CRi's New Vectra(TM) Platform Rapidly Analyzes Tissue Slides and Microarrays in Brightfield and Fluorescence

DENVER, April 22 /PRNewswire/ -- Cambridge Research & Instrumentation, Inc. (CRi) introduced the Vectra(TM) Intelligent Slide Analysis System at the 100th Annual Meeting of the American Association for Cancer Research (AACR) in Denver. The Vectra system is the world's only multispectral bright...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

...en most common subtypes of the disease. The scientists used several techniques to catalog the changes, including single-nucleotide-polymorphism (SNPs) microarrays to chart genome-wide regions of DNA gain or loss, which are known as copy number alterations (CNAs). To identify point mutations, the researchers also...

St. Gallen consensus 2009: A radically different approach to treating early breast cancer

...sitive disease, while its use is less clear-cut for patients with ER-positive, HER2-negative disease. The increasing use of genetic profiling using microarrays (gene chip technology) is expected to help in such cases where treatment decisions are more difficult. Another of the authors, Professor Aron Goldhirs...

Ovarian cancers detected early may be less aggressive, questioning effectiveness of screening

...g-term survival -- over seven years -- and patients who had done extremely poorly, and died within three years of diagnosis. The researchers used microarrays a method for examining thousands of snippets of DNA -- with about 22,000 probe sets to examine patterns of gene expression among the samples, and ide...

CompuCyte Corporation and Program in Cellular and Molecular Medicine at Children's Hospital Boston Announce Joint Program for Quantitative Imaging Cytometry Research Services

...r Scanning Cytometry (LSC) technology has become a gold standard in quantitative automated analysis of intact adherent cells, tissue specimens, tissue microarrays and small cellular samples, such as small needle aspirates," explained Dr. Elena Holden, CompuCyte's President and Chief Executive Officer. "The reput...

Cell microenvironments hold key to future stem cell therapies

... researchers led by Berkeley Lab's Mark LaBarge and Mina Bissell appear to be well on the road to finding out. Working with unique microenvironment microarrays (MEArrays) of their own creation, LaBarge and Bissell and their collaborators have shown that the ultimate fate of a stem or progenitor cell in a woma...

Microarrays in Medical Technology

Getting More From Whole-Transcript Microarrays

MELBOURNE, Australia , May 22 /PRNewswire/ -- The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published today in the open access journal BMC Bioi...

WaferGen and University of Texas Southwestern Medical Center Establish Biomarker Research Collaboration for SmartChip(TM) Real-Time PCR System

...ticipates that whole genome assay time may be significantly reduced with the SmartChip Real-Time PCR System as compared to several days or months with microarrays or real-time PCR, respectively. This decrease in research time has broad economic implications across the drug development industry, particularly for...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

...21 children with high-risk leukemia (i.e. a high chance of relapse) who had been treated in an existing COG study. They conducted their analysis using microarrays and DNA sequencing -- technologies which allow researchers to quickly and efficiently identify and analyze multiple genes simultaneously in the same c...

Rubicon Provides Genome Amplification for the Cancer Genome Atlas Project

...ntration and quality necessary for reproducible and accurate analysis using microarrays and PCR. The amplified DNA libraries will be deposited into the Internation...ingle cells, plasma, serum and formalin-fixed tissue to be analyzed by PCR, microarrays and next-gen sequencing. Furthermore, GenomePlex allows investigators and c...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

... adverse events being mild or moderate local or systemic reactions(1). Gene Profiling in Melanoma: abstract # 9045(2) Gene expression profiling by microarrays was used to identify markers predictive of the clinical activity of the MAGE-A3 ASCI recorded in the phase II melanoma study. Gene expression profilin...

Ipsogen Announces Three Studies at the American Society of Clinical Oncology (ASCO) Meeting Extending the Utility of the Genomic Grade Index for Predicting Response to Chemotherapy in Breast Cancer

... In the second study to be presented (abstract 527, (3)), Dr. Pusztai and colleagues showed a pionnering application of multi-testing on genome-wide microarrays by combining the GGi, for the prediction of chemotherapy response, with the 200-gene endocrine-sensitivity index, for the prediction of hormonotherapy...

