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Methotrexate in Medical News

Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal

Copenhagen, Denmark, Thursday 11 June 2009: Elevated levels of the inflammatory biomarkers Myeloid Related Protein (MRP*) 8/14 predict an increased risk of relapse following withdrawal of methotrexate (MTX) therapy in children with juvenile idiopathic arthritis (JIA) who have achieved inactive dis...

Etanercept, Methotrexate Safe for Juvenile RA

Review finds use, even in combo, an effective long-term treatment MONDAY, Oct. 27 (HealthDay News) -- The drugs etanercept and methotrexate are safe and effective for long-term, continuous treatment of juvenile rheumatoid arthritis, new research finds. In a three-year study that en...

Increased incidence of melanoma found in rheumatoid arthritis patients treated with methotrexate

A chronic, inflammatory disease of unknown origin, rheumatoid arthritis (RA) affects about 1 percent of adults worldwide. Marked by joint destruction, RA often leads to disability and diminished quality of life. It can also lead to an early death from cancer. Various studies have linked RA to a...

Enbrel Joins with Methotrexate to Cure Rheumatoid Arthritis

An international one year TEMPO trial reports in addition to the usual methotrexate therapy, rheumatoid arthritis patients also benefits //from ENBREL* (etanercept), a biological treatment. A report presented in the Annual European Congress of Rheumatology, (the European League Against Rheumatism (...

Combination Therapy With ENBREL And Methotrexate Found Effective In RA Treatment

Combination therapy with anti-TNF agents (etanercept) and chemotherapy drug methotrexate has been shown to be effective in the treatment of Rheumatoid Arthritis.// Furthermore, the progression of joint damage has been considerably slowed down in over three quarters of patients. The chronic nature o...

TNF Blockers May Help Some With Rheumatoid Arthritis

...(RA) who respond poorly to standard treatment with methotrexate may benefit from additional treatment with tumor n... to 40 percent of patients have a good response to methotrexate therapy and don't need more intensive combination ...s, the 258 patients with an inadequate response to methotrexate were randomly assigned to receive either the TNF b...

Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers

...re rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone. ENBREL is indicated for reduc...arthritis. ENBREL can be used in combination with methotrexate in patients who do not respond adequately to methotrexate alone. ENBREL is indicated for reducing sign...

Rigel Announces Second Quarter 2009 Financial Results

...nd chief executive officer of Rigel. "As I have previously mentioned, our objective with R788 in rheumatoid arthritis is to position the product after methotrexate and before biological therapies are used. We have shown excellent results in TASKi1 and TASKi2 studies, and we believe that patient population repres...

Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis

...o successfully completed a drug-drug interaction (DDI) study of LX2931 with methotrexate in patients with rheumatoid arthritis, with no clinically significant drug-...ny expects to enroll up to 120 patients with rheumatoid arthritis on stable methotrexate therapy. Three dose levels will be evaluated: a 70 mg dose, a 110 mg dose...

Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Earnings Growth Outlook for 2009

...LAR) annual congress showed that patients with moderate to severe early rheumatoid arthritis (RA) initially treated with the combination of HUMIRA and methotrexate (MTX) for two years had greater inhibition of radiographic progression at five years than patients initially treated with either of the monotherapies....
Methotrexate in Medical Technology

Five-Year Data Demonstrate Long-Term Efficacy and Safety with ORENCIA(R) (abatacept) in Adults with Rheumatoid Arthritis Who had an Inadequate Response to Methotrexate

- Data Presented at American College of Rheumatology Annual Meeting - BOSTON, Nov. 9 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company (NYSE: BMY ) today announced that cumulative five-year data from an open-label long-term extension of a Phase IIb trial demonstrate the long-term effica...

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

... "Our objective with R788 in RA is to position the product after methotrexate and before biological therapies are used. We have shown excellent results ...t improvement in RA patients treated with R788 who had failed to respond to methotrexate treatment. Conference Call and Webcast Information Rigel w...

