miRNA

miRNA profiling

To be published in the June 1 issue of G&D, Dr. Thomas Tuschl and colleagues describe the most comprehensive profile to date of microRNA (miRNA) expression during zebrafish development. The authors cloned 154 distinct miRNAs (10 of which are completely novel) in a developmental and tissue-specific manner. They also identified ?for the first time ever in a vertebrate ?a new class of sma...

miRNAs and musculature

In an effort to understand the biological function of the microRNA mir1, Drs. Nicholas Sokol and Victor Ambros (Darmouth Medical School) have studied the expression profile, transcriptional regulation and loss-of-function phenotype of Drosophila mir-1 (Dmir-1). Mir-1 is an evolutionarily conserved miRNA, whose expression in mouse and humans is limited to heart and skeletal muscle. Strikingly, th...

MiRNA fingerprint identified in platelet formation

Scientists have identified a handful of microRNAs (miRNAs) that appear to play a significant role in the development of platelets ?blood cells critical to the body's ability to form clots following an injury. They also say some of these same miRNAs, when acting abnormally, may contribute to certain forms of leukemia. "Basically, we found that a specific set of miRNA genes are turned off in...

Biologists develop genome-wide map of miRNA-mRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). MicroRNAs bind to messenger RNA (mRNA) in a specific section, called 3'UTR, and are known to regulate them. Parts of th...

miRNA-mediated silencing of mRNAs

Dr. Elisa Izaurrralde and colleagues (EMBL; Max-Planck-Institute for Developmental Biology-Tuebingen) provide new mechanistic insight into gene silencing by miRNAs MicroRNAs (miRNAs) are a novel class of small regulatory RNAs that silence the expres...

miRNA at Biology Products

mirVana™ miRNA Bioarray Essentials Kit from Ambion

Description:The Vana miRNA Labeling Kit. The kit also includes a positive control miRNA (Bioarray ID BA10001) that should be spiked into your miRNA prep...
Company:Ambion

mirVana miRNA Isolation Kit from Ambion

Description:Traditional mRNA isolation procedures were developed to efficiency recover mRNA and can result in the loss of substantial amounts of small RNAs. Ambions mirVana miRNA Isolation Kit purifies all RNA species (including small RNAs), both single- and double-stranded. Through an enrichment procedure included in the mirVana miRNA Isolation Kit, RNA molecules less tha...
Company:Ambion

miRNA at Biology Technology

Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

Ambion has developed a complete line of research tools for the analysis of microRNAs (miRNAs). Recently, we introduced the Vana miRNA microarray platform (consisting of the Vana miRNA Labeling Kit and the Vana miRNA Probe Set) and several miRNA tools for interrogating miRNA function and identifyin...

Detecting miRNA & siRNA

In the past few years, interest in the identification, detection, and use of small RNA molecules has exploded. This interest has primarily stemmed from two interrelated lines of research. In one, small double-stranded RN...

miRNA Expression in White Blood Cells

microRNAs (miRNAs) are endogenous, 21-24 nt RNAs that mediate post-transcriptional gene regulation by pairing with the 3' untranslated region of messenger RNAs and acting as translational repressors. The study of miRNA is an emerging...

Isolate It All: siRNA miRNA Total RNA Native Protein

, Ambion, Inc Isolate total RNA and native protein from the same sample Enrich for small RNAs ( Ideal for assessing siRNA or miRNA expression and processing Small interfering R...

Get the miRNA OutPlant Applications

Patricia Powers & Emmanuel Labourier, Ambion, Inc Quantitative recovery of small RNA such as small interfering RNA (siRNA) and microRNA (miRNA) requires optimized RNA isolation procedures [1]. The <A href="http://www.ambion.com/catalog/CatNum.php?1560">...

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Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Mar 22, 2007 - AlnylamPharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeuticscompany, announced today publication of a study in the journal Cellby Alnylam and Stanford University scientists on the role of miRNAsin immunity. In the pre-clinical study, a specific miRNA, miR-181a,was shown to play an important role in controlling T cellresponsivenes...