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mediated in Medical News

Reprints Desk Makes Pharmaceutical ePrint Procurement Service Available Through FIZ AutoDoc Document Delivery System

...aceutical industry." FIZ AutoDoc is the document delivery system of choice for many of Europe's largest corporations, supporting unmediated and mediated ordering for single journal articles, patent documents, reports, conference papers, proceedings or other publications. Reprints Desk offers ePrint pr...

A Curse or Two Might Quell the Pain

...eased even more than men's. "Swearing may raise levels of aggression, downplaying feebleness in favor of a more pain-tolerant machismo, most likely mediated by classic fight-or-flight mechanisms," said the study's lead author, Richard Stephens, a lecturer in psychology at Keele University. "Swearing has...

New role discovered for molecule important in development of the pancreas

...cursors. Pdx1 binds directly to the Ngn3 gene, controlling its expression; it does this by forming a molecular complex with the protein Hnf6, which is mediated by the Pdx1 C terminus. Pdx1 also binds directly to and controls the expression of two additional endocrine cell genes, Hnf1b and Foxa2. "Pdx1 not...

Pharmacyclics Sets Record Date for Rights Offering

...R) is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the Company is to create a profitable business by generating income from products it develops, licenses and commerc...

Gene's novel role may provide key to treating liver and neurodegenerative diseases

...in-animal model to study the role of FAIM in detail. FAIM triggers a mechanism that ultimately impedes an important pathway to apoptosis, which is mediated by a key protein called Fas. Using their mouse model, the scientists elucidated part of the sequence of molecular events that regulates Fas-mediated a...

Risk of cancer

..., which activates pathways that are central to the development of cancer. The impacts of this altered genetic regulation on cell division are probably mediated via the MYC cancer gene, which is one of the best known accelerator genes in cancer. Single-base changes are the most common type of variation foun...
mediated in Medical Technology

Pharmacyclics Announces Preclinical Results Supporting Development of Its Novel Btk Inhibitor in Immune Mediated Diseases

SAN DIEGO and SUNNYVALE, Calif., April 14 /PRNewswire-FirstCall/ -- Pharmacyclics, Inc. (Nasdaq: PCYC ) today presented results from its preclinical program evaluating PCI-32765, an orally available, selective inhibitor of Bruton's tyrosine kinase, or Btk, in B-cell receptor (BCR) modulated d...

Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints

... of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA and marketed by J...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

...s in the area of type 1 diabetes. Beyond diabetes, we also look forward to investigating teplizumab with MacroGenics to potentially treat other T-cell mediated autoimmune diseases." About Teplizumab Teplizumab, an investigational compound under development for the treatment of individuals with recent...

Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia

... of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the treatment...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

...4 hours after dosing and a complete amelioration of disease was achieved with a single dose. When compared to anti-TNF-a therapy (etanercept), PR-957 mediated a more rapid resolution of clinical symptoms, including joint inflammation, and was more effective than etanercept in a model of aggressive arthritis....

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

.... Monia, G.W. Cline, V.T. Samuel, G.I. Shulman. Matrix Metalloproteinase-9: Association With Insulin Resistance and Obesity and PKC-alpha mediated Regulation by Pioglitazone Authors: R. Unal, A. Yao-Borengasser, V. Varma, N. Rasouli, B. Phanavanh, C. Labbate, B.P. Monia, P.A. Kern, G. Ran...
mediated in Medical Products

Vasopressin (AVP) RIA Test

Description:...eep and exercise [1]. The primary function of AVP is the regulation of water permeability of the renal collecting tubules and ascending loop of Henle. mediated through activation of cAMP, the effect of AVP is to allow the kidney to reabsorb water and concentrate urine [1]. At high plasma concentrations, AVP i...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, w/ Extraction IRMA Test

Description:...ch is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the recepto...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, w/ Extraction ELISA Test

Description:...ch is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the recepto...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, Non-Extraction IRMA Test

Description:...ch is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the recepto...
Company:Diagnostic Systems Laboratories, Inc.