Rigel's R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial

...patients in the U.S., Latin America and Europe who had failed to respond to methotrexate alone. The patients were randomly assigned to two cohorts and thus receive...lacebo. All of the patients continued to receive their same stable dose of methotrexate throughout the clinical trial period. Efficacy assessments for each ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...atoid arthritis trials, SIMPONI was shown to be effective regardless of prior treatment experience, which included patients inadequately responding to methotrexate and patients previously treated with anti-TNF agents. Centocor Ortho Biotech Inc. developed and discovered golimumab and has exclusive marketing ...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

...in combination with methotrexate; and active ankylosing spondylitis in adults. Indications in Canada: In Canada, SIMPONI, in combination with methotrexate (MTX), is indicated for reducing the signs and symptoms in adult patients with moderately to severely active RA; reducing signs and symptoms in adult ...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

...in combination with methotrexate; and active ankylosing spondylitis in adults. Indications in Canada: In Canada, SIMPONI, in combination with methotrexate (MTX), is indicated for reducing the signs and symptoms in adult patients with moderately to severely active RA; reducing signs and symptoms in adult ...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

...l joint damage compared with patients treated with methotrexate alone. These data will be presented at the 10th A...nts treated with ACTEMRA (4 mg/kg or 8 mg/kg) plus methotrexate experienced a significant inhibition in the progre...harp score(2), compared with patients treated with methotrexate plus placebo (0.29, 0.34 versus 1.1, respectively;...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

...ts treated with ACTEMRA (8 mg/kg and 4 mg/kg) plus methotrexate achieved a significant reduction in the progressio...y and safety of ACTEMRA (8 mg/kg and 4 mg/kg) plus methotrexate compared with placebo plus methotrexate in RA patients. Patients in the LITHE study receiv...

Medarex Announces Primary Endpoint Achieved in MDX-1100 Anti-IP-10 Antibody Phase 2 Trial for Rheumatoid Arthritis

...f-concept trial in patients with active rheumatoid arthritis (RA) receiving methotrexate successfully met its primary endpoint. The top-line results from the recent...ficant when compared with placebo (p=0.0024). The antibody combination with methotrexate was generally safe and well-tolerated. Full results from this Phase 2 trial...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

...were taking concomitant immunosuppressants such as methotrexate or corticosteroids. CIMZIA should be discontinued ...ng CIMZIA 200 mg every other week with concomitant methotrexate (n=640) and more frequently than with placebo with concomitant methotrexate (n=324) were upper respiratory tract infection (6%...
Methotrexate in Medical Dictionary

Radioisotope

...... CONDIT PT, RIDINGS GR, COIN JW, WILLIAMS GR, MITCHELL D Jr, BOLES GW. Mesh Terms: ... Radioisotope Teletherapy* Substances: Cobalt Isotopes. methotrexate ... Encyclopedia article about radioisotope . Information about radioisotope in the Columbia Encyclopedia, Computer Desktop Encyclopedia, compu...
Methotrexate in Biological News

'Corrective genes' closer thanks to enzyme modification

...at our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate a result we never predicted and one that offers promise." The research team made its discovery as it sought ways to help correct genetic diseases....

Hypertension and cholesterol medications present in water released into the St. Lawrence River

... products and certain hypertension and cholesterol medications. Bezafibrate (cholesterol reducing medication), enalapril (hypertension medication), methotrexate and cyclophosphamide (two products used in the treatment of certain cancers) have all been detected in wastewater entering the Montreal treatment stat...

New guidelines for treating rheumatoid arthritis

...de: Methotrexate or leflunomide therapy is recommended for most RA patients. Anti-TNF agents etanercept, infliximab, or adalimumab along with methotrexate can be used in new or early RA cases with worsening and severe symptoms. Doctors should not initiate or resume treatment with methotrexate, leflun...

Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors

...ncer with 141 women with sporadic breast cancers. The women had been treated with anthracycline-based or taxane-based regimens, CMF (cyclophosphamide, methotrexate and fluorouracil 5FU) or other chemotherapy regimens. BRCA2 women had a higher response rate to chemotherapy (89% versus 50%), a longer progression...

