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Mantle in Medical News

Intense chemotherapy wards off recurrence in half of mantle cell lymphoma patients after seven years

SAN FRANCISCO - More than half of younger mantle cell lymphoma patients who received an intensive regimen of chemotherapy as frontline treatment remain in remission seven years later, researchers at The University of Texas M. D. Anderson Cancer Center report today at the 50th annual meeting of the...

Researchers aim to over-stress already taxed mantle cell lymphoma cells

AUGUSTA, Ga. - Cancer cells are already stressed by the fast pace they require to grow and spread and scientists believe a little more stress just may kill them. "Think about an assembly line in a factory that is working five times faster than normal," said Dr. Kapil Bhalla, director of the Me...

Incidence of Mantle Cell Lymphoma on Rise

Aggressive form of non-Hodgkin disease puts older men chiefly at risk, study finds FRIDAY, July 18 (HealthDay News) -- The prevalence of mantle cell lymphoma, an aggressive form of non-Hodgkin lymphoma, is increasing, and most patients are diagnosed with advanced stages of the disease...

Sports Icons Troy Aikman, Clyde Drexler, Mike Piazza, Ivan Lendl and Dara Torres are Among the Elite Named 2009 'Great Sports Legends'

... Miami Project's spinal cord injury research programs. Legend and Honoree Alumni include Michael Jordan , Muhammad Ali , Jack Nicklaus , Mickey mantle , Wayne Gretzky , Lance Armstrong , John Elway , Helio Castroneves , Earvin "Magic" Johnson , Joe DiMaggio, Dan Marino , Tommy Lee Jones, Mar...

Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research

...of which are rare diseases. A member of LRF's mantle Cell Lymphoma Consortium (MCLC), Dr. Fu's work will focus on mantle cell lymphoma (MCL), an aggressive malignant B-cell form of non-Hodgkin lymphoma (NHL). mantle cell lymphoma is a rare form of NHL accounting for...

New Report Just Published: World Multiple Myeloma Therapeutics Market Report

...iopharm Oncology Receives Approval to Commence ZIO-101 and ZIO-201 Trial II-44 FDA Grants Approval for Use of VELCADE(R) for Patients with mantle Cell Lymphoma II-44 4. Recent Industry Activity II-45 CytRx to Acquire Innovive II-45 Launch of Epoetin alfa Hexal II-45 PDL and Bris...

Make No Small Plans: M. D. Anderson Cancer Center Endeavors to Make Cancer History

...harles A. "Mickey" LeMaistre, M. D., was appointed in 1962 to the first U.S. Surgeon General's Advisory Committee on Smoking and Health, picked up the mantle in 1978 and served for 18 years. He was at the center of a powerful public health movement that awakened the nation to cancer prevention and instilled...

Pitt, Berkeley researchers reconstruct seashells to model nervous system function

...begins with a mollusk's tongue-like organ called a mantle and leads to the cells that produce the shell and ... shells, they retrace their previous work with the mantle and use those "memories" to continue the pattern. ...nd the neurons connecting the sensing cells in the mantle with the secretory cells that produce calcium carb...

Data on VELCADE(R) (Bortezomib) for Injection Based Therapies to be Presented at the International Myeloma Workshop

...so is indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior...e of peripheral neuropathy has not been studied in mantle cell lymphoma. Acute development or exacerbation o... liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulate...

Healthcare Businesswomen's Association Announces 2009 Woman of the Year, Dr. Deborah Dunsire, President and CEO of Millennium: The Takeda Oncology Company

...ze-winning science. It has been prescribed to more than 100,000 people in 87 countries worldwide, treating patients with multiple myeloma and relapsed mantle cell lymphoma, a sub-type of non-Hodgkin's lymphoma. Dr. Dunsire presided over Millennium's acquisition by Takeda Pharmaceutical Company Limited in Ma...
Mantle in Medical Technology

New Data Show TORISEL Improves Progression-Free Survival for Patients With Relapsed/Refractory Mantle Cell Lymphoma

- Data From Phase 3 Study Presented at ASCO - COLLEGEVILLE, Pa., May 31 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE ), today announced results of a three-arm phase 3 clinical trial that show patients with relapsed and/or refractory mantle cell ...