IGF-II, Non-Extraction ELISA Test

Description:...ch is secreted primarily by the liver and is postulated to have mitogenic and metabolic actions involved in cellular growth. The actions of IGF-II are mediated by binding to target cell receptors. IGF-II binds with high affinity to the Type II IGF receptor, a monomeric protein which also serves as the recepto...
Company:Diagnostic Systems Laboratories, Inc.

hGH IRMA Test

Description:...somatostatin, while the amplitude of GH release is determined by GHRF. GH has profound effects on tissue growth and metabolism, which is thought to be mediated through GH-dependent production of IGF-I and IGF-II, and their associated binding proteins. GH apparently stimulates IGF production after binding to s...
Company:Diagnostic Systems Laboratories, Inc.
mediated in Medical Definition

Blind loop syndrome

... 4 Signs and tests 5 Treatment Physiology The obstruction of a section of intestine causes ineffective bile salt mediated digestion of fats, causing fatty stools and poor absorption of fat and fat-soluble vitamins. Vitamin B12 deficiency may occur because the increased ...

Depolarization-induced suppression of inhibition

...o way of producing an in vitro endocannabinoid mediated effect. DSI is classically produced in a brain s...conds. After the depolarization, inhibitory GABA mediated neurotransmission is reduced. This has been demons...ss to GABA during DSI. Somehow, DSI appeared to be mediated by a retrograde synaptic messenger whose synthesis...

Therapeutic gene modulation

...ry protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly. Modulation of gene expression can be mediated at the level of transcription by artificial transcription factors or at the level of translation through RNA interference . See also ...

Thymocyte

... the thymus showing the cortex and medulla Minute structure of thymus. The ability of T cells to recognise foreign antigens is mediated by the T cell receptor , which is a surface protein able to recognise short protein sequences ( peptides ) that are presented on MHC . During the do...
mediated in Medical Dictionary

Vesicle

...e using ... The mechanism of GLUT4 vesicle exocytosis in response to insulin is not understood. ... Vesicle binding to microtubules was not mediated through direct binding ... The Alzheimer Research Forum, a dynamic online scientific knowledge base, reports on the latest Alzheimer's ... and the...

Vasoconstriction

...sed by ... associated with renal vasoconstriction favour the vasodilatory response ... Vasoconstriction , narrowing of blood vessels. It is mediated by the vasomotor center in the brain stem, causing reflex changes in the heart rate with. Wolff suggested that the vasoconstriction occurring ...

Vasodilation

...f vasoconstriction, or the... Vasodilation and vasoconstriction are also used antagonistically as ... Vasodilation is a similar process mediated by antagonistically acting mediators. ... ... function in human subjects as indexed by flow-mediated arterial vasodilation . ... Key Words: aldo...

Smell

... Olfaction refers to the sense of smell . This sense is mediated by specialized sensory cells of the nasal cavity of vertebrates, and, by analogy, sensory cells of the antennae of invertebrates. For air-breathing ...

Olfactory

... Olfaction refers to the sense of smell. This sense is mediated by specialized sensory cells of the nasal cavity of vertebrates, and, by analogy, sensory cells of the antennae of invertebrates. For air-breathing ...

Monocyte

...te -derived DC may be closest to the interstitial DC or CD14+-derived ... During atherogenesis, monocyte -EC interaction in stimulated ECs may be mediated ... Cyclical strain increases monocyte chemotactic protein-1 secretion in human ... Monocyte -derived macrophages (MDMs) play a central role ...
mediated in Biological News

Stem cell research: From molecular physiology to therapeutic applications

...cal properties of stem cells and developing nonhuman primate models for stem cell-based therapy of degenerative diseases. He has developed a stem cell mediated expression system for treating Parkinson's disease and his research using pancreatic progenitor cells for treating diabetes has demonstrated efficacy ...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...s complex mental functions such as thinking, learning, memory or emotion is mediated by a large number of chemical neurotransmitters and neuromodulators. Distur...and minimising adverse events. For instance, the signalling of serotonin is mediated by 14 receptor subtypes. As one of the main mediators of the neurotransmitt...

