MicroRNA

Exiqon Announces New Grant Program for MicroRNA Research

Exiqon A/S (NASDAQ OMX Copenhagen: "EXQ") today announced the launch of a new research grant program, open to researchers from academic and non-profit institutions across North America. (PRWEB) May 15, 2009 -- Exiqon A/S (NASDAQ OMX Copenhagen: "EXQ"...

Throwing the micro switch: MicroRNA may link smoking risk gene to neurobiology of addiction

Philadelphia, PA, April 23, 2009 During the past several years, significant progress has been made in identifying susceptibility genes for nicotine dependence through genetic linkage and association analyses. Although a large number of genes have been associated with tobacco smoking, only a very...

Gladstone scientists identify single microRNA that controls blood vessel development

Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs. The researc...

Need microRNA processing? Get Smad

BOSTON (embargoed until June 11, 2008, 1:00 p.m. ET) Researchers at Tufts University School of Medicine and Tufts Medical Center have found that Smad proteins regulate microRNA (miRNA) processing. Understanding the role of Smad proteins enables researchers to investigate abnormal miRNA processing ...

Single microRNA fine-tunes innate immune response

Findings: A single microRNA, microRNA-223, in mice controls the production and activation of granulocytes, white blood cells essential for host defense against invading pathogens. Relevance: This is the first microRNA shown to play a crucial role in the innate immune response. Absence of microR...

Sigma-Aldrich Announces mirPremier(TM) microRNA Isolation Kit for miRNA Purification

Provides researchers tool for 50% faster miRNA preparation with no detectable large RNA and further supports Sigma's commitment to the rapidly developing area of RNAi ST. LOUIS, Nov. 1 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) is pleased to introduce ...

Role of MicroRNA in Cancer Suppression Identified

Rosetta Genomics Ltd, a leading microRNA company, announced today research published in the journal Molecular Cell by scientists from the Weizmann Institute of Science and Rosetta Genomics . The findings suggest the potential for a specific, single microRNA (miR-34a) to be used as a drug candidate ...

Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world. Their findings, published in the December 15 iss...

Cancer diagnosis easier from microRNA

MicroRNA profile analysis has been developed as a tool to diagnose cancer by scientists of Broad Institute// of MIT and Harvard. Researchers have also been able to develop a technology that will be able to test the microRNA profile through an easy and not expensive diagnostic test. MicroRNA (m...

Isis Pharmaceuticals to Present at Canaccord Adams' 29th Annual Global Growth Conference

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

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MicroRNA in Medical Technology

Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer

PHILADELPHIA, and REHOVOT Israel, February 12 /PRNewswire-FirstCall/ -- Rosetta Genomics Ltd. (Nasdaq: ROSG ) reported today the first ever in-vivo efficacy data for a systemic microRNA-based cancer therapeutic. The animal-model study demonstrated a marked suppression of a microRNA that was f...

Rosetta Genomics Identifies Potential microRNA Biomarkers in Blood Serum

The Study Demonstrates microRNAs Extracted From a Simple Blood Draw Have the Potential to Serve as Effective Clinical Biomarkers for a Wide Range of Indications Using This Proprietary Technology, Rosetta Genomics is Currently Developing a Blood-Based Te...

First Cancer Diagnostic Test Based on Rosetta Genomics' Proprietary MicroRNA Technology Receives Regulatory Approval

Test Developed and Validated by Columbia University Medical Center Based on Rosetta Genomics' Proprietary MicroRNA Technology The Test Differentiates Squamous From Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Classifying Squamous-Cell Carcinoma of the Lung With Sensitivity...

Rosetta Genomics Signs Agreement With West Coast CLIA Certified Lab to Develop and Validate Tests Applying Company's MicroRNA Technology

Tests Will be Developed and Validated Clinically at Clinical Laboratory Improvement Amendments (CLIA) Certified Laboratory at the University of California, Irvine School of Medicine Rosetta Genomics Expects Three Tests Applying its MicroRNA Technology to be Developed and...

Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica

The Laboratory-Developed Test is Designed to Differentiate Squamous From Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Classifying Squamous Cell Carcinoma of the Lung With Sensitivity of 96 Percent and Specificity of 90 Percent. Accurate Diagnosis is Importa...

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...pharmacological effect in immune cells by specific microrna inhibition. Excluding non-cash compensation... efforts to build its team to support its internal microrna programs and its GSK collaboration. Regulus gener...he discovery, development and commercialization of microrna therapeutics. Isis also has made significant inno...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

Isis and Collaborators Present New Research at the ATVB Annual Conference

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

...00 human genes. The short bits of genetic material it produces during its dicing activities are termed microRNAs. "Prior research showed that the microrna profiles of cancer cells are different from those of normal tissue, which pointed toward a possible role for DICER1 in cancer," says senior author Pau...

Prometheus and Rosetta Genomics Announce License and Collaboration Agreement

...ted substances, primarily asbestos particles and heavy metals. About microrna MicroRNAs (miRNAs) are recently discovered, naturally occurring, smal...portant factors, including risks related to: Rosetta's approach to discover microrna technology and to work on the application of this technology in the develop...