New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis

...ly (either 4mg/kg or 8mg/kg) every four weeks plus methotrexate weekly or placebo infusions plus methotrexate weekly. The study was conducted in 73 trial sites...and ACR70) reduction of symptoms with Actemra plus methotrexate compared to the control arm. Fifty nine per cent, ...
Methotrexate in Biological Technology

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

...were taking concomitant immunosuppressants such as methotrexate or corticosteroids. CIMZIA should be discontinued...ng CIMZIA 200 mg every other week with concomitant methotrexate (n=640) and more frequently than with placebo with concomitant methotrexate (n=324) were upper respiratory tract infection (6%...

Raptiva Withdrawal Offers Upside for Enbrel and Humira According to Latest BioTrends Survey of U.S. Dermatologists

... the second year in a row. Use of oral agents is divided primarily between methotrexate and Steifel's (now owned by GSK) Soriatane. Almost half of the surveyed Dermatologists identify methotrexate as the first line oral choice whereas 43% choose Soriatane. On April...

Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...ondylitis (AS). With this approval in Canada, SIMPONI, in combination with methotrexate (MTX), is indicated for reducing the signs and symptoms in adult patients w...tis. In Canada, SIMPONI is approved for: -- In combination with methotrexate (MTX), reducing signs and symptoms in adult patients with moderately...

RoundTable Healthcare Partners Facilitates Product Acquisition for CorePharma

...iously marketed by Burroughs Wellcome. Leucovorin Calcium tablets are indicated for diminishing the toxicity and counteracting the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists. Financial terms of the transaction were not disclosed. CorePharma is a le...

New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis

... psoriasis in adults who failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapies including ciclosporin, methotrexate and PUVA (psoralen plus ultraviolet A light). With the approval by the European Commission, ustekinumab is approved in 27 countries in the EU. Psori...

Golimumab Phase 3 Data Show Significant Improvement In Physical Function In Patients with Rheumatoid Arthritis

...mprovement of 2.2 +/- 9.5 among patients receiving methotrexate alone (P < 0.001). According to the Arthritis Fo...hysical function, compared with patients receiving methotrexate alone. At 24 weeks, 70 percent of those receiving golimumab plus methotrexate experienced a clinically relevant improvement in p...

ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting

..., Room 307 [Oral Presentation during the RA Treatment: Biologic Efficacy RCT's session], "The AMBITION Study: Superiority of Tocilizumab vs. methotrexate Monotherapy in Patients with Rheumatoid Arthritis" (Presenter: Graeme Jones, M.D.) -- October 28, 3:15 pm - 3:30 pm PDT, Room 307 [Oral Pr...

33rd ESMO Congress in Stockholm, 12-16 September 2008

...h early stage breast cancer that has spread to the lymph nodes, adding docetaxel into a sequential regimen of epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) reduces the risk of recurrence and death, updated long-term results show. This advantage comes at the cost of an increased, but...

Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis

...f golimumab (CNTO 148) 50 mg and 100 mg and weekly methotrexate (MTX) experienced significant improvements in the ... "Since some patients do not respond adequately to methotrexate alone, this combination therapy could prove to be ... another Phase 3 study, GOlimumab Before Employing methotrexate as the First-line Option in the treatment of Rheum...

Unmet Needs Provide Challenges and Opportunities for Rheumatoid Arthritis Drug Developers According to MedPredict Report

...nbrel (etanercept; Wyeth/Amgen); Humira (adalimumab; Abbott), Orencia (abatacept; Bristol-Myers Squibb); MabThera (rituximab; Roche/Biogen/Genentech); methotrexate (generic); denosumab (Amgen); golimumab (Centocor/Schering-Plough/Essex); Actemra (tocilizumab; Roche/Chugai); Cimzia (certolizumab; UCB); GA101 (anti...
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