The SIB recognizes the next generation of bioinformaticians

...terization of protein sequences. A key feature of the method is that it is able to disentangle direct interactions from indirect interactions that are mediated via other residues. As such the method greatly improves the prediction of contacting amino acids in the 3-dimensional structure of proteins and is thu...

One size does not fit all

...spect of MS, allowing MNI researchers to determine the direct effect of long-term statin therapy on remyelination, independent of its indirect effects mediated via immune modulation. "The results of our study indicate that simvastatin has in fact, a slightly deleterious effect on myelin under non-pathologi...

FANTOM findings boost for biologists

...l's open access journals, including Genome Biology and BMC Bioinformatics , provide further insight into HCNE (highly conserved non-coding element) mediated long-range gene regulation at the core of animal multicellularity regulation. Now at its fourth stage, FANTOM4, prominently led by OSC's Yoshihide ...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

... at the annual ASPB meeting in 2010. David Seung, University of Sydney Mentor: Jan Marc The interaction of abscisic acid and phospholipase D mediated pathways in environmental stress signaling: The role of the cytoskeleton It is with great honor and excitement that I accept this award. I would lik...
mediated in Biological Technology

Pharmacyclics, Inc. Rights Offering Oversubscribed

...)) is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the company is to create a profitable business by generating income from products it develops, licenses and commerc...

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

...VHD is an inflammatory disease initiated by T cells in the donor graft that recognize histocompatibility and other tissue antigens of the host, and is mediated by a variety of effector cells and inflammatory cytokines. GVHD presents in both acute and chronic forms. The symptoms of cGVHD typically present at b...

Novavax Announces Selection of a Respiratory Syncytial Virus Vaccine Candidate for Advanced Preclinical Studies

...ce of the native virus. The particle nature of the vaccine holds the promise for inducing a broad set of immune responses including antibody and cell mediated immune responses to prevent infection of the respiratory tract and attack respiratory cells that may already be infected with RSV. The ...

Pharmacyclics Announces Subscription Price for Rights Offering

...R) is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative small-molecule drugs for the treatment of immune mediated disease and cancer. The purpose of the Company is to create a profitable business by generating income from products it develops, licenses and commerc...

Bion Announces Approval of New U.S. Patent that Broadens Protection for the Company's Livestock Waste Environmental Treatment Processes

...es, Inc. (OTC Bulletin Board: BNET) announced today that it was notified that its U.S. Patent application 11/592,513 entitled "Low Oxygen Biologically mediated Nutrient Removal" has been approved. The patent application was made on November 6, 2006; upon publication and issuance, the patent will be officially...

Centocor Ortho Biotech Inc. Awarded $1.67 Billion Patent Jury Verdict from Abbott Laboratories

...assert intellectual property rights for our immunology therapies, as they offer significant advances in treatment for patients with a number of immune mediated inflammatory diseases," Taylor added. About Centocor Ortho Biotech Inc. Centocor Ortho Biotech Inc. redefines the standard of care in immunol...

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mediated in Biological Products

Mouse Anti-67kD Laminin Receptor Prediluted Monoclonal Antibody, Unconjugated, SPM278 from GeneTex

Description:...ther species. Background Information Laminin, one of the major glycoproteins of basement membrane, displays multiple biological activities which are mediated through its interaction with specific cell membrane receptors. Overexpression of Laminin Receptor is reportedly an independent prognostic factor in br...
Company:GeneTex

GenoStat Inducible Expression System from Upstate

Description:...tly regulated control of exogenous gene expression in mammalian cells and is capable of repeated on/off expression kinetics. This degree of control is mediated by the highly specific interaction between the GenoStat Ligand and the chimeric bipartite nuclear receptor complex. Gene expression levels are easily ...
Company:Upstate

Phagocytosis Fluorometric (dichlorofluorescein) Assay Kit, OxyBURST from Molecular Probes (Invitrogen)

