MicroRNA

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

Research in the laboratory of Assistant Professor Frank J. Slack at Yale University has identified a new way that a familiar gene is regulated in lung cancer, presenting new possibilities for diagnosis and treatment. The work is reported in March issues of the journals Cell and Developmental Cell. The oncogene Ras is out of control in about 20 percent of cancers where it is over-expressed...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

A group of scientists at The Scripps Research Institute is reporting a discovery that sheds light on an area of research fundamental to everything from the normal processes that govern the everyday life of human cells to the aberrant mechanisms that underlie many diseases, including cancer and septic shock. The discovery concerns tiny fragments of RNA known as microRNA and their relations...

NYU, Rockefeller researchers find complexity of regulation by microRNA genes

Collaborating researchers at New York University and Rockefeller University have discovered that microRNA genes, which have recently been shown to have key roles in gene regulation, can team up and regulate target genes in mammals. MicroRNAs are a recently discovered large class of regulatory, non-coding genes, which bind to partially complementary sites in target messenger RNA to regulate their...

MicroRNAs play a big part in gene regulation - and evolution

Regulating when and where certain proteins are made is crucial to the normal functioning of living things. To make proteins, information from DNA is transcribed into RNA molecules and then translated into the amino acids building blocks of proteins. But not all genes code for proteins--some make RNA molecules called microRNAs. These small RNA molecules interfere with--and therefore control--the p...

Molecular steps involved in the creation of gene-silencing microRNAs identified

First discovered only a few brief years ago, microRNAs are small, remarkably powerful molecules that appear to play a pivotal role in gene silencing, one of the body's main strategies for regulating its genome. A scant 22 nucleotides in length, miRNAs appear to work by binding to and somehow interfering with messenger RNA, itself responsible for translating genes into proteins. But how do...

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MicroRNA at Biology Products

microRNA Expression Profiling - Comprehensive Service from LC Sciences

Description:LC Sciences provides a genome-wide microRNA (miRNA) expression profiling service using Paraflo technology and proprietary probe design, which enable highly sensitive and specific direct detection of miRNAs (1-3). We have standard arrays for mature miRNA of all species available in the latest version of the Sanger miRBase database (Release 8.2). Our service is comprehensive and includes small RNA...
Company:LC Sciences

Mammals microRNA Microarray from LC Sciences

Description:Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. The Mammals microRNA Microarray contains all known mammal microRNAs (802 unique mature sequences). The comprehens...
Company:LC Sciences

Soil Nematode microRNA Microarray from LC Sciences

Description:Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. The Soil Nematode microRNA Microarray contains all known soil nematode microRNAs (114 unique mature sequences). T...
Company:LC Sciences

Viruses microRNA Microarray from LC Sciences

Description:Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. The Viruses microRNA Microarray contains all known virus microRNAs (98 unique mature sequences). The comprehensiv...
Company:LC Sciences

Maize microRNA Microarray from LC Sciences

Description:Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. The Maize microRNA Microarray contains all known maize microRNAs (43 unique mature sequences). The comprehensive...
Company:LC Sciences

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MicroRNA at Biology Technology

Novel MicroRNA Array Technology for Sensitive miRNA Profiling

The miRNA gene family contains hundreds of translation regulators, yet their presence and function has only recently been reported in the literature (see <A...

MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

Jaclyn Shingara, Kerri Keiger, Ila Wolf, Jeffrey Shelton, Emmanuel Labourier, and David Brown R&D Division, Ambion, Inc. MicroRNAs (miRNAs) are small, siRNA-like molecules, encoded in the genomes of plants and animals,...

Highly Sensitive microRNA Array Performance

Vana miRNA Labeling Kit MicroRNAs (miRNAs) are extremely small RNA species that represent approximately 0.01% of the total mass of RNA in a sample (10 g total RNA contains ~1 ng miRNA). Due...

Getting Started with MicroRNA Research

Illumination of a Critical Regulation Pathway of Protein Expression MicroRNAs (miRNAs) are a recently identified class of cellular RNAs that regulate protein expression at the translational level. The active, mature miRNAs are 1724 base, single-stranded RNA molecules...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

Drs. Frank Slack, Steven Johnson, and Helge Grosshans, and Ms. Kristy Reinert at Yale University, in collaboration with Ambion scientists, discovered that the microRNA (miRNA) family regulates the expression of C. elegans...

MicroRNA at Biology Dictionary

MicroRNA

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MicroRNA at Medicine News

MicroRNA provides new insight into birth defects

Molecules of microRNAs may be responsible for birth defects, cancer and other health problems.// The researchers of UF Genetics Institute have used genetically modified mice to see how the microRNAs are responsible for the physiological growth of animals. When the mice were grown without the microRNA molecules they grew to be malformed and with nonfunctional limbs. MicroRNA...

Cancer diagnosis easier from microRNA

MicroRNA profile analysis has been developed as a tool to diagnose cancer by scientists of Broad Institute// of MIT and Harvard. Researchers have also been able to develop a technology that will be able to test the microRNA profile through an easy and not expensive diagnostic test. MicroRNA (miRNA) are small RNA molecules that control the level of proteins made from transcribed genes....

microRNA And Its Role In Synaptic Regulation

microRNA belong to the non-coding region of the genome. They play a very important role in regulating the other gene activities like synapses. Researchers at Children's Hospital, Boston says that they are involved in the development of the nervous system.// Synapses are the junctions where the brain cells communicate with each other. This region is very important in the process of developing lea...

Role Of MicroRNAs In Angiogenesis Researched

According to recent research, MicroRNAs are fine targets for future therapies.Researchers belonging to the University of Pennsylvania School of Veterinary //Medicine have demonstrated how microRNA molecules are responsible for the growth of blood vessels in a human colon cancer model. This process, known as angiogenesis, is a result of the ravenous cancer cells using blood vessels to gorge on a...

Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world. Their findings, published in the December 15 issue of Cancer Research, demonstrate that miRNAs are emerging as powerful regulators of gene exp...

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Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression

Findings Published in Molecular Cell Show Potential of microRNAs asNovel Cancer Drug Targets REHOVOT, Israel and NORTH BRUNSWICK, New Jersey, July 05, 2007/PRNewswire-FirstCall/ -- Rosetta Genomics Ltd , a leading microRNAcompany, announced today research published in the journalMolecular Cell by scientists from the Weizmann Institute of Scienceand Rosetta Genomics . The findings suggest...

Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Mar 22, 2007 - AlnylamPharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeuticscompany, announced today publication of a study in the journal Cellby Alnylam and Stanford University scientists on the role of miRNAsin immunity. In the pre-clinical study, a specific miRNA, miR-181a,was shown to play an important role in controlling T cellresponsivenes...