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Metabolites in Medical News

Survey of metabolites finds new prostate cancer marker

Howard Hughes Medical Institute researchers have identified a new biological marker present in the urine of patients with prostate cancer that indicates whether the cancer is progressing and spreading. In experiments reported in the February 12, 2009, issue of the journal Nature, the scientis...

Therapy should extend beyond childhood

...and tryptophan), which are components of proteins, but produce pathological metabolites that accumulate and can damage the developing brain. Even before birth, ...hers hypothesize that in the course of the disease, abnormally accumulating metabolites not only give rise to acute, but also to chronic toxic damage. For treatmen...

Common household pesticides linked to childhood cancer cases in Washington area

...se Control and Prevention to look for evidence of organophosphates (OP), the chemical name of some household pesticides. The body breaks down OP into metabolites which can be tracked in urine samples. The researchers say pesticides were detected in the urine of more than half of the participants, but levels of...

Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009

...aters ACQUITY TQD System, the MassTrak Immunosuppressants XE RUO Kit achieves high specificity in measuring the target analyte in the presence of drug metabolites and addresses some of the analytical weaknesses of immunoassay immunosuppressant drug measurement. The new MassTrak Immunosuppressants XE RU...

New Urine Drug Test to Detect for 6 Major Drugs, Now Available at Drugstore.com -- 'DrugConfirm' Is a New Revolutionary Urine Drug Test

... -Push Button Technology: The new DrugConfirm SplitScreen Cup is a fully integrated, self contained drug screening cup for detecting drugs and drug metabolites in urine. The Push Button technology ensures the integrity of both the sample and results. -No leaks, no mess: Leak proof snap-top lid. Fully Int...

Exposure to phthalates may be a risk factor for low birth weight in infants

...t bowel movement that occurs after birth, and cord blood to determine phthalate levels. They found quantifiable levels of phthalate and phthalate metabolites in more than 70% of the samples. Infants with low birth weight had consistently higher levels of phthalates. According to Dr. Ge, "The results showe...
Metabolites in Medical Technology

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

...nce Inc. today announced its integrated radiolabeled clinical pharmacology studies in compliance with Food and Drug Administration (FDA) guidance on metabolites in Safety Testing (MIST). Recent MIST guidance requires earlier human absorption, metabolism and excretion (AME) testing in support of Investigative ...

Researchers Discover Metabolite Linked to Aggressive Prostate Cancer

...f Pathology at the U-M Medical School. The researchers looked at 1,126 metabolites across 262 samples of tissue, blood or urine associated with benign prostat...nd advanced, or metastatic, prostate cancer. They mapped the alterations in metabolites and identified about 10 that were present more often in prostate cancer tha...

ELAD(R) Liver Support System Study Initiated at Multiple U.S. Centers

...real Liver Assist Device (ELAD). ELAD could provide support for patients with severe liver failure by processing toxins and synthesizing proteins and metabolites that are key products of normal human liver function. ELAD is in investigational clinical trials and VTI completed a pivotal trial and filed for marke...

MRI Emerges As Vital Resource in Treatment of Back Pain

...t type of MR imaging or CT imaging can be used successfully. However, if you want to find out which disk is causing pain, which nerve is firing, which metabolites are present in abnormal amounts, or how well the spinal elements are functioning, MR will provide the answers," adds Dr. Haughton. Discl...

Tigris Pharmaceuticals Signs CRADA with the National Cancer Institute

... Preclinical studies into AFP-464's mechanism of action have shown that AFP-464 induces CYP1A1/1A2 and CYP1B1 protein expression and is converted to metabolites that are covalently bound to DNA, resulting in phosphorylation of p53 with induction of the p53 downstream target p21(Waf1/Cip1) and apoptosis. AFP-46...

Biomarkers May Reduce the Need for Biopsies and Offer Personalized Care for Heart and Lung Transplant Patients

...gnatures of a disease process like rejection by measuring mRNA, proteins or metabolites in the blood or urine. Distillation of such data, along with clinical featu...alysis of gene expression in white blood cells, proteins in the plasma, and metabolites in blood and urine. The latter biomarkers provide information on the immune...
Metabolites in Medical Products

Cocaine & Metabolites Detection

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

SureStep Benzodiazepines (BZO 300)

Description:... For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Company:Inverness Medical Professional Diagnostics

SureStep Benzodiazepines (BZO 200)

Description:... For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Company:Inverness Medical Professional Diagnostics

AMPII/BAR/BZO300/COC/MAMP/MTD/MOP/THC

Description:... For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Company:Inverness Medical Professional Diagnostics

SureStep Propoxyphene (PPX)

Description:... For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Company:Inverness Medical Professional Diagnostics

SureStep Methadone (MTD)

Description:... For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Company:Inverness Medical Professional Diagnostics

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Metabolites in Medical Dictionary

Vitamin D

...Vitamin D is a group of fat-soluble prohormones, the two major forms of which are vitamin D2 and vitamin D3 . The term vitamin D also refers to metabolites and other analogues of these substances. Vitamin D3 is produced in... Information on vitamin D , sources, deficiency, and health risks of exc...

