Macrophage

Stripping leukemia-initiating cells of their 'invisibility cloak'

...ein on the surface of those cells that sends a "don't eat me" signal to the macrophage immune cells that serve as a first line of defense, according to the report... stem cells co-opt this ability and take it to an extreme in order to evade macrophage killing. With their colleagues Ravindra Majeti and Mark Chao at Stanford...

Patient Enrollment Complete for Phase I/II Clinical Trial for GALNS for Morquio A Syndrome

...auses a systemic skeletal dysplasia, short stature, and joint abnormalities, which limit mobility and endurance. Malformation of the thorax as well as macrophage dysfunction in the lung likely impairs respiratory function and contributes to sinopulmonary infections. Odontoid dysplasia and ligamentous laxity ca...

Phase 1 Study Initiated with Micromet Anti-GM-CS Human Antibody MT203

...for the treatment of cancer, inflammation and autoimmune diseases, today announced the initiation of the first clinical trial for the anti-granulocyte macrophage colony-stimulating factor (GM-CSF) human antibody MT203 by its collaboration partner Nycomed. The double-blind, randomized, placebo controlled st...

Lung Enzyme Both Friend and Foe

...lved in the development of emphysema also defends the lungs against bacterial infection, a new study finds. It had been thought that the only thing macrophage elastase, matrix metalloproteinase-12 (MMP-12), did was degrade lung elasticity as part of the tissue destruction seen in emphysema patients. "But ...

New target for maintaining healthy blood pressure discovered

...atherosclerotic lesions were smaller and less abundant in mice that had both the low-density lipoprotein and PG F2-alpha receptors knocked out, as was macrophage infiltration and inflammatory cytokine production, both of which are indicators of the inflammatory response that marks these plaques. Prostagland...

JCI online early table of contents: April 13, 2009

... conclude from these results that targeting lipoprotein pintocytosis should be considered when developing novel atherosclerotic therapies that prevent macrophage uptake of lipoproteins. TITLE: Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesi...

New test may predict spread of breast cancer

...c trio of cells are present together in the same microanatomic site: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces Mena. The protein Mena was shown to enhance a cancer cells invasivene...

Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs

...ain immune system cell lines: in particular, memory B-cells which create antibodies in bone marrow; memory T-cells which can quickly produce a massive macrophage response, when you are re-infected; and regulator T-cells, which prevent auto-immune diseases by destroying anti-nuclear antibodies. US military r...

Stunning finding: Compounds protect against cerebral palsy

...c oxide-producing enzymes found in endothelial and macrophage cells. Endothelial cells regulate blood pressure, and macrophage cells play an important role in the immune system....owed good selectivity of the brain enzyme over the macrophage enzyme but with no selectivity over the endothelia...

Blocking protein leads to fewer, smaller skin cancer tumors

... the base of the outer layer of skin, and squamous cell carcinoma, which forms in cells that compose the surface of the skin. The protein is called macrophage migration inhibitory factor, or MIF. It is a pro-inflammatory cytokine present in human blood that generates inflammation in response to infection, of...

Macrophage in Medical Technology

Doctors Urge Precaution to Shield Against Swine Flu

...ll activity in people with low NK cell function, improving the coordination of many aspects of immune response, including the interaction of dendritic macrophage cells, T-cells and B-cells, resulting in improved health. The benefit of AHCC's NK Cell supporting effect, and its role in defense against influ...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

...auses a systemic skeletal dysplasia, short stature, and joint abnormalities, which limit mobility and endurance. Malformation of the thorax as well as macrophage dysfunction in the lung likely impairs respiratory function and contributes to sinopulmonary infections. Odontoid dysplasia and ligamentous laxity ca...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

...nd the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in vitro , PGN635 induced antibody-dependent death of endothelial cells, the same ce...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... shown that in addition to inhibiting anthrax toxin, Valortim(R) augments the immune system's ability to kill anthrax bacilli. In an in vitro mouse macrophage model, Valortim(R) enhanced the killing of B. anthracis (anthrax) by macrophages in a time and dose-dependent manner. The new data presented by...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

...tion at all doses tested (p<0.001). The second trial, the carotid endarterectomy (CEA) trial, missed its primary endpoint of percentage reduction in macrophage inflammatory cells in plaque tissue, but met key secondary endpoints including reduction of high sensitivity C-reactive protein (hs-CRP) (p<0.01). "...

Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors

...al efficacy in animal models. Based on these results, the Company announced that it is advancing one of these compounds into preclinical development. macrophage Migration Inhibitory Factor, or MIF, is linked to many conditions, including arthritis, asthma, cancer, sepsis, inflammatory bowel disease and various...

Data Presented at AACR Meeting Shows Peregrine's Selective Anti-VEGF Antibodies are as Effective as Avastin(R) in Preclinical Cancer Models

...consistent with the finding that the VEGFR2 receptor dominates VEGF-induced macrophage recruitment into tumors. The researchers also tested an equivalent fully ... 2128: Blockade of tumor-derived VEGF activation of VEGF receptor 2 reduces macrophage infiltration into tumors and decreases metastasis in a pre-clinical orthoto...

Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine

...ibody library screening method, when tested by Peregrine on a pancreatic cancer model, showed significant reduction of the growth, vascularization and macrophage infiltration of pancreatic tumors in mice. This is the first antibody from Affitech's library that has been tested in a preclinical development model....

Xanthus Presents Novel Approach for Autoimmune Disease Reversal with Symadex

...dex' ability to reverse chronic autoimmune disease in this animal model is notable. The study results suggest this activity may result from inhibiting macrophage function rather than inhibiting T cell function. This mechanism is novel in my experience," said Dr. Karlik. "We now have a significant body of prom...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

...r session titled, "Mast Cells," on Monday, May 21 at 8:15 a.m.) -- "Enzymatically Inactive Chitinase-Like Protein YKL-40 Promotes macrophage Activation and Lung Inflammation" (Publication Page A471, Poster Board #D63, presented in a poster session titled, "Macrophages and Ly...

Macrophage in Medical Products

Uretex® Self-Anchoring Urethral Support System

Features:...ith separate symmetrical passage. Omnidirectional stability: Retains memory and shape. Controlled elongation. Macroporous: Encourages ingrowth. Allows macrophage access. High tear resistance: Strength on warp and weft. ...
Company:C. R. Bard, Inc.

Macrophage in Medical Dictionary

Macrophage

A macrophage of a mouse stretching its "arms" (Pseudopodia) to engulf two ... One important role of the macrophage is the removal of necrotic cellular debris ... Macrophage colony-stimulating factor, or M-CSF, is a secreted cytokine which influences hemopoietic stem cells to...

VLDL

...iglycerides, and attempts ... pathways of chicken HDL are believed to be similar to those of VLDL . ... The ability of the β- VLDL to stimulate macrophage cholesteryl ester accumulation ... The triglyceriderich, α2-migrating VLDL from the affected family members ... Starting with A for "ACE inhibi...

Phagocyte

...iendly Phagocyte . Phagocyte Force ... Help keep the Phagocyte full of yummy little germs while avoiding nasty yellow germs. ... Granulocyte macrophage colony-stimulating factor (GM-CSF) enhances phagocyte -mediated ADCC. ... The ability of phagocytes to mediate efficient ADCC against ... ...

Monocyte

...oes a low monocyte number indicate? ... Monocyte Count, Monocyte , macrophage ... Monocyte Count. Neutropenia. Neutropenia Causes. Neutrophil ... Mono...es ... The IL1A gene is also known by other names, listed below. ... macrophage ; monocyte ; nucleotide ; osteomyelitis ; polymorphism ; protein ; ....

Lymphocyte

... The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease. ... of lymphocyte - and macrophage ... More often, though, the Env-binding lymphocytes were admixed with nonstaining cells. ... Dynamics of HIV-specific CD8+ T lymphocytes with...

