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Metabolize in Medical News

Patents Issued Covering Stable Tablet Formulation and Once Daily Dosing Regimen for Kuvan

...ynthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA)...

European Medicines Agency (EMEA) Approves Cell Therapeutics, Inc.'s September Meeting Request to Discuss OPAXIO(TM) Marketing Authorization Application

...ed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may b...

The microbial hydrocarbon diet

...t the hydrocarbon n-hexadecane. The bacterium was initially isolated from the Daqing oil field in North East China where it had evolved the ability to metabolize this chemical. Bioremediation of hydrocarbons usually involves the application of a cultured bacterium that has been optimized to feed on the speci...

Some Antidepressants May Thwart Tamoxifen's Effect on Breast Cancer

...etrozole (Femara) and exemestane (Aromasin), "are one possible alternative to tamoxifen. There are also genotyping issues -- how different individuals metabolize the various drugs. This is not standard of care but it can be checked." More information There's more on tamoxifen at the U.S. National Cance...

BioMarin Receives 2009 Corporate Award for the Development of Kuvan

...g genetic metabolic disorder that, when left untreated, can result in mental retardation and other neurological problems. Individuals with PKU cannot metabolize an essential amino called phenylalanine, or Phe, which is found in most foods; this results in a dangerous accumulation of Phe in the blood, which can...

Do Fad Diets Really Work?

...: Eating at night makes you gain weight. While a full belly might not make for the most restful night of sleep, our bodies don't metabolize food differently in the evening than at other times of the day. Weight gain has nothing to do with when we eat, but rather what we eat and how much. ...

ASHG hosts fourth annual DNA Day essay contest, supports genetics education efforts

...ing the surprising complexity of phenylketonuria (or PKU), which is a rare, inherited single-gene disorder that affects a person's ability to properly metabolize the amino acid phenylalanine and, if left untreated, can cause problems with brain development that could lead to mental retardation. In her essay, Li...

Scientists From 25 Countries Sequence Cow Genome

...nce, both cows and humans have a gene for growth hormone, Taylor said. Scientists were able to tell that cows have specialized genes that help them metabolize food. And both genomes may have adapted to each other. "Humans drink a lot of cow's milk and that's resulted in a change in the human genome so we ...

Genetic changes outside nuclear DNA suspected to trigger more than half of all cancers

...is team found 106 genes specific to head and neck cancer that were activated by the demethylation process. "Some of the genes regulate growth, others metabolize sugars and some have already been linked to cancer development," says Califano, who is director of head and neck cancer research at the Milton J. Danc...

Nuvilex, Inc. Launches Spring Break Initiatives Designed to Raise Visibility Among Key Demographic Group

...y is packaged in a 2 ounce tube and it meant to be taken in one shot, followed by 16 ounces of water, before going to sleep. Last Shot helps the body metabolize the sugar in alcohol, thereby eliminating or at least minimizing hangovers. About Nuvilex, Inc. Nuvilex, formerly eFoodSafety.com, is an e...
Metabolize in Medical Technology

OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer

...ed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may b...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

...ed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may b...

ELAD(R) Liver Support System Study Initiated at Multiple U.S. Centers

...32,000 hollow fibers. The patient's plasma flows inside of the hollow fibers to allow two-way transfer of metabolites. During ELAD therapy the cells metabolize toxins and synthesize proteins and other liver specific products essential for life. The ELAD cell cartridges are produced at VTI's GMP-compliant faci...

Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin

... nervous system(5) and may help some women reduce severe nausea or vomiting during pregnancy(6). It also helps the body maintain blood glucose levels, metabolize proteins, formulate neurotransmitters for normal nerve cell communication and makes hemoglobin to carry oxygen to tissues(7). Pregnant women ...

Complete Study Results Comparing CTI's OPAXIO(TM) With Gemcitabine or Vinorelbine in Performance Status (PS 2) NSCLC Patients Published in Journal of Thoracic Oncology

...ed allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. Once inside the tumor cell, enzymes metabolize the protein polymer, releasing the paclitaxel chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may b...

BioMarin Announces FDA Approval for Kuvan

...ynthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential treatment option for approximately 30 percent to 50 percent of the estimated 5...

Synvista Therapeutics Announces Initiation of Phase 2 Study With Alagebrium for Chronic Heart Failure

...largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical diagnost...

Vital Therapies Announces Presentation of ELAD(R) 'Artificial Liver' Data at American Association for the Study of Liver Diseases 2007 Annual Meeting

...pe and severity of liver disease. The system consists of four cartridges containing cells that function like normal human liver hepatocytes. The cells metabolize toxins and remove waste products while delivering essential proteins into the plasma. These cartridges are incorporated into a blood pumping system at...

