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Malignancy in Medical News

Do patients at risk for B-cell malignancy need antiviral treatment?

Some studies have shown that a relationship of hepatitis C (HCV) infection with type II mixed cryoglobulinemia exists. However the precise mechanism remains unclear. A research article to be published on April 7, 2009 in the World Journal of Gastroenterology addresses this question. The resea...

A new measure for the malignancy of melanoma

Every tumor, starting from a size of a few millimeters, depends on a supply of nutrients and oxygen. Therefore, using special growth factors, it induces vascular wall cells of neighboring blood vessels to sprout new capillaries in order to get connected to the blood circulation. This process c...

Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer

Data Presented at the Society of Gynecologic Oncologists' 40th Annual Meeting on Women's Cancer Proves Superiority of HE4, CA125 and ROMA(TM) Over Existing Tools MALVERN, Pa., Feb. 11 /PRNewswire/ -- New data presented on Saturday during the plenary session at the Society of Gynecologic Oncol...

Cell Protein Could Help Spur Malignancy

Discovery may lead to new cancer treatments, scientists say THURSDAY, June 25 (HealthDay News) -- A protein called STAT3 plays a major role in the change of normal cells into cancerous cells, according to U.S. researchers, who say the finding could lead to new cancer treatments. STA...

Breast Cancer Genes Also Raise Men's Risk for Malignancy

Few men understand the danger from BRCA1/2, researchers say FRIDAY, Dec. 14 (HealthDay News) -- Men whose mothers, sisters or daughters test positive for a breast cancer-causing mutation in the BRCA1 or BRCA2 genes may also have the mutation and be at increased risk for cancer, a new study finds...

McGill researchers link enzyme to breast cancer malignancy

This release is available in French . McGill University researchers have uncovered the crucial role played by the enzyme focal adhesion kinase (FAK) in the onset of breast cancer. The research, led by Dr. William Muller along with colleagues from McGill and the Beatson Institute for Cancer...

Indian Researcher Discovers Reason For Malignancy of Skin Cancer

An Indian origin researcher and his team have discovered one of the reasons why melanoma, a serious form of skin cancer, is so malignant//. Piyush Gupta, lead author of the Massachusetts Institute of Technology research team, found that melanoma, unlike other cancers, is born with its metastat...

A better test than cytology for Urinary Malignancy

A new method has been found for detecting upper urinary tract transitional cell carcinoma by a team of researchers working Kingston, Ontario, Canada. This method checks for fibrinogen/fibrin degradation products. It appears to be more effective and accurate when compared to standard urinary cytolog...

NCCN Updates Infection Guidelines to Include Information About H1N1 Virus (Swine Flu)

..., Aug. 5 /PRNewswire-USNewswire/ -- Infectious diseases are important causes of morbidity and mortality in patients with cancer. In certain cases, the malignancy itself can predispose patients to severe or recurrent infections. The National Comprehensive Cancer Network (NCCN) recognizes the importance of pr...

Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers

...(certolizumab pegol) and Simponi(R) (golimumab)]. This safety review was the subject of an FDA Early Communication in June 2008 pertaining to cases of malignancy in pediatric patients exposed to a TNF blocker. As a result of this review, the FDA has required strengthened warnings about the occurrence of lymphom...
Malignancy in Medical Technology

Oncology Drug Development Update - Molecular Profiling Redefines the Nature of Malignancy and Increases the Adoption of Targeted Therapeutics

The Next Step Involves Combining the 350+ Targeted Drugs on the Market and in Clinical Development with Each Other to Block Key Pathways to Combat Drug Resistance, Enhance Anticancer Effects, and Expand the Markets for Targeted Drugs LAKE FOREST, Calif., Feb. 19 ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...atients with COPD, caution should be exercised when using any TNF-blocking therapy in COPD patients, as well as in patients with an increased risk for malignancy due to heavy smoking. Worsening congestive heart failure (CHF) and increased mortality due to CHF have been reported with another TNF blocker. ...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...ponse were all in the capecitabine + placebo arm; 2 patients were inevaluable due to toxicity (days 14, 46) and 1 patient was inevaluable due to a new malignancy on day 6. The median prior treatment regimens was two, with prior treatment regimens as follows: 91% of the patients received prior FOLFIRI (Ir...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...ponse were all in the capecitabine + placebo arm; 2 patients were inevaluable due to toxicity (days 14, 46) and 1 patient was inevaluable due to a new malignancy on day 6. The median prior treatment regimens was two, with prior treatment regimens as follows: 91% of the patients received prior FOLFIRI (Irin...