Metabolite

... metabolites are the intermediates and products of metabolism. ... . The metabolome represents the collection of all metabolites in a biological... Medical Health Encyclopedia...nds. Hundreds of Stores. When doctors talk of metabolites , they are often referring to a product of the ......

Liver

...called liver cancer. ... The liver is a large vertebrate organ positioned in the upper region of the ... liver regulates the level of many metabolites in the blood. 2.2 The liver ... Browse our comprehensive Liver Health Test Menu and find a center near you. ... Albumin is made in the liver ...

Galactose

...in milk. ... Galactose is a type of sugar found in milk products and sugar beets. ... It is converted to galactose -1-phosphate and other metabolites by several ... Brief and Straightforward Guide: What is Galactose ? ... Galactose is created by taking the natural substances found in hemicell...

Alcoholic neuropathy

...sial but may be the toxic effect ... Alcoholic neuropathy . ... features of alcoholic neuropathy , taking the effect ... of ethanol or its metabolites can cause alcoholic neuropathy . ... Alcoholic neuropathy - Overview, Alcoholic neuropathy is a disorder involving decreased nerve fu...

Aflatoxins

... toxic and among the most carcinogenic... Paper discussing the aflatoxins and their effects on humans and animals. ... Aflatoxins are toxic metabolites produced by certain fungi in/on foods and feeds. ... Aflatoxins are poisonous, carcinogenic. byproducts of the growth of several species ... I...
Metabolites in Biological News

Munich researchers discover new target for tailored antibiotics

...blocks dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP). Mammals and a large number of other organisms generate these essential metabolites via the so-called mevalonate pathway. But most human pathogens, including Plasmodium falciparum , have developed an alternate mechanism for producing...

U Alberta researcher in same group as Darwin and Hawking

... 50 per cent of hospital-acquired infections are resistant to common antibiotics. Veredas' work also centres around biosynthesis by fungi of important metabolites including cholesterol-lowering drugs such as statins. "The appointment is a great honour and I was very surprised and pleased," said Vederas. "The...

An easy way to find a needle in a haystack by removing the haystack

...d enables researchers to measure a large number of metabolites in biological samples, opening doors for targeted ...ad of improving the search for the "needles", i.e. metabolites such as sugars, fatty acids, amino acids, and othe... provided rich mass spectra of particular kinds of metabolites in real samples. With the new experimental pro...

From the glass to the brain in 6 minutes

...anes," says Dr. Armin Biller. Is all consumption of alcohol harmful for the brain? "Our follow-ups on the next day showed that the shifts in brain metabolites after moderate consumption of alcohol by healthy persons are completely reversible," says Dr. Armin Biller. "However, we assume that the brain's abili...

SRI International receives $100,000 Grand Challenges Explorations grant

...rgets are prone to mutations that can result in antibiotic resistance, researchers will target non-protein components of cells. Small organic molecule metabolites that are essential for the growth and survival of pathogenic bacteria will be used as targets for antibiotic discovery. "Antibiotic resistance is a...

Experts lay to rest long-held misconceptions about high fructose corn syrup at ILSI-USDA workshop

...ence that high fructose corn syrup and sugar (or sucrose) have differing effects on satiety, overall energy balance, metabolic hormones or biochemical metabolites such as triglycerides and uric acid all suggesting no unique causal role for high fructose corn syrup in obesity. According to Suzanne P. Murphy, ...
Metabolites in Biological Technology

Codexis Launches Codex(TM) MicroCyp Platform to Produce Drug Metabolites and Novel Lead Compounds

Introduced at Informex 2008 REDWOOD CITY, Calif., Jan. 29 /PRNewswire/ -- Codexis(R), Inc., a private biotechnology company and leading developer of clean manufacturing processes, today introduced the Codex(TM) MicroCyp Plate, a research productivity tool which can be use...

Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP System

Purpose In this application note, several different metabolite identification approaches are evaluated for their merits. A comprehensive examination of four Information Dependent Acquisition (IDA) survey modes was performed to illustrate data quality and types of metabolites ...

Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System

Purpose This application note describes the use of the new Q TRAP LC/MS/MS system with Metabolite ID software for Phase I and Phase II metabolite identification and discusses its unique capabilities that increase your productivity and confidence in your results. Ov...

Simultaneous Detection of CYP3A4, CYP2D6 and CYP2C9 Metabolites with a Single, Sensitive, LC/MS/MS Method

Jason S. Wood, Varian, Inc. Introduction Cytochrome P450s (CYPs) are heme-containing enzymes responsible for initial metabolism of xenobiotics within the human body 1 . CYPs are part of the Phase I (oxidative) metabolism within the body, which introduces a hydrophil...

