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Methylation in Medical News

Rubicon Genomics Announces a Licensing Agreement With Abbott to Develop and Commercialize DNA Methylation Cancer Tests

ANN ARBOR, Mich., Jan. 12 /PRNewswire/ -- Rubicon Genomics today announced a licensing agreement with Abbott, which marks the achievement of significant milestones within their on-going Research and Option Agreement for development and commercialization of Rubicon MethylPlex(TM) methylation detect...

Mouse model highlights histone methylation as distinguishing feature for leukemia subtypes

Research using a new mouse model has led to the identification of a potential therapeutic target for a type of leukemia commonly associated with an unfavorable prognosis. The study, published by Cell Press in the November issue of the journal Cancer Cell , also validates examination of histone mo...

Work with fungus uncovering keys to DNA methylation

Researchers in a University of Oregon lab have shed more light on the mechanism that regulates DNA methylation, a fundamental biological process in which a methyl group is attached to DNA, the genetic material in cells of living organisms. DNA methylation is essential for normal growth and dev...

Silenced genes as a warning sign of blood cancer

...why healthy cells and cancer cells differ in their methylation patterns and why it is particularly the cancer inh...s from birth. They discovered first cancer-typical methylation patterns in mice that were only three months old. This means that deviations in methylation occur long before the first signs of disease appea...

Diagnostic tools and innovative therapies improve patient prognosis

...ugust, 4, 2009 at 12:50 pm PT in Moscone West, Room 2020-2022, Level 2. methylation ANALYSIS IN SPONTANEOUS SPUTUM IS SUITABLE FOR LUNG CANCER DIAGNOSIS (ABSTR...ps, however, the sensitivity increased to 61 percent, supporting the use of methylation analysis in sputum as a way to potentially diagnose lung cancer. "This t...

C-Section Stress Could Alter Baby's Immune Cells

...ection have higher DNA-methylation rates after delivery, the researchers said. "Animal studies have shown that negative stress around birth affects methylation of the genes, and therefore it is reasonable to believe that the differences in DNA-methylation that we found in human infants are linked to differenc...
Methylation in Medical Technology

New Gene Methylation Test for Prostate Cancer Available

RARITAN, N.J., May 16 /PRNewswire/ -- Veridex, LLC announced today that its licensing collaborator, Laboratory Corporation of America Holdings (LabCorp), has commercially launched a new gene methylation test for prostate cancer. The new assay uses the biological specificity of 'DNA methylation...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... single nucleotide polymorphism (SNP) genotyping and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP discovery, and oligonucleotide quality control. About SEQUENOM ...

Blood Testing Identifies Abnormal Cells Up to Six Years Prior to Leukemia Diagnosis

...gressive disease in women with epithelial ovarian cancer. The company is also developing a molecular blood test based on Epigenomics AG's Septin 9 DNA methylation biomarker that can help physicians detect colorectal cancer based on a patient's blood specimen. About Quest Diagnostics Quest Diagnostics i...

Lenetix Launches Screening Study of New Down Syndrome Test

... able to test the chromosomes directly, and that's very exciting." About the Lenetix PloidYX Test The Lenetix PloidYX Test makes use of methylation differences between the fetal and maternal DNA that is found in maternal blood in order to achieve selective amplification of the fetal component. Fol...

Rubicon Provides Genome Amplification for the Cancer Genome Atlas Project

... Sigma-Aldrich. In addition, Rubicon partners with diagnostic companies, using its pre-analytical MethylPlex platform to discover and validate new DNA methylation biomarkers, and to co-develop cancer diagnostic tests. For more information contact John Langmore, VP Commercial Development, at langmore@rubicongenom...

Pharmion Submits European Marketing Authorization Application (MAA) for Vidaza(R) in Patients with Higher-Risk Myelodysplastic Syndromes (MDS)

... changes in the regulation of gene expression. DNA methylation and histone deacetylation are two of the more wide...n of Vidaza required for maximum inhibition of DNA methylation in vitro does not cause major suppression of DNA s...nges in the regulation of gene expression, and DNA methylation and histone deacetylation are two of the more stud...
Methylation in Biological News

DNA methylation shown to promote development of colon tumors

CAMBRIDGE, Mass. (December 1, 2007) Damaged or defective genes have long been known to be the cause of some cancers. Over the past decade, however, scientists have discovered that even healthy genes can be switched on or off and can cause cancer without any changes in the underlying DNA sequencea...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...ncer and Georgia Cancer Coalition Scholar. DNA methylation is a piece of a relatively new research field call...cer, obesity, depression and other disease. DNA methylation inhibitors already are under study at MCG and othe...ow," Dr. Shi says. "A tumor is not only gaining methylation in certain areas and turning this gene off, it's l...