Callisto Pharmaceuticals Announces Publication of Research Article on Atiprimod Preclinical Studies in Mantle Cell Lymphoma

Article Published in Recent Issue of Journal Blood NEW YORK, April 11, 2007 /PRNewswire-FirstCall/ -- Callisto Pharmaceuticals, Inc. (FWB: CA4), a developer of new drug treatments in the fight against cancer and other major health threats, announced today the publication of a research article on A...

Gemin X Biotechnologies Announces Publication in Blood of Positive Preclinical Data of Lead Compound in Mantle Cell Lymphoma

MONTREAL--(BUSINESS WIRE)--May 15, 2007 - Gemin X Biotechnologies Inc. announced today that a report published in the journal Blood demonstrated that its lead compound, obatoclax (GX15-070), induced cell death in vitro in Mantle Cell Lymphoma (MCL) cell lines and primary cells from 11 MCL patients....

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...ancers affecting the immune system, such as DLBCL, mantle cell lymphoma and follicular lymphoma(2). Up to 60... lymphoma, Hodgkin's disease, follicular lymphoma, mantle cell lymphoma, DLBCL and small lymphocytic lymphom... disease (53% ORR), follicular lymphoma (50% ORR), mantle cell lymphoma (32% ORR), DLBCL (30% ORR) and small...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

...omib has demonstrated single-agent activity in hematologic malignancies and solid tumors, including multiple myeloma, Waldenstrom's macroglobulinemia, mantle cell lymphoma and renal cell carcinoma. Proteolix is conducting a comprehensive clinical development program evaluating carfilzomib for the tre...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

...omib has demonstrated single-agent activity in hematologic malignancies and solid tumors, including multiple myeloma, Waldenstrom's macroglobulinemia, mantle cell lymphoma, and renal cell carcinoma. Proteolix is conducting a comprehensive clinical development program evaluating carfilzomib for the tr...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

...so is indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior...e of peripheral neuropathy has not been studied in mantle cell lymphoma. Acute development or exacerbation o... liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulate...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

...e of peripheral neuropathy has not been studied in mantle cell lymphoma. Acute development or exacerbation o... liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulate... was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis,...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

...e of peripheral neuropathy has not been studied in mantle cell lymphoma. Acute development or exacerbation o... liposome injection] study) and previously treated mantle cell lymphoma (N=155) were integrated and tabulate... was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...( LBH589 ), showing early activity across a broad range of cancers, including acute myeloid leukemia, cutaneous t-cell lymphoma, multiple myeloma and mantle cell lymphoma The most significant presentations at the CTRC-AACR San Antonio Breast Cancer Symposium (SABCS) will include: ...
Mantle in Medical Products

UC-Plus Solution

Description:...ons, and achieves a wide area of contact between the femoral and tibial components. Large, uninterrupted pockets of cement create a homogeneous cement mantle to ensure good long-term stability....
Company:Plus Orthopedics

Primaloc™ Cemented

Features:...area Provides consistent and reproducible cement mantle in the proximal area Macro M/L Steps: Distrib...ds into compression forces between stem and cement mantle Greater rotational stability in the calcar region Increases cement mantle in the proximal A/P region where loads are transfe...
Company:Ortho Development Corporation

SHP Acetabular Cup

Features:...able in diameters 46 mm to 60 mm to meet all patient needs. ArCom polyethylene - 47% increase in wear resistance. PMMA spacers for uniform 3 mm cement mantle and avoid polyethylene/bone contact. Integral flange with scalloped peripheral rim maintains cement pressurization while allowing excess cement to esc...
Company:Biomet Orthopedics, Inc

PE-Plus

Features:... It is a high quality, cost effective option. Made from all polyethylene. The Pe-Plus is fixated using cement. The cement mantle can be individualized for each patient for greater clinical flexibility. Circular grooves allow for optimized cement distribution to pressurize and co...
Company:Plus Orthopedics

MS-30 Hip

Features:... A tri-tapered design and rounded trapezoidal cross-section provide implant stability and an optimal cement mantle interface, standard and offset stems are available for the best anatomical fit; proximal and distal centralizer options are available for the ideal im...
Company:Zimmer, Inc.