Histiocyte

...part of the organism's immune system. The histiocyte is a tissue macrophage . A histiocyte is a type of immune cell that eats foreign substa...tiocytosis X. ... histiocyte ( ) n. A relatively inactive, immobile macrophage found in normal connective tissue. ... The most common histiocyte disord...

Granulocyte

...e colony-stimulating factor (rhGM-CSF) on ... Granulocyte -macrophage and macrophage colony stimulating factors activate ... Vancouver, Canada), which stimulates the growth of granulocyte and macrophage colonies. ... AW, Metcalf D. Granulocyte colony-stimulating factor induc...

Macrophage in Biological News

Older men more likely than women to die after pneumonia

...3 in The FASEB Journal, GenIMS researchers led by Drs. Yende and Angus found that people with certain gene variations associated with higher levels of macrophage migration inhibitory factor, an innate immune response regulator, were less likely to die following CAP. "Macrophage migration inhibitory factor i...

New study overturns orthodoxy on how macrophages kill bacteria

...a or in mice lacking the ability to make superoxide. This suggests that the superoxide and other reactive oxygen species are not making it from the macrophage into the bacterial cytoplasm, Slauch said. "We conclude from all this data that the most sensitive target of ROS in the macrophages lies outside th...

New mediator of smoking recruits

...ing-initiated lung disease. The article from Prasse et al "suggest[s] that chronic nicotine stimulation induced by cigarette smoking promotes macrophage and Langerhans cell accumulation in the lung via an increase in [osteopontin production]." Osteopontin and cellular receptors for nicotine may therefo...

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

...nd the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in vitro, PGN635 induced antibody-dependent death of endothelial cells, the same cell...

UC Davis researchers exploring gene therapy to fight AIDS

...bout the investigation. "The virus targets cells that are descendants of hemopoeitic stem cells." During the first stages of infection, HIV targets macrophage cells, gaining entrance into the cell by binding to a receptor called CCR5 on the cell's surface. Later in the infection it targets CD4+ T cells, bind...

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

...e to demonstrate the endogenous level of LC3-II in macrophage phagosomes through the combination of sensitive pr...cobacterium tuberculosis are phagocytosed into the macrophage cell, they are able to subvert various host defens...hether certain mycobacterial products can modulate macrophage autophagy activity. They are also looking for prot...

TB bacterium uses its sugar coat to sweeten its chances of living in lungs

...-presenting cell. As part of what is called the innate immune response, the macrophage activates specific molecules that make pieces of the bacteria visible to in..., and that allows it to avoid an inflammatory response by slipping into the macrophage through this scavenger receptor," Schlesinger said. During his presentat...

Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers

...se to eat their own kind. Like a police dog, a macrophage responds to a signal that means let go, Dennis Dis...s as well as plastic particles. In all cases, the macrophage binds to a target, often identified by a cloak of ...eir surface that is specifically recognized by the macrophage to switch off the headlock, thus stopping engulfme...

2 genes are important key to regulating immune response

...on -- is a boon to medical research," Dr. Ma explains. Prior studies had already shown that CD36 -- a protein receptor lying on the surface of the macrophage -- was important for the recognition of apoptotic cells by macrophages. In this work, the researchers observed that CD36 also helped to trigger IL-10 ...

Cornell researcher seeks clues to how tuberculosis infects cells

...immune system cells called macrophages initially make contact; but the bacterium's genes become activated minutes after the pathogen is enveloped by a macrophage and contained in one of its membrane-bound compartments called vacuoles. David Russell, professor of molecular microbiology at Cornell's College of V...

Macrophage in Biological Technology

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

Dr. Eugene Trogan, Ph.D., Mount Sinai School of Medicine of New York University Abstract Macrophage foam cells are integral in the development of atherosclerotic lesions, however gene expression studies are complicated by the cellular heterogeneity of atherosclerotic plaque. This ap...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

...ti murine CSF-1R monoclonal antibodies (mAb), M279 and AFS98 were evaluated for their effect on mouse corneal angiogenesis and corneal macrophage recruitment in vivo Lead author: Liu H. Abstract No. 1106 (Sunday, April 19, 2009, 1:00 pm - 5:00 pm) -- Complementary and oppos...

