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Mast in Medical News

What is the effect of fluoxetine on mast cell?

Mast cells are now recognized as "granular cells of the connective tissue", whose activation exacerbates allergic immune responses and as key players in the establishment of innate immunity as well as modulators of adaptive immune responses. The role of mast cells in the gastrointestinal mucosa is...

Lungs' mast cells could provide new treatment target for asthma, other respiratory disease

NEW YORK (Jan. 29, 2008) -- An enzyme released by mast cells in the lungs appears to play a key role in the tightening of airways that is a hallmark of asthma -- pointing to a potential new target for treatment against the illness. Reporting in the online edition of Proceedings of the National ...

Cancer and psoriasis triggered by mast cells

The body's mast cells are linked to allergic reaction in a manner with which histamine and other inflammatory substances are released. However, researchers at Karolinska// Institute have now shown how mast cells can cause diseases like psoriasis and cancer. Mast cells have been known for the...

Unhooking the Obesity-Diabetes Connection

...udy looked at another class of immune cells called mast cells, which are more commonly linked to allergies. An over-abundance of mast cells contributed to obesity and diabetes in mice, but when mast cells were removed from the system the problem was...

Abbott and Oasmia Pharmaceutical Announce Exclusive Distribution Agreement for Paccal(R) Vet, a New Chemotherapeutic Agent for Dogs

...ing studied to treat Grade II and Grade III canine mast cell tumors where curative surgery cannot be perfo...important tool for treating Grade II and Grade III mast cell tumors - both of which can be life-threatenin...one cause of death in dogs over two years of age. mast cell tumors are among the most common skin tumors ...

Dermatologic and Ophthalmic Drugs Advisory Committee Unanimously Recommends Bepreve(TM) for the Treatment of Ocular Itching Associated with Allergic Conjunctivitis

...ophthalmic solution) 1.5% Bepreve is a non-sedating, highly selective antagonist of the histamine (H1) receptor. It has a stabilizing effect on mast cells, and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an e...

ISTA Pharmaceuticals Announces FDA Advisory Committee to Review Bepreve(TM) for the Treatment of Ocular Itching Associated with Allergic Conjunctivitis

...stine ophthalmic solution) Bepreve is a non-sedating, highly selective antagonist of the histamine (H1) receptor. It has a stabilizing effect on mast cells and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an ef...

Adhesion Barrier Market to Skyrocket to Over $550 Million by 2013

...ioSurgery, Covidien, CryoLife, Davol (a subsidiary of C.R. Bard), Ethicon (a Johnson & Johnson company), Genzyme Biosurgery, King Pharmaceuticals, mast Biosurgery, Orthovita, Pfizer, and many more. About Millennium Research Group Millennium Research Group ( www.MRG.net ), a Decision Resources...

Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis

...ain nerve fibers themselves, connective tissue and mast cells, the latter of which circulate in the blood ...nteraction between NF1-/- Schwann cells and NF1+/- mast cells. While Schwann cells appear to be the primary tumor causing cell, mast cells appear to stimulate tumor growth by recruiti...

Cancer requires support from immune system to develop, UT Southwestern researchers report

...that makes nerve cells electrically efficient, and mast cells. Because of their complexity, plexiform n...xiform neurofibroma begins to form around a nerve, mast cells migrate into the area. In the current st...esent in other cells. Bone marrow is the source of mast cells, blood cells and many other types of cells t...

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Mast in Medical Technology

Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis

...cedure and sending it to a pathologist to look for mast cells because, when mast cells reach a certain density, patients seem to benefit from allergy testing and treatment. mast cells elsewhere in the body are key players in all...

PARI Pharma's Nebulized DSCG Shows Results Similar to Inhaled Steroids in Asthma Studies Presented at ATS

...lished by PARI Pharma and other studies demonstrating that chymase-positive mast cells primarily located in the distal lungs play a crucial role in asthma. ...anti-asthmatic and antiviral potency of DSCG. "Since the relevance of mast cells in lung vascular remodeling and the development of pulmonary hyperten...

