Drug combination shrinks breast cancer metastases in brain
SAN ANTONIO, Texas--A combination of a "targeted" therapy and chemotherapy shrank metastatic brain tumors by at least 50 percent in one-fifth of patients with aggressive HER2-positive breast cancer, according to data presented by Dana-Farber Cancer Institute investigators at the San Antonio Breast...
Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054
Macclesfield, UK, 25 September 2007. New Phase II data presented today suggest that ZD4054, a novel compound in development for the treatment of men with Hormone Resistant Prostate Cancer (HRPC), could offer a promising improvement in overall survival in men with metastatic HRPC who were asymptoma...
Pharmacyclics Receives Non-Approvable Letter from the FDA for Xcytrin for the Treatment of Lung Cancer Brain Metastases
SUNNYVALE, Calif., Dec. 21 /PRNewswire-FirstCall/ -- Pharmacyclics,
Inc. (Nasdaq: PCYC ) today announced that it has received a non-approvable
letter from the U.S. Food and Drug Administration (FDA) for the company's
new drug application (NDA) for Xcytrin(R) (motexafin gadolinium) Injection
MRI with nanoparticles highly sensitive in detecting prostate cancer metastases
High-resolution MRI with magnetic nanoparticles is highly sensitive in detecting clinically occult lymph-node metastases
in prostate cancer, according to a new report. In fact, routine use of this modality preoperatively could obviate many unneeded surgeries.//
The nanoparticles, which are give...
Amgen's Second Quarter 2009 Adjusted Earnings Per Share Increased 13 Percent To $1.29
...lts of its pivotal, Phase 3, head-to-head study where denosumab demonstrated superiority versus Zometa((R)) (zoledronic acid) in the treatment of bone metastases
in advanced breast cancer patients.
Vectibix: The Company discussed the approval of revisions to the U.S. prescribing information for the ep...
Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform
... it represents a unique target for the vascular imaging of tumors and tumor metastases
in patients with cancer.
"PS-targeting antibodies such as bavituximab ...antibodies may be useful for the non-invasive detection of tumors and their metastases
in cancer patients."
The new patent claims methods for imaging solid t...
Lab Study Finds Protein That May Inhibit Cancer Spread
...c tumor cells and injected them into mice.
in the mice were reduced by 80 percent, lymph node metastases
disappeared, and there was a significant increase ... tumors cells, there was a large reduction in lung metastases
and the mice lived at least 30 percent longer than...
Potent metastasis inhibitor identified
...atic, but to which they had added prosaposin, lung metastases
were reduced by 80 percent and lymph node metastases
were completely eliminated, and survival time was ...f tumor cells, the tumor cells formed virtually no metastases
in the lung, or, if they did, formed much smaller ...
$16.8 million study will breathe new life into cancer battle
...ts with hypoxic tumours respond less well to treatment.
Furthermore, hypoxia also appears to increase the chance that a tumour will spread and form metastases
in other parts of the body. If a tumour begins to spread to other areas it becomes much more difficult to treat and so most cancer-related deaths are ...
St. Gallen consensus 2009: A radically different approach to treating early breast cancer
...volvement, and which is easily removable by surgery. However, there are many different types, some of which carry a much higher risk of recurrence and metastases
Therefore, the report emphasises the importance of identifying which type of breast cancer a patient has and which treatment, or combi...
metastases in Medical Technology
Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)
THOUSAND OAKS, Calif., Aug. 3 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN ) today announced positive top-line results from a pivotal Phase 3 head-to-head trial evaluating denosumab administered subcutaneously versus Zometa((R)) (zoledronic acid) administered as an intraveno...
Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer
OSLO, Norway, January 14 /PRNewswire-FirstCall/ --
- Results Highlight the Potential of Alpharadin to Treat Bone Metastases
in Major Cancer Indications
Algeta ASA (OSE: ALGETA), the cancer therapeutics company, announces that
with the results of the BC1-04 study reported today i...
