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MicroRNAs in Medical News

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

A newly discovered mechanism controls whether muscle cells in blood vessels hasten the development of both atherosclerosis and Alzheimer's disease, according to an article published online today in the journal Nature . The study was led by the Gladstone Institute of Cardiovascular Disease (GIC...

Putting microRNAs on the stem cell map

CAMBRIDGE, Mass. (August 7, 2008) Embryonic stem cells are always facing a choiceeither to self-renew or begin morphing into another type of cell altogether. It's a tricky choice, governed by complex gene regulatory circuitry driven by a handful of key regulators known as "master transcript...

Replacing absent microRNAs could make tumors less invasive, more treatable

One group of small, non-coding RNA molecules could serve as a marker to improve cancer staging and may also be able to convert some advanced tumors to more treatable stages, report a University of Chicago-based research team in the April 1, 2008, issue of the journal Genes & Development. Carcin...

2 microRNAs promote spread of tumor cells

(Philadelphia) The more scientists learn about microRNAs short strands of RNA that can interfere with normal gene activity the more obvious it becomes how closely they are associated with cancer. In a new study, scientists at The Wistar Institute and their colleagues have identified two microRN...

Role Of MicroRNAs In Angiogenesis Researched

According to recent research, MicroRNAs are fine targets for future therapies.Researchers belonging to the University of Pennsylvania School of Veterinary //Medicine have demonstrated how microRNA molecules are responsible for the growth of blood vessels in a human colon cancer model. This process,...

Study Shows a Link Between Schizophrenia & Genetic Mutations

... schizophrenia, as illustrated by the recent movie "The Soloist". micrornas (miRNA) are a large family of small, non-coding RNAs that down-regulate the...It may be feasible to treat schizophrenia by restoring expression of normal micrornas in the central nervous system with current technologies". About M...

Small Molecule Might Play Big Part in Lung Cancer

...R-21 is also elevated in tobacco-related adenocarcinoma, but to a lesser extent. Earlier research also showed that elevated levels of miR-21 and other micrornas were markers for poor survival in smoking-related lung cancer. All lung cancers are notoriously difficult to treat. They have an overall five-year...

Exiqon Announces 2009 North American Grant Award Winners

...ni will receive funding to pursue research aimed at elucidating the role of micrornas (miRNAs) in physiological and pathophysiological bone remodeling in vivo. T... Dr. Zhang will receive funding to pursue research aimed at determining how micrornas (miRNAs) regulate the maintenance and development of epidermal stem cell po...

Cancer Researchers Link DICER1 Gene Mutation to Rare Childhood Cancer

...ugh intermediary molecules known as microRNAs. Scientists have learned that micrornas can fine-tune the expression of many other genes, which is particularly imp...nt from normal when found in cancer cells; some suggest that the pattern of micrornas in cancers resembles an embryonic stage. "When we realized that ...

AUA Foundation announces 2009 Research Scholar Program award winners

...ge PEMPA1 Promotes Cell Proliferation Through Down-Regulating p21WAF1/Cip1 in Prostate Joshua Meeks, MD, PhD, Northwestern University The Role of micrornas in Prostate Development Ted Skolarus, MD, University of Michigan Prostate Cancer Expenditures: Variation and Implications Ye Sun, MD, PhD, Childre...
MicroRNAs in Medical Technology

Rosetta Genomics and Collaborators Identify MicroRNAs That Can Accurately Discriminate Between Primary and Metastatic Tumors in the Brain

Study Demonstrates Differentiation of Primary Tumors From Metastases in the Brain With Accuracy Near 90% Identifying Whether a Brain Malignancy is a Primary Tumor or a Metastasis is a Recurring Challenge for Pathologists Using Current Technologies Accurately Differentiating...

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

...tures make angiogenesis an ideal target for the development of novel anti-cancer strategies." The recent discovery that non-coding RNAs, called micrornas (miRNAs), play a critical role in gene regulation provides new opportunities to discover RNAs that can control angiogenesis. The major aim of this pro...

Prometheus and Rosetta Genomics Announce License and Collaboration Agreement

...cles and heavy metals. About MicroRNA micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of human diseases. In addition, micrornas have been shown to have different expression in va...

Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer

...cal/biotech category. About MicroRNA micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of human diseases. In addition, micrornas have been shown to have different expression in va...

Rosetta Genomics Announces Commercial Availability of its First MicroRNA-Based Diagnostic Test; Will Host Teleconference to Discuss Launch of Future Tests

... be archived for 30 days thereafter. About micrornas micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of h...

Johns Hopkins University Researchers to Clinically Assess Rosetta Genomics' miRview(TM) Squamous Assay

...and specificity of 90 percent. About microRNAs micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of human diseases. In addition, micrornas have been shown to have different expression in va...

MicroRNA First Disclosed by Rosetta Genomics may Increase Efficacy of Imatinib (Gleevec(R)(1)) in Glioblastoma

...effectiveness in treating GBM. About microRNAs micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of human diseases. In addition, micrornas have been shown to have different expression in va...