ISTA Pharmaceuticals' New Drug Application for Bepreve(TM) Accepted for Review by U.S. Food and Drug Administration

... $560 million in sales in 2007. Bepreve is a non-sedating, highly selective antagonist of the histamine (H1) receptor. It has a stabilizing effect on mast cells and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an ...

Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma

...uses a potent combined blockade of both B-cell and mast cell activation," said Joseph J. Buggy, Ph.D., vic... critical enzyme involved in B-cell activation and mast cell function, and inhibition of its function may ...eful in the treatment of immune mediated diseases. mast cells play a key role in the inflammatory process ...

ISTA Pharmaceuticals Announces New Phase III Clinical Findings to Support Bepreve NDA Filing

...three primary mechanisms of action: it is a non-sedating, highly selective antagonist of the histamine 1 (H1) receptor, it has a stabilizing effect on mast cells, and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an ef...

Rigel Announces Initiation of Phase 1 Clinical Trial of R343 for Allergic Asthma by its Partner Pfizer

...ger the production of immunoglobulin E (IgE) antibodies, which then bind to mast cells and transmit intracellular signals causing the allergic response. In ...development aimed at inhibiting IgE receptor signaling in respiratory tract mast cells by blocking the activation of syk kinase. R343 will be delivered vi...

Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP, Rheumatoid Arthritis and Lymphoma

...s. R788 is a novel, oral syk kinase inhibitor that blocks the activation of mast cells, macrophages and B-cells that promote swelling, inflammatory response... R788 is a novel, oral syk kinase inhibitor that blocks the activation of mast cells, macrophages and B-cells that promote swelling, inflammatory response...

ISTA Pharmaceuticals Announces Statistically Significant Preliminary Results From its U.S. Phase II/III Clinical Study Of Bepotastine

...three primary mechanisms of action: it is a non-sedating, highly selective antagonist of the histamine 1 (H1) receptor, it has a stabilizing effect on mast cells, and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an ef...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

...tion and hyperresponsiveness, mucin production and mast cell generation. Earlier preclinical study results... expand our body of knowledge about IL-9's role in mast cell regulation, airway remodeling, and other func...L-9 plays a critical and unique role in regulating mast cells, which are centrally important in allergic i...
Mast in Medical Dictionary

Skin Cancer

... Information about skin cancer in dogs including symptoms, risk factors, diagnosis, treaments and prognosis. ... many types of skin cancer but mast cell tumors ... Melanoma is a type of skin cancer . Find skin cancer information and treatment options and how you ... Home Cancer He...

Mastocytosis

...dren and adults caused by the presence of too many mast cells (mastocytes) and CD34+ mast cell precursors in a person's body. Mas...ic mastocytosis is caused by the accumulation of mast cells in the tissues ... Mastocytosis . Mast...

Hyposensitization

...rate grandchild. ... With hyposensitization , you have your grandson spend increasing amounts of time ... Anaphylactic hyposensitization of rat mast cells in vitro was demonstrated by ... The hyposensitization could not be ascribed to blocking antibodies. Full text ... ...

Histamine

...esponse. As part of an immune... histamine n. A physiologically active amine, C 5 H 9 N 3 , found in plant and animal tissue and released from mast cells as part of an allergic Definition of Histamine from Your About.com Guide to Food Allergies ... The release of histamine causes inflamma...

Eosinophil

...re white blood cells that are one of the immune system components responsible for combating infection and parasites in vertebrates. Along with mast cells, they also... provides an easy to understand definition for the medical term, eosinophil . ... level of eosinophils to be too ... What is...

Enterotoxin

...9 V. ... Aerosolized staphylococcal enterotoxin B-induced pulmonary lesions in rhesus ... Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in ... ...

Bronchospasm

...nchial spasm is a sudden constriction of the muscles in the walls of the bronchioles. It is caused by the release (degranulation) of substances from mast cells or basophils under the influence of anaphylatoxins. It causes difficulty in breathing... Up-to-the-minute news coverage of national, regiona...

