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Metronidazole in Medical News

Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials?

... used to analyze the influence of aspirin on the expression of the related OMPs genes. They found that the mutations in rdxA gene did not change in metronidazole resistant isolates treated with aspirin. The radioactivity of H. pylori increased when treated with aspirin, indicating that aspirin improved the pe...

Advances in C. difficile research

...tite, fever, bowel inflammation and possible perforation, which can be fatal. Only two antibiotics are regularly used to treat C. difficile infection: metronidazole and vancomycin, but relapse is a common problem following treatment. In 2004, a hypervirulent strain (C. difficile 027/NAP1/BI) was reported, which ap...

Report raises C. diff concerns; yeast-based probiotic shown to help significantly reduce recurrence

... soon-to-be-launched Your Health Choice radio program, traditional treatment for C. diff-associated disease is the use of powerful antibiotics such as metronidazole or vancomycin, but one of the most troublesome aspects of the disease is its high rate of recurrence. But studies show that adding the yeast-based pr...

FLAVORx Teams up with Wedgewood Pharmacy to Make it Even Easier to Make Pet Medications Taste Good

...x customers: -- Potassium bromide 250MG/ML, commonly prescribed for treatment of seizures in dogs; -- Clindamycin 25MG/ML, an antibiotic; -- metronidazole Benzoate 50MG/ML and 100MG/ML, an antifungal; -- Prednisolone 5MG/ML, a glucocorticoid; -- Methimazole 5MG/ML: commonly prescribed for hyperthyroidi...

ViroPharma Incorporated Reports Third Quarter and Nine-Month 2007 Financial Results

... Vancocin(R) is superior in clinical success to metronidazole and Genzyme's experimental compound in patient...compared clinical success with Vancocin to that of metronidazole and their investigational compound in patients wit...ed a higher clinical success rate than patients on metronidazole or the investigational compound. These data confir...

Metronidazole Increases Risk Of Premature Deliveries.

... at St Thomas's Hospital, London said that previously the usage of the drug metronidazole was recommended by many organizations but now they have stopped the usage o...up in the hospitals during various tests. In all these cases the antibiotic metronidazole is prescribed. Prof Shennan and colleagues showed that the number of pr...

New Treatment for Rosacea

.... Many rosacea patients are generally treated with metronidazole gel, an antibiotic commonly used to treat infectio...ared the safety and efficacy of azelaic gel versus metronidazole gel in rosacea patients. They found the azelaic ge...t reducing the redness in patient’s faces than the metronidazole gel. Also, the...

Dental Procedure Reduces Preterm Births

...; scaling and root planing with a placebo; or scaling and root planing plus metronidazole -- an antibiotic used to treat infections. Results of the study show...on that is thought to induce early labor. Results also show adjunctive metronidazole therapy did not improve pregnancy outcome. In fact, women who were given th...
Metronidazole in Medical Technology

Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria

Novel Antibiotic Candidate Rapidly Bactericidal Against Both Cultures and Spores of the Anaerobic Bacterium Using Multiple in Vitro Methods CHICAGO, Sept. 19 /PRNewswire/ -- Targanta Therapeutics Corporation today released data from two studies comparing the in vitro activity of its lead anti...

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

...tics that disrupt normal gastrointestinal (gut) flora, allowing C. difficile bacteria to flourish. Current therapeutic options for CDI include metronidazole and oral vancomycin. However, approximately 20% to 30% of CDI patients who initially respond to these treatments experience a clinical recurrence fol...

Novexel's NXL104/ceftazidime Combination Commences Second Phase II Clinical Trial in Hospital Patients With Complicated Intra-Abdominal Infections (cIAIs)

...tients being included in each treatment arm. The primary objective of the study is to evaluate the clinical response to NXL104/ceftazidime plus metronidazole in the treatment of adult patients with cIAIs as compared to meropenem. This evaluation will be based on the Test of Cure visit two weeks post-therapy...

Replidyne's Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile

...hibited toxin production at low concentrations (< 1 ug/mL) for all C. difficile strains tested. In contrast, widely used agents such as vancomycin and metronidazole did not reduce toxin production in these high density cultures even at drug concentrations well above those required to inhibit growth of the bacteria...

Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea

... 300 sites in North America, Europe, and Australia, is the largest of its kind ever to be conducted for CDAD. In this trial, tolevamer was compared to metronidazole and vancomycin. Aside from testing tolevamer's efficacy, this was also the first large, rigorously designed, multi-center clinical study that will com...
Metronidazole in Biological News

Scientists sequence genome of parasite responsible for common sexually transmitted infection

...artners. Pregnant women with trichomoniasis may deliver a low birthweight (less than five pounds) or premature infant. Although the prescription drugs metronidazole and tinidazole usually cure trichomoniasis, drug resistance has become an increasing concern. T. vaginalis is pear-shaped with thread-like flagel...
Metronidazole in Biological Technology

NewBridge Pharmaceuticals Announces Licensing of Pylera(R) for Middle East, Africa, Turkey & Caspian Region

... was developed by Axcan over the last ten years, is a patented 3-in-1 capsule therapy. Each Pylera (R) capsule contains bismuth subcitrate potassium, metronidazole and tetracycline hydrochloride. Pylera (R) is clinically proven to be as effective as the most widely prescribed therapeutic regimen for the eradicat...

Optimer Pharmaceuticals Announces Lower Recurrence Rates for Fidaxomicin Versus Vancocin(R) in Subgroup Analyses from Its Phase 3 Study for the Treatment of CDI

...tics that disrupt normal gastrointestinal (gut) flora, allowing C. difficile bacteria to flourish. Current therapeutic options for CDI include metronidazole and oral vancomycin. However, approximately 20% to 30% of CDI patients who initially respond to these treatments experience a clinical recurrence fol...

NimbleGen Systems CGS technique helps identify stomach bacteria

...to antibiotics, according to a study published online in Nature Methods. Mutations that adapted H. pylori to increasing levels of the antibiotic metronidazole were rapidly identified in nearly a dozen serially adapted, antibiotic-resistant strains. The characterization of H. pylori strains in this study repr...
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