Synvista Announces New Data Showing Haptoglobin Type Predicts Effectiveness of Tight Glycemic Control on Cardiovascular Outcomes in Patients with Diabetes

...largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical diagnost...

Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes

...largest pharmaceutical markets. The Company's portfolio includes orally bioavailable, organoselenium mimics of glutathione peroxidase. These compounds metabolize lipid peroxides and have the potential to limit myocardial damage subsequent to a myocardial infarction. The Company is developing a clinical diagnost...
Metabolize in Medical Dictionary

Metabolize

Metabolism. From Wikipedia, the free encyclopedia (Redirected from Metabolize ) ... replace glucose in tissues such as the brain that cannot metabolize fatty acids. ... metabolize ( ) v. , -lized , -lizing , -lizes . v.tr. To subject (a substance) to metabolism. To produce (a substan...

Polyuria

...mounts of water can be lost from the body, resulting in polyuria and dehydration. ... Polyuria in diabetes shows that the body is unable to metabolize carbohydrates properly. ... Polyuria , Polydipsia & Diabetes Insipidus--WSAVA 2002-Nelson ... ...

Pku

...cessive genetic disorder characterized by a deficiency in the enzyme hepatic phenylalanine hydroxylase. :541 This enzyme is necessary to metabolize the amino acid phenylalanine to the... Online resource that offers Phenylketonuria ( PKU ) related information, facts, news, personal stories...

Phenylketonuria

...cessive genetic disorder characterized by a deficiency in the hepatic enzyme phenylalanine hydroxylase. :541 This enzyme is necessary to metabolize the amino acid phenylalanine to the... Phenylketonuria — Comprehensive overview covers symptoms, treatment (including diet information)...

Lipid Disorders

...(fats) accumulate in some of the body’s cells and tissues. People with these disorders either do not produce enough of one of the enzymes needed to metabolize lipids or they produce enzymes that do not work properly. Over time, this... Disorders " provide recommendations for the screening and ... Scree...

Lactose intolerance

... Lactose intolerance is the inability to metabolize lactose , a sugar found in milk and other dairy products, because the required enzyme lactase is absent in the intestinal system or its avai...

Lactose

...t varies among species and individuals. It is extracted from sweet or sour whey. The name comes from... Lactose intolerance is the inability to metabolize lactose , a sugar found in milk and other dairy products, because the required enzyme lactase is absent in the intestinal system or its avai...

Lactase

...charide lactose into constituent galactose and glucose monomers. In humans, lactase is present... Lactose intolerance is the inability to metabolize lactose, a sugar found in milk and other dairy products, because the required enzyme lactase is absent in the intestinal system or its availa...

Kinins

...harmacological ... Vasoactive Peptides and NO flashcards, matching games, crossword, hangman and other study tools. ... kinins ... enzymes that metabolize kinins ... Nevertheless, if kinins play a significant role in some physiological or ... The volume of research in kinins increased exponent...

Galactosemia

... Galactosemia is a rare genetic metabolic disorder that affects an individual's ability to metabolize the sugar galactose properly. Galactosemia is sometimes confused with Lactose-Intolerance, but unlike lactose-intolerance,... Galactosemia...
Metabolize in Biological News

Common allergy drug reduces obesity and diabetes in mice

...In contrast, type 2 diabetes is a strictly metabolic condition in which cells grow increasingly deaf to insulin signals and thus lose their ability to metabolize glucose. In both cases, glucose mounts in the blood, at times to fatal levels. But it is becoming increasingly clear that we should also think of ...

Phthalic symbol

...ate as the only source of carbon for the microbes. Successive divisions of microbial cells quickly leads to the evolution of a strain that can quickly metabolize the phthalate and convert it into the raw materials for microbial growth and reproduction. The researchers then tested this phthalate-digesting mic...

A little java makes it easier to jive, researcher says

...singly common for athletes before competing to consume a variety of substances that include caffeine, motivated by "the notion that it will help you metabolize fat more readily." "That research isn't actually very compelling," Motl said. "What's going on in my mind is people are doing it for that reason, ...

Stanford scientists find new solutions for the arsenic-poisoning crisis in Asia

.... Normally, bacteria use oxygen to breathe. But in an anaerobic environment, they can use other chemicals, including rust and arsenic. As the bacteria metabolize the iron and arsenic, they convert it to a form that readily dissolves in water. "As these sediments get buried very rapidly, the bacteria go throu...

Fowl soil additive breaks down crude oil

... remediation exercise is complete. A more environmentally benign approach is to bioremediation, which uses natural or engineered microbes that can metabolize the organic components of crude oil. Stimulating such microbial degradation in contaminated soil often involves the use of expensive fertilizers conta...