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Mast in Biological News

Common allergy drug reduces obesity and diabetes in mice

...e a population of inflammatory immune cells called mast cells. In the second study, researchers found that...h a connection when, in a previous study, he found mast cells present in a variety of inflammatory vascular diseases. mast cells are immune cells that facilitate healing in ...

Allergy season: Cigarettes to the rescue?

...he allergic response by inhibiting the activity of mast cells, the major players in the immune system's re...versity in the Netherlands found that treatment of mast cells with a cigarette smoke-infused solution prev... in response to allergens, without affecting other mast cell immune functions. The...

Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma

...eate a type of immune cell (mast cells). Too many mast cells lead to an over-aggressive immune response, ...response (the "on switch") are added to developing mast cells, the developing cells die. Because bone marrow makes both mast cells and these cytokines, the researchers conclud...

Malfunction of the respiratory epithelium is a cause of allergy?

...helium of allergic patients but not of healthy subjects within one minute after the exposure. An allergic reaction developed when the allergen reached mast cells under the basement membrane. During the research it became evident that during spring, in allergic patients the birch pollen allergen Bet v 1...

A worm-and-mouse tale: B cells deserve more respect

...e body maintains to fight off invaders like bacteria, viruses, and parasites. Besides B cells, there are T cells, macrophages, neutrophils, monocytes, mast cells and others, all working in concert to keep an organism healthy. The cells cruise our bodies, looking to eliminate infectious threats before they...

Global warming linked to European viral epidemic

... Clement, "Since 1993, each NE peak has been preceded by increased autumnal mast formation the year before, resulting in yearly NE numbers significantly higher than those during the mast years themselves". PUUV is a hantavirus, a group of viruses known to cau...

New study finds uncontrollable stress worsens symptoms of endometriosis

...est colon length, the highest levels of MPO, the greatest number of colonic mast cells, and an increase in peritoneal fluid immune cell infiltration, all in...ikely a connection with the immune system because of the observed levels of mast cells in the colon and the increased levels of inflammatory cells in the pe...

Where college students live can impact their weight, eating and exercise habits

...est colon length, the highest levels of MPO, the greatest number of colonic mast cells, and an increase in peritoneal fluid immune cell infiltration, all in...ikely a connection with the immune system because of the observed levels of mast cells in the colon and the increased levels of inflammatory cells in the pe...

Study helps explain how allergic reactions are triggered

...fundamental discovery regarding the functioning of mast cells. Their findings appear in the January 2008 i...immune cells found in tissues throughout the body, mast cells were once exclusively known for their role i... Instructor of Medicine at Harvard Medical School. mast cells store inflammatory cytokines and compounds [...

An 'attractive' man-machine interface

... as component parts. Weve harnessed a biological control system, but we can control it at will, using magnetic forces. In a demonstration involving mast cells (a kind of cell in the immune system), Ingber and Mannix showed that the beads, when bound to cell receptors and exposed to a magnetic field, we...

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Mast in Biological Technology

Spinning carbon nanotubes spawns new wireless applications

... a very pleasant surprise, how easy it was to do," mast says. "The hardest thing is to manipulate them. Th...bcam for the lab using these thread antennas so mast says that the key to the new applications is the q...hundred pounds of copper as cables and wiring." mast points out that the threads have what he calls an ...

MedImmune Advances Asthma Program With Start of Phase 2 Clinical Trial for Antibody Targeting IL-5 Receptor

...IL-5R alpha chain is restricted largely to eosinophils, basophils, and some mast cells in humans. The alpha-chain exclusively binds IL-5 and the intracellul...dy in the management of asthma. Eosinophils, and perhaps basophils and some mast cells, can be preferentially targeted for antibody-dependent cell cytotoxic...