Analysis of Nitrofurans Metabolites by Positive Ion Electrospray LC/MS/MS

Z. Yang, Varian, Inc. Introduction Nitrofuran antibiotics are veterinary drugs. The use of these in food production is already banned in the United States, Australia, Canada, Japan, Singapore, Bangladesh, and the European Union because of a possible increased cancer...

High sensitivity quantitation of metabolites of nitrofuran antibiotics in animal tissue using LC/MS/MS

A sensitive and simple high performance liquid chromatograph tandem mass spectrometry (LC/MS/MS) method is presented for a simultaneous analysis of the metabolites of four nitrofuran antibiotics in chicken tissue. Abstract The animal meat samples were prepared by ho...

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Metabolites in Biological Products

Human 25-Hydroxy Vitamin D EIA Kit from IDS Ltd

Description:...S 25-Hydroxy Vitamin D kit is an enzymeimmunoassay intended for the quantitative determination of 25-hydroxyvitamin D (25-OH D) and other hydroxylated metabolites in human serum or plasma. Our patented DIRECT assay technology eliminates the inconvenience of solvent precipitation and centrifugation and therefore ...
Company:IDS Ltd

8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha from Cayman Chemical

Description:...03b1; is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infuse...
Company:Cayman Chemical

Amphetamine ELISA Kit, Ultra from Neogen Corporation

Description:...zyme-linked immunosorbent assay (ELISA) test kits are qualitative one-step kits designed as screening devices for the detection of drugs and/or their metabolites in forensic samples. The kits are intended for forensic use only. It is recommended that all suspect samples be confirmed by a quantitative method suc...
Company:Neogen Corporation

LTQ XL Linear Ion Trap from Thermo Scientific

Description:...niques (PQD, ETD, CID) Extensive coverage for predicted and unpredicted metabolites Fast polarity switching for high-sensitivity analysis of unknowns I... Whether you analytical challenge is metabolic profiling, mining for metabolites or biomarker discovery, the LTQ XLs exceptional suite of innovative techniq...
Company:Thermo Scientific

Imaging Mass Spectrometry for Small Molecule Localization from Protein Discovery, Inc.

Description:...ions and aligns them with histological images so you can localize drugs and metabolites prior to synthesizing radiolabeled compound. Imaging mass spectrometry enab...beled fraction Nonradioactive Differentiates drug compound from metabolites Preserves spatial information No microdissection No homog...
Company:Protein Discovery, Inc.
Metabolites in Biological Definition

ATPase

...iological membranes ), and move solutes across the membrane. (These are called transmembrane ATPases ). Transmembrane ATPases import many of the metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. An important example is the sodium-potass...

Bioinformatics

...ems Main article: Systems biology Systems biology involves the use of computer simulations of cellular subsystems (such as the networks of metabolites and enzymes which comprise metabolism , signal transduction pathways and gene regulatory networks ) to both analyze and visualize the complex co...

Chloroplast membrane

...6 and 8 nm thick, and the two are separated by a gap of 10-20nm, called the intermembrane space. The outer membrane is permiable to most ions and metabolites , but the inner membrane is highly specialised with transport proteins . Within the inner membrane, in the region called the stroma , there is a s...

Bioinformatics

...ems Main article: Systems biology Systems biology involves the use of computer simulations of cellular subsystems (such as the networks of metabolites and enzymes which comprise metabolism , signal transduction pathways and gene regulatory networks ) to both analyze and visualize the complex co...

Liver

... A number of liver function tests are available to test the proper function of the liver. These are enzymes that are most abundant in liver tissue, metabolites or products. Liver transplantation Liver transplantation is an option for those with irreversible liver failure. Most transplants are done fo...

Mycology

... model organisms Saccharomyces cerevisiae and Schizosaccharomyces pombe . Many fungi produce toxins , antibiotics , and other secondary metabolites . For example, the cosmopolitian (worldwide) genus Fusarium and their toxins associated with fatal outbreaks of alimentary toxic aleukia in humans...
Metabolites in Biological Dictionary

Secondary metabolite

... Secondary metabolites are organic compounds that are not directly involv...ve evolved a... The search for new secondary metabolites from microorganisms in general, however, ... Ferm... metabolite . ... However, many other secondary metabolites are induced by JA elicitation of N. ... Screen...

Herbivores

...ew and used books like Herbivores Their Interactions with Secondary Plant metabolites Volume 2... Online Shopping at SpotCost.com - New and used books like Herbivores Their Interactions with Secondary Plant metabolites Volume 2 Second Edition Ecological and... ...

Chemiosmosis

... membrane during cellular respiration. chemiosmosis A process in which a proton gradient across a mitochondrial membrane and ATP synthesis pump metabolites across a Chemiosmosis is central to the metabolism of many types of cells: a methane ... In each of these situations, chemiosmosis is the pro...
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