Cost-effectiveness of cetuximab in metastatic colorectal cancer
From a health-care system perspective, it may be more efficient to use the drug cetuximab only in colorectal cancer patients whose tumors have a wild-type KRAS gene, according to a study published online August 7 in the Journal of the National Cancer Institute .
Earlier, patients whose tumors ...
Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer
EMERYVILLE, Calif., August 4 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI ) today announced positive results from the Phase 1B clinical trial of Bezielle (formerly BZL101), their lead drug candidate for advanced breast cancer. In the trial, Bezielle showed an excellent sa...
Researchers Identify New Method to Selectively Kill Metastatic Melanoma Cells
An international team of researchers has identified a new method for selectively killing metastatic
melanoma cells, which may lead to new areas for drug development in melanoma - a cancer that is highly resistant to current treatment strategies.
Richmond, Va. (Vocus) Au...
Researchers identify new method to selectively kill metastatic melanoma cells
RICHMOND, Va. (August 3, 2009) An international team of researchers has identified a new method for selectively killing metastatic
melanoma cells, which may lead to new areas for drug development in melanoma a cancer that is highly resistant to current treatment strategies.
Researchers from V...
Chicago team uses artificial intelligence to diagnose metastatic cancer
WASHINGTON, D.C. July 28, 2009 -- When doctors are managing care for women with breast cancer, the information available to them profoundly influences the type of care they recommend. Knowing whether a woman's cancer has metastasized, for instance, directly affects how her doctors will approach tr...
Smoking increases potential for metastatic pancreatic cancer
(PHILADELPHIA) Smoking has once again been implicated in the development of advanced cancer. Exposure to nicotine by way of cigarette smoking may increase the likelihood that pancreatic ductal adenocarcinoma will become metastatic, according to researchers from the Kimmel Cancer Center at Jeffers...
Positive CHMP Opinion for JAVLOR(R) in Metastatic Treatment of Bladder Cancer After Failure of a Prior Platinum-Containing Regimen
CASTRES, France, June 26 /PRNewswire/ -- Laboratoires Pierre Fabre
announce today that the Committee for Medicinal Products for Human Use
(CHMP), the scientific advisory committee of the European Medicines Agency
(EMEA), has issued a positive opinion supporting approval and is recommending
Clinical Studies Validate Cancer Gene Delivery Platform: Landmark Publication Confirms Rexin-G Effectively Targets Metastatic Cancers and Improves Patient Survival
SAN MARINO, Calif., June 22 /PRNewswire/ -- Epeius Biotechnologies ( www.epeiusbiotech.com ) stuns the medical and scientific communities with a dramatic demonstration of single-agent efficacy with its lead product, Rexin-G, for metastatic
cancer. The landmark article (accessible online as of Ju...
2-drug combination appears safe and active in metastatic kidney cancer
ORLANDO (May 31, 2009)Fox Chase Cancer Center investigators report that a two-drug blockade of mTOR signaling appears safe in metastatic
kidney cancer in a phase I trial. Early data suggests that a combination of temsirolimus and bryostatin may be active in patients with rare forms of renal cell c...
Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer
ORLANDO (June 1, 2009)Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic
breast cancer who have progressed on previous trastuzumab b...
Metastatic in Medical Technology
Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer
THOUSAND OAKS, Calif., Aug. 6 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN ) today announced that Vectibix((R)) (panitumumab), administered in combination with FOLFOX (an oxaliplatin-based chemotherapy), significantly prolonged progression-free survival (PFS) compared with F...
Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy
NEWPORT BEACH, Calif., July 28 /PRNewswire/ -- Hoag Memorial Hospital Presbyterian today announced promising data from a clinical study showing patient-specific cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated and resulted in impressive lo...
Enrollment in Delcath's Pivotal Phase III Metastatic Melanoma Clinical Trial Achieves Seventy-Five Percent Accrual
NEW YORK, June 8 /PRNewswire-FirstCall/ -- Delcath Systems, Inc. (Nasdaq: DCTH ), a medical technology company testing its proprietary percutaneous hepatic perfusion (PHP(TM)) system for the treatment of cancers of the liver, announced today that it has achieved the seventy-five percent enroll...
Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival
PARIS and BRISBANE, California, June 3 /PRNewswire-FirstCall/ --
- Data Highlighted in Plenary Session of 2009 American Society of
Clinical Oncology Annual Meeting
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY ) and its fully owned
subsidiary, BiPar Sciences, today announced resu...
Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
KRX-0401 + Capecitabine More Than Doubles Time to Progression and Overall Response Rate as well as Extends Overall Survival vs. Capecitabine + Placebo in Patients with 2nd or 3rd Line Metastatic
NEW YORK, June 1 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasda...
Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
KRX-0401 + Capecitabine More Than Doubled Time to Progression and Overall Response Rate as well as Extended Overall Survival vs. Capecitabine + Placebo in Patients with 2nd or 3rd Line Metastatic
NEW YORK, May 31 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: ...
Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer
KRX-0401 Demonstrates Impressive Single Agent Efficacy in Patients who Progressed after Failing Treatment Either with a VEGF Receptor Inhibitor or after Treatment with both a VEGF Receptor Inhibitor and an mTOR Inhibitor
NEW YORK, May 29 /PRNewswire-FirstCall/ -- Keryx Biopharmaceuticals, I...
Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer
- New Progression-Free Survival, Disease Control and Neurotoxicity Data To Be Presented at 2009 ASCO Annual Meeting Continue to Support Picoplatin as a Neuropathy-Sparing Alternative to Oxaliplatin for First-Line Treatment of Colorectal Cancer -
- Poniard Management Team to Host Analyst and I...
Oncolytics Biotech Inc. Announces Start of Patient Enrolment in Translational Clinical Trial Investigating REOLYSIN(R) in Patients with Metastatic Colorectal Cancer
CALGARY, Jan. 27 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ONCY ) announced today that patient enrolment has begun in a U.K. translational clinical trial investigating intravenous administration of REOLYSIN(R) in patients with metastatic
colorectal cancer p...
Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer
SAN ANTONIO, Dec. 14 /PRNewswire/ -- Results from a Phase 3 study show
that patients with metastatic
breast cancer who were treated previously with
an anthracycline in the adjuvant setting experienced a significant improvement
in time to disease progression (TTP) and overall response rates after
Metastatic in Medical Products
KRONUS OptiQuant™ Thyroglobulin (OQTg) Kit
Description:...; Thyroglobulin (OQTg) Kit is intended for the quantitative determination of thyroglobulin (Tg) in human serum as an aid in the detection of local and metastatic
thyroid tissue in patients who have had thyroid gland ablation (using thyroid surgery with or without radioiodine) and who lack serum thyroglobulin an...
Biomet Low Profile Tibial Nail
Description:... of difficult tibial fractures. The Biomet Low Profile Tibial Nail is primarily indicated in the treatment of unstable fractures, tibial nonunion, and metastatic
disease with pathologic or impending fractures but particularly useful in the treatment of very distal tibial fractures....
Company:Biomet Orthopedics, Inc
Description:...cer, which is a common cancer in the United States. The ability to identify metastatic
tumors in the liver has a significant impact on physicians' treatment plans for cancer. Because treatment plans can vary widely based on the level of metastatic
disease, proper staging is a critical component of patient management. Diag...
Company:Advanced Magnetics, Inc.
Features:...opic Plate Spacer (TPS) Spinal System implants are intended to replace vertebral body structures following a vertebrectomy/corpectomy of the spine for metastatic
spine disease in the cervical and /or Cervico- thoracis spine (C3 T2). The TPS Spinal System implants are intended to correct spinal alignment and st...
Company:Interpore Cross International, Inc.
Metastatic in Medical Definition
4.1 Specific types
Origin and location
Eye cancers can be primary (starts within the eye) and metastatic
cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung ca...
Metastatic in Medical Dictionary
...led ... INTRODUCTION VIPomas are rare neuroendocrine tumors that secrete vasoactive ... Radiofrequency Ablation Has a Valuable Therapeutic Role in metastatic
VIPoma . ... VIPoma ... VIPoma is a very rare type of cancer that usually grows from ... VIPoma causes cells in the pancreas to produce...
...ow. Detailed, Factual, In-depth, information to ... that produce the claw are situated in the dorsal aspect of the ungual crest. ... Ungual : metastatic
Melanoma resources and information at ungual .com. ... Melanoscan® Full-Body Digital Imaging Helps Dermatologists Reduce Spread of ... Bartleby.c...
...Health Professional Brain Tumor FAQ Glossary Publications Reports ... Some tumor types are assigned a grade, ranging from Grade I (least ... A metastatic
brain tumor is brain cancer that has spread from another part ... Many tumor or cancer types can spread to the brain, the most common being lu...
Salivary gland tumors
...Salivary gland tumors (SGTs), which can be benign or malignant ( onco_pix ... Malignant salivary gland tumors : Treatment of recurrent and metastatic
disease ... ...