Microarrays in Medical Products

GeneChip System 3000Dx

Description:...luidics Station which automates hybridization, washing and staining of the array, the GCS3000Dx Scanner with AutoLoader Dx which allows you to load 48 microarrays to be scanned without operator intervention, and a Workstation with GCOSDx software. The GeneChip System 3000Dx (GCS 3000Dx) is now available in th...
Company:Affymetrix

GeneMachines Hyb4

Description:...s built upon the success of the first automated hybridization for microarrays. The unit automates all thermal and wash cycles for the hybridization of microarrays spotted on standard glass slides. A 4-position GeneMachines Hyb4 allows 4 slides to be hybridized, while the individual ports allow for independent p...
Company:Genomic Solutions

GeneMachines HybStation

Description:...HybStation is the first automated system for the hybridization of microarrays. The unit automates all thermal and wash cycles for the hybridization of microarrays spotted on standard glass slides. A 12-position GeneMachines HybStation allows for six different sets of hybridizations, while the individual ports a...
Company:Genomic Solutions

Microarrays in Medical Definition

Pathology

... refers to the use of nucleic acid-based techniques, such as in-situ hybridization, reverse-transcriptase polymerase chain reaction, and nucleic acid microarrays for specialised diagnostic studies of disease in tissues and cells. Autopsies are used to provide definitive evidence of the disease processes...

Microarrays in Biological News

Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand gene activation. The new method, which blends experiment and computation, strengthens DNA microarray a...

Agilent Technologies introduces advanced zebrafish, mouse microarrays for stem cell and developmental biology research

Which is more likely to happen - you being in a car wreck or being bitten by a shark? Those who answered that cars are greater killers win a free trip to the beach. It's really no contest, says a Texas A&M University professor. Your chances of being in a wreck are far greater than being a sh...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

For everyone doing or reading a paper about microarray-based experiments, reproductibility, especially inter-lab, is the #1 concern. Can I trust these results? If I redo the same experiment in one month, will I be able to compare both? The NIH recently demonstrated that microarrays experiments pe...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...en most common subtypes of the disease. The scientists used several techniques to catalog the changes, including single-nucleotide-polymorphism (SNPs) microarrays to chart genome-wide regions of DNA gain or loss, which are known as copy number alterations (CNAs). To identify point mutations, the researchers also...

Will IVF work for a particular patient? The answer may be found in her blood

...opposed to genome-wide screening of all the human genes with high density DNA microarrays, as used by Dr. Allen and her team. The advent of tools like microarrays that can simultaneously probe for up to 29,000 genes has radically changed scientific approaches to this type of research. "It's like looking at how a...

Poison: It's what's for dinner

... In the new study, Dearing and colleagues used microarrays designed to scan laboratory rat genes a glass sli...tified in lab rats. Dearing decided to try lab rat microarrays on closely related packrats. "We never have be...sin or with finely ground juniper leaves. Then the microarrays were used to determine which genes had been activa...

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Microarrays in Biological Technology

Fred Hutchinson Cancer Research Center and NSB POSTECH, Inc. to Collaborate on Development of New Class of Proteomic Microarrays

SEATTLE, March 20 /PRNewswire/ -- Fred Hutchinson Cancer Research Center (FHCRC) and NSB POSTECH, Inc. (NSB) have reached a collaboration agreement to coordinate their efforts and to determine the efficacy of the NSB's NanoCones surface technology in creating high quality proteomic microarrays...

NimbleGen microarrays speed genetic findings

Madison, Wis. - Research into the genetic underpinnings of mental retardation has been expidited thanks in part to technology from a local biotechnology company. Researchers at the University of Washington and the Howard Hughes Medical Institute discovered new genetic causes of mental reta...

Preserve Samples for RNA Expression Microarrays RNAlater Around the World

RNA later protects cellular RNA within specimens during sample collection and during shipping. Whether you are in the lab, in the OR, or out in the field, you can use this aqueous, non-toxic Tissue Collection:RN...

Amplification of Mouse cDNAs for Microarrays Using the Eppendorf MasterTaq Kit

Katrine Verdun, Richard Rouse, and Gary Hardiman BIOGEM, Division of Biology, University of California San Diego, La Jolla, CA 92093-0349 e-mail: ghardiman@ucsd.edu www.biogem.ucsd.edu Introduc...

A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays

Abstract This application note describes a method for extracting and isolating total RNA from rodent tissues that have been fixed in formalin and embedded in paraffin, and the subsequent amplification of mRNA from these tissues for use in microarray experiments. We have used this...

Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays

Se-Jin Yoon and Kyung-Ah Lee Infertility Medical Center, CHA General Hospital, Seoul 135-081, Korea Abstract Laser Capture Microdissection (LCM) is an innovative technique which permits the rapid and reliable procurement of pure cell populations from heterogeneous tissue sec...