BioCis Pharma Starts a Phase I Clinical Trial With a New Cancer Drug

...men and tenth among women. In addition, the recurrence rate is high, being almost 70 % in patients with the non-invasive form of the cancer, where the malignancy is typically found in the surface layers of the bladder. Non-invasive bladder cancer is treated by urologists using local surgery and intravesical dru...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... Small Molecule Stem Cell Modulator Administered in Dual Cord Blood Transplant for Hematologic malignancy LA JOLLA, Calif., May 27 /PRNewswire/ -- Fate Therapeutics, Inc. announced today that the first patient has been treated in a Phase 1b clinic...

BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting

...ncer accounts for 47,000 new cases (3% of all new cancer cases and 2% of all cancer deaths) in the United States annually. It is the fifth most common malignancy worldwide , or an estimated 644,000 new cases annually. Patients with locally advanced tumors are best treated with concurrent chemo radiation, ...

Moffitt Cancer Center Signs Licensing Agreement with Frantz BioMarkers, LLC

...en in the United States will undergo surgery for a suspected ovarian neoplasm. More than two-thirds of women undergoing surgery for suspected ovarian malignancy do not have cancer. The only clinical blood biomarker available for diagnosis is CA125, which is unreliable, especially for accurate diagnosis ...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

...t helps regulate expression of other genes. The children studied came from families with a history of PPB or related disorders. "PPB is the first malignancy found to be directly associated with inherited DICER1 mutations, making the cancer an important model for understanding how mutations and loss of DICE...

Landmark Study in The New England Journal of Medicine Shows HPV Testing Significantly Reduces Deaths from Cervical Cancer, Compared to other Methods Including Pap

...HPV and cervical cancer Worldwide, cervical cancer affects approximately 500,000 women annually and, after breast cancer, is the second-most-common malignancy found in women. Since the cause of cervical cancer -- HPV -- is known and women who have it can be identified, it is a highly preventable and treatabl...
Malignancy in Medical Products

Ferritin IRMA Test

Description:...vocated as a screening test for iron deficiency [7]. Elevated serum ferritin levels have been observed in acute and chronic liver disease and lymphoid malignancy (leukemia and Hodgkin lymphoma) [1,2]. High serum ferritin levels have also been associated with an elevated risk for myocardial infarction in men [8]...
Company:Diagnostic Systems Laboratories, Inc.
Malignancy in Medical Definition

Hematopathology

...cytometry - Blood bank - Microbiological culture - Serology v • d • e Pathology : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , CLL , HCL ) • Lymphoma ( Hodgkin's disea...

Pathology

...eoplastic phenomenon - ICD-O - List of oncology-related terms v • d • e Pathology : hematology / hematological malignancy (primarily C81-C96 , D50-D77 ) White blood cells Lymphoid : Lymphoid leukaemia ( ALL , CLL , HCL ) • Lymphoma ( Hodgkin's disea...

Ocular oncology

...tely 325 children per year in North America, early detection has allowed for cures exceeding 95%. [ citation needed ] The most common orbital malignancy is orbital lymphoma . This tumor can be diagnosed by biopsy with histopathologic and immunohistochemical analysis. Most patients with orbital lymphoma...

Personalized medicine

... known as a targeted cancer drug. In addition because of new molecular testing for c-kit, tumors such as GIST GastroIntestinal Stromal Tumours a solid malignancy never associated with blood bourne cancer are also treated with this drug. It works by killing specific cells whereas chemotherapy can kill both deran...
Malignancy in Medical Dictionary

Malignancy

User-created article describing cancer, including its nomenclature, symptoms, ... Pre- malignancy , pre-cancer or non-invasive tumor: A neoplasm that is not ... Hematological malignancies are the types of cancer that ... Hematological malignancy /leukemia histology (ICD-O 9590-9989,...

Uterine Cancer

... Endometrial cancer refers to several types of malignancy which arise from the endometrium, or lining of the uterus. Endometrial cancers are the most common gynecologic cancers in the United States, with ove...

Polyuria

...s urine output of > 3 L/day; it must be distinguished from frequency, ... Polyuria caused by diabetes insipidus is suggested by a history of malignancy or ... Answers to your questions about polyuria and more! ... Polyuria can trigger other symptoms associated with uncontrolled diabetes, ... ...

Parotid glands

...ciated ... Salivary Gland Cancer Los Angeles Parotid Salivary Gland Cancer Treatment by Los ... Mucoepidermoid Carcinoma is the most common malignancy in the parotid gland . ... Benign Parotid Masses Grand Rounds Presentation from the Bobby R. Alford Department of Otolaryngology-Head ... Th...