Renal cell carcinoma
...l Carcinoma . Neha Vapiwala, MD and Charles B. Simone, II, MSIV ... Since metastatic
renal cell carcinoma is one of the most treatment-resistant ... I...arcinoma . Molecularly targeted therapy for advanced renal cell ... metastatic
Renal Cell Carcinoma in the Postcytokine Era. Search. Query ... Rena...
Primary lung cancer
...y lung cancer and pulmonary metastases: a ... The primary sites of metastatic
lung cancer were the colon in 4, tongue in 2, ... INTRODUCTION ..... If it spreads to the brain, it would be called primary lung cancer metastatic
to the brain. ... Primary lung cancer is cancer that usually st...
...use of the anatomic ... operative management of pancreatic . metastases from breast carcinoma . ... Unlike primary pancreatic carcinoma , metastatic
lesions to the pancreas are ... Context Unlike primary pancreatic carcinoma , metastases to the pancreas are rare ... We present 3 cases ...
...ses in which a ... Information about neoplasm in the free online English dictionary and encyclopedia. ... malignant neoplasm , malignant tumor, metastatic
tumor - a tumor that is ... What is neoplasm ? Meaning of neoplasm medical term. What does neoplasm mean? ... neoplasm /neo·plasm/ (ne'...
... Original Article from The New England Journal of Medicine -- Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for metastatic
Renal ... Those donating a kidney have two minimally invasive surgical options to choose from at Barnes-Jewish Hospital, the mini- nephrectomy...
...e past, milk - alkali syndrome was often a side effect of treating ... If unrecognized and untreated, milk - alkali syndrome can lead to metastatic
... Milk - alkali syndrome is caused by the ingestion of large amounts of calcium and ... Milk - alkali syndrome is an acquired conditio...
Metastatic in Biological News
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
Hoag Memorial Hospital Presbyterian today announced promising data from a clinical study showing patient-specific cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated and resulted in impressive long-term survival rates in patients with metastatic
Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
DENVER, CO and AUCKLAND, NZ (April 21, 2009) MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to significantly reduce the number and size of metastatic
tumors in preclinical mouse models of lung and breast cancers, Innate Therapeutics (formerly Virionyx Corpo...
Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
Berlin, Germany: The first study to investigate the effects of chemotherapy on metastatic
breast cancer in women with the BRCA1 or BRCA2 gene mutation has shown that standard chemotherapy works better in these patients than in women without the BRCA1/2 mutation.
The authors of a study presente...
$2.7 million awarded for metastatic colon cancer research
PHILADELPHIA Through the generous philanthropic support of the Littlefield 2000 Trust, the American Association for Cancer Research (AACR) is pleased to announce four recipients of the 2007 Jeannik M. Littlefield-AACR Grants for Metastatic
Colon Cancer Research, totaling $2.7 million. Now in its ...
First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
Two compounds that zero in on cancer cells spreading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weapon in the fight against tough-to-treat metastatic
disease, according to Weill Medical College of Cornell University researchers.
The compounds, ...
Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth
...as a vector for the nanoparticle delivery of a DNA encoding diphtheria toxin suicide gene. These nanoparticles were injected into mice with primary or metastatic
To test the efficacy of this technique, the researchers measured tumor volume before and after treatment. They found that while tr...
Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research
...el cancer therapy, culminating in the production of an anti-HER2 monoclonal antibody that since 1998 has been used successfully to treat patients with metastatic
breast cancer. This was the first targeted therapeutic agent developed on the basis of a newly discovered gene with an oncogenic function in human ca...
... genetic signature which distinguishes tumors with metastatic
potential from those that do not metastasize.
.... They discovered that this gene is more active in metastatic
tumors and metastases than in non-metastatic tumor...s will help determine early on whether a tumor has metastatic
potential. The doctors could then adapt the therap...
Green tea may affect prostate cancer progression
...yte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and VEGF are good prognostic indicators of metastatic
The study included 26 men, aged 41 to 72 years, diagnosed with prostate cancer and scheduled for radical prostatectomy. Patients consumed ...
New method separates cancer cells from normal cells
... The vast majority of cancer deaths are due to metastasis, the spread of cancer cells from its primary site to other parts of the body. These metastatic
cells tend to move more than their non-metastatic variants but this movement is poorly understood. Scientists are studying cancer cells intently with ...
Metastatic in Biological Technology
Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer
RARITAN, N.J., July 13 /PRNewswire/ -- Measuring the change in circulating tumor cell (CTC) count can accurately predict the prognosis and survival in patients with metastatic
breast cancer (MBC), according to a newly published report in the July 10 issue of the Journal of Clinical Oncol...