Rosetta Genomics Identifies Potential microRNA Biomarkers in Blood Serum

... The Study Demonstrates micrornas Extracted From a Simple Blood Draw Have the Potent...ed journal PLOS One. The findings demonstrate that micrornas have the potential to be used as clinical biomarke...velopment of a blood-based test which will utilize micrornas to detect patients with colon cancer. "This stud...

M. D. Anderson to Initiate Clinical Validation Study on Rosetta Genomics' MicroRNA-based Diagnostic Assay Identifying the Origin of Cancer Metastases

...e with current tests for CUP." About microRNAs micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of human diseases. In addition, micrornas have been shown to have different expression in va...

Michael J. Fox Foundation Funds $1.1 Million for Cutting-Edge Approaches to Parkinson's Disease Under Rapid Response Innovation Awards 2008

...rojects funded so far this year: -- Asa Abeliovich, MD, PhD, of Columbia University is working to determine whether a gene silencing technique using micrornas -- short, noncoding molecules of RNA -- can be effective in reducing alpha-synuclein, a protein whose aggregation, or clumping, in the brain is a hall...
MicroRNAs in Biological News

Mass. General's Warren Triennial Prize honors discoverers of microRNAs

Two investigators who helped to uncover a previously unsuspected world of tiny RNA molecules will be recognized next month by Massachusetts General Hospital (MGH) with its highest award for research. Victor Ambros, PhD, of the University of Massachusetts Medical School, and Gary Ruvkun, PhD, of t...

Scientists dig deeper into the genetics of schizophrenia by evaluating microRNAs

NEW YORK Researchers at Columbia University Medical Center have illuminated a window into how abnormalities in microRNAs, a family of molecules that regulate expression of numerous genes, may contribute to the behavioral and neuronal deficits associated with schizophrenia and possibly other brain...

Making sense of antisense microRNAs

Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. The studies from Drs. Alexander Stark and Manolis Kellis (MIT) and colleagues, and from Dr. Eric Lai (MSKCC) and colleagues, both reveal that anti...

Twin molecular scissors link creation of microRNAs with gene-silencing

One of the body's primary strategies for regulating its genome is a kind of targeted gene silencing orchestrated by small molecules called microRNAs, or miRNAs. First observed only a few years ago, these molecules appear to inactivate messenger RNA, itself responsible for translating genes into pro...

Scientists find microRNAs regulate plant development

The plant hormone indole-3-acetic acid (IAA), commonly referred to as auxin, plays a major role in regulating plant growth and development. Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tis...

Molecular steps involved in the creation of gene-silencing microRNAs identified

First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interf...

Advances in lung cancer research announced at conference

...well as several high-tech imaging characteristics all associated with the spread of lung cancer to the brain. The biological significance of these micrornas are being explored, and more studies are warranted, according to the team, which was funded by the Ibis Foundation of Arizona, the TGen Foundation and...

$2 million grant aids study of lung cancer in people who never smoked

...archers will use lung-cancer cell lines, tumor and lung tissue, and blood specimens to conduct studies in proteomics, gene mutations and copy numbers, micrornas (ribonucleic acid), methylation, mitochondrial mutations and gene expression. Many of these studies will examine the entire genome. "By pooling our...

International research team seeks to unravel flatworm regeneration

...ulate genes, such as the small RNAs and especially micrornas (miRNAs). Of the hundreds of known planarian s... new microRNA genes and could demonstrate that ten micrornas are specifically linked to stem cell biology and m...refore play a role in regeneration. A few of these micrornas also exist in humans. Furthermore, the researc...

MicroRNAs help control HIV life cycle

... LA JOLLA, Calif., June 26, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific micrornas (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role i...

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MicroRNAs in Biological Technology

Accurate Identification of Tumor Origin Using MicroRNAs is Published by Rosetta Genomics' Scientists and Collaborators in Nature Biotechnology

A Published Study Shows the Potential of microRNAs to be Used as Biomarkers for Diagnosing the Primary Tumor Site in Patients With Cancer of Unknown Primary (CUP) Rosetta Genomics is Currently Developing a Technology That Will be the Basis of a CUP Diagnostic Test...

LNA-Based RNA oligonucleotides Potently Inhibit Cancer microRNAs

COPENHAGEN, April 20 /PRNewswire/ -- Santaris Pharma announced today promising findings on the in vitro and in vivo activity of microRNA-targeted therapeutics against cancer developed on the basis of its proprietary Locked Nucleic Acid (LNA) Drug Platform. In both in vitro and in vivo models S...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...d an article titled: Uncovering growth suppressive micrornas in lung cancer. Cancer Research In J...d an article titled: Uncovering growth suppressive micrornas in lung cancer Nature Cell Biology I...ndon/UK - BioEurope Spring/Milan/Italy - micrornas in human disease/Boston/USA - Girindus Leader...