Mesothelioma

...ma as a primary tumor of ... with describing two cases of probable mesothelioma in a study of ... Mesothelioma cancer is an aggressive malignancy that spreads over time. ... Throughout the past decade, the term " mesothelioma " has become more and more recognizable. ... Provides those diagn...

Laryngeal Cancer

...What treatments are available for individuals with laryngeal cancer ? What is a laryngectomy? ... Laryngeal cancer is a gastrointestinal malignancy with an insidious onset and a poor prognosis ... T STAGE: LARYNGEAL CANCER ... Larynx - laryngeal cancer s ... Treatment statement fo...

Hairy cell leukemia

... Overview: Hairy cell leukemia (HCL) is a chronic lymphoid leukemia that was ... Hairy cell leukemia is recognized as a clonal B-cell malignancy as identified by ... Hairy cell leukemia (HCL) is a cancer of lymphocytes (B cells) that leads to low ... For patients with advanced hai...

Esophageal cancer

... Esophageal cancer is malignancy of the esophagus. There are various subtypes, primarily squamous cell cancer and adenocarcinoma. Squamous cell cancer arises from the cells t...

Endometrial cancer

... Endometrial cancer refers to several types of malignancy which arise from the endometrium, or lining of the uterus. Endometrial cancers are the most common gynecologic cancers in the United States, with o...

Endometrial ablation

...has been classically used for treatment of proven menorrhagia. ... INTRODUCTION Women with abnormal uterine bleeding known to be unrelated to malignancy ... Office based endometrial ablation . STANDARD VERSUS GLOBAL TECHNIQUES ... Pros and cons of endometrial ablation techniques ... Endome...
Malignancy in Biological News

Biomarker predicts malignancy potential of HG-PIN lesions in the prostate

PHILADELPHIA Men whose prostate cancer screenings show high grade prostatic intraepithelial neoplasia (HG-PIN) may find themselves in limbo, stuck between diagnoses they are told prostate cancer has not yet developed, but it might, and they are advised to undergo repeated needle biopsies as a pr...

NYU Langone Medical Center awarded NIH grants totaling $1,560,000

...e and esophageal cancer. Dr. Pei's work focuses on the type of cancer linked to heartburn due to gastroesophageal reflux diseases, the fastest rising malignancy in the United States. The recent increases in this cancer cannot be explained by any known environmental or host factors. He postulates that gastroeso...

GenWay Biotech obtains exclusive rights to AMDL's DR-70 cancer test in US and Canada

... quantifies Fibrin and Fibrinogen Degradation Products (FDP) in the blood, which are elevated in the presence of a malignant tumor and increase as the malignancy grows. International studies have linked the DR-70 cancer test to at least 14 different types of cancer, including lung, breast, stomach, liver, col...

Tips from the American Journal of Pathology

... prostate cancer progression. These data are presented in the April 2009 issue of The American Journal of Pathology . Prostate cancer is a common malignancy among men over the age of 50. The stage at which prostate cancer is diagnosed is critical for determining prognosis as well as choosing appropriate th...

New research findings may enable earlier diagnosis of uterine cancer

...an extremely complex disease. Cancer of the uterus, or endometrial carcinoma, is no exception. Cancer of the uterus is the commonest gynaecological malignancy in the West and accounts for between five and six per cent of all cancers in Swedish women. However, the symptoms are often vague, and we know little ...

Phoenix conference highlights TGen's and Scottsdale Healthcare's contributions to molecular oncology

...rested in new cancer diagnostics and therapeutics. Key objectives of the conference include: Explaining the molecular and cellular features of malignancy in diagnostic and therapeutic approaches to the treatment of cancer, and identifying new diagnostic tools. Assessing the effects and early clinica...

Washington University scientists first to sequence genome of cancer patient

...irector of the National Human Genome Research Institute. "In the past, cancer researchers have been 'looking under the lamppost' to find the causes of malignancy - but now the team from Washington University has lit up the whole street. This achievement ushers in a new era of comprehensive understanding of the ...

PET/CT imaging proves golden for detecting cancer in children

...oves staging of patients with Ewing tumor. The co-authors note, There are inherent advantages of PET/CT over PET in lesion detection, determination of malignancy and, therefore, overall staging for patients with Ewing tumor. Ewings tumor is a malignant bone tumor occurring in children and young adults. ...

Purdue research finds similarities in dog, human breast cancer pre-malignant lesions

...ep, Mohammed will determine the prevalence of lesions in dogs with no tumors. In addition, she and Miller are looking at cats, which have a 90 percent malignancy rate when they are diagnosed with breast cancer. ...