Perfecta IMC Stems

Features:... A variety of design features facilitate an even cement mantle thickness, while the intramedullary collars (IMC) promote compressive loading of cement minimizing subsidence and medial migration. Two neck offset op...
Company:Wright Medical Technology, Inc.

The APR Hip Family - CoCr Cemented

Features:...and torsional stability. The 2.5 mm proximal polymethylmethacrylate (PMMA) spacers and distal centralizers help to ensure a continuous, uniform cement mantle and help ensure correct positioning. The stem is slightly undersized from the broach (~2 mm) to ensure the continuous cement mantle. The proximal port...
Company:Zimmer, Inc.

Perfecta IMC Slim Neck

Features:...im neck geometry increases range of motion and minimizes impingement, polished surface texture to minimize debris generation, cobalt chrome for cement mantle protection and longevity, medial collar for calcar load support, intramedullary collars provide compressive load transfer in the proximal femur, rough...
Company:Wright Medical Technology, Inc.

Perfecta PDA Stems

Features:... The Perfecta PDA cobalt chrome promotes long-term mechanical integrity and cement mantle protection....
Company:Wright Medical Technology, Inc.

The Natural-Hip Family - Revision/Trauma CoCr Revision

Features:...ellent cemented option. Several features ensure successful cementing, including proximal and distal centralizers for correct alignment and even cement mantle and a roughened proximal surface for enhanced cement bonding, with normalization steps providing optimal cement compression....
Company:Zimmer, Inc.
Mantle in Biological News

Journey to the center of the earth: Discovery sheds light on mantle formation

HOUSTON, April 10, 2008 Uncovering a rare, two-billion-year-old window into the Earths mantle, a University of Houston professor and his team have found our planets geological history is more complex than previously thought. Jonathan Snow, assistant professor of geosciences at UH, led a team...

AGU journal highlights -- Aug. 6, 2009

...ming and brightening Can seismic variation in the mantle be explained by temperature alone? New model show...8JD011470 8. Can seismic variation in the mantle be explained by temperature alone? The structure and dynamics of Earth's mantle are of great importance because they determine the...

Extraterrestrial platinum was 'stirred' into the Earth

...ok all the available platinum with it, leaving the mantle and crust with none," Dr Barnes said. "Following...lications for the people who study the dynamics of mantle processes and the mechanisms that cause plate tect.... Osmium isotopes are widely used as tracers of mantle processes, but there has been a mismatch between s...

Mollusks taste memories to build shells

...biology. "The shell is laid down in layers, so the mantle is sensing the history of the mollusk's 'thoughts'...ork of neurons connecting the sensing cells in the mantle with the secretory cells that produce calcium carb...tential mates. "The pigment is a cue to get the mantle in register so it builds the right shaped shell, a...

AGU journal highlights -- March 12, 2009

...nwelling material that underwent these observed crystal lattice transformations. Title: Transformation textures in post-perovskite: Understanding mantle flow in the D'' layer of the Earth Authors: N. P. Walte, F. Heidelbach, N. Miyajima, D. J. Frost, and D. C. Rubie: Bayerisches Geoinstitut, Univ...

February 2009 Geology and GSA Today media highlights

... related to flood basalts suggest the existence of mantle plumes with large heads and thin trailing tails (c...ity plumes). Seismic data suggest the existence of mantle plumes with thick tails (diapir plumes). The condi...ion are different, and in a chemically homogeneous mantle both types are not predicted to coexist. Lenardic ...

The continents as a heat blanket

... The enormous heat in the Earth's core and Earth's mantle generates the flow of rocks within the Earth's man...tion between the convective movement in the Earths mantle and the continental drift. V. Trubitsin, M. Kaban ...n of the continents, the structures of the Earth's mantle obtained through geophysical measurements, and the...

January-February GSA Bulletin media highlights

...t this process is of general applicability to this rock type. Formation of such volcanoes, thus, depends on a suitable source of heat from the Earth's mantle during mountain building processes. Formation and dating of a salt pillar in Mount Sedom diapir, Israel Amos Frumkin, Department of Geogr...