New Drug Combination is Able to Eradicate Breast Metastases in Mice
SAN ANTONIO, Dec. 17 /PRNewswire/ -- A novel combination of drugs was
able to completely eradicate human breast metastases
growing in mice, and
shows promise for the effective treatment of patients with advanced
metastatic breast cancer. Dr. Sophia Ran from Southern Illinois University
Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases
THOUSAND OAKS, Calif., July 7 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN ) today announced that a pivotal, Phase 3, head-to-head trial evaluating denosumab versus Zometa(R) (zoledronic acid) in the treatment of bone metastases
in 2,049 patients with advanced breast cancer met its primary and ...
M. D. Anderson to Initiate Clinical Validation Study on Rosetta Genomics' MicroRNA-based Diagnostic Assay Identifying the Origin of Cancer Metastases
The Study Will Correlate the Results of Rosetta Genomics' MicroRNA-Based
CUP Assay With Diagnostic Work Conducted at M.D. Anderson Cancer Center
Data on the Company's MicroRNA-Based CUP Assay and its High Sensitivity and
Accuracy was Recently Published in the April Issue of Nature Biotechnolo...
Perioperative Eloxatin(R)-Based Regimen Significantly Reduced the Risk of Relapse Versus Surgery Alone in Eligible Colorectal Cancer Patients with Initially Resectable Liver Metastases
- EPOC Results Published in March 22 Issue of The Lancet -
BRIDGEWATER, N.J., March 20 /PRNewswire-FirstCall/ -- Sanofi-aventis
today announced that efficacy results of the randomized phase III EORTC
40983 Intergroup study published in the March 22 issue of The Lancet showed
that in eli...
The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved
Progression Free Survival When Given Before and After Surgery in
Patients With Resectable Liver Metastases From Colorectal Cancer
Presentation at ASCO Plenary Session Reports EORTC 40983 (EPOC)
Intergroup Study Results
CHICAGO, June 04, 2007 /PRNewswire-FirstCall/ -- Results of the
randomized phase III EORTC 40983 Intergroup study, or EPOC study,
demonstrate for the first time that peri-operative (pre and post
Allos Therapeutics Reports Results for Phase 3 Enrich Study of
Efaproxyn in Women With Brain Metastases Originating From Breast
Study Fails to Meet Primary Endpoint of Improvement in Overall
WESTMINSTER, Colo., June 19, 2007 /PRNewswire-FirstCall/ --
Allos Therapeutics, Inc. today announced top line results from
ENRICH, the Company's pivotal Phase 3 study of Efaproxyn
(efaproxiral) plus whole brain radiation ther...
Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and
Effective in Colorectal Cancer with Liver Metastases
- Initial Phase II Study Results Presented at Society of Nuclear
Medicine Annual Meeting -
WASHINGTON, June 04, 2007 /PRNewswire-FirstCall/ --
Immunomedics, Inc. , a biopharmaceutical company focused on
developing monoclonal antibodies to treat cancer and other serious
diseases, today announced th...
Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy
...e study. "Patients with metastatic melanoma are at high risk for additional metastases
During the study, 54 patients with regionally recurrent...though they had widely metastatic disease and/or repeated appearance of new metastases
despite various therapies. The vaccine treatment was well-tolerated, with m...
metastases in Medical Products
Description:...e treatment plans can vary widely based on the level of metastatic disease, proper staging is a critical component of patient management. Diagnosis of metastases
at an early stage can be difficult because small tumors are frequently not accompanied by detectable physical symptoms. We believe that contrast-enhan...
Company:Advanced Magnetics, Inc.
metastases in Medical Dictionary
Primary brain tumor
...imary or metastatic, benign or malignant) are usually ... Primary brain tumors rarely spread to other areas of the body, but they can ... metastases
to the brain from a primary tumor that is outside the central nervous ... Primary malignant brain tumors represent 2.4 percent of all ...
...omic ... operative management of pancreatic . metastases
from breast carcinoma . ... Unlike primary p...Context Unlike primary pancreatic carcinoma , metastases
to the pancreas are rare ... We present 3 cases of pancreatic metastases
from breast lobular carcinoma . ... Pancre...
... cancer cells from one organ or tissue ... Metastatic cancer; Cancer metastases
. Text Continues Below. Information: ... Skin metastasis , cutaneous metastases
. Authoritative facts about the skin from the New Zealand ... very rare c...