New genetic variant associated with prostate cancer in African-Americans

...r this type of cancer -- led us to a different locus within that region and directly to a gene of interest. Prostate cancer is the most common male malignancy and the second leading cause of cancer death in men. According to the American Cancer Society, it will affect nearly 220,000 men in the United States ...
Malignancy in Biological Technology

Boston Scientific's SpyGlass(R) Direct Visualization System Featured in Broad Range of Clinical Studies at Upcoming Digestive Disease Week(R)

...contribute to the poor prognosis in patients. Direct visualization of the biliary system is not yet a standard tool for excluding malignancy in bile duct stenoses, but certain cholangioscopic characteristics of CC have been described. This podium presentation will be gi...

Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...rapy in the development of malignancies is not known. Caution should be exercised when considering TNF-blocking therapy for patients with a history of malignancy or when considering continuing treatment in patients who develop malignancy. Worsening congestive heart failure (CHF) and new onset CHF have be...

Vermillion, Inc. Files a Voluntary Petition for Reorganization Relief Under Chapter 11 of the United States Bankruptcy Code

...ze a panel of biomarkers to help identify women with a higher likelihood of malignancy so they can be referred to a gynecologic oncologist for their initial surge...ne the ability of its proprietary OvaCalc algorithm to estimate the risk of malignancy in pre and postmenopausal women who were scheduled for surgery with an ovar...

Vermillion Announces Notice of Issuance of U.S. Patent Covering Hepcidin as a Biomarker for Ovarian Cancer

...anced of Vermillion's programs is the OVA1 test, which is designed to utilize a panel of biomarkers to help identify women with a higher likelihood of malignancy so they can be referred to a gynecologic oncologist for their initial surgery. Vermillion filed a 510(K) Application with the U.S. Food and Drug Admi...

New Biologic STELARA(TM) Receives Approval in Europe for Treatment of Moderate to Severe Plaque Psoriasis

...erved in patients receiving STELARA in clinical trials. Caution should be exercised when considering the use of STELARA in patients with a history of malignancy or when considering continuing treatment in patients who develop a malignancy. References Schafer T. Epidemiology of Psoria...

Mexican Department of Public Health to Launch Screening for Human Papillomavirus (HPV), Cause of Cervical Cancer

...d theHPVtest.com/espanol) Worldwide, cervical cancer affects nearly 500,000 women annually and, after breast cancer, is the second-most-common malignancy found in women. Cervical cancer is caused by "high-risk" types of the human papillomavirus (HPV). It's estimated that 80 percent of women will get an ...

Gynecologic Oncologist, With Board Certification in GYN Oncology, OB/GYN, and Surgery Offers Women With Cancer the Newest Treatment Frontier: the Surgical Robot

...ften means that a cancer that attacks one of the reproductive organs can easily spread to the bladder, colon, or other vital organs. Not only must the malignancy in the reproductive organ be removed, but sections of other major organs may also need to be removed or repaired to give the patient her best chance f...

Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study

...s to identifying and combating this disease." According to the COG, progress in the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy of children, is one of the leading success stories in all of cancer research and cancer care. The survival rate has risen from about 15% to 85% over t...

Millennium to Receive $40 Million Milestone Payment for Achievement of Sales Threshold for Velcade(R) (Bortezomib) for Injection

...nt and regulatory approvals and sales milestones outside of the U.S. About Multiple Myeloma Multiple myeloma is the second most common hematologic malignancy and although the disease is predominantly a cancer of the elderly (the median age of onset is 70 years of age), recent statistics indicate both increa...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

...c microorganisms that infect mammals, possessing some characteristics of both bacteria and viruses. myeloma Lymphocytic cancer; a malignancy normally found in bone mar row. nucleic acids DNA or RNA: long, chainlike molecules composed of nucleotides. ...
Malignancy in Biological Definition

Cancer

...ection of an incidentaloma - a benign lesion that may be interpreted as a malignancy and be subjected to potentially dangerous investigations. Treatment of...cation. However, carcinoma in situ may develop into an invasive, metastatic malignancy and, therefore, is usually removed surgically, if possible. Heredity ...
Malignancy in Biological Dictionary

Esophagus

...the pharynx to the stomach. The word esophagus is derived from the Latin œsophagus, which derives from the Greek word... Esophageal cancer is malignancy of the esophagus . There are various subtypes, primarily squamous cell cancer and adenocarcinoma. Squamous cell cancer arises from the cells...
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