Pushmi-pullyu of B-cell development discovered

...rangement of DNA on the tiny histone spools inside the cell nucleus and the methylation of the B-cell gene. "We knew that the two complexes were capable of influ... different genes, but were pleasantly surprised that they also affected the methylation state of the genes," said Dr. Hagman. ...

The evolutionary foundation of genomic imprinting in lower vertebrates

...nclear. In this study, the authors examined the methylation status of the teleost homologue of mammalian impri...ted DMR of maternal allele could not resist methylation reprogramming and started de novo methylation at the cleavage stage, while the paternal Igf2 all...

Environmental exposures may damage DNA in as few as three days

...rogramming due to a chemical transformation called methylation have been found in the blood and tissues of lung c...osure to particulate matter induced changes in DNA methylation in blood from healthy subjects who were exposed to...odify human health," he added. "The changes in DNA methylation we observed are reversible and some of them are cu...

New early detection studies of lung cancer in non-smokers launched today

...croRNA Profiles of a Lung Cancer Cell Line Panel (PI: Muneesh Tewari, Fred Hutchinson Cancer Center, Seattle, Wash.) Genome analysis: Genome-Wide DNA methylation Profiling of Lung Adenocarcinomas from Never Smokers and Current Smokers (PI: Ite Laird-Offringa, University of Southern California, Los Angeles) ...
Methylation in Biological Technology

SEQUENOM Announces Launch of MassARRAY Compact 96 System

...r classes - somatic mutations via the OncoCarta mutation panel, SNPs, CNVs, methylation patterns, expression signatures - with an unmatched combination of quantita...lotyping, CNV analysis, quantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP di...

New Report Just Published: World Prostate Cancer Therapeutics Market Report

...and PSA-Alpha-1-Protease Inhibitor Levels II-25 Insulin-like Growth Factor (IGF-1) and Intact IGF- Binding Protein-3 (IGF-BP3) II-25 GSTP1 methylation Levels and Prostate Cancer Diagnosis II-25 Microbubble Ultrasound II-26 Staging of Prostate Cancer II-26 Gleason Score II-27 Gleason S...

Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C

...leared as an aid in monitoring epithelial ovarian cancer. The company is also developing a molecular blood test based on Epigenomics AG's Septin 9 DNA methylation biomarker that can help physicians detect colorectal cancer based on a patient's blood specimen. About Quest Diagnostics Quest Diagnostics i...

Applied Biosystems SOLiD System Named Life Science Innovation of the Year : The Scientist Magazine Cites the Technology's High Throughput, Lower Sequencing Cost, and Rapid Technology Innovation for Unlocking New Approaches to Clinical Research

...lications such as whole genome sequencing, targeted resequencing, whole transcriptome analysis, gene expression profiling, small RNA characterization, methylation profiling, and chromatin-immuno precipitation sequencing analysis. These productivity and performance enhancements will enable genomic, transcriptomic...

Sigma-Aldrich Introduces Methylated DNA Quantification Technology for Epigenetic Research

...n Kit significantly simplifies the study of Global methylation with results in half the time of ...radioactivity or chromatography, to measure global methylation in less than four hours. The kits are effective wi...ples, providing insight into conditions that alter methylation status and facilitating advanced disease research....

Frost & Sullivan Awards Genpathway 2008 Healthcare Innovation Award

... --Honor recognizes excellence in ChIP, DNA methylation innovation and service-- SAN DIEGO, Oct. 23 /PRN...s for chromatin immunoprecipitation (ChIP) and DNA methylation assays that directly contribute to discoveries in ...thway. "As interest in and demand for ChIP and DNA methylation assays continues to expand rapidly, our goal is to...
Methylation in Biological Products

EZ-96 DNA Methylation Kit - Deep Well from Zymo Research

Description: The EZ DNA Methylation Kit uses a simplified procedure and streamlines the bisulfite method for DNA methylation analysis. The kit is based on the three step reaction that takes place between cytosine and sodium bisulfite where cytosine is converted into uracil. The EZ DNA Methylation Kits innovativ...
Company:Zymo Research

EZ DNA Methylation Kit from Zymo Research

Description: The EZ DNA Methylation Kit uses a simplified procedure and streamlines the bisulfite method for DNA methylation analysis. The kit is based on the three step reaction that takes place between cytosine and sodium bisulfite where cytosine is converted into uracil. The EZ DNA Methylation Kits innovativ...
Company:Zymo Research

