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MYC in Medical News

Risk of cancer

... pathways that are central to the development of cancer. The impacts of this altered genetic regulation on cell division are probably mediated via the myc cancer gene, which is one of the best known accelerator genes in cancer. Single-base changes are the most common type of variation found in the hum...

Scripps Research cancer biology department awarded more than $8 million in new research grants

...the regulation and role of the enzyme ornithine decarboxylase (Odc). This enzyme plays key roles in cancer and is directly regulated by cancer-causing myc oncoproteins and also by mutated Ras oncogenes, which together are activated in more than 80 percent of all human tumors. This new study focuses on de...

Cancer-Causing Gene Discovery Suggests New Therapies

...ion. But the new research shows that this altered myc gene, called an oncogene, can also act directly on... trials for cancer, might help treat cancers where myc is over active, the scientists suggest. The di... on the paper with Barna. "The ability of the myc oncogene to directly alter this process may well e...

Stopping ovarian cancer by blocking proteins coded by notorious gene

...by the notorious oncogene, MYC, and blocking these myc proteins halts cell proliferation in the deadliest...isco. In 30-60 percent of human ovarian tumors, myc is overly active, or amplified, usually as a resu...l copies of the cancer-causing gene. The extra myc encourages the ovarian cells to manufacture too mu...

Blocking Oncogene Can Stop Spread of Ovarian Cancer

...ews) -- Blocking proteins produced by the oncogene myc can stop the spread of ovarian cancer, researchers...r. In up to 60 percent of human ovarian tumors, myc is overly active. This causes the ovarian cells to...tures of human ovarian cancer cells with amplified myc by using RNA interference (RNAi) to block c-Myc pr...

Dormant stem cells for emergencies

...ed blood cells. This result is not only relevant for our understanding of stem cells, but it also explains the damage that can be caused by overactive myc genes. Trumpp explains: "In tumors, too, c-Myc and N-Myc are presumably responsible for the self-renewal of cancer stem cells and, thus, for uncontrol...

CSHL scientists show how a protein that determines cell polarity prevents breast cancer

...sent in abnormal quantity, in human breast cancer. myc is known to activate pathways of both growth and d.... In fact, the only way that cancer can occur when myc is overexpressed is if some other mechanism blocks... by the CSHL team to lack Scribble and overexpress myc not only stayed alive, but also went into a growth...

Cold Spring Harbor science teams identify 13 new tumor-suppressor genes in liver cancer

...d to over-produce a cancer gene product called Myc. In cells with these myc mutations, an additional "trigger" such as the shutting off of a tumor supp...Ai would be sufficient to cause cancer. The engineered cells that carried a myc mutation and an shRNA were injected into mice. Dramatically, those that rec...

Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis

...an 75 percent reduction in cell migration. Cells turned cancerous by the oncogene ErbB2 showed a 50 percent drop in migration. Cells made cancerous by myc also had 50 percent less migration. The researchers performed a proteomic analysis, testing the expression of many proteins at once to see which mi...

Scientists Find Way to Dim Cancer Switch

...this push, cancer can develop." A gene known as myc is considered a major player in this process. At t...eered mice to develop a way to slightly adjust the myc switch instead of turning it on or off. The stu... The researchers found that by turning down the myc switch, like using a dimmer switch on a lamp, they...

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MYC in Biological News

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

Philadelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB). B-cell lymphoma is a cancer in whi...

Cancer: Another step towards medication

... release is available in German . The gene myc is an important factor for the growth of organisms...m is that pharmacological substances do not target myc as it does not have enzymatic activity of its own....For the first time, the scientists have shown that myc suppresses the expression of the gene BASP1. This ...

CSHL scientists find a new class of small RNAs and define its function

..., the question naturally arises: what do they do? Using a human gene called myc as a model, the team studied how the presence of PASRs at the start site of...t if the level of expression of PASRs was increased, the expression of the myc gene was reduced. PASRs thus seem to modulate the production of mature RNA ...

Cancer-causing gene discovery suggests new therapies

...ion. But the new research shows that this altered myc gene, called an oncogene, can also act directly on... trials for cancer, might help treat cancers where myc is over active, the scientists suggest. The dis...uthor on the paper with Barna. "The ability of the myc oncogene to directly alter this process may well e...

St. Jude defines eye cancer gene's role in retinal development

... This represents the first example of a role for a myc gene in retinal development, Dyer said. On the bas...ith eye growth during development. Genes in the myc family carry out vital roles during prenatal devel...tion, size, differentiation and survival of cells. myc genes are also proto-oncogenesgenes in which a mut...

University of Pennsylvania researchers zero in on the tiniest members in the war on cancer

...us. As reported in Nature Genetics this week, the myc protein can stop the production of at least 13 mic...a cells. Mendells team had previously found that myc could turn on one particular group of growth-promo...ma cells. In those cells that had high amounts of myc protein, the researchers found significant change...

Spelling out cancer on the nanoscale

...ork, the Felsher group had shown that inactivating myc induces sustained tumor regression in mice. The re...ar lymphoma. The nano-fluidic system reported that myc was overexpressed in Burkitt’s, while BCL2 was ove... Western blots were performed to confirm BCL-2 and myc levels. "Our strategy can be used to repeti...

Once given 'no respect,' cells' tiny RNAS take driver's seat

...flies and are off-kilter in human cancers, but the myc protein is the first factor identified that controls the production of microRNAs. myc (pronounced "mick") is already known to regulate a...he extent to which they are used to make proteins. myc also is faulty and overactive in many human cancer...
MYC in Biological Dictionary

Oncogene

... a gene that disposes normal cells to change into cancerous ... The proto- oncogene c-myc in hematopoietic development and leukemogenesis. ... myc oncogene involved in a t(8;22) ... MeSH myc+Proto- Oncogene +Proteins ... Definition and other additional information on Oncogene from Biology-...

Expression Vector

...s (see figure at right) ... The Forsburg lab pombe pages: directory of fission yeast plasmids ... full strength nmt expression vector with 12x myc tag fusion at C-terminus. ... 37000 Full Length TrueORF cDNA clones from Origene. ... Cloning and Expression Vectors . DNA Kits ... Gene Expr...

Chromatin

...ell with a ... Chromatin is DNA "packaged" with histones and other proteins. ... The mechanisms underlying this global chromatin function of myc remain to be ... Today, the word " chromatin " is mostly used by molecular geneticists to describe ... Chromatin modifications including cytosin...
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