Researchers discover metabolite linked to aggressive prostate cancer

AUDIO: Researchers from the University of Michigan Comprehensive Cancer Center have identified a panel of small molecules, or metabolites, that appear to indicate aggressive...

How DDT metabolite disrupts breast cancer cells

Research has shown that the main metabolite of the insecticide DDT could be associated with aggressive breast cancer tumours, but there has been no explanation for this observation to date. Now a report published in the open access journal Breast Cancer Research shows how DDT could act to disrupt ...

Immunosuppressive Action Of Fungal Metabolite - Gliotoxin

Researchers from Japan have recently demonstrated the first evidence that mast cell is a direct target of gliotoxin. Fungal secondary metabolites such as gliotoxin, an epipolythiodioxopiperazine toxin produced by pathogenic fungi like Candida and Aspergillus//, possess immunosuppressive activit...

Daiichi Sankyo and Lilly Receive U.S. FDA Approval for Effient(TM)

... as omeprazole, also inhibit CYP2C19(iii). As stated in the Plavix prescribing information, studies have shown that formation of clopidogrel's active metabolite may be affected by patients with reduced CYP2C19 function or by drugs that inhibit CYP2C19, including certain proton pump inhibitors such as omeprazol...

Hyperion Therapeutics Raises $60 Million Series C

...aration. The most common adverse reactions associated with BUPHENYL were amenorrhea dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these dr...

Jazz Pharmaceuticals to Present Data From First Phase III Study of Sodium Oxybate in Patients With Fibromyalgia

...by the end of 2009. About Sodium Oxybate Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sod...

Metabolite in Medical Technology

Researchers Discover Metabolite Linked to Aggressive Prostate Cancer

Finding could lead to test to help guide treatment decisions ANN ARBOR, Mich., Feb. 11 /PRNewswire-USNewswire/ -- Researchers from the University of Michigan Comprehensive Cancer Center have identified a panel of small molecules, or metabolites, that appear to indicate aggressive prostate c...

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

...etes. Preclinical animal studies with the Company's compounds or its active metabolite have demonstrated reductions in blood pressure, triglycerides, cholesterol ...ntrol required for clinical study and it is converted to the natural active metabolite in the gastrointestinal tract. It effectively combines the properties of an...

Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints

...s to the editor About Sodium Oxybate Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sod...

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

...perienced radiochemical and chemical analysis services to obtain definitive metabolite disposition data in humans. Covance offers 24-hour turnaround of Goo...f parent compound; total radioactivity; pharmacokinetic interpretation; and metabolite profiling and identification. Covance's clinical development service...

Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia

...rations accordingly. About Sodium Oxybate Sodium oxybate is the sodium salt form of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sod...

Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders

...aration. The most common adverse reactions associated with BUPHENYL were amenorrhea dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these dr...

Metabolite in Medical Products

Trimipramine & Metabolite Quantitation, Urine

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Trimipramine & Metabolite Quantitation, Serum or Plasma

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Triazolam & Metabolite Quantitation, Serum or Plasma

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Psilocybin Metabolite Quantitation, Serum or Plasma

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Psilocybin Metabolite Quantitation, Urine

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Propoxyphene & Metabolite Confirmation/Quantitation, Serum or Plasma

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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Metabolite in Medical Dictionary

Metabolite

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. A secondary metabolite is not directly involved in those processes, but usua...

Pregnanediol

... ... A test can be done to measure the amount of pregnanediol in urine. ... pregnanediol ( preg′nanə′dī′öl ) ( biochemistry ) C 21 H 36 O 2 A metabolite of progesterone, present in urine during the progestational phase of the pregnanediol a compound found in women's urine during certain phas...

Metabolite in Biological News

First finding of a metabolite in 1 sex only

Researchers at the University of Illinois at Chicago have discovered a chemical compound in male blue crabs that is not present in females -- the first time in any species that an entire enzyme system has been found to be activated in only one sex. The research, performed using nuclear magneti...

Chemicals in common consumer products may play a role in pre-term births

...ine samples collected during the third trimester and compared them to the control group who carried to term. They found significantly higher phthalate metabolite levels in the women who delivered prematurely. Premature birth is a significant risk factor for many health problems in childhood that can persist...

Embryology study offers clues to birth defects

...es that control the growth and differentiation of progenitor cells by regulating specific genes. One of these signaling molecules is retinoic acid, a metabolite produced from vitamin A (retinol), which plays a key role in the development of limbs and other organs. Dr. Duester's lab was instrumental in identify...

Simulating pharmaceutical and personal care product transport

...-equilibrium sorption in macropores using data from experiments on the transport of three PPCPs (atenolol, carbamazepine, and triclosan), the nicotine metabolite cotinine, and the strongly sorbing dye rhodamine WT applied in LMB. The study was financed by grants from the European Union (ERAPharm, project no. 51...

