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Metastasis in Medical News

Potent metastasis inhibitor identified

Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online Early Edition of the Proceedings of the National Academy of Sciences duri...

Identification of 5 genes involved in the metastasis of breast tumors to the lung

This release is available in Spanish . The identification of five genes involve in the metastasis of breast tumours to the lung is the principal finding of a scientific team made up of two bodies from the University of Navarra, the Applied Medical Research Centre (CIMA) and the University H...

Molecular Cause of Breast Cancer Metastasis Discovered

Signaling events in tumor pave the way for lung invasion, study shows THURSDAY, April 3 (HealthDay News) -- Certain cancers tend to spread to specific tissues, and now researchers have gained a molecular handle on how that happens. Working with breast tumors, Joan Massague, chairman...

Cancer stem cell subpopulation drives metastasis of human pancreatic cancer

Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer. The research, published by Cell Press in the September issue of the journal Cell Stem Cell, provides insight into the role of CSCs in cancer initi...

M. D. Anderson launches graduate program in cancer metastasis

HOUSTON - A one-of-a-kind graduate program that focuses on the most lethal aspect of cancer will open this fall at The University of Texas M. D. Anderson Cancer Center with support from a highly competitive grant from The University of Texas System. The Graduate Program in Cancer Metastasis Res...

Lung cancer cells activate inflammation to induce metastasis

A research team from the University of California, San Diego School of Medicine has identified a protein produced by cancerous lung epithelial cells that enhances metastasis by stimulating the activity of inflammatory cells. Their findings, to be published in the January 1 issue of the journal Na...

UNC researchers find clue to stopping breast-cancer metastasis

CHAPEL HILL If scientists knew exactly what a breast cancer cell needs to spread, then they could stop the most deadly part of the disease: metastasis. New research from the University of North Carolina at Chapel Hill School of Medicine takes a step in that direction. Carol Otey, Ph.D. and UNC...

Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis

(PHILADELPHIA) Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have made a key discovery about the mechanism of breast cancer metastasis, the process by which cancer spreads. Focusing on a gene dubbed "Dachshund," or DACH1, they are beginning to pinpoint new t...

'Smart bomb' nanoparticle strategy impacts metastasis

A new treatment strategy using molecular "smart bombs" to target metastasis with anti-cancer drugs leads to good results using significantly lower doses of toxic chemotherapy, with less collateral damage to surrounding tissue, according to a collaborative team of researchers at the University of C...

A new weapon for attacking tumor invasion and metastasis

In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration. This study, performed by a team led by Professor Ji-Kun Li from the Shanghai Jiao Tong University is described in a r...

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Metastasis in Medical Technology

Data Presented at AACR Annual Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Tumor Growth By Up to 95% and Halts Metastasis in a Model of Hormone-Refractory Prostate Cancer

-No Metastatic Lesions Were Detectable After Combination Therapy Treatment- -Survival Time More Than Doubled in Animals Treated with Combination Therapy- -Established Tumors Regressed by 50% After Combination Therapy Treatment- SAN DIEGO and TUSTIN, Calif., April...

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... Capanna R, Coia LR, Coleman R. et al. eds. Textbook of Bone Metastases. Hoboken, NJ: Edition: John Wiley and Sons; 2005:105. (2) Mundy GR. metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer . 2002 Aug;2(8):584-93. (3) Schulman K and Kohles J. Cancer. 2007;109:...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

... Capanna R, Coia LR, Coleman R. et al. eds. Textbook of Bone Metastases. Hoboken, NJ: Edition: John Wiley and Sons; 2005:105. (2) Mundy GR. metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer . 2002 Aug;2(8):584-93. (3) Schulman K and Kohles J. Cancer. 2007;109:...

New Small and Medium Sized Enterprises Join TI Pharma by Signing Two New Projects

...are needed more than ever," says Roel Schaapveld, Chief Executive Officer, InteRNA. There is a large body of evidence indicating that tumor growth and metastasis formation are dependent on the formation of new blood vessels. Furthermore, angiogenesis is an early event in the development of tumors, being already...

/C O R R E C T I O N -- Agendia B.V./

..., addressing the panel's recommendations. The FDA-cleared assay is always clinically useful and indicates whether a patient is at low or high risk for metastasis and the resulting clarity is vital in helping physicians personalize treatment options. "St. Gallen's guideline inclusion is a key step in furt...