... occurs as a result of reduced local blood supply... Cancer patients taking bisphosphonate drugs for the prevention of fractures due to bone metastases
appear more likely to develop jaw disease than patients who do not ... jaw n. Either of two bony or cartilaginous structures that in most ve...
.... Bone pain represents one of the most debilitating side effects of the metastases
... At Chemocare.com, find answers about bone pain as a side effect..... Tennessee Oncology doctors provide quality cancer care, ... Bone metastases
are usually diagnosed because the patient experiences pain near the metas...
...noma ... the gland tissue are seldom actually refered to as adenocarcinoma or adeno carcinoma . ... Adenocarcinoma of the Lung and Brain metastases
Symptoms, Treatments and Medications ... Adenocarcinoma of the lung is the most common type of lung cancer and ... Learn about lung therapies ...
metastases in Biological News
CSHL scientists identify cells that promote formation of lethal lung metastases
Cold Spring Harbor, NY Cancer patients usually ask what can be done after a primary tumor has already spread, or metastasized, to other organs. In many cases, they learn, little can be done. Hence the importance of a discovery by scientists at Cold Spring Harbor Laboratory (CSHL) of a type of cel...
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
...e study. "Patients with metastatic melanoma are at high risk for additional metastases
During the study, 54 patients with regionally recurrent or ...though they had widely metastatic disease and/or repeated appearance of new metastases
despite various therapies. The vaccine treatment was well-tolerated, with m...
...ew genes had been associated with the formation of metastases
in colorectal cancer. Now, researchers of the Max ...nes Fritzmann, "but the dangerous metastases."
arise when single cells break off from the primary... this gene is more active in metastatic tumors and metastases
than in non-metastatic tumors.
LSUHSC research describes function of key protein in cancer spread
... location, the cancer cells continue growing. The spread of a tumor to a new part of the body is called metastasis. Most people who die of cancer have metastases
at the time of their death, and metastatic disease is directly responsible for the majority of cancer deaths. This year, about 562,340 Americans are e...
Society of Interventional Radiology Foundation awards $191,000 in grants
...arvard Medical School, Boston, Mass., "Hepatic Arterial Chemoembolization (HACE), Yttrium-90 Radioembolization and Drug-eluting Bead-HACE in Carcinoid metastases
to the Liver."
IMPAKT -- Breast cancer conference highlights
...ymph nodes, offering reassurance to patients and reducing the need for a second operation. The new technique allows you to make the diagnosis of micro metastases
while the surgery is underway, meaning the patient does not have to suffer the disruption of undergoing another operation.
ANDROGEN-RECEPTOR: A NEW...
Lithium may help radiation target cancer, spare healthy tissue
...thy brain tissue. The team is launching an investigation of the safety and feasibility of lithium treatment in patients with low-grade glioma or brain metastases
from small cell lung cancer.
"Right now, the problem is that we cannot kill the tumor completely because normal tissue toxicity limits the dose," X...
Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
...e David Geffen School for Medicine, University of California, Los Angeles showed that MIS416 significantly inhibited tumor growth and the formation of metastases
when tested as a stand-alone agent. When administered as an adjunct to localized tumor irradiation, MIS416 also demonstrated synergistic activity agai...
Skin cancer study uncovers new tumor suppressor gene
...important measures of cancer aggression in melanoma. In contrast, mice injected with cells expressing mutated MMP-8 went on to develop ulcerations and metastases
in their lungs.
New tumor markers determine therapy intensity
...us far, oncologists could estimate this risk only on the basis of histology findings, age at diagnosis, residual tumor after surgery, and existence of metastases
Patients with a poor prognosis can be treated more intensively
Stefan Pfister and his research group "Molecular Genetics of Pedi...
metastases in Biological Technology
YM BIOSCIENCES RECEIVES CLEARANCE TO INITIATE RANDOMIZED DOUBLE-BLIND CLINICAL TRIALS OF NIMOTUZUMAB IN LUNG CANCER AND BRAIN METASTASES FROM LUNG CANCER
MISSISSAUGA, ON, Jan. 5 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Alternext US:YMI, TSX:YM, AIM:YMBA), an oncology company that identifies, develops and commercializes differentiated products for patients worldwide, today announced that it has received clearance from Canadian regulatory a...