MicroRNA in Biological News

Yale scientists show that a microRNA can reduce lung cancer growth

New Haven, Conn. A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle. Cancer afflicts 1.5 million people...

MIT reports new twist in microRNA biology

CAMBRIDGE, Mass. - MIT scientists have found a new way that DNA can carry out its work that is about as surprising as discovering that a mold used to cast a metal tool can also serve as a tool itself, with two complementary shapes each showing distinct functional roles. Professor Manolis Kellis...

Massive microRNA scan uncovers leads to treating muscle degeneration

Researchers have discovered the first microRNAs tiny bits of code that regulate gene activity linked to each of 10 major degenerative muscular disorders, opening doors to new treatments and a better biological understanding of these debilitating, poorly understood, often untreatable diseases. Th...

Scientists identify novel inhibitor of human microRNA

Scientists at The Wistar Institute and their colleagues have identified, for the first time, a molecule that can regulate microRNAs short strands of RNA that play a vital role in gene expression and are closely associated with cancer. The discovery points the way to the development of a new gener...

Xie Lab demonstrates the role of microRNA pathway

Ting Xie, Ph.D., Associate Investigator, and Zhigang Jin, Ph.D., Postdoctoral Research Associate in the Xie Lab, have published results showing that the microRNA pathway is essential for controlling self-renewal of germline stem cells and somatic stem cells in the Drosophila ovary. The paper, ...

Unicellular microRNA discovery

In the May 15th issue of Genes & Development, an international collaboration of researchers, led by Dr. Yijun Qi (National Institute of Biological Sciences, China), report on their discovery of microRNAs in the unicellular green alga, Chlamydomonas reinhardtii. This is the first finding of micr...

Pair of microRNA molecules controls major oncogene in most common leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world. Their findings, published in the December 15 issue of C...

Activation of microRNA inhibits cancer gene in human cancer cells

Scientists report that tumor cells display a dramatic reduction of cancer-causing genes when a newly discovered method is used to activate the expression of protective microRNAs in the cancer cell genome. The research, published in the June issue of Cancer Cell, demonstrates that agents known to re...

Single microRNA causes cancer in transgenic mouse

Scientists in the Ohio State University Comprehensive Cancer Center say that just one, single, malfunctioning microRNA is sufficient to cause cancer in mice. The discovery offers new insight into the development of some forms of leukemia and lymphoma and at the same time underscores the powerful ro...

Role of microRNA identified in thyroid cancer

The presence of only five tiny strands of RNA is enough to clearly distinguish cancerous thyroid tissue from otherwise normal tissue, scientists say. The findings provide more evidence that an emerging set of RNA genes called microRNA (miRNA) is a powerful regulatory force in the development of ...

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MicroRNA in Biological Technology

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

GERMANTOWN, Md., March 5 /PRNewswire/ -- GeneCopoeia announces the launch of a suite of miRNA functional analysis reagents and tools. They include 1) miExpress(TM) vector based precursor miRNA expression clones; 2) miTarget(TM) miRNA target sequence (3' UTR) expression clones; and 3) All-in-One(TM...

Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum

PHILADELPHIA, Pennsylvania and REHOVOT Israel, January 16 /PRNewswire-FirstCall/ -- Rosetta Genomics Ltd. (Nasdaq: ROSG ) and collaborators, today unveiled initial data relating to the company's colorectal cancer screening diagnostics test, miRscreen(TM) colon, which is based on a simple bloo...

Rosetta Genomics Leverages its MicroRNA Platform Technologies to Launch Plant Biotech Initiative

Initiates Rosetta Green, a Project Which Will Leverage Rosetta Genomics' Proprietary microRNA Technologies and Strong IP Position to Develop a Wide Range of Plant-Based Applications The Company has Recently Secured Up to $1.5M From Private Investors, Which Will be Invested...

Rosetta Genomics and the National Institute of Health (NIH) to Identify Potential MicroRNA Drug Targets for HIV

Collaboration Will Seek to Identify microRNAs Implicated in HIV Viral Replication and Their Function Samples Will be Screened and Analyzed Using Rosetta Genomics' Proprietary microRNA Technologies REHOVOT, Israel and JERSEY CITY, New Jersey, August...

Rosetta Genomics Announces Expansion of its MicroRNA Intellectual Property Estate

Rosetta Genomics In-Licenses, on a Non-Exclusive Basis, Proprietary MicroRNAs for Research Applications From Rockefeller University Following This Agreement, Rosetta Genomics has Access to a Full Range of Potential MicroRNA Applications Based on These MicroRNAs REHOVOT, Israel an...

Rosetta Genomics Announces Allowance of Two Additional microRNA Patents

Allowances Further Strengthen Company's Leading microRNA Intellectual Property Position Company's microRNA Patent Portfolio now Includes 2 Issued Patents, 2 Allowed Patents, and More Than 60 Pending Patent Applications REHOVOT, Israel and NORTH BRUNSWICK, New Je...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

Research Summary Drs. Frank Slack, Steven Johnson, and Helge Grosshans, and Ms. Kristy Reinert at Yale University, in collaboration with Ambion scientists, discovered that the let-7 microRNA (miRNA) famil...