OncoGenex Pharmaceuticals Completes Amendment to Phase 3 Special Protocol Assessment for Confirming Survival Benefit in Patients Receiving OGX-011 with First-Line Docetaxel for Metastatic Prostate Cancer
BOTHELL, WA, and VANCOUVER, June 24 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI ) announced today that the company has reached an agreement with the U.S. Food and Drug Administration (FDA) via the special protocol assessment process (SPA) on an amendment to the design ...
The World's Smallest Hero! Rexin-G, Targeted Therapy for Metastatic Cancers
SAN MARINO, Calif., June 9 /PRNewswire/ -- Epeius Biotechnologies' Rexin-G is the world's smallest hero ( www.epeiusbiotech.com ). Imagine if you will, a tiny particle that can travel freely within the human body seeking out cancerous tissues and metastatic
tumors that have spread far and wide. ...
OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer
Webcast at 7:10 p.m. Eastern Time Today
BOTHELL, WA, and VANCOUVER, May 30 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI ) today announced the final results of a Randomized Phase 2 Trial presented during an oral presentation at the American Society of Clinical Oncol...
Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Picoplatin in Patients with Metastatic Colorectal Cancer
- Safety and Tumor Response Data from Dose-Escalation Study Presented at
American Association for Cancer Research's 100th Annual Meeting 2009 -
SOUTH SAN FRANCISCO, Calif. and DENVER, April 21 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical com...
Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing normal tissue April 21 at an American Association of Anatomists (AAA) sci...
BioVex Commences OncoVEX (GM-CSF) Phase 3 Trial in Metastatic Melanoma
WOBURN, Mass., April 14 /PRNewswire/ -- BioVex Inc, a company developing next generation biologics for the treatment and prevention of cancer and infectious disease, announced today that its OPTiM (OncoVEX Pivotal Trial in Melanoma) Phase 3 study with OncoVEX (GM-CSF) in previously treated patie...
Sopherion Therapeutics Announces Completion of Enrollment in Phase III Study of Myocet in Metastatic Breast Cancer
PRINCETON, N.J., March 18 /PRNewswire/ -- Sopherion Therapeutics, LLC, a biopharmaceutical company focused on the development and commercialization of anti-cancer therapies, announced that it completed enrollment in its pivotal Phase III study of nonpegylated liposomal doxorubicin (Myocet(T...
REXIN-G Shrinks Metastatic Tumors and Triples Survival Time in Chemotherapy-Resistant Pancreatic Cancer: Analysis of a U.S. Phase I/II Clinical Trial (Proceedings of ASCO GI Symposium 2009)
SAN MARINO, Calif., Jan. 20 /PRNewswire/ -- Epeius Biotechnologies ( www.epeiusbiotech.com ) announced the results of a U.S. Phase I/II study evaluating the safety and efficacy of Rexin-G in chemotherapy-resistant metastatic
pancreatic cancer (ASCO GI Symposium, #249; Sant P Chawla, P.I., Santa ...
Poniard Pharmaceuticals Announces Positive Tumor Response and Neuropathy Data from Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer
- Incremental Data to be Presented at ASCO GI Symposia Continue to Support Picoplatin as Neuropathy-Sparing Alternative to Oxaliplatin in First-Line Colorectal Cancer Treatment -
SOUTH SAN FRANCISCO, Calif., Jan. 14 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a ...
Metastatic in Biological Products
Metastatic in Biological Definition
...noma in situ refers to an uncontrolled growth of cells that remains in the original location. However, carcinoma in situ may develop into an invasive, metastatic
malignancy and, therefore, is usually removed surgically, if possible.
Most forms of cancer are "sporadic", and have no basis in hered...
...on of iron in the body, eventually leading to liver damage
Cancer of the liver (primary hepatocellular carcinoma or cholangiocarcinoma and metastatic
cancers, usually from other parts of the gastrointestinal tract )
Wilson's disease , a hereditary disease which causes the body to retain copp...
Metastatic in Biological Dictionary
...organism differing from the wildtype . ... Findings from three studies demonstrate the increased efficacy of Erbitux® (cetuximab) in patients with metastatic
colorectal cancer (mCRC) who have a wild-type ... Britannica online encyclopedia article on wild type (genetics), ...code. ... Aspects of the...
...11th, 2009, from www.yourdictionary.com/ proteol ysis . Comments: ... Background—The process of proteolysis is important at several stages of the metastatic
cascade. ... This is indicative of proteolysis occurring in vivo and has ... By performing concentration-dependent proteolysis , HDAC1 double ...