Santaris Pharma Director Appointed Adjunct Professor in RNA Biology at the University of Aalborg, Denmark

...rations with academia are essential for Santaris Pharma's expanding microRNA therapeutics program, which aims at translating the basic knowledge about micrornas in disease into development of novel medicines with the potential to improve human health. I am looking forward to interacting closely with Aalborg Un...

Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting

...e broad applicability of antisense technology and adds to our previously published work using antisense to target different classes of RNAs, including micrornas and other non-coding RNAs. We and our collaborators have shown that antisense inhibition of non-coding RNAs can impact splicing patterns in cells to ...

Frost & Sullivan Hosts Presentation on MicroRNAs: From Stem Cells and Cancer to Diagnostics and Therapeutics

...t, a microRNA expert from academia, and a provider of microRNA tools and services. Supporting Quote "The rapid discoveries linking micrornas to various diseases have propelled the microRNA field and tools market in recent years. Moving forward, however, the microRNA field requires more inno...

Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum

...iation ( http://www.fdhn.org ) [2] 'Serum micrornas as Biomarkers', Gilad et. al., PloS ONE, Sep 2008 About MicroRNA micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of h...

Rosetta Genomics Announces Exclusive Distribution Agreement With Teva Pharmaceutical Industries Ltd.

...y asbestos particles and heavy metals About micrornas micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of h...

Rosetta Genomics Announces Commercial Availability of Its Third MicroRNA-Based Diagnostic Test: miRview(TM) meso

...iew(TM) meso is available for $3170. About micrornas micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of h...

Rosetta Genomics to Webcast Panel Presentation at RBC Capital Markets 2008 Healthcare Conference

...ter the conference. About MicroRNA micrornas (miRNAs) are recently discovered, naturally occurr...y to selectively regulate protein activity through micrornas could provide the means to treat a wide range of human diseases. In addition, micrornas have been shown to have different expression in va...
MicroRNAs in Biological Products

Rice microRNA Microarray from LC Sciences

Description:...re available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Rice microRNA Microarray contains all known rice micrornas (98 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Jul...
Company:LC Sciences

Arabidopsis microRNA Microarray from LC Sciences

Description:...s part of our comprehensive microRNA Expression Profiling Service. Probe Content The Arabidopsis microRNA Microarray contains all known arabidopsis micrornas (74 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Jul...
Company:LC Sciences

Fishes microRNA Microarray from LC Sciences

Description:... available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Fishes microRNA Microarray contains all known fish micrornas (234 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Ju...
Company:LC Sciences

Cow microRNA Microarray from LC Sciences

Description:... are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Cow microRNA Microarray contains all known cow micrornas (108 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Ju...
Company:LC Sciences

Maize microRNA Microarray from LC Sciences

Description:... available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Maize microRNA Microarray contains all known maize micrornas (43 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Jul...
Company:LC Sciences

Viruses microRNA Microarray from LC Sciences

Description:...vailable as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Viruses microRNA Microarray contains all known virus micrornas (98 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Jul...
Company:LC Sciences

Soil Nematode microRNA Microarray from LC Sciences

Description:...rt of our comprehensive microRNA Expression Profiling Service. Probe Content The Soil Nematode microRNA Microarray contains all known soil nematode micrornas (114 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Ju...
Company:LC Sciences

Mammals microRNA Microarray from LC Sciences

Description:...ailable as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Mammals microRNA Microarray contains all known mammal micrornas (802 unique mature sequences). The comprehensive probe content is based on the latest version of the Sanger miRBase sequence database (Release 8.2, Ju...
Company:LC Sciences

miRCURY LNA Northern Blotting Detection probes from Exiqon

Description:... Exiqon's miRCURY LNA technology enables sensitive and specific detection of micrornas (miRNAs) by Northern blotting. miRCURY LNA Detection probes have high binding affinity and discrimination, enabling the specific and sensitive detecti...
Company:Exiqon

miRCURY LNA in situ Detection probes from Exiqon

Description:... Exiqon's miRCURY LNA technology enables sensitive and specific detection of micrornas (miRNAs) by in situ hybridisation. miRCURY LNA in situ detection probes have high binding affinity and discrimination, enabling the specific and sensi...
Company:Exiqon
MicroRNAs in Biological Definition

RNA

...all "higher" cells. dsRNA forms the genetic material of some viruses . In eukaryotes, it may play a role in the process of RNA interference and in micrornas . See also Genetics Molecular biology RNA Ontology Consortium ...
MicroRNAs in Biological Dictionary

Unicellular

...d other specialized cell... Scientists discover micrornas in the unicellular green alga, Chlamydomonas reinhardtii. This is the first finding of micrornas in a unicellular organism. This is the first finding of micrornas in a unicellular organism. ... The researchers s...

MicroRNA

... In genetics, micrornas (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA...

Genetic material

... into the genomes of cells, but ... Science and technology news stories tagged with keyword: genetic material . ... Linking genetic material micrornas with cells that regulate the immune system ... ... of transfer of genetic material is one way; DNA is transferred from a donor to a ... res...
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