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Macrolide in Medical News

Advanced Life Sciences Announces Posting of Briefing Documents for FDA Advisory Committee Meeting on Restanza(TM) (cethromycin)

...zations occurring annually. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Rib-X Granted Key Antibiotic Patent in China

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the Rx-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus , multidrug-resistant Streptococcus pneumoniae and S. pyogenes . Both delafloxacin and radezolid a...

Sagent Pharmaceuticals Announces U.S. FDA Approval of Azithromycin for Injection

...ld specialty pharmaceutical company, today announced U.S. Food and Drug Administration (FDA) approval of azithromycin for injection, a semi-synthetic, macrolide antibiotic that is used to treat a wide variety of bacterial infections. Sagent will offer azithromycin in a 500 mg vial for intravenous use. The Co...

Long-term antibiotics reduce COPD exacerbations, raise questions

... Long-term use of a macrolide antibiotic may reduce the frequency of exacerbatio..."Our results show a significant effect of low-dose macrolide therapy, reducing exacerbation frequency and sever...his scenario, substantial, widespread emergence of macrolide bacterial resistance is virtually foreordained, wi...

China Pharma Holdings, Inc. Reports Third Quarter 2008 Financial Results and Corporate Updates

...ly generic version of Aleve-D(R) available in China; Buflomedil, a treatment for peripheral blood vessel diseases; Roxithromycin dispersible tablet, a macrolide antibiotic; and Bumetanide, a diuretic approved by the SFDA in January 2008 for the treatment of edema caused by heart disease and hypertension. The C...

Antibiotic treatment targets difficult asthma

...dicine, a top international journal, indicate that macrolide antibiotics could prove a successful therapy in co...ir regular asthma therapy, participants received a macrolide antibiotic (called klacid) or placebo medication f... In this study we have shown that treatment with a macrolide antibiotic for eight weeks significantly reduced i...

Cystic Fibrosis foundation lays out new treatment guidelines

...cacy and safety of the use of aerosolized antibiotics, recombinant human DNase (dornase alfa), hypertonic saline inhalation, anti-inflammatory agents, macrolide antibiotics, the use of bronchodilators and N-acetylcysteine. They analyzed the clinical results with regard to the number of studies, strength of th...

Pharma Major Ind-Swift to Enter US, Japan

...rithromycin active pharmaceutical ingredient (API) manufacturing unit, its managing director N.R. Munjal said here Thursday. Clarithromycin is a macrolide antibiotic molecule used in the treatment of the lower respiratory tract infections. Munjal said the inspection would help the company roll out...

Study Urges Doctors to Go Easy on Antibiotics

...ly conclusive proof of this. Goossens and his team analysed the use of macrolide antibiotics which are widely used drugs in the treatment of ear, throat and lung infections. The scientists, compared two macrolide antibiotics - clarithromycin and azithromycin - against a placebo, or dummy...

SARS: India's drugs in demand

...China and Southeast Asia, which forms the epicenter of the epidemic. China is turning to India at this stage as it traditionally meets some of its macrolide requirements. While medical practitioners are still struggling to find the cure for the killer disease, the macrolides, widely used for trea...
Macrolide in Medical Technology

Advanced Life Sciences Announces Outcome of FDA's Anti-Infective Drugs Advisory Committee Review of Restanza(TM) (cethromycin)

...zations occurring annually. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Rib-X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R&D Directions 100 Great Investigational Drugs of 2009

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the Rx-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus , multidrug-resistant Streptococcus pneumoniae and S. pyogenes . Both delafloxacin and radezolid a...

Abbott and Enanta Initiate Phase 1 Clinical Trial on ABT-450 HCV Protease Inhibitor

...tease, polymerase and cyclophilin-based inhibitors targeted against the Hepatitis C virus (HCV). Additionally, the company has created a new class of macrolide antibiotics, called Bicyclolides, which overcomes bacterial resistance. Antibacterial focus areas include superbugs, respiratory tract infections and...

Biotica Strikes Significant Collaboration Deal With GlaxoSmithKline

...ering technology to produce compounds that are not readily accessible via conventional medicinal chemistry approaches. GSK will apply its expertise in macrolide drug discovery to optimize further the properties of candidate drugs, and will have responsibility for development and commercialisation. Under...

Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the Rx-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus, multidrug-resistant Streptococus pneumonia and S. pyogenes. Additionally, Rib-X is developing delaflox...

Novexel Reports Positive Phase II Trial Results With NXL103 in Adult Patients With Community Acquired Pneumonia

...am positive bacteria including methicillin resistant Staphylococcus aureus (MRSA) as well as the important respiratory pathogens including penicillin, macrolide and quinolone resistant strains. The NXL103 Phase II study was a double-blind, multinational, randomized, comparative study that evaluated this nove...