Description:... Green reagent (F-2902) was developed in collaboration with Elizabeth Simons of Boston University to permit measurement of the kinetics of Fc receptor mediated internalization and the subsequent oxidative burst directly in the phagovacuole.2 The Fc OxyBURST Green assay reagent consists of bovine serum albumin...
Company:Molecular Probes (Invitrogen)

Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex

Description:... Mouse monoclonal [HDAC8-48] to HDAC8 Regulation of gene expression is mediated by several mechanisms such as DNA methylation, ATP-dependent chromatin remodeling, and post translational modifications of histones, which include the...
Company:GeneTex

Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Description:...d promotes the rapid degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14^ARF^ and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both ...
Company:Lab Vision

FRT flanked, Pro and Euk. Neomycin Selection Cassette plus loxP site(FRT-PGK-gb2-neo-FRT-loxP) from Gene Bridges GmbH

Description:...ction sites can be introduced by adding the corresponding sequence in the PCR primer. The template can easily be used to generate targeting constructs mediated by Red/ET Recombination. The FRT-PGK-gb2-neo-FRT-loxP template is not linear but plasmid based (3485 bp in size). Due to its R6K origin the plasmid c...
Company:Gene Bridges GmbH
mediated in Biological Definition

Active transport

... Active transport is the mediated transport of biochemicals , and other atomic / molecular substances, across membranes . Unlike passive transport , this process requires chemi...

Dendrite

...shown that action potentials do propagate back into the dendrites once initiated in the axon in most neurons. This backpropagating action potential is mediated by the activation of voltage-gated ion channels and can interact with synaptic input to alter the synaptic activity. The structure and branching of ...

Enzyme

...2 Structure and function 2.1 Rate of enzyme mediated reactions 2.2 Specificity 2.3 Kinetics 2....ed reactions in one direction. Rate of enzyme mediated reactions Main article: Rate of enzyme mediated reactions Enzymes can increase reaction rate ...

Facilitated diffusion

...nsport ) is a process of passive transport ( diffusion ) via which molecules diffuse across membranes , with the help of transport proteins ( mediated transport ). Small uncharged molecules can easily diffuse across cell membranes. However, due to the hydrophobic nature of the lipids that make up...

Michaelis-Menten kinetics

...elis-Menten kinetics describe the rate of enzyme mediated reactions for many enzymes. It is named for Leon...tant. To determine the maximum rate of an enzyme mediated reaction, the substrate concentration ( [S] ) is...city , the factors that effect the rate of enzyme mediated reactions (ie. pH, temperature, etc) are at optim...

Neuron

...of thousands of other cells. Types of signalling Neurons communicate with one another across synapses. This communication is usually chemically mediated by rapid secretion of neurotransmitter molecules . Pre-synaptic neurons (i.e.the neurons which release the neurotransmitter) may produce in the p...
mediated in Biological Dictionary

Trans-splicing

...ntinuity of genetic information in ... Cis- and trans - splicing of mRNAs mediated by ... Trans - splicing Trans - splicing is a special form of RNA ...s a modification of an RNA after ... Cis- and trans - splicing of mRNAs mediated by tRNA sequences in eukaryotic cells". Proc. ... leader RNA was tested ...

Transport protein

...sequence are ... The transport protein molecules that arrive at the surface membrane contribute ... Insulin-activation of GLUT4 transport is mediated by GTP-binding proteins . ... of transport proteins in the outer cell membrane. In principle the GLUT family ... Glucose transport prot...

Transduction

...asic biological processes, their ... The Signal Transduction Laboratory (STL) is involved in defining the molecular mechanisms of the G protein mediated signal transduction pathways. ... Definition of transduction from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, W...

Tet resistance

...f the Tet (B) antiport protein.Antimicrob. ... tetracycline resistance mediated by hybrid Tet proteins. ... ... tetracycline resistance determin...istance . Resistance to the TET for gram-neg and gram-pos bacteria is mediated by ... Absorption of TET is impaired by food in the stomach, milk product...

