Maraviroc

Pfizer Awaits FDA Approval for New AIDS Drug, Maraviroc

Washington –According to the recent communiqué from US drug reviewers, the experimental AIDS drug from Pfizer Inc. promises to contain the HIV virus when used in combination with popular drugs.// The drug, in question named as maraviroc may find a prominent place amongst drugs meant for AID...

California Medicaid Establishes Coverage for Trofile(TM)

...cal trials utilizing our products, the outlook for maraviroc and our Trofile Assay, the number of patients each...e a molecular diagnostic for patient selection for maraviroc or other HIV drugs; risks related to the implement...ile Assay may not be utilized for patient use with maraviroc and other CCR5 inhibitors; our ability to successf...

IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide

... we are committed to searching for ways our drugs can be used to slow down or stop this epidemic." Under this agreement, IPM would work to develop maraviroc as a vaginal microbicide with the right to develop, manufacture and distribute the microbicide in developing countries. Pfizer has granted these right...

Mixed HIV Coreceptor Use Associated With Lower CD4 Count

...al-tropic virus for response to CCR5 antagonists. However a recent study of maraviroc in highly-treatment experienced patients with low CD4 cell counts who had d...virus has shown that while viral load suppression is not improved by adding maraviroc to a new regimen, CD4 cell responses were significantly better in the marav...

Maraviroc in Medical Technology

Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay

... CCR5 co-receptor, the CXCR4 co-receptor or both co- receptors to infect healthy cells. This helps clinicians determine whether a CCR5 antagonist like maraviroc may be a good therapeutic option for treating individual patients. Currently available in the U.S., Selzentry is the first drug in a new oral class of...

Maraviroc in Biological Technology

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

...ed disease. Guidelines from the U.S. Department of Health and Human Services recommend tropism testing prior to the start of a CCR5 inhibitor, such as maraviroc (Selzentry TM). Three out of four people taking HIV drugs experience treatment failure linked to drug resistance. "CCR5 antagonist entry inhibito...

Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy

... HIV resistance to new drug targets/classes. Monogram has assays in advanced development that accurately assess resistance to CCR5 antagonists such as maraviroc (Selzentry, Pfizer) and vicriviroc (Schering-Plough), and integrase inhibitors such as raltegravir (Isentress, Merck) and elvitegravir (Gilead Science...

New York Medicaid Program Establishes Coverage for Trofile(TM)

...cal trials utilizing our products, the outlook for maraviroc and our Trofile Assay, the number of patients each...e a molecular diagnostic for patient selection for maraviroc or other HIV drugs; risks related to the implement...ile Assay may not be utilized for patient use with maraviroc and other CCR5 inhibitors; our ability to establis...

Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity

...CCR5 Antagonists -- Changes in V3 Loop Sequence Associated with Failure of maraviroc Treatment in Patients Enrolled in the MOTIVATE 1 and 2 Trials The firs...ackground therapy in the phase II and phase III clinical trials of Pfizer's maraviroc (Selzentry(TM)) and Schering Plough's vicriviroc, Monogram has also recentl...

Study Reaffirms Superiority of Trofile(TM) Assay

...chieved a significant reduction in viral load when maraviroc was added to an optimized background therapy, whil...nificant reduction in viral load when treated with maraviroc plus an optimized background regimen. About Mono...cal trials utilizing our products, the outlook for maraviroc and our Trofile Assay, the number of patients each...

Monogram Announces Third Quarter 2007 Financial Results

...r 30, 2007. Monogram's Trofile Assay and Pfizer's maraviroc "This has been a pivotal quarter for our HIV busi...tients enrolled in both the phase III trial of maraviroc in treatment-experienced patients and the sepa...h the FDA and the European Commission (EC), of maraviroc for use in treatment-experienced patients selected...

Maraviroc in Biological Dictionary

Tropism

...n in a way by Leibniz, ... However, viral tropism can. be CCR5, CXCR4, or "dual/mixed" (or ... The tropism test is helpful in deciding. whether maraviroc will be useful in ... Encyclopedia article about tropism . Information about tropism in the Columbia Encyclopedia, Computer Desktop Encyclopedia...