Rib-X Pharmaceuticals, Inc. Announces Recent and Upcoming Presentations at Scientific Conferences

... Disease: Overcoming Resistance and Extending the Antimicrobial Spectrum of macrolide Antibiotics." In his presentation on August 3 and 4, Dr. Bhattacharjee high...se programs is focused on design and development of an IV and orally active macrolide for treatment of infections in the nursing home and hospital setting, inclu...

Rib-X Pharmaceuticals Initiates Phase 2 Trial for RX-3341 In Complicated Skin and Skin Structure Infections

.... Additionally, the Company has multiple drug discovery programs. The first of these programs is focused on design and development of an orally active macrolide for community use for treatment of skin infections, including those caused by MRSA. The second discovery program is directed towards identifying a new...

Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community- Associated Methicillin Resistant Staphylococcus Aureus (CA-MRSA)

...ctions such as community acquired pneumonia. Macrolides and clindamycin are currently the front-line treatments for respiratory tract infections. As macrolide and clindamycin resistance to current pathogens grows and has the potential to cause more clinical failures, there is a need for new antibiotics with ...

Rib-X Pharmaceuticals Renews Collaborative Agreement with the Medical Research Council

.... Additionally, the Company has multiple drug discovery programs. The first of these programs is focused on design and development of an orally active macrolide for community use for treatment of skin infections, including those caused by MRSA. The second discovery program is directed towards identifying a new...
Macrolide in Biological News

UTSA, Health Science Center collaborate with Merck & Co. to develop chlamydia vaccine

...achomatis infection in females can lead to pelvic inflammatory disease, ectopic pregnancy, serious complications for newborn infants and infertility. macrolide (erythromycin-like) antibiotics can successfully eradicate the pathogen in most patients, but treated individuals are highly susceptible to re-infecti...

UIC scientists discover how some bacteria survive antibiotics

...and activate production of the resistance genes." Erythromycin and newer macrolide antibiotics azithromycin and clarithromycin are often used to treat respira...and gonorrhea. The drugs can be used by patients allergic to penicillin. macrolide antibiotics act upon the ribosomes, the protein-synthesizing factories of t...

Researchers make gains in understanding antibiotic resistance

... of erythromycin ?among the most widely prescribed macrolide antibiotics ?bound to a mutated version of the Hma...ring synthesis. This tunnel is normally blocked by macrolide antibiotics. In the mutant form, the tunnel widens, which may explain why macrolide antibiotics are no longer effective. According ...
Macrolide in Biological Technology

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Radezolid in Community-Acquired Pneumonia

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the RX-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus , multidrug-resistant S. pneumoniae and S. pyogenes . In addition to these internally developed pr...

Advanced Life Sciences Receives Complete Response Letter From FDA for Restanza(TM) (Cethromycin) in Community Acquired Pneumonia

...tions occurring annually. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Rib-X Pharmaceuticals, Inc. Appoints Dr. Russell Greig to Board of Directors

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the Rx-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus , multidrug-resistant Streptococcus pneumoniae and S. pyogenes . For more information on the...

Rib-X Pharmaceuticals Announces Presentations at the 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the RX-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus , multidrug-resistant Streptococcus pneumoniae and S. pyogenes . For more information on the...

Advanced Life Sciences Announces 2008 Fourth Quarter and Full Year Financial Results

...ndard of care treatments. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Rib-X Pharmaceuticals Announces Positive Phase 2 Study Results for Delafloxacin and a $25 Million Financing

... classes of antibiotics active against multi-drug resistant Gram-negative bacteria and the RX-02 discovery program is focused on developing an IV/oral macrolide active against methicillin-resistant S. aureus , multidrug-resistant Streptococcus pneumoniae and S. pyogenes . Both delafloxacin and radezolid a...

Advanced Life Sciences Announces Cethromycin NDA Accepted for Filing by FDA for the Treatment of Community Acquired Pneumonia

...ndard of care treatments. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Advanced Life Sciences Announces Third Quarter 2008 Financial Results

...ent standard of care treatments. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Advanced Life Sciences Announces Second Quarter 2008 Financial Results

...ent standard of care treatments. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...

Advanced Life Sciences Selected as Founding Member of the New NASDAQ OMX AeA Illinois Tech Index

...ent standard of care treatments. Macrolides and penicillins are currently the front-line treatments for respiratory tract infections such as CAP. As macrolide and penicillin resistance grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of a...
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