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Metalloproteinases in Medical News

ConvaTec Launches Hydrofiber(R) Technology Web Site

...) and alginate dressing. Biomaterials . 2003;24(5):883-890. Walker M, Bowler PG, Cochrane CA. In vitro studies to show sequestration of matrix metalloproteinases by silver-containing wound care products. Ostomy Wound Manage . 2007;53(9):18-25. Jones SA, Bowler PG, Walker M. Antimicrobial activity of silv...

Study in Nature Medicine establishes major new treatment target in diseased arteries

...iotensin II. In AAA, past studies have confirmed that angiotensin II, in part by driving up ROS production, excessively turns on enzymes called matrix metalloproteinases (MMPs). As part of normal healing, MMPs chew through strong flexible proteins like elastin that give tissues shape (extracellular matrix) to make room...

Durability of dental fillings improves if the enzyme activity of teeth is inhibited

... bacteria to enter and this brings a high risk of further tooth decay. Professor Tjderhane has researched the occurrence of certain enzymes, matrix metalloproteinases (MMPs), in the dental tissue and their role in dental conditions. The MMPs break down the extracellular matrix, including collagen, which is a major c...

Also in the July 8 JNCI

...othelial growth factor (VEGF), one of the key factors in angiogenesis. In the current study, Persson's team examined expression of cyclin A1, VEGF, metalloproteinases (MMPs) in primary malignant tumors, and adjacent benign prostatic tissues from 482 patients with prostate cancers of various stages. The team further ...

Viral Therapy Slows Pediatric Tumors in Mice

...tein, human tissue inhibitor of metalloproteinase 3 (TIMP3). TIMP3 blocks enzymes that aid the development and progression of cancer, called matrix of metalloproteinases (MMP). MMPs help break down molecules that are important for the structural support and normal development of cells, organs and maintenance of tiss...

First Potential Treatment for Dengue

...stimulating these same target cells to overproduce metalloproteinases (gelatinolytic matrix metalloproteinases – MMP-9) and secrete them into the cellular supern...of viral particles present. To verify that the metalloproteinases were the only agents responsible for the increased...

More Stress, More Cancer

...ersity. Glaser and Eric Yang, a research scientist in the same institute, focused on the role of these three compounds. Two of them, both matrix metalloproteinases -- MMP-2 and MMP-9 -- play a role in breaking down the scaffolding that cells attach to in order to maintain their shape. The third compound, vascular...

Breast Cancer Advance

...breast cancer, an effective strategy to treat the disease is not so far // . The ADAMTS genes are recent additions to a large family known as the metalloproteinases – many of which can break down tissues and have therefore been linked with tumor metastasis, or spread, through the body. Earlier studies have shown t...

Simple Urine Test Can Help To Monitor Disfiguring Birthmarks

...n and other problems. Marsha Moses, PhD of Children's Vascular Biology Program, senior investigator on the study, had been studying the matrix metalloproteinases (MMPs), a family of enzymes required for angiogenesis, or growth of new blood vessels. Angiogenesis is also critical to a cancer's expansion, ...
Metalloproteinases in Medical Technology

Conatus Pharmaceuticals Initiates a Second Phase 2 Clinical Trial for the Treatment of Hepatitis

...ater this year. CTS-1027 is an oral, small molecule compound that inhibits the activity of key members of a class of protease enzymes, the matrix metalloproteinases or MMPs. CTS-1027 had previously been shown to be effective in multiple preclinical models of inflammatory liver disease and HCV infection. Th...

Conatus Pharmaceuticals Reports Positive Results of CTS-1027 in Multiple Preclinical Studies of Liver Disease

...se. In previous clinical trials in other therapeutic areas, CTS-1027 was chronically administered to over 500 people, some for over 18 months. Matrix metalloproteinases (MMPs) are a well studied family of proteolytic enzymes. In the liver, as in other solid organs, MMPs play a key role in maintaining the integrity of ...
Metalloproteinases in Biological News

Experimental treatment halts hypoxic-ischemic brain injury in newborns

...the activity of both tPA and another brain enzyme, urokinase-type plasminogen activator. It also blocked hypoxic-ischemia-induced activation of matrix metalloproteinases and damage to the blood-brain barrier. The researchers also applied magnetic resonance imaging tests and microscopic analysis of brain tissues, which ...

Christopher McCulloch receives the IADR Research in Oral Biology Award

...hanosensory signals. This work led to advances such as guided tissue regeneration, the first automated periodontal probe, and clinical studies linking metalloproteinases and progression of periodontitis, as well as several patents. Sponsored by Church & Dwight Company, the Research in Oral Biology Award is one of the...

Researchers isolate protein domain linked to tumor progression

... 1990s, researchers were disappointed by the debilitating side effects that limited the trials. The drug inhibited a family of enzymes known as matrix metalloproteinases (MMPs). Now, researchers at Rensselaer Polytechnic Institute have shown that creating drugs that inactivate a different part of the MMP enzyme could h...

UCR researchers propose minocycline as a promising drug for patients with Fragile X syndrome

... members in UCR's Division of Biomedical Sciences, describe how dendritic spine development in mice with Fragile X is delayed by enzymes called matrix metalloproteinases (MMPs), which are involved in normal brain development and physiological processes. They report that high levels of certain MMPs keep the synapses imm...

Potential new target for multiple sclerosis therapy

...ple sclerosis (MS), providing a potential new way to combat this debilitating disease. Collagenase-2 is a member of a protein family called matrix metalloproteinases (MMPs, collagenase-2 is MMP8), a large group of enzymes that break down collagen and other components of the body's connective tissue. MMPs have been...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

...ein, human tissue inhibitor of metalloproteinase 3 (TIMP3). TIMP3 blocks enzymes that aid the development and progression of cancer, called matrix of metalloproteinases (MMP). Specifically, MMPs help break down molecules that are important for the structural support and normal development of cells, organs and maintena...

Natural product discovery by Cleveland medical researchers blocks tissue destruction

...called Croton palanostigma, was a remarkably potent antioxidant and prevented the destruction of human cartilage by molecular s scissors called matrix metalloproteinases (MMPs). According to the researchers, these enzymes cut collagen, which forms the backbone of the cartilage, into tiny pieces during states of inflamm...

A genetic 'gang of 4' drives spread of breast cancer

...stitute for Research in Biomedecine in Spain, focused on four of these genes. These genes, which code for proteins called epiregulin, COX2, and matrix metalloproteinases 1 and 2, were already known to help regulate growth and remodeling of blood vessels, said Massagué. "Our understanding of the genes for these four...

New molecular pathway could reveal how cells stick together

...her and to surfaces. Andrea Page-McCaw, assistant professor of biology at Rensselaer and principal investigator for the project, has focused on matrix metalloproteinases (MMPs) -- proteins that play a role in development and immunity. "MMPs have gotten a lot of attention primarily because of their regulation in a...

Stress hormones may play new role in speeding up cancer growth

...ersity . Glaser and Eric Yang, a research scientist in the same institute, focused on the role of these three compounds. Two of them, both matrix metalloproteinases -- MMP-2 and MMP-9 -- play a role in breaking down the scaffolding that cells attach to in order to maintain their shape. The third compound, vascular...
Metalloproteinases in Biological Technology

Conatus Pharmaceuticals Initiates a Phase 2 Clinical Trial for the Treatment of Hepatitis

...ammatory damage to the liver resulting from infection by HCV. CTS-1027 inhibits the activity of key members of a class of protease enzymes, the matrix metalloproteinases or MMPs. In the liver and in other solid organs, MMPs play an important role in regulating inflammation as well as in maintaining the integrity of the...
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