Great Lake's sinkholes host exotic ecosystems

...as associated with rotting eggs. Where the sinkholes are deeper still and light fails, microorganisms use chemical means rather than photosynthesis to metabolize the sulfurous nutrients. Biddanda, Ruberg, and their team are probing the origins of ancient minerals flowing in from beneath this fresh inland sea...

Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants

... CINCINNATI Screening for mutations in a gene that helps the body metabolize a kidney transplant anti-rejection drug may predict which children are at h... a specific point mutation in the gene that helps break down the drug, UGT, metabolize the drug slower. This point mutation, called UGT1A9-331, causes overexposur...

States expand newborn screening for life-threatening disorders

...Giana was born in was part of a pilot program to expand newborn screening in California." 3MCC is a serious disorder that leaves newborns unable to metabolize leucine an essential amino acid found in many forms of protein. But because Giana, now age six, was diagnosed early, she was put on a special diet an...

MUHC and McGill scientists explain genetic disease first discovered in Quebec 24 years ago

...indow into its basic properties and how it behaves in healthy cells." The cblF idisease is a rare genetic disorder characterized by an inability to metabolize vitamin B12. Patients afflicted with this condition build up toxic levels of homocysteine and methylmalonic acid in their bodies. Vitamin B12, which i...

New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease

... recessive genetic disease that is characterized by a deficiency in an enzyme called phenylalanine hydroxylase (PAH). Without PAH, the body cannot metabolize the amino acid phenylalanine. It then builds up in the blood, crosses the bloodbrain barrier and causes severe brain damage. Fortunately, PKU can be d...
Metabolize in Biological Technology

Kuvan Receives Priority Review Status From Health Canada

...ynthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA). ...

Kibow Biotech, Inc. to Present at BIO 2009 International Convention: Innovations to Heal, Fuel, and Feed the World

... (probiotics) that possess a high affinity for various nitrogenous waste products. When the kidneys are unable to filter toxins normally, the microbes metabolize the renal waste products and use them as nutrients for growth. As the microbes grow and replicate, they create colonies capable of utilizing even more...

Kibow Biotech, Inc. Launches Breakthrough Probiotic Dietary Supplement for Kidney Health in USA and Canada

...esearched and specifically selected beneficial microbes (probiotics) that possess a high affinity for various nitrogenous waste products. The microbes metabolize the waste products and use them as nutrients for growth. As the microbes grow and replicate, they create colonies capable of utilizing even more nitro...

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

...ynthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. Kuvan has received orphan drug designation from both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMEA). ...

Video: Accera Launches Axona(TM), First Medical Food Therapy to Help Manage Mild-to-Moderate Alzheimer's Disease

...zheimer's." Alzheimer's disease is a progressive and fatal neurological disease characterized by a substantial decrease in the brain's ability to metabolize glucose, which is the brain's primary source of energy. Known as hypometabolism, this defect may contribute to both the clinical and pathological cour...

Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing

...an vary due to each person's ability to process or metabolize thiopurines. Most people have no problem metaboliz... one percent of patients have almost no ability to metabolize these drugs. Failure to metabolize thiopurines can result in myelosuppression and hep...

Kuvan Receives Positive Opinion From CHMP for European Approval

...ynthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential treatment option for approximately 30 percent to 50 percent of the estimated 5...

ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems

...ne. This can be very useful in new FDA-mandated drug safety testing to evaluate active/toxic human drug metabolites. Studies have shown that drugs can metabolize differently in humans than in other animals, resulting in potentially toxic levels of drug metabolites that can't be identified by animal studies alon...

New yeast trick for eating favorite food: Details in Nature paper

...that the glucose network actively shuts down the galactose network by degrading messenger RNA that would otherwise go on to form the enzymes needed to metabolize galactose. "To find something new in the well-known galactose network after predicting it is extremely exciting," said Matthew Bennett, the first a...

Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU

...ynthetic form of 6R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalanine hydroxylase (PAH) to metabolize Phe. BioMarin and Merck Serono estimate that Kuvan could be a potential treatment option for approximately 30 percent to 50 percent of the estimated 5...
Metabolize in Biological Definition

Ames test

...lawn" is observed. S-9 In some Ames assays an S-9 mix is added. The S-9 mix contains liver enzymes , generally from a rat. These enzymes can metabolize the agent being tested in order to predict the mutagenic properties within a living system, specifically the source of the S-9 enzymes. Mutageni...
Metabolize in Biological Dictionary

Genomic library

...lus fumigatus. ... pWE15 and pLORIST2 genomic cosmid libraries of A. nidulans ... Second, we digest the genomic DNA of an organism that can metabolize lactose ... this strategy to make a library of genomic E. coli fragments in plasmids that ... ...
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