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Metformin in Medical News

FDA Approves ACTOplus met(R) XR (pioglitazone HCl and metformin HCl extended-release) Tablets for the Treatment of Type 2 Diabetes

First and only oral antidiabetic fixed-dose combination medication approved with the extended-release form of metformin DEERFIELD, Ill. and OSAKA, Japan, May 13 /PRNewswire/ -- Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Pharmaceuticals North America, Inc., t...

Single Dose Of Extended Release Metformin Found To Be Effective In Type 2 Diabetes

Researchers have found that a new extended-release formulation of metformin can be safely taken only once a day for type 2 diabetes as opposed// to the traditional twice a day dosage of immediate-release metformin. The new drug, which is marketed under the brand name Glumetza, appears to impr...

Metformin May Lower Diabetics' Odds for Pancreatic Cancer

...his risk?" "So here we found that if people use metformin they have a 60 percent lower risk for pancreatic c...ings in the August issue of Gastroenterology . metformin is an extremely popular oral medication commonly p...able, the American Diabetes Association recommends metformin as a first-line treatment for type 2 diabetes. ...

Pancreatic cancer risk decreased by one anti-diabetic therapy, increased by others

..., MD (August 1, 2009) The antidiabetic medication metformin is associated with a reduced risk of pancreatic ca...t study demonstrated a robust protective effect of metformin against pancreatic cancer in diabetes. Our major o...." Study authors found that diabetics who took metformin had a 60 percent lower risk of pancreatic cancer, ...

For Treatment of Type 2 Diabetes, 89 Percent of Surveyed Endocrinologists Identify a Need for Additional GLP-1 Analogues and 71 Percent Say the Same About DPP-IV Inhibitors

... with treatment. Additionally, clinicians indicate that the shortcomings of Merck's DPP-IV inhibitor Januvia include less glucose-lowering compared to metformin and a lack of long-term safety data. The new Physician & Payer Forum report entitled A Clinician and Payer Perspective on Changing Dynam...

PatientAssistance.com Releases the Top 20 Most Popular Searches for Patient Assistance Programs

...0) 12. LISINOPRIL (333) 13. LAMICTAL (327) 14. Suboxone (319) 15. SYNTHROID (306) 16. AMBIEN (303) 17. OXYCONTIN (302) 18. metformin HCL (297) 19. EFFEXOR XR (291) 20. Seroquel (284) To find where your company ranks click here: http://www.patientassistance.com/p...

Benefit of glinides is not proven

...er antidiabetics available in tablet form, such as metformin and sulfonylureas. As a result, there is also no p... glinides, this group also contains sulfonylureas, metformin and glitazones, for example. The individual substa...nes. It was only possible to compare glinides with metformin and sulfonylureas. Neither benefit nor harm cou...

What is the relationship between hepatocellular carcinoma and type 2 diabetes mellitus?

...or HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were calculated. The prevalence of diabetes mellitus was 31.2% in HCC, ... with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy. ...

Landmark Study Published in New England Journal of Medicine

...er outcomes -- insulin-providing (increasing the amount of insulin) or insulin-sensitizing (lowering the body's resistance to its own insulin, such as metformin or rosiglitazone). The study was not a comparison between angioplasty and bypass surgery, but rather a comparison between a prompt procedure and medic...

Drugs Best First Defense Against Heart Disease for Diabetics

...utcomes for the entire group were tracked for five years after treatment. All got intensive drug therapy, either with insulin or with drugs such as metformin that increase the body's sensitivity to insulin, while some also had procedures to improve blood flow. At five years, 87.8 percent of those getting...
Metformin in Medical Technology

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

CHICAGO--(BUSINESS WIRE)--Jun 23, 2007 - Late breaking data presented at the American Diabetes Association (ADA) 67th Annual Scientific Sessions showed that, when used investigationally as initial therapy, JANUVIA(TM) (sitagliptin) in combination with metformin provided significant glycemic improve...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

CHICAGO--(BUSINESS WIRE)--Jun 25, 2007 - New data from an investigational study released at the American Diabetes Association (ADA) 67th Annual Scientific Sessions showed that initial combination therapy with Januvia(TM) (sitagliptin) and metformin demonstrated significant improvement in markers of...

Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic Control in Subjects with Type 2 Diabetes Compared to Metformin Alone

Additional Findings Reported Safety & Tolerability Profile in Subjects with Type 2 Diabetes and Healthy Subjects CHICAGO, June 25 /PRNewswire-FirstCall/ -- Phase III data presented this week at the annual meeting of the American Diabetes Association demonstrated that saxagliptin, an inhibito...

Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic Control in Subjects with Type 2 Diabetes Compared to Metformin Alone

-- Additional Findings Reported Safety & Tolerability Profile in Subjects with Type 2 Diabetes and Healthy Subjects -- CHICAGO, June 25, 2007 /PRNewswire-FirstCall/ -- Phase III data presented this week at the annual meeting of the American Diabetes Association demonstrated that saxagliptin, a...

Exenatide Once Weekly Provided Superior Glucose Control Compared to Lantus(R) in Head-to-Head DURATION-3 Study

...tients with type 2 diabetes taking stable doses of metformin alone or in combination with a sulfonylurea. Exena...ekly versus 19 percent with Lantus for patients on metformin background therapy, and 20 percent with exenatide ...ekly versus 44 percent with Lantus for patients on metformin and a sulfonylurea background therapy, differences...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

...rently using metformin, a sulfonylurea, or a thiazolidinedione. BYETTA provides sustained A1C control and low incidence of hypoglycemia when used with metformin or a thiazolidinedione, with potential weight loss. BYETTA is not a weight loss product. BYETTA was approved in April 2005 and has been used by more t...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

...rently using metformin, a sulfonylurea, or a thiazolidinedione. BYETTA provides sustained A1C control and low incidence of hypoglycemia when used with metformin or a thiazolidinedione, with potential weight loss. BYETTA is not a weight loss product. BYETTA was approved in April 2005 and has been used by more ...

Study Shows GSK's Novel Diabetes Treatment SYNCRIA(R) (albiglutide) Improves Glucose Control and Reduces Weight

...l was a randomized, multi-center, double-blind, parallel-group study in 356 subjects with type 2 diabetes previously treated with diet and exercise or metformin (mean baseline A1C 8%). Patients received subcutaneous placebo, albiglutide weekly, (4, 15 or 30 mg), biweekly (15, 30 or 50 mg) or monthly (50 or 10...

Boehringer Ingelheim Unveils Diabetes Pipeline

...ype 2 diabetes patients inadequately controlled on metformin (placebo-corrected changes from baseline; -0.40 pe... from the study The addition of linagliptin to metformin treatment for 12 weeks resulted in clinically rele...vels with linagliptin 5 mg and 10 mg compared with metformin alone (both p<0.001) were observed from week fo...

Large, Long-Term Study Shows Avandia Has No Increased Overall Cardiovascular Risk Compared to Other Commonly Used Diabetes Medicines

...vandia (rosiglitazone) compared to those receiving metformin and sulfonylurea. Results from the 4,447-pati...ovascular outcomes of patients on Avandia added to metformin or sulfonylurea to those on metformin and sulfonylurea. The study confirmed its primary ...
Metformin in Medical Dictionary

Lactic acidosis

...acidosis is clearly due to excessive production alone ... Type A lactic acidosis refers to circumstances where the clinical assessment is ... metformin useful but small risk of potentially fatal lactic acidosis ... He was well for six weeks, then developed lactic acidosis and died within 3 day...

Contraindications

...... Contraindications : ... TREATMENT BASICS Contraindications ... Absolute contraindications ... Relative contraindications ... Use of metformin is contraindicated when combined with Thiazide, Cimetidine, ... Side Effects and Contraindications : Side effects may include sudden sleep, ... ...
Metformin in Biological News

Long-term use of diabetes drugs by women significantly increases risk of fractures

...rials lasted from one to four years and all were double-blinded. There is no clear evidence that other drugs used to treat type 2 diabetes, such as metformin and sulfonylurea, cause an increased risk of fractures. ...

Drug could improve pregnancy outcomes in wider range of women with insulin resistance

...nding, published online in Diabetes, suggests that metformin could benefit women with type 2 diabetes or polycy...he patient may be prone to insulin resistance. metformin is often given to women with PCOS, an endocrine di...tes and obesity. Recent studies have shown that metformin not only aids conception in women with PCOS but al...

