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Metalloproteinase in Medical News

Compound in Berries May Lessen Sun Damage

...imental Biology 2009 meeting in New Orleans. In human skin cells, ellagic acid protects against ultraviolet damage by blocking production of matrix metalloproteinase enzymes that break down collagen and reduce the expression of ICAM, a molecule involved with inflammation. More information The American Acad...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

... 10 agents targeting FLT-3 9 agents targeting c-Kit Additional targets include 20S proteasome; polyamine; 5T4 oncofetal antigen; a disintegrin and metalloproteinase domain 17 (ADAM17), TACE; acidic fibroblast growth factor (aFGF); activin receptor IIA (ActrIIA); adenosine deaminase; adenosine monophosphate (AMP); ...

Viral Therapy Slows Pediatric Tumors in Mice

...-targeted viral therapy to fight cancer." The gene added to the virus carries instructions for a cancer-fighting protein, human tissue inhibitor of metalloproteinase 3 (TIMP3). TIMP3 blocks enzymes that aid the development and progression of cancer, called matrix of metalloproteinases (MMP). MMPs help break down...

ImClone and Bristol-Myers Squibb Announce Joint Agreement With Merck KGaA to Co-Develop and Co-Commercialize ERBITUX(R) in Japan

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Success of Hip Replacement Surgery Decided by Genes

... Research suggests that genes responsible for generating matrix metalloproteinase 1 and vitamin D synthesis may determine the success// of long term hip repl...s to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis. MMP1 is a...

Europeans Developing First-Ever Dengue Fever Vaccine

... pour le development (IRD) investigated the enzyme metalloproteinase and its effect on the cement holding blood vessels...r. They have uncovered evidence showing that metalloproteinase is responsible for effectively poking holes in the... by dissolving the proteins holding them together. metalloproteinase is a naturally occurring compound involved in crit...

Naturally Occurring Enzyme Can Break Down Key Part of Alzheimer's Plaques

... them seek new therapies. Researchers at Washington University School of Medicine in St. Louis showed earlier this summer that the enzyme, matrix metalloproteinase 9 (MMP-9), degrades abnormally aggregated proteins known as amyloid fibrils, a main ingredient of brain plaques. In the brain, MMP-9 is made by suppor...
Metalloproteinase in Medical Technology

ThromboGenics Announces Promising Results of MITI IV Phase II Trial in the Treatment of Acute Stroke with Microplasmin

...ly significant improvement in the level of damage to the blood brain barrier compared to placebo-treated patients, measured using the marker of matrix metalloproteinase (MMP). MMP activation plays a crucial role in the pathogenesis of brain edema and hemorrhagic transformation after ischemic stroke. Professor Vincen...

New England Journal of Medicine Study Shows ERBITUX(R) Improves Survival in Advanced Colorectal Cancer

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Conatus Pharmaceuticals Reports Positive Results of CTS-1027 in Multiple Preclinical Studies of Liver Disease

... SVP Research and Development. "We plan to initiate a Phase 2 clinical trial within the next few months." CTS-1027 is an oral, small molecule, matrix metalloproteinase (MMP) inhibitor under development for chronic use to protect the liver from damage due to a variety of insults including virus infection, obesity, alc...

Survival Data in FDA Approval for ERBITUX(R) (Cetuximab) Supports use as a Single Agent in Patients with Advanced Colorectal Cancer

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

ERBITUX(R) Meets Primary Endpoint of Increasing Survival in Phase III Lung Cancer Study

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Survival Data Available from Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Survival Data Available From Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Data Available from Erbitux Phase III Study in First-Line Treatment of Advanced Pancreatic Cancer

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Randomized Phase III Trial Showed Erbitux Significantly Improved Secondary Endpoints of Progression-Free Survival and Disease Control in Metastatic Colorectal Cancer Patients

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...

Extensive Clinical Data on Erbitux Presented at the 2007 ASCO Annual Meeting

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...
Metalloproteinase in Medical Products

Growth Hormone Binding Protein ELISA Test

Description:...he GH receptor or a splice variant of the GH receptor gene. Growth Hormone receptor cleavage /GHBP shedding is effected by TNF-a converting enzyme, a metalloproteinase of the ADAM family, and possibly related enzymes (1). GHBP circulates in plasma in nanomolar concentrations, sufficient to complex approximately 50% ...
Company:Diagnostic Systems Laboratories, Inc.
Metalloproteinase in Biological News

Skin cancer study uncovers new tumor suppressor gene

...y other types of cancer. The NIH analysis found that one-quarter of human melanoma tumors had changes, or mutations, in genes that code for matrix metalloproteinase (MMP) enzymes. The findings lay the foundation for more individualized cancer treatment strategies where MMP and other key enzymes play a functional r...

Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors

...dy, Dr. Cripe and his colleagues genetically armed oHSV with a gene that carries instructions for a cancer-fighting protein, human tissue inhibitor of metalloproteinase 3 (TIMP3). TIMP3 blocks enzymes that aid the development and progression of cancer, called matrix of metalloproteinases (MMP). Specifically, MMPs hel...

Genes may determine success of hip replacement surgery

...g the artificial implants. DNA samples were taken from all participants to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis. MMP1 is an enzyme that breaks down collagen, the main protein found in bone and car...

Expanding waistlines triggered by your genes

...d by researchers Tae-Hwa Chun, Stephen Weiss, and Alan Saltiel at U-M's Life Sciences Institute (LSI), discovered that the gene membrane-type 1 matrix metalloproteinase (MT1-MMP) shears the collagen meshwork that holds fat cells in place and frees expanding fat cells, allowing their spread and expansion underneath the...

Anthrax inhibitors identified by Burnham team

...ds were synthesized and validated as highly potent and selective against LF in vitro. In in vitro assays, the compounds did not affect prototype human metalloproteinase enzymes that are structurally similar to LF. This is very important as selectivity is a fundamental prerequisite for a drug to be safe for use in huma...
Metalloproteinase in Biological Technology

ThromboGenics N.V.: Business Update

...ly significant improvement in the level of damage to the blood brain barrier compared to placebo-treated patients, measured using the marker of matrix metalloproteinase (MMP). MMP activation plays a crucial role in the pathogenesis of brain edema and hemorrhagic transformation after ischemic stroke. It remains Throm...

Lilly to Acquire ImClone Systems in $6.5 Billion Transaction

...ks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased matrix metalloproteinase and vascular endothelial growth factor production. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human...
Metalloproteinase in Biological Products

RayBio Human Matrix Metalloproteinase Antibody Array I & 1.1 Service from Raybiotech, Inc.

Description: Request Info...
Company:Raybiotech, Inc.

Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated from Lab Vision

Description:... MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 resp...
Company:Lab Vision
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