ISTA Pharmaceuticals Files New Drug Application with U.S. FDA for Bepreve(TM)

...s three primary mechanisms of action: it is a non-sedating, highly selective antagonist of the histamine (H1) receptor, it has a stabilizing effect on mast cells, and it suppresses the migration into and activation of eosinophils in inflamed tissues. The compound's primary mechanisms of action are believe...

UTSA/UTHSCSA publish results on bio-threat agent

...-40 percent mortality rate. "We have found that mast cells, historically associated with allergic condi...iate professor of biology. "Our studies show that mast cells can interact with other cells and control th... This opens up a new dimension into how we look at mast cells against this organism, Francisella tularensi...

UTSA/UTHSCSA publish results on bio-threat agent

...-40 percent mortality rate. "We have found that mast cells, historically associated with allergic condi...iate professor of biology. "Our studies show that mast cells can interact with other cells and control th... This opens up a new dimension into how we look at mast cells against this organism, Francisella tularensi...

UTSA/UTHSCSA publish results on bio-threat agent

...-40 percent mortality rate. "We have found that mast cells, historically associated with allergic condi...iate professor of biology. "Our studies show that mast cells can interact with other cells and control th... This opens up a new dimension into how we look at mast cells against this organism, Francisella tularensi...

Depth of MedImmune's Respiratory Disease Research Program Highlighted at Annual Meeting of the American Thoracic Society

... IL-33, the Ligand for T1/ST2, Induces Airway Hyperresponsiveness Via a mast Cell but Not T Cell Dependent Mechanism, publication page A63) - Sunday...- 11:00 a.m., Metro Toronto Convention Centre, Room 205A. -- Eosinophils, mast Cells and Neutrophils as Modulators of Immunity and Injury -- Poster...

JADO Reports Clinical Proof of Concept With Raft Modulator in Atopic Dermatitis

.... TF002 showed a trend of reducing total number of mast cells. "This study demonstrates clinical proof o...ble to the outer layers of the skin, an area where mast cells congregate most. The plan will then be to re...tudies of diseases such as atopic dermatitis where mast cell activation plays a key role," Charl van Zyl, ...

Israel's Ministry of Communications, 012 Smile.Communications, Intel and Alvarion Join in Launching WiMAX Initiative for Sderot, a City in the Western Negev

...for ages 4-7 that includes early reading, math, games, artwork, etc., and the Second Authority for Television and Radio donated access to the existing mast at the Sapir College campus on which the project transmission equipments was installed. Fixed & Mobile WiMAX Technology This community initiative ...

Mission Statement 2003: Do More with Less and Do it Faster!

...of the Judging type for consistent deliverables, even as conditions change rapidly. Both types need each other; if they work synergistically, like the mast (Judging) and the sail (Perceiving) of a sailboat, a company can profitably navigate the troubled waters of 2003. In addition to psychological typ...

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Mast in Biological Definition

Antibody

...ifferent physiological effects of antibodies ( opsonization , cell lysis , mast cell, basophil and eosinophil degranulation and other processes). The va.... It can be found on the surface of the plasma membrane of basophils and mast cells of connective tissue . IgE plays a role in immediate hypersensitiv...
Mast in Biological Dictionary

Eosinophils

...ponsible for combating infection and parasites in vertebrates. Along with mast cells, they also... Eosinophils are a type of white blood cell (corp...centration is between 0 and 0.5 x 109 eosinophils per litre of blood. ... mast cells and macrophages stimulates the production of eosinophils . ... ...

Central cell

... and Characterization of the Central Cell ... Offers cellular phone with plan offers nationwide throughout the United States. Prognosis of mast cell tumors of the skin is directly related to the ... All information on this web site is copyright © 2004 Vet Surgery Central Inc. VCS Inc. .....

Basophils

...en basophils are triggered they release a ... mast cells and basophils are effector cells in IgE-associated ... basophils and mast cells, as well as briefly considering evolv ... ...es in myeloproliferative diseases and ... 1.3.1 mast cells and basophils ... Basophils are the sm...
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