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Microarrays in Biological Products

Coverslips for Microarrays from GE Healthcare, formerly Amersham Biosciences

Description: Coverslips for Microarrays, 1. *Category: MICROARRAY ACCESSORIES....
Company:GE Healthcare, formerly Amersham Biosciences

Antibody validation service with UNIchip protein microarrays from Protagen AG

Description: The Antibody Validation Service enables early selection of the best antibody for further development by providing quantitative data for sensitivity, dynamic range, and detection limit of each antibody. Furthermore quantitative antibody fingerprints can be generated revealing the off-target activity...
Company:Protagen AG

SigmaScreen APS Coated Slides for Microarrays from Sigma-Aldrich

Description: General description: Aminopropylsilane is perhaps the most commonly used slide chemistry for microarray experiments. SigmaScreen APS Coated Slides for Microarrays provide a quality, reliable glass substrate for printing PCR products or oligos for microarray analysis....
Company:Sigma-Aldrich

Custom 60-mer Oligonucleotide Microarrays from Agilent Technologies

Description: These extended-length microarrays are custom designed to meet your needs. Two probe density format configurations are available: 8,455 features per array (2 arrays/1" x 3" glass slide) or 22,575 features per array (1 array/slide). Features 60-mer oligonucleotide probe length - This extended l...
Company:Agilent Technologies

SpliceArray Service from ExonHit Therapeutics Inc.

Description:... SpliceArray is a new generation of microarrays to detect alternative splicing. SpliceArray Service enables you to rapidly elucidate alternatively spliced events in gene families known to be relev...
Company:ExonHit Therapeutics Inc.

Flat Block Moto Alpha Unit With Integrated Motorized Heated Lid and Skirted Inner Lid from Bio-Rad

Description:... The Flat Block Moto Alpha unit with motorized heated lid and skirted inner lid has a flat surface that is useful for microarrays and chips. The four screw-down points allow attachment of customized sample blocks. The sealing force of the motorized lid is set with software and is...
Company:Bio-Rad

Microarrays in Biological Definition

Bioinformatics

...iction of gene regulation with data from mRNA microarrays or mass spectrometry . Making sens... mRNA levels with multiple techniques including microarrays , expressed cDNA sequence tag ( EST ) sequencing, ...udy ). Protein expression analysis Protein microarrays and high throughput (HT) mass spectrometry (MS)...

Biotechnology

...oremediation ), and produce biological weapons . There are also applications of biotechnology that do not use living organisms . Examples are DNA microarrays used in genetics and radioactive tracers used in medicine. Modern biotechnology is often associated with the use of genetically altered microorg...

Bioinformatics

...iction of gene regulation with data from mRNA microarrays or mass spectrometry . Making sens... mRNA levels with multiple techniques including microarrays , expressed cDNA sequence tag ( EST ) sequencing, ...udy ). Protein expression analysis Protein microarrays and high throughput (HT) mass spectrometry (MS)...

Expressed sequence tag

...whose length is limited by current technology to approximately 500 to 800 nucleotides . ESTs are also a useful resource for designing probes for DNA microarrays used to determine gene expression . External links The NCBI Handbook, Part 3, Chapter 21 has a very nice overview. ...

Tumor

...umor to occur. A combination of a number of mutations is necessary. DNA microarrays can be used to determine if oncogens or tumor repressor gens have been mutated. Possibly in the future tumors can be treated better by using DNA microarrays to determine the exact characteristics of the tumor. As people get older,...

Microarrays in Biological Dictionary

Transcriptome

... transcriptome represents the very small percentage of the genome - less than 5 ... The ENS transcriptome platform is intended to produce DNA microarrays and to offer for scientific community use facilities to make the most of these DNA micorarrays. Transcriptome analyses: experimental design, m...

Protein array

...free protein array technology produces protein microarrays by performing in vitro synthesis of the target ...A templates. This method of synthesizing protein microarrays overcomes the many obstacles... Protein arra...32 2 732 5688 ... Protein Arrays ... Protein microarrays are compatible with hardware ... Protein arr...

Primer extension

...anges in primer concentration and extension temperature modulate ... SNP typing by apyrase-mediated allele-specific primer extension on DNA microarrays ... Prior to spotting, the extension primer solutions were spiked with 2 µM of the ... Go to: eXtension .org Gardens, Lawns, and Landscape's Na...

Pleiotrophy

... article on pleiotropy (genetics), ...of independent traits, each determined by one gene. A "trait" is really an abstraction, a term ... ... cDNA microarrays to explore the potential pleiotropy of HMB-PP-activated V9/V2 T cells. ... novel molecular definitions of the cells' pleiotropy in vitro. ... ...

Microarray

...uidelines for microarray data ... Agilent DNA microarrays provide solutions for successful genomics resear...Web site! ... Resources for gene expression microarrays in model organisms. ... University of Oklahoma ...icroarray . Basic steps involved in Microarr... microarrays Inc produces array-based products for basic resear...

Encapsidation

...dation assay demonstrated that the identified ... Encapsidation . and. Release. Exploring Herpesvirus Research. with Dr. Ed Wagner ... Use of DNA microarrays to Analyze Gene ... Encapsidation and Nuclear Egress ... Summary and Introduction: Little is known about the genetic HBV variations associated .....