EZ-96 DNA Methylation Kit from Zymo Research

Description: The EZ DNA Methylation Kit uses a simplified procedure and streamlines the bisulfite method for DNA methylation analysis. The kit is based on the three step reaction that takes place between cytosine and sodium bisulfite where cytosine is converted into uracil. The EZ DNA Methylation Kits innovativ...
Company:Zymo Research

CpG WIZ® DAP-KINASE AMPLIFICATION KIT from CHEMICON

Description:... Methylation-specific PCR (MSP) is a new technology for sensitive detection of abnormal gene methylation utilizing small amounts of DNA (5). This process employs an initial bisulfite reaction to modify the DNA, followed by PCR amplification with specific ...
Company:CHEMICON

Rice microRNA Microarray from LC Sciences

Description:...also provides the flexibility of synthesizing microarrays containing probes with modifications such as, 5-amino linker, phosphate, biotin, and various methylation or other types of modifications. Incorporation of modifications greatly increases the number of applications for these microarrays. LC Sciences offer...
Company:LC Sciences

Arabidopsis microRNA Microarray from LC Sciences

Description:...also provides the flexibility of synthesizing microarrays containing probes with modifications such as, 5-amino linker, phosphate, biotin, and various methylation or other types of modifications. Incorporation of modifications greatly increases the number of applications for these microarrays. LC Sciences offer...
Company:LC Sciences
Methylation in Biological Definition

Barr body

...rr body. These changes include histone modifications, such as histone H3 methylation and histone H2A ubiquitylation , as well as direct modification of the DNA itself, via the methylation of CpG sites . These changes help inactivate gene expression on the inac...

Cancer

...o a genetic instability of the cell. The instability increases to a point where the cell loses whole chromosomes , or has double ones. Also, the DNA methylation pattern of the cell changes, activating and deactivating genes more or less at random. Cells that divide at a high rate, such as epithelials , sho...

Chromatin

...atin packaged genes. Changes in chromatin structure are effected mainly by methylation and acylation of the nucleosome proteins. Chromatin structure is also...matin packaged genes. Changes in chromatin structure are effected mainly by methylation and acylation of the nucleosome proteins. Chromatin structure is also of im...

Epigenetics

...ation encoded in the DNA. In recent years, there has been rapid progress in understanding epigenetic mechanisms, which include differences in DNA methylation , as well as difference in chromatin structure. Another possibility involves the genomes of cytoplasmic elements ( chloroplasts and mitochondria )...

Gene

...ts . So, to be expressed, our DNA strand needs to be properly regulated by other DNA strands. The DNA strand may also be silenced through DNA methylation or by chemical changes to the protein components of chromosomes (see histone ). This is a permanent form of regulation of the transcription. ...

Histone

...ct to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation , acetylation , phosphorylation , ubiquitination , and ADP -ribosylation. This effects their function of gene regulation (see functions). In g...
Methylation in Biological Dictionary

Methylation

Methylation in the chemical sciences denotes the attachment or substitution of a methyl group on various substrates. This term is commonly used in chemistry, biochemistry, soil science and the biological sciences. DNA methylation is a type of chemical modification of DNA that can be inhe...

DNA methylation

DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation ... ... i...

Thymine

... pyrimidine nucleobase. As the name suggests, thymine may be derived by methylation of uracil at the 5th carbon. In RNA,... A thymine dimer is the cova... pyrimidine nucleobase. As the name implies, thymine may be derived by methylation of uracil at the 5th carbon. ... Thymine was the first pyrimidine ...

Spermatogonia

...f spermatocytes, and ... Undifferentiated type A spermatogonia could repopulate the seminiferous ... Loss of spermatogonia and wide-spread DNA methylation defects in newborn male ... were conducted on postnatal primitive type A spermatogonia lacking DNMT3L. ... Strong mosaicisms towards expansions ...

Ribosomal DNA genes

... genes during evolution: 1) gradual ... Natural variation in DNA methylation in ribosomal RNA genes of Arabidopsis thaliana. ... The ribosomal g...ATION, and TECHNOLOGY ... player in both histone deacetylation and DNA methylation of ribosomal RNA genes . ... ... Instability in the Ribosomal DNA...

Promoter

...es, Furnishings and More for your Kitchen, Bedroom and Yard. aligning promoter regions to find a binding site - (reply: 2) panomics promoter methylation PCR kit - results not what i expected (reply: 1) ... ...
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