microsomal Membranes by FTIR Spectroscopy. Aytac A. Seymen, Ankara University, Turkey, Beneficial Effects of Long-term Treatment with Beta-adrenergic Block...

New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds

...corporated the genetically modified mice created in this study. The JCI study found a drug target that might substitute for COX-2: an enzyme called microsomal prostaglandin E synthase (mPGES)-1. The researchers showed that this drug did not predispose the animals to thrombosis or elevate blood pressure. ...

Therapeutic prospects beyond Vioxx

...ors in the first place." A surprising finding came when the investigators turned to a drug target that might substitute for COX-2 ?an enzyme called microsomal prostaglandin E synthase (mPGES)-1. Other investigators had shown previously that deletion of this enzyme seemed as effective as treatment with NSAIDs...
Microsomal in Biological Technology

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

Chromatography and Mass Spectrometry Application Note Key Words Metabolism Study Structure Elucidation Metabolite ID Mass Frontier Mark R. Kagan, Thermo Electron Corporation Introduction The characterization of a drugs metabolites plays a ...

AEterna Zentaris Presents Two Posters on its PI3K Inhibitor Compound, AEZS-126, at AACR Annual Meeting

...potent inhibitor of class I PI3Ks in biochemical and cellular assays and demonstrated favorable properties in early in vitro ADMET screening including microsomal stability, plasma stability and screening against a large safety profile composed of receptors, enzymes and cardiac ion-channels. During the course of...

Surface Logix Achieves Objectives With SLx-4090 in Phase 2a Clinical Trial

...macokinetic sampling was performed at regular intervals. About SLx-4090 in Dyslipidemia and Obesity SLx-4090 is a novel non-systemically available microsomal triglyceride transfer protein (MTP) inhibitor being developed for the treatment of dyslipidemia (high cholesterol and triglyceride levels in the blood...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

...s 2 and 3. Moreover, compound 2 displayed significant higher potency for topoisomerase II inhibition than AEZS-112; - In vitro plasma and liver microsomal stability of the follow-up candidates are comparable to AEZS-112, thus demonstrating suitability for in vivo efficacy studies; - Interference w...

Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP System

...ication software give you more useful information per sample. Experimental Conditions Researchers prepared microsomal incubations of glyburide using S9 derived P450 enzymes. Glyburide was incubated at 30 C for two hours at a final concentration of 20 μM. The reac...

Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System

... Metabolite ID application software makes it easy to go straight to the answers Experimental Conditions Rat liver microsomal incubate samples were injected on a Hypersil- Betasil C18 column (1 x 100 mm). Samples were eluted using Shimadzu 10 AD pumps with a gradient of water...

In-Vitro Metabolism Studies Using Data-Dependent LC/MSn

...xtures (250 L) with 5 or 50 M glyburide, 1 mg of microsomal protein/mL, 0.1 M potassium phosphate pH 7.25, 1...the site of metabolism. Since the samples utilized microsomal preparations fortified with NADPH, only o... An LC/MS n experiment was performed on a microsomal sample. The Data-Dependent analysis affor...
Microsomal in Biological Products

Canine Pancreatic Microsomal Membranes from Promega

Description: Microsomal vesicles are used to study co-translational and initial post-translational processing of proteins. Processing events such as signal peptide cleavage, membrane insertion, translocation and core glycosylation can be examined by the translation of the appropriate mRNA in vitro in the presen...
Company:Promega

Mouse Anti-Na+ / K+ ATPase alpha-1 Monoclonal Antibody, Unconjugated, Clone C464.6 from Upstate

Description:...lla Formulation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide Quality Assurance: routinely evaluated in immunoblot on rat brain microsomal preparations Recognizes α-1 subunit isoform...
Company:Upstate

Mouse Anti-PSD-95, PDZ Domain Monoclonal Antibody, Unconjugated, Clone K28/86.2 from Upstate

Description:...DZ Domain) Formulation: 0.01M Tris pH 7.4, 0.075M NaCl containing 0.05% sodium azide Quality Assurance: routinely evaluated by immunoblot on rat brain microsomal protein preparation Recognizes PDZ domains of PSD-95, SAP97 and Chapsyn 110/PSD-93...
Company:Upstate

NDPase (GDPase, UDPase, ADPase) Assay Kit from Sigma-Aldrich

Description:... The kit was tested on rat tissue extracts (liver, kidney, spleen, and heart) and on a yeast ( S. cerevisae ) extract. It was also tested with microsomal fractions prepared from rat tissues and cell lines. Application: A simple and reliable method for measuring NDPase activity in sub-cellular fractions ...
Company:Sigma-Aldrich
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