Agendia's Breast Cancer Recurrence Test MammaPrint Included in International St. Gallen Expert Consensus Recommendations

..., addressing the panel's recommendations. The FDA-cleared assay is always clinically useful and indicates whether a patient is at low or high risk for metastasis and the resulting clarity is vital in helping physicians personalize treatment options. "St. Gallen's guideline inclusion is a key step in furt...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

...cally confirmed, locally advanced adenocarcinoma or squamous cell carcinoma of the esophagus or gastro-esophageal junction with no evidence of distant metastasis received weekly paclitaxel poliglumex (50mg/m2) and cisplatin 25mg/m2 for six weeks with concurrent 50.5Gy of radiation. Twenty-three eligible patient...

Prometheus and Rosetta Genomics Announce License and Collaboration Agreement

...primary origin is critical for determining optimal treatment, enabling better patient outcomes. Current diagnostic methods to identify the origin of a metastasis include a range of costly, time-consuming and at times inefficient tests. miRview(TM) mets offers physicians a fast, accurate and easy-to-interpret di...

Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients

...of patients will develop metastases during the course of their disease. The only chance of long-term survival comes with curative resection of hepatic metastasis by liver surgery with reported five and 10 year survival rates of 41 percent and 22 percent, respectively. Previous trials of combination chemotherapy...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

...th nimotuzumab in combination with radiation. These two indications - brain metastasis from lung cancer and palliative therapy in non-small cell lung cancer (NSCL...cations of high unmet need. In the US, approximately 140,000 cases of brain metastasis are diagnosed annually and the frequency is increasing as more patients liv...
Metastasis in Medical Products

MammaPrint Breast Cancer Diagnostic Test

Description:... MammaPrint is a gene expression profiling test that predicts the risk of metastasis in breast cancer patients. It is based on groundbreaking research performed at the Netherlands Cancer Institute and the Antoni Van Leeuwenhoek Hospita...
Company:Agendia Corporate

Feridex I.V.®

Description:...r's natural function, the agent is taken up by macrophages found only in healthy liver cells but not in most tumors. The liver is a principal site for metastasis of primary cancer originating in other parts of the body, particularly colon cancer, which is a common cancer in the United States. The ability to ide...
Company:Advanced Magnetics, Inc.
Metastasis in Medical Definition

Pathology

...umor - Cyst - Pseudocyst - Hamartoma - Benign neoplasm Malignant progression Dysplasia - Carcinoma in situ - Invasive cancer - metastasis Topography Anus - Bladder - Bile duct - Bone - Brain - Breast - Cervix - Colon/rectum - Duodenum - Endometrium - Esophag...

Ocular oncology

...er, MD. 1.Choroidal Hemangioma [2] 2.Choroidal Melanoma [3] 3.Choroidal metastasis [4] 4.Choroidal Nevus [5] 5.Choroidal Osteoma [6] 6.Ciliary Body Mela...nant progression Dysplasia - Carcinoma in situ - Invasive cancer - metastasis Topography Anus - Bladder - Bile duct - Bone - Brain - ...
Metastasis in Medical Dictionary

Metastasis

Metastasis , or Metastatic disease, sometimes abbreviated mets, is the spread of a disease from one organ or part to another non-adjacent organ or part. Only malignant tumor cells and infections have the established capacity... metastasis n. , pl. -ses ( ). Pathology. Transmission ...

Renal cell carcinoma

...carcinoma . ... Management of renal cell carcinoma with solitary metastasis ... Distant metastasis are common in Renal cell carcinoma (RCC) nearly one forth of ... ...

Rectal cancer

...Features information about colon cancer , also known as colorectal cancer . ... Rectal cancer , X-ray. Sigmoid colon cancer , X-ray. Spleen metastasis - CT scan ... The rectum is the part of the large intestine right before the anus. ... cancer screening tests include digital rectal .....

Oral cancers

...Oral cancer is any cancerous tissue growth located in the mouth. It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity or the... ... oral cancer fa...

Oral cancer

...al cancer is any cancerous tissue growth located in the mouth. It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity or the... Discover more about o...

Carcinoid syndrome

...e synonyms listing to find the alternate ... carcinoid syndrome ( ′kärsən′öid ′sin′drōm ) ( medicine ) A complex of symptoms arising from the metastasis of a carcinoid tumor to the Carcinoid syndrome — Comprehensive overview covers symptoms, causes, treatment of condition caused ... who ...

Bone pain

...s for bone pain may be to refer a patient for ... Bone Pain . Pain is the most common symptom and usually the first symptom ... Bone metastasis patients often describe the pain as gradually increasing over a ... ... cause unexplained, progressively worsening bone pain , swelling, or ...
Metastasis in Biological News

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

NEW YORK CITY (February 5, 2009)Scientists have long wondered how melanoma cells travel from primary tumors on the surface of the skin to the brain, liver and lungs, where they become more aggressive, resistant to therapy, and deadly. Now, scientists from NYU Langone Medical Center have identifi...