MyCancerPain.org Launched as Resource for Patients with Painful Bone Metastases
TIRAT CARMEL, Israel, December 16 /PRNewswire/ -- InSightec Ltd.
announced today that cancer patients suffering pain caused by tumors that
have spread to their bones have a new online resource for information about
their condition. The website, http://www.MyCancerPain.org , provides
New Publications Show Noninvasive Magnetic Resonance-Guided Focused Ultrasound to be a Potentially Safe, Effective Pain-Relieving Treatment for Bone Metastases
TIRAT CARMEL, Israel, December 2 /PRNewswire/ -- InSightec Ltd. announced
today that new publications show that Magnetic Resonance-guided Focused
Ultrasound (MRgFUS) with the ExAblate(R) system has the potential to be an
effective noninvasive pain-relieving treatment for tumors that have sprea...
GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment of HER2 Positive Breast Cancer Brain Metastases
Study Shows TYKERB Combination Reduced the Size of Brain Tumors Associated with HER2-Positive Breast Cancer
SAN ANTONIO, Texas, Dec. 17 /PRNewswire/ -- GlaxoSmithKline announced
today results from the extension arm of a Phase II study on its
first-in-class, oral small molecul...
Amgen to Collaborate With GlaxoSmithKline to Commercialize Denosumab in Europe for Postmenopausal Osteoporosis (PMO)
...ets RANK Ligand and is being investigated for its potential to prevent and treat a broad range of bone disease conditions including osteoporosis, bone metastases
and their consequences, cancer treatment-induced bone loss due to hormone ablative therapy, multiple myeloma and bone erosions in rheumatoid arthritis...
A Swiss Team Uses Transcranial MR-Guided Focused Ultrasound to Treat Patients With Functional Brain Disorders
...erine fibroids. 5,000 women have been treated worldwide to date. ExAblate 2000 received the European CE Mark certification for pain palliation of bone metastases
in June 2007.
InSightec Ltd. is a privately held company owned by Elbit Imaging, General Electric, MediTech Advisors...
Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August
...nopausal osteoporosis and bone loss in patients undergoing hormone ablation for prostate and breast cancer, as well as for its potential to delay bone metastases
and inhibit and treat bone destruction across many stages of cancer.
Often referred to as the "silent epidemic," osteoporo...
OncoGenex Pharmaceuticals Announces OGX-011 Treatment Provides Survival Benefit in Randomized Phase 2 Trial in Advanced Metastatic Prostate Cancer
...variate analysis indicated that the
significant predictors of overall survival were treatment arm,
performance status, and presence of metastases
other than in bone or
lymph nodes. Patients treated with OGX-011 had a rate of death 51%
lower than patients treated with docetaxel al...
Independent Data Monitoring Committee Supports Continuation of Picoplatin Phase 3 SPEAR Registration Trial in Small Cell Lung Cancer
...n accordance with the National Comprehensive Cancer Network's guidelines and includes analgesics, radiation therapy for painful bone metastases, brain metastases
or relief of obstructive symptoms from lesions in the chest, nutritional support and treatment of anemia, dyspnea, infections, paraneoplastic syndrome...
Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
...motherapy in a number of cancers.
In earlier work using animal models, Dr. Chang's group delivered functional p53 genes to tumor cells and tumor metastases
in 16 different types of cancer, including prostate, pancreatic, melanoma, breast cancer and head and neck cancer. The presence of the replacement gen...
metastases in Biological Products
metastases in Biological Definition
altered ability to differentiate
no ability for contact inhibition
ability to invade neighbouring tissues
ability to build metastases
at distant sites
ability to promote blood vessel growth ( angiogenesis )
A cell that degenerates into a tumor cell does usually not acquire al...
...ither malignant or benign .
Malignant tumors are called cancer . Cancer has the potential to invade and destroy neighboring tissues and create metastases
. Benign tumors do not invade neighboring tissues and do not seed metastases, but may locally grow to great size. They usually do not return after sur...