Traditional Chinese medicine for diabetes has scientific backing

...ce body weight". Current medicines for treating type 2 diabetes include metformin and the TZD group of drugs. However, alarge number of patients cannot tolerate metformin and the TZDs can cause undesirable weight gain.Therefore, it is critical to...
Metformin in Biological Technology

New Drug Application for Exenatide Once Weekly Accepted for Review by FDA

...rently using metformin, a sulfonylurea, or a thiazolidinedione. BYETTA provides sustained A1C control and low incidence of hypoglycemia when used with metformin or a thiazolidinedione, with potential weight loss. BYETTA is not a weight loss product. BYETTA was approved in April 2005 and has been used by more ...

Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions

...of ITCA 650 treatment among 44 type 2 diabetes patients (10-12 patients/dose arm) on a stable treatment regimen of diet and exercise or treatment with metformin and/or thiazolidinediones. The study included four dose arms to which patients were randomized to receive 10 mcg/day, 20 mcg/day, 40 mcg/day or 80 mcg...

Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes

...rently using metformin, a sulfonylurea, or a thiazolidinedione. BYETTA provides sustained A1C control and low incidence of hypoglycemia when used with metformin or a thiazolidinedione, with potential weight loss. BYETTA is not a weight loss product. BYETTA was approved in April 2005 and has been used by more t...

Exenatide Clinical Data Analysis Shows No Increased Risk of Cardiovascular Events

...rently using metformin, a sulfonylurea, or a thiazolidinedione. BYETTA provides sustained A1C control and low incidence of hypoglycemia when used with metformin or a thiazolidinedione, with potential weight loss. BYETTA is not a weight loss product. BYETTA was approved in April 2005 and has been used by more ...

Surveyed Experts Indicate That Byetta LAR and Victoza Have Advantages Over Actos in the Treatment of Type 2 Diabetes

...s: Endocrinologists' Satisfaction with Inexpensive metformin Sets High Hurdles for Emerging Agents finds that a drug that is substantially more effective than metformin (Bristol-Myers Squibb/Merck Serono's Glucophage, g...s: Endocrinologists' Satisfaction with Inexpensive metformin Sets High Hurdles for Emerging Agents is a Decisi...

Cardiovascular Side Effects of Pioglitazone and Rosiglitazone Linked to Vascular and Energy Pathways by Genomas Clinical Study

...n support system for diabetic pharmacotherapy. TZDs are powerful diabetes drugs currently utilized in patients failing first-line therapy with metformin and sulfonylureas. Patients given TZDs typically are at greater risk of diabetic complications and represent an advanced stage of the disease. However...

ConjuChem Provides Development Update

...ted the efficacy and safety of three months of weekly injections of PC-DAC(TM):Exendin-4 in patients with Type 2 diabetes not adequately controlled by metformin monotherapy. The trial enrolled approximately 120 evaluable patients randomized to one of three parallel treatment groups: a 1.5mg fixed-dose weekly c...

Phenomix and Forest Laboratories to Collaborate on Development and Commercialization of Dutogliptin in Diabetes

...condary endpoints, including statistically significant reductions in HbA1c when administered once-daily in combination with metformin, a glitazone, or metformin and a glitazone for the treatment of Type 2 diabetes. The trial demonstrated dutogliptin's excellent safety and tolerability profile. An ongoing two-y...

Amylin Pharmaceuticals Reports Third Quarter Financial Results

...ompleted enrollment of DURATION-2, which compares exenatide once weekly against a thiazolidinedione and a DDP-4 inhibitor on a background of metformin therapy. Obesity Program -- Completed enrollment of a phase 2B study to evaluate different dosing combinations of pramlintide and metrelept...

New Data From Head-to-Head Phase 3 Trial Demonstrate That Liraglutide is More Effective Than Exenatide in Treatment of Type 2 Diabetes

...n add-on to their existing treatment consisting of metformin and/or a sulphonylurea. The overall rate of hypo...atide 10 micrograms, BID + metformin and/or SU metformin and/or SU N=...
Metformin in Biological Definition

Diabetes mellitus

...weight lost is modest e.g. around 5 kg (10 to 15 lb). The next step, if necessary, is treatment with oral antidiabetic drugs : the sulphonylureas , metformin , or (if these are insufficient) thiazolidinediones . When these have failed, insulin therapy may be necessary to maintain normal glucose levels. ...
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