T cell

... system. ... T cells belong to a group of white blood cells known as lymphocytes and play a ... Their major role is to shut down T cell mediated immunity towards the end of an ... Immunobiology is intended as an introductory text for use in immunology courses for ... Naive T cells requ...

Spliceosome

... is ... Mechanical Devices of the Spliceosome : Motors, Clocks, Springs, and Things ... EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics mediated by Brr2p, a ... ... spliceosome , a big ribonucleoprotein particle composed of some 300 proteins and five RNAs. But, where and how does the spl...
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(Date:9/30/2014)... (PRWEB) September 30, 2014 The ... to improve breast cancer risk prediction and to ... a study published in Breast Cancer Research (BCR ... density and breast cancer risk: a case-control study ... strong connection between breast density and breast cancer ...
(Date:9/30/2014)... partners successfully established a visual mapping of the ... suppressor cells (MDSC). The damage and immune suppression ... this is a major stepping stone in creating ... factors from precursors present in hematopoietic organs such ... population of cells suppresses the activity of various ...
(Date:9/30/2014)... University of Eastern Finland shows that dietary polyunsaturated fatty ... The sources of polyunsaturated fatty acids include fish, vegetable ... Arteriosclerosis, Thrombosis & Vascular Biology , an esteemed journal ... not found an association between the consumption of saturated ... that the mere reduction of saturated fats from the ...
(Date:9/30/2014)... This two-day, advanced PT continuing education course ... may arise following a concussion or mild traumatic brain ... from sports related injuries, car accidents, falls, to the ... of returning soldiers from war zone regions. While at ... can result in similar injuries, the course will emphasize ...
(Date:9/30/2014)... By Dennis Thompson ... -- Every day, people receive medical implants -- artificial ... may not have been rigorously tested before or after their ... studies contend. The studies -- conducted by prominent nonprofit ... Medicine -- lay the blame for inadequate medical device ...
Breaking Medicine News(10 mins):Health News:Mammographic Density Offers Potential to Improve Prediction of Breast Cancer Risk and Development of Personalized Screening 2Health News:Mammographic Density Offers Potential to Improve Prediction of Breast Cancer Risk and Development of Personalized Screening 3Health News:Mammographic Density Offers Potential to Improve Prediction of Breast Cancer Risk and Development of Personalized Screening 4Health News:Dietary polyunsaturated fatty acids linked to smaller risk of coronary heart disease 2Health News:North American Seminars Presents Traumatic Brain Injury and Concussions in Conduction with St. Anthony's Medical Center in St. Louis, MO on November 8-9, 2014 2Health News:North American Seminars Presents Traumatic Brain Injury and Concussions in Conduction with St. Anthony's Medical Center in St. Louis, MO on November 8-9, 2014 3Health News:Medical Implant Devices Skate Through Review Process, Studies Claim 2Health News:Medical Implant Devices Skate Through Review Process, Studies Claim 3Health News:Medical Implant Devices Skate Through Review Process, Studies Claim 4
(Date:9/30/2014)... , Sept. 30, 2014  Spectra ... solutions for the biotech and power generation ... new RECONN Bioprocess Manager, an easy-to-use and ... geared towards bioprocess development laboratories. ... disparate bioreactor and analyzer systems. Accessing and ...
(Date:9/30/2014)... 30, 2014) People who suffer from asthma may ... control their asthma besides properly taking medications and avoiding ... in the Annals of Allergy, Asthma and Immunology ... Allergy, Asthma and Immunology (ACAAI), asthma sufferers can learn ... The woman described in the Annals article improved her ...
(Date:9/29/2014)... Clostridium ramosum , coupled with a high-fat diet, may ... week in mBio , the online open-access journal of ... from the German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal ... ramosum gained weight when fed a high-fat diet. Mice ... obese even when consuming a high-fat diet, and mice that ...
Breaking Biology News(10 mins):Spectra Automation Introduces RECONN Bioprocess Manager 2Asthma symptoms kicking up? Check your exposure to air pollution 2Gut bacteria promote obesity in mice 2
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