Getting Started with MicroRNA Research

Illumination of a Critical Regulation Pathway of Protein Expression MicroRNAs (miRNAs) are a recently identified class of cellular RNAs that regulate protein expression at the translational level. The act...

Highly Sensitive microRNA Array Performance

mir Vana miRNA Probe Set and mir Vana miRNA Labeling Kit Detecting miRNAs on Microarrays MicroRNAs (miRNAs) are extremely small RNA species that represent approximately 0.01% of the total mass ...

Novel MicroRNA Array Technology for Sensitive miRNA Profiling

Uncover Critical Regulatory Pathways by Analyzing a Complete Set of Human and Mouse miRNAs The miRNA gene family contains hundreds of translation regulators, yet their presence and function has only re...

MicroRNA in Biological Products

Rice microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Rice microRNA Microarra...
Company:LC Sciences

Arabidopsis microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Arabidopsis microRNA Mi...
Company:LC Sciences

Fishes microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Fishes microRNA Microar...
Company:LC Sciences

Cow microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Cow microRNA Microarray...
Company:LC Sciences

Maize microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Maize microRNA Microarr...
Company:LC Sciences

Viruses microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Viruses microRNA Microa...
Company:LC Sciences

Soil Nematode microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Soil Nematode microRNA ...
Company:LC Sciences

Mammals microRNA Microarray from LC Sciences

Description: Microarrays designed for genome-wide microRNA expression profiling and built on the flexible and powerful Paraflo microfluidic on-chip synthesis platform. These microarrays are available as part of our comprehensive microRNA Expression Profiling Service. Probe Content The Mammals microRNA Microa...
Company:LC Sciences

microRNA Expression Profiling - Comprehensive Service from LC Sciences

Description:... LC Sciences provides a genome-wide microrna (miRNA) expression profiling service using Paraflo technology and proprietary probe design, which enable highly sensitive and specific direct detectio...
Company:LC Sciences

miRCURY LNA Array microarray slides from Exiqon

Description:... miRCURY Array LNA microarray slides for microrna expression profiling miRCURY LNA Array microarr...ty and excellent mismatch discrimination for short microrna (miRNA) targets. miRCURY LNA Arrays work on less than 1 g total RNA (no need for microrna enrichment) labeled using the miRCURY Array labeli...
Company:Exiqon

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MicroRNA in Biological Dictionary

MicroRNA

In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated... A gateway to all types of information about microRNAs, including art...

Stem cell

...t subject in the debate over ... Perfect candor should rule in stem cell research. ... STEM CELLS Promotes Miodrag Stojkovi to Editor. ... microrna 92b Controls the G1/S Checkpoint Gene p57 in Human Embryonic Stem Cells ... ... dark side of stem cells . ... leukemia initiation in stem ...

SiRNA

...nce (RNAi) is a system within living cells that helps to control which genes are active and how active they are. Two types of small RNA molecules – microrna (miRNA) and small interfering RNA ( siRNA ) – are central... At some point the siRNA duplex unwinds, and it appears that the antisense strand ...

RNAi

...e ( RNAi ) is a system within living cells that helps to control which genes are active and how active they are. Two types of small RNA molecules – microrna (miRNA) and small interfering RNA (siRNA) – are central... RNAi .net - News, posters, events and suppliers from the main portal site for the fie...

RNA interference

... (RNAi) is a system within living cells that helps to control which genes are active and how active they are. Two types of small RNA molecules – microrna (miRNA) and small interfering RNA (siRNA) – are central... RNA interference ( ¦är¦en¦ā ′intər′firəns ) ( cell and molecular biology ) The...

RNA editing

...ientists investigating these diverse processes ... microrna processing and expression through RNA editi... the human ... Keywords: A-to-I RNA editing , microrna repression, microrna target sites, tissue ... RNA editing can ...

Recombinant clones

...ields multiple, identical clones of the original recombinant molecule. ... Search largest collection of ready to express: ORF cDNA, ShRNA & microrna clones . ... Validated Human Kinome shRNA Clones . OmicsLink™ Recombinant Proteins ... Construction & Cloning of a DNA Recombinant . Cat...

Primary transcript

...ipt that becomes a messenger RNA (mRNA) after processing, and a primary microrna transcript (pri-miRNA) becomes a microrna (miRNA) after processing. Researchers found that the primary RNA t...

Peptide

...ation about Diabetes Mellitus, Type 2, Type 1, and Metabolic Disorders ... " Peptide " is derived from the Greek word "peptein" (to digest) ... ... microrna qRT-PCR, Gene Expression, Antibodies, Custom Peptide & Primer ... The general scheme for solid phase peptide synthesis is outlined in Figure 1...

Natural selection

...fitness' of ... The theory of evolution by natural selection is one of the cornerstones of ... Natural Selection , Inc.'s Algorithms for microrna Discovery Highlighted by EpiGenie ... Dr. Gary Fogel Becomes CEO of Natural Selection , Inc. 9/3/08 ... Discusses natural selection as a con...