Newly identified gene powerful predictor of colon cancer metastasis

Cancer Researchers at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and the Charit Universitts Medizin Berlin (Germany) have identified a gene which enables them to predict for the first time with high probability if colon cancer is going to metastasize. Assistant Professor Dr. ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

In the work defended at the University of the Basque Country (UPV/EHU), an in vitro culture model of human colon cancer was created in order to reproduce the gene regulation that is expressed in these cancer cells during their growth as metastasis in the liver of patients. This in vitro culture mo...

A gene for metastasis

Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver. In an article recently published in the journal Cancer Research, Prof. Avri Ben-Zeev and Dr. Nancy Gave...

Inflammation may play role in metastasis of prostate cancer

Many would assume that "mounting an immune response" or "having your body fight the cancer" is a good thing. Now, research at the University of California, San Diego (UCSD) School of Medicine strongly suggests that inflammation associated with the progression of tumors actually plays a key role in...

'Trojan Horse' agent halts bone metastasis in mice

A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. ...

Two-faced protein can stop metastasis or promote it, researchers say

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found. The study, published in the Sept. 18 online issue of the ...

Advances in lung cancer research announced at conference

...rain. In non-small cell lung cancer (NSCLC), brain metastasis is a devastating complication that occurs in as ma...ity to identify those at risk for developing brain metastasis may guide new therapies. A team led by Dr. Weis...ues to predict, treat and ultimately prevent brain metastasis in patients with non-small cell lung cancer," Dr. ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...rophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those cancers," Wellstein says. Researchers at Lombardi/Georgeto...

Colorectal cancer

...ne BAMBI is associated with two import signaling pathways and thus promotes metastasis formation," Dr. Fritzmann said. "These signaling pathways (Wnt and TGF-beta...4 genes more closely, in order to better understand the individual steps of metastasis formation. Aim To predict at an early stage whether the tumor will spre...

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Metastasis in Biological Technology

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

...ponse in vivo . Cathepsin K expression is well known as a key biomarker and therapeutic target in a range of bone-related diseases, including cancer metastasis to bone, as well as in atherosclerosis. The new Cat-K FAST (TM) agent is expected to significantly expand research and enhance drug development ...

Agendia to Present Multiple Predictive and Prognostic Studies on Breast and Colorectal Cancers at ASCO Annual Meeting

...ikely to develop metastases within five years following surgery. Several authoritative studies have shown that chemotherapy particularly reduces early metastasis risk. In planning treatment, the MammaPrint test results provide doctors with a clear rationale to assess the benefit of chemotherapy in addition to o...

OncoGenex Pharmaceuticals Announces Release of Two ASCO Abstracts: Impact of OGX-011 on Survival in Randomized Phase 2 Trial and Phase 1 Safety Data for OGX-427

...les predictive of overall survival. The analysis defined only three variables predictive of overall survival: performance status, presence of visceral metastasis and assignment to the OGX-011 treatment arm. Based on the multivariate analysis, patients treated with OGX-011 had a rate of death 46% lower than pati...

Micromet, Inc. To Regain Rights to Blinatumomab in North America; Reports Financial Results for the Fourth Quarter and Full Year ended December 31, 2008

...ect to initiate a randomized, controlled, multicenter phase 2 clinical trial for relapsed colorectal cancer patients after complete resection of liver metastasis with adecatumumab, an EpCAM-targeting human monoclonal antibody that we develop in collaboration with Merck Serono; Before the end of 2009, we...

Agendia Publishes Direct Evidence That MammaPrint Predicts Benefit of Chemotherapy in Breast Cancer

...y, since MammaPrint is highly prognostic for early metastasis risk. Only early metastasis risk can be reduced by chemotherapy as shown by th...ccurate, MammaPrint identifies patients with early metastasis risk - those patients who are likely to develop me...

UK's Institute of Cancer Research and Silicon Graphics Establish Long-Term Alliance to Design and Outfit World-Class Network Biology Lab

...ract within the larger biological network, The Institute's researchers hope to achieve breakthroughs that lead to new drugs or treatments that prevent metastasis - the stage when cancer can turn deadly. "Studying the dynamics of cellular networks will put unprecedented demands on our technology infrastruc...

Agendia's Breast Cancer Test MammaPrint(R) Standard of Care at Netherlands Cancer Institute - AVL

... analytical validation and reporting systems to ensure patient safety issues are addressed. Highly accurate, MammaPrint identifies patients with early metastasis - those patients who are likely to develop metastases within five years following surgery. Several authoritative studies have shown that chemotherapy ...