BioMarin's Clinical Trial Application for GALNS for Morquio A Syndrome Accepted by the MHRA

...auses a systemic skeletal dysplasia, short stature, and joint abnormalities, which limit mobility and endurance. Malformation of the thorax as well as macrophage dysfunction in the lung likely impairs respiratory function and contributes to sinopulmonary infections. Odontoid dysplasia and ligamentous laxity ca...

Morria Biopharmaceuticals Plc Announces Results From its Pre-Clinical Screening of Novel Anti-Inflammatory Compounds

...d assess the anti-inflammatory properties of Morria's proprietary multi-functional anti-inflammatory compounds. The Immunoprofiler(TM) Screen uses rat macrophage cells which are stimulated using endotoxin (LPS), a potent inflammation-inducing agent. The assay measures key inflammatory mediators, which are relea...

A single VSOP can do a 'proton' magic!

...oltage Sensor Only Protein/ Hv1, can carry protons even without making a multimeric complex. Since VSOP is known to be expressed in phagocytes such as macrophage and neutrophil that remove infected pathogens, this finding may help to design new medications for enhancing the activities of innate immunity. They r...

LifeQuest World Launches Immune System Boosting Supplement to the North American Market

...ippi. "Our research has shown that this extract is the most powerful, natural immune-stimulatory dietary supplement discovered to date with respect to macrophage activation," says Dr. David Pasco, Assistant Director at NCNPR. The results of this research were published in Planta Medica (Pugh et al, 2001 67(8): ...

PharmAthene Reports Year-End 2007 Financial Results

... the Department of Defense. -- Presenting new mechanistic data for Valortim(TM) showing that Valortim(TM) may possess the ability to enhance macrophage killing of Bacillus anthracis (anthrax) spores within macrophages, potentially blocking the ability of the spores to develop into bacteria and...

Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA

...att Regulski said, "Because of its capability as a debrider, anti-inflammatory, free-radical absorber, odor fighter, and properties for fibroblast and macrophage enhancement, this dressing is incredibly versatile and cost-effective. It takes the place of two or three dressings which saves money, and it is very ...

Amarin Signs Agreement to Acquire Ester Neurosciences

... indirect inhibitory effect on key pro-inflammatory cytokines via modulation of AChE-R, as well as a direct anti-inflammatory effect via modulation of macrophage activity mediated by interaction with the toll-like receptor or TLR signalling pathway. Ester Integration Preparations for the integration of Este...

Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology

..." Zenotech has received three Indian approvals for Oncology Biopharmaceuticals i.e. GCSF (Granulocyte Colony Stimulating Factor), GM-CSF (Granulocyte macrophage Colony Stimulating Factor) and IL-2 (Interleukin-2). For the latter two, Zenotech is the first to receive approvals in India, and has a pipeline of fu...

Macrophage in Biological Definition

Antibody

...tem, because this enables that in different situations only certain immune mechanisms respond to antigens. The humoral immune response When a macrophage ingests a pathogen , it attaches parts of its proteins to a class II MHC protein. This complex is moved to the outside of the cell membrane , w...

Immune system

.../ perforin / apoptosis /clonal selection immunosuppression immunosuppressive drug immunotherapy lymphatic system / lymphocyte macrophage major histocompatibility complex / class I MHC /class II MHC monoclonal antibody / polyclonal antibody ...

Macrophage in Biological Dictionary

Lipid

...by up to 34% and triglycerides by up to 76% while also improving circulatory health. Just $29.95 Nature - the world's best science and medicine ... macrophage lipid droplets: Inert? ... Lipid structure database. Gene/protein database. MS analysis tools ... This is a targeted update of the February 200...