January GEOLOGY media highlights

...k units can perform very well as safe seals to store injected CO 2 and prevent upward leakage for time scales much longer than required. Deep mantle diamonds from South Australia: A record of Pacific subduction at the Gondwanan margin Ralf Tappert et al., Geology and Geophysics, School of Earth...

Ancient magma 'superpiles' may have shaped the continents

...awned the other, Panero said. Plates sink into the mantle as part of the normal processes that shape the con...oblem," Panero said. "We know that the rest of the mantle is always moving. So why are the piles still there... Hot rock constantly migrates from the base of the mantle up to the crust, she explained. Hot portions of th...
Mantle in Biological Technology

Proteolix Presents Clinical Data from Two Clinical Studies of Carfilzomib in Multiple Myeloma at the 14th Congress of the European Hematology Association

...omib has demonstrated single-agent activity in hematologic malignancies and solid tumors, including multiple myeloma, Waldenstrom's macroglobulinemia, mantle cell lymphoma and renal cell carcinoma. Proteolix is conducting a comprehensive clinical development program evaluating carfilzomib for the tre...

Proteolix to Present Carfilzomib Clinical Data During the 2009 ASCO Annual Meeting

...omib has demonstrated single-agent activity in hematologic malignancies and solid tumors, including multiple myeloma, Waldenstrom's macroglobulinemia, mantle cell lymphoma, and renal cell carcinoma. Proteolix is conducting a comprehensive clinical development program evaluating carfilzomib for the tr...

Gemin X Pharmaceuticals Selects and Deploys Clinical Force CTMS

...etic programs. Potential treatment indications for the full scope of pipeline programs span a broad range of hematological and solid tumors, including mantle cell lymphoma (MCL), melanoma, glioblastoma, small cell lung cancer (SCLC), refractory acute lymphoblastic leukemia (ALL) and mastocytosis. For mo...

2009 is Healthy for Asia

...niche Medtech players in China & India such as Meditronics, Alpha X-ray & Shinva. 2009 represents an opportunity for Asia to takeover the mantle of leadership from the US & Europe to become the key driver of innovation and profitability for Healthcare companies. About Frost & Sull...

Millennium Announces VELCADE(R) (Bortezomib) for Injection First-Quarter 2008 U.S. Net Sales

...prior therapy. VELCADE is also indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior therapy. VELCADE is cont...safety profile of VELCADE was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis, the most commonly reported adver...

Micromet, Inc. Reports Fourth Quarter and Full Year 2007 Financial Results

...bone marrow and other infiltrated organs from tumor cells. Particularly encouraging was the observation of complete responses in patients with mantle cell lymphoma (MCL) -- a disease that is difficult to treat. In Europe, Micromet has initiated a phase 2 study in acute lymphoblastic leukemi...

Millennium Over-Delivers on 2007 Goals and Financial Guidance

...g treatment for relapsed multiple myeloma and mantle cell lymphoma. Sales increased steadily throu... also indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior... was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis, the mos...

Millennium Announces 2008 Goals for Growth, Building on Record 2007 Results

... one prior therapy. VELCADE is indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior therapy. VELCADE is cont...safety profile of VELCADE was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis, the most commonly reported adver...

Millennium to Receive $40 Million Milestone Payment for Achievement of Sales Threshold for Velcade(R) (Bortezomib) for Injection

... one prior therapy. VELCADE is indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior therapy. VELCADE is cont...safety profile of VELCADE was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis, the most commonly reported adver...

Millennium Reports Outstanding Third-Quarter Results Driven by VELCADE(R) (Bortezomib) for Injection Sales

...of VELCADE based combinations and re-treatment. In mantle cell lymphoma, our launch continues successfully w...DE is indicated for the treatment of patients with mantle cell lymphoma who have received at least one prior... was similar in patients with multiple myeloma and mantle cell lymphoma. In the integrated analysis, the mos...
Mantle in Biological Dictionary

Mantle

The mantle is a part of an astronomical object. The interior of the Earth, similar to the other terrestrial planets, is chemically divided into layers. The mantle is a highly viscous layer between the crust and the outer... Mantle (climbing), a rock climbing move used to surmount a ledg...
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