Genetic switch potential key to new class of antibiotics

...f by the riboswitch. In the current study, Wedekind and colleagues solved the crystal structure of a preQ1 riboswitch in complex with its precursor metabolite preQ0. They chose to study the riboswitch from Thermoanaerobacter tengcongensis, a tough bacterium that lives at extreme temperatures and was first fo...

Malaria parasite zeroes in on molecule to enhance its survival, team finds

...abolic processes by simultaneously measuring the levels of all of the more than 500 core metabolites that make up an organism's "metabolic network." A metabolite is a chemical involved in metabolism, the process by which an organism takes up nutrients from the environment and converts them to energy and the mol...

Metabolite in Biological Technology

XenoTech LLC Offers Drug Industry New Metabolite Profiling Services Following Acquisition of Waters Synapt HDMS System

Investing in Groundbreaking Mass Spectrometry Technology Allows Contract Research Organization to Offer Pharmaceutical Clients Comprehensive Pre-Clinical Study Data MILFORD, Mass., Feb. 16 /PRNewswire-FirstCall/ -- Waters Corporation (NYSE: WAT ) announced today that XenoTech (Lenexa, K...

Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing

SAN DIEGO, Oct. 30 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostics company, announced that the U.S. Patent and Trademark Office (USPTO) has issued two separate patents covering the technology for PROMETHEUS(R) Thiopurine Metabolites, a diagnostic test t...

Codexis Licenses New Drug Metabolite Profiling and Lead Diversification Technology From the California Institute of Technology

Potential Earlier Identification of Toxicity, Efficacy for Pharmaceutical Developers REDWOOD CITY, Calif., Aug. 29 /PRNewswire/ -- Codexis, Inc., a private biotechnology company and leading developer of clean manufacturing processes, today announced it has licensed...

Determination of Acepromazine and its Major Metabolite in Equine Serum by LC-MS/MS using the Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer

Chromatography and Mass Spectrometry Application Report Key Words Sensitivity Quantitation Finnigan LCQ Deca XP Plus Equine serum Acepromazine Gargi Choudhary, Thermo Electron Corporation, San Jose, CA USA Wayne Skinner and Scott Stanley, Universi...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

Chromatography and Mass Spectrometry Application Note Key Words Metabolism Study Structure Elucidation Metabolite ID Mass Frontier Mark R. Kagan, Thermo Electron Corporation Introduction The characterization of a drugs metabolites plays a ...

Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS

With the advent of liquid chromatography/ mass spectrometry and information dependent data acquisition function in mass spectrometry, it has become possible to characterise metabolites while to quantifying their parents during metabolic stability studies. This was once impossible to be an...

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Metabolite in Biological Products

Cocaine Metabolite ELISA Kit, Single from Bio-Quant Inc.

Description: Request Info...
Company:Bio-Quant Inc.

Prostaglandin E1-d4 from Cayman Chemical

Description:.... It is intended for use as an internal standard for the quantification of PGE1 by GC- or LC-mass spectrometry. PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes ...
Company:Cayman Chemical

20-HETE-d6, Deuterium Conjugated/Tagged from Cayman Chemical

Description:... 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pr...
Company:Cayman Chemical

20-HETE-d6, Deuterium Conjugated/Tagged from Cayman Chemical

Description:... 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature. In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pr...
Company:Cayman Chemical

8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha from Cayman Chemical

Description:...to Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys...8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-i...
Company:Cayman Chemical

LTQ XL Linear Ion Trap from Thermo Scientific

Description:...combination with new software packages, the LTQ XL delivers complete solutions for your structural elucidation questions MetWorksTM - Automated metabolite Identification Mass FrontierTM 5 - Structure Elucidation BioWorksTM 3.3 - Protein Identification SIEVETM - Automated Label-Free Differenti...
Company:Thermo Scientific

Metabolite in Biological Definition

Secondary metabolite

Secondary metabolites , also known as natural products , are those products (chemical compounds) of metabolism that are not essential for normal growth, development or reproduction of an organism . In this sense they are "secondary". The function or importance of these compounds to the orga...

Metabolite in Biological Dictionary

Secondary metabolite

Secondary metabolites are organic compounds that are not directly involved in the normal growth, development, or reproduction of organisms. Unlike primary metabolites, absence of secondary metabolities does not result in immediate death, but rather in long-term... Aspects of the topic sec...

Coenzymes

...rred to as cosubstrates. ... The term coenzymes is sometimes defined in such a way as to include prosthetic ... Coenzymes fall into two groups: metabolite ... Of the metabolic coenzymes , the most widely used is adenosine triphosphate, ATP, ... which is itself a coenzyme . ... Get information, fac...