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Micronucleus in Medical News

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... ovary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. rat fertility studies with oral gavage doses of 125, 250, and 1000mg/kg, males were treated for 4 weeks prior to mating, during mating, ...

TetraQ recognized for toxicology services

...se toxicology services include cytotoxicity assays, genotoxicity assays - bacterial mutation (Ames) tests; mouse lymphoma assay; mammalian erythrocyte micronucleus testing; dose range finding; safety pharmacology (cardiovascular, central nervous and respiratory systems); off-target screening; and hERG binding ass...

DNA-damage Test Could Aid Drug Development

...cts toxicity in humans, not animals, and you could obtain human bone marrow thats left over from medical procedures.' 'If you could change the micronucleus assay to have a human cell readout, that would be pretty amazing,' says Samson. Down the road, she suggests, such a test might offer a new way to exam...
Micronucleus in Medical Technology

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

...vary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, during mat...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...vary (CHO) chromosome aberration assay, an in vitro cytogenetics assay in CHO, an in vitro rat hepatocyte DNA alkaline elution assay, and an in vivo micronucleus assay. In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, during mat...
Micronucleus in Biological News

DNA-damage test could aid drug development

...dicts toxicity in humans, not animals, and you could obtain human bone marrow that's left over from medical procedures." "If you could change the micronucleus assay to have a human cell readout, that would be pretty amazing," says Samson. Down the road, she suggests, such a test might offer a new way to exam...
Micronucleus in Biological Technology

Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

Key words: Micronucleus assays • toxicology • image analysis • IN Cell Analyzer Micronucleus induction is a key characteristic of genotoxic compounds and analysis of micronuclei formation resulting from DNA strand breakage (clastogens) o...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

... observed. Results from both a Chinese hamster lung (CHL) cell-chromosomeaberration test and mouse bone-marrow micronucleus assay were negative. Gendicine will not replicate in the infected cells and is incapable of multi-cycle infection and of spreading to the...

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

... Precise and cost-effective micronucleus analysis made easy with the icroFlow micronucleus Analysis Kit Dorothea K. Torous Carol R. ... Mark J. Dycaico Stratagene The icroFlow micronucleus Analysis Kit provides researchers with the neces...
Micronucleus in Biological Dictionary

Micronucleus

A micronucleus is the smaller nucleus in ciliate protozoans, such as the paramecium. In fission it divides by mitosis, and in conjugation furnishes the pairing of gamete nuclei, by whose reciprocal fusion a zygote nucleus is formed, which gives rise to the macronuclei and micronuclei of...

Macronucleus

...raded and replaced by a new one, ... Each cell contains a germ line micronucleus and a somatic macronucleus . ... All endogenous RPB3 genes in the macr...ls ... Color the macronucleus red. ... 7. What do the macronucleus and micronucleus do? 8. Define conjugation. ... Macronucleus - Wikipedia, the free enc...
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(Date:10/15/2014)... the 44th Rosenstiel Award for Distinguished Work in Biomedical ... the mechanisms of genomic instability and its implications for ... second alumnus to win the Rosenstiel Award; the first, ... Alt is the Charles A. Janeway Professor of Pediatrics ... an investigator at the Howard Hughes Medical Institute at ...
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