Rosetta Genomics Announces Exclusive Distribution Agreement With Teva Pharmaceutical Industries Ltd.

...ication of the metastases' primary origin can be critical for determining appropriate treatment.Current diagnostic methods to identify the origin of a metastasis include a wide range of costly, time consuming, and at times inefficient tests. miRview(TM) mets offers physicians with a fast, accurate, and easy to ...

Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting

...s on Colon and Rectal Cancers that included the recommendation that a determination of the KRAS gene status of either the primary tumor or a site of metastasis should be part of the pre-treatment work-up for patients diagnosed with metastatic colorectal cancer. Further, the guidelines recommended that EGFr in...

Delcath Adds University of Pittsburgh Medical Center to Phase III Trial

...l at Pittsburgh as we complete enrollment in this study, and explore other viable options for its use, including colorectal metastasis, neuroendocrine metastasis and primary liver cancer." Richard L. Taney, President and CEO of Delcath commented, "Dr. Pingpank has continued his commitment to and invo...
Metastasis in Biological Definition

Cancer

...he body where the cells are not normally located ( metastasis ). Cancer is caused by damage to DNA (genetic ma...ing), ulceration or jaundice . Symptoms of metastasis (spreading) : enlarged lymph nodes , cough and... extent of the disease and whether there has been metastasis to regional lymph nodes . Staging determines the...

Muscle

...e uterus ), leiomyosarcoma (malignant, very rare) Striated muscle: rhabdomyoma (benign) and rhabdomyosarcoma (malignant) - both very rare metastasis from elsewhere (e.g. lung cancer ) Smooth muscle has been implicated to play a role in a large number of diseases affecting blood vessels , the...
Metastasis in Biological Dictionary

Mouth

... Oral cancer is any cancerous tissue growth located in the mouth . It may arise as a primary lesion originating in any of the oral tissues, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity or the... Our mouth and teeth ...

Epigenetics

...n Medline/PubMed and ... epigenetics ... Epigenetics : Principles of Eukaryotic Genome Control (2008), by ... DNA Methylation, Epigenetics and metastasis (2005), by Manel Esteller (Ed. ... How life experiences — from toxin exposure to receiving affection — can alter genome expression. ... Epigenet...

Cancer

... Cancer is a class of diseases in which a group of cells display uncontrolled growth, invasion, and sometimes metastasis . These three malignant properties of cancers differentiate them from benign tumors, which are... Dedicated to helping everyone who faces cancer ...
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(Date:10/22/2014)... (PRWEB) October 22, 2014 Healthcare ... completing their continuing education at home or on-the-go ... access to 20 brand new, premium Seminar-on-Demand CE ... catalog of over 2,000 hours of ... customize their educational experience. With such a diverse ...
(Date:10/22/2014)... Lintelus, Inc., an event software provider, announced ... will be speaking on the subject of “Event Technology ... 28, at the Holiday Inn in New York City. ... as a Tech Demo at 12:45pm, to educate event ... engaging event experience. , The Annual Meetings Technology Expo ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, 2014 (HealthDay ... be showing a genetic propensity for obesity as toddlers, a ... linked to increased body fat, but the same genes in ... researchers said. At 1 year, kids with these genes ... however, these genes were linked to excessive weight gain, the ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... among young adult men may lead to increased blood pressure, ... cause a similar rise in blood pressure for young adult ... when young adult women drank lightly or moderately, their risk ... found. "This finding parallels studies in older adult men ...
(Date:10/22/2014)... Thompson HealthDay Reporter , MONDAY, ... Monday officially tightened guidelines for health workers treating Ebola patients, ... use of a respirator at all times. The U.S. ... tougher rules after two Dallas nurses contracted Ebola while caring ... Liberian national Thomas Eric Duncan. Nina Pham is currently being ...
Breaking Medicine News(10 mins):Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2Health News:Jay Cormier, Sr. Vice President of Sales for Lintelus, Speaks about Event Technology Integration at Meetings Technology Expo in NYC 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:CDC Tightens Rules on Caring for Ebola Patients 2Health News:CDC Tightens Rules on Caring for Ebola Patients 3
(Date:10/14/2014)... study published in Cancer Research shows SIRT6—a ... colon cancers—can promote the development of skin cancers by ... survival of sun-damaged skin cells. , Previously considered protective, ... called sirtuins that help regulate genomic stability and prevent ... helps repair DNA damage, which can lead to cancer. ...
(Date:10/14/2014)... leading questions is how to produce enough food to ... Food and Agriculture Organization of the United Nations predicts ... 40 years to feed a growing global population, and ... in food production. Plants—grains, cereals, fruits, vegetables, and ... Current research must